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Post-transcriptional regulation of seed dormancy and germination: Current understanding and future directions

Plant Communications 2021年第4期2卷 1-22页

作者： Rocío Soledad Tognacca javier Francisco Botto Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de FisiologíaBiología Molecular y Neurociencias(IFIBYNE)Facultad de Ciencias Exactas y NaturalesCP1428 Buenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Investigaciones Fisiològicas y Ecològicas Vinculadas a la Agricultura(IFEVA)Facultad de AgronomíaCP1417 Buenos AiresArgentina

Seed dormancy is a developmental checkpoint that prevents mature seeds from germinating under conditions that are otherwise favorable for *** and light are themost relevant environmental factors that regulate seed dormancy and *** environmental cues can trigger molecular and physiological responses including hormone signaling,particularly that of abscisic acid and *** balance between the content and sensitivity of these hormones is the key to the regulation of seed *** and light tightly regulate the transcription of thousands of genes,as well as other aspects of gene expression such asmRNAsplicing,translation,and *** remodeling determines specific transcriptional outputs,and alternative splicing leads to different outcomes and produces transcripts that encode proteins with altered or lost *** regulation of chromatin remodeling and alternative splicing may be highly relevant to seed ***,microRNAs are also critical for the control of gene expression in *** review aims to discuss recent updates on post-transcriptional regulation during seed maturation,dormancy,germination,and post-germination *** propose future prospects for understanding howdifferent post-transcriptional processes in crop seeds can contribute to the design of genotypes with better performance and higher productivity.

关键词： alternative splicing chromatin remodeling dormancy germination microRNA(miRNA) seeds

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Modeling of titration experiments by a reactive transport model

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Mining Science and Technology 2011年第2期21卷 273-276页

作者： Ma Hongyun Samper javier Xin Xin Xi＇an Center of Geological Survey Xi＇an 710054 China Civil Engineering School University of A Corufia A Coruria 15008 Spain School of Environment and Resources Jilin university Changchun 130026 China

Acid mine drainage（AMD） is commonly treated by neutralization with alkaline *** treatment is supported by titration experiments that illustrate the buffering mechanisms and estimate the base neutralization capacity（BNC） of the *** explanation of titration curves requires modeling with a hydro-chemical *** this study the titration curves of water samples from the drainage of the As Pontes mine and the corresponding dumps have been investigated and six buffers are selerted by analyzing those *** curves have been simulated by a reactive transport model to discover the detailed buffering *** simulations show seven regions involving different buffering *** BNC is primarily from buffers of dissolved Fe,Al and hydrogen *** BNC can be approximated by：BNC = 3（C_（Fe）＋ C_（Al））＋ 0.05C_（sulfate）,where the units are mol/*** BNC of the sample from the mine is 9.25×10^（-3） mol/L and that of the dumps sample is 1.28×10^（-2） mol/L

关键词： Titration experiment Reactive transport model Buffering mechanism Base neutralization capacity

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Long-term survival after liver transplantation for alcoholic liver disease

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World Journal of Gastroenterology 2013年第48期19卷 9198-9208页

作者： Paula Iruzubieta javier Crespo Emilio Fábrega Gastroenterology and Hepatology Unit Marqués de Valdecilla University Hospital Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV) 39008 Santander Cantabria Spain

Currently,alcoholic cirrhosis is the second leading indication for liver transplantation in the United States and *** quality of life and survival after a liver transplantation(LT)in patients with alcoholic liver disease(ALD)are similar to those in patients with other cirrhosis *** alcoholic relapse rate after a LT varies from 10%-50%,and these relapse patients are the ones who present a reduced long-term survival,mainly due to cardiovascular diseases and the onset of de novo neoplasms,including lung and upper aerodigestive *** 40%of ALD recipients resume smoking and resume it early ***,our pre-and post-LT follow-up efforts regarding ALD should be focused not only on alcoholic relapse but also on treating and avoiding other modifiable risk factors such as *** psychiatric and psychosocial pre-LT evaluation and the post-LT follow-up with physicians,psychiatrists and addiction specialists are important for reversing these problems because these professionals help to identify patients at risk for relapse as well as those patients who have relapsed,thus enabling responsive actions.

关键词： Alcoholic liver disease Alcohol recidivism Alcohol relapse prevention Long term survival Liver transplantation

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Transverse　Dimension　of　R^n　Actions　on　Compact　Foliated　Manifolds

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Chinese Quarterly Journal of Mathematics 1995年第4期10卷 86-97页

作者： Francisco javier Geometria Y

Consider a foliate Rn-action on a compact connected foliated manifold (M,F). Let mand r be the codimension of F and the (transverse)rank of (M,F)respectively. Suppose r<*** this paper we prove that either there exists an orbit of the Rn-action of transverse dimension< (m + r)/2 or F can be arbitrarily approached by foliations with rank≥r+1. Moreover weshow that this kind of orbits exists in the following three cases: if F is Riemannian ;when all itsleaves are closed or if X(M)≠0(then r=0).On the other hand all foliate Rn-action on (S3,F) has a fixed leaf if dimF=*** result generalies a well known Lima's theorem about Rn-actions on surfaces.

关键词： transverse action foliation

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Dermic-derived fibroblasts for the study of amyotrophic lateral sclerosis

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Neural Regeneration Research 2020年第11期15卷 2043-2044页

作者： javier Riancho Sara Arozamena Adolfo Lopez de Munain Service of Neurology Hospital Sierrallana-IDIVALTorrelavegaSpain Department of Medicine and Psychiatry University of CantabriaSantanderSpain Centro de Investigacion en Red de Enfermedades Neurodegenerativas Instituto Carlos IIIMadridSpain Neurosciences Area Biodonostia Research InstituteService of NeurologyHospital Universitario DonostiaDepartment of NeurosciencesSchool of Medicine and NurseryUniversity of the Basque CountrySan SebastianSpain

Among neurodegenerative diseases,amyotrophic lateral sclerosis(ALS)is the most frequent one involving motor neurons(MNs).ALS incidence varies throughout the world ranging from 0.7 to 4 cases per 100,000 habitants and year(Riancho et al.,2016).This disease,which currently lacks an effective therapy,is characterized by a variable combination of upper and lower MN degeneration,leading to progressive muscle wasting which usually results in a terminal respiratory failure within 3 years after symptom onset(Zufiria et al.,2016).A small proportion of ALS cases show familial *** are related to mutations in specific causative genes(Cr9ORF72,TARDBP,FUS,SOD1 and others)which directly determine disease onset in *** contrast,more than 90 percent of cases are considered to be sporadic,in which generally unknown environmental and internal factors interact with genetic predisposing factors finally leading to disease(Riancho et al.,2018).From a histopathological point of view,ALS is characterized by MN damage and *** from ALS sporadic and most of familial patients exhibit prominent transactive response DNA-binding protein 43(TDP-43)cytoplasmic aggregates which are considered as the“pathological hallmark”of the disease,excepting those related to SOD1 and FUS mutations(Zufiria et al.,2016).TDP-43 is a DNA/RNA binding protein encoded by the TARDBP gene that controls the expression of many different genes.

关键词： al. amyotrophic degeneration

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Benchmarking Approach to Compare Web Applications Static Analysis Tools Detecting OWASP Top Ten Security Vulnerabilities

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Computers, Materials & Continua 2020年第9期64卷 1555-1577页

作者： Juan R.Bermejo Higuera javier Bermejo Higuera Juan A.Sicilia Montalvo javier Cubo Villalba Juan JoséNombela Pérez Escuela Superior de Ingeniería y Tecnología Universidad Internacional de La RiojaLa Rioja26006Spain

To detect security vulnerabilities in a web application,the security analyst must choose the best performance Security Analysis Static Tool(SAST)in terms of discovering the greatest number of security vulnerabilities as *** compare static analysis tools for web applications,an adapted benchmark to the vulnerability categories included in the known standard Open Web Application Security Project(OWASP)Top Ten project is *** information of the security effectiveness of a commercial static analysis tool is not usually a publicly accessible research and the state of the art on static security tool analyzers shows that the different design and implementation of those tools has different effectiveness rates in terms of security *** the significant cost of commercial tools,this paper studies the performance of seven static tools using a new methodology proposal and a new benchmark designed for vulnerability categories included in the known standard OWASP Top Ten ***,the practitioners will have more precise information to select the best tool using a benchmark adapted to the last versions of OWASP Top Ten *** results of this work have been obtaining using widely acceptable metrics to classify them according to three different degree of web application criticality.

关键词： Web application benchmark security vulnerability Security Analysis Static Tools assessment methodology false positive false negative precision f-measure

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Improved organs at risk segmentation based on modified U‐Net with self‐attention and consistency regularisation

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 850-865页

作者： Maksym Manko Anton Popov Juan Manuel Gorriz javier Ramirez Electronic Engineering Department Igor Sikorsky Kyiv Polytechnic InstituteKyivUkraine Department of Signal Theory Telematics and CommunicationsUniversity of GranadaGranadaSpain

Cancer is one of the leading causes of death in the world,with radiotherapy as one of the treatment *** planning starts with delineating the affected area from healthy organs,called organs at risk(OAR).A new approach to automatic OAR seg-mentation in the chest cavity in Computed Tomography(CT)images is *** proposed approach is based on the modified U‐Net architecture with the ResNet‐34 encoder,which is the baseline adopted in this *** new two‐branch CS‐SA U‐Net architecture is proposed,which consists of two parallel U‐Net models in which self‐attention blocks with cosine similarity as query‐key similarity function(CS‐SA)blocks are inserted between the encoder and decoder,which enabled the use of con-sistency *** proposed solution demonstrates state‐of‐the‐art performance for the problem of OAR segmentation in CT images on the publicly available SegTHOR benchmark dataset in terms of a Dice coefficient(oesophagus-0.8714,heart-0.9516,trachea-0.9286,aorta-0.9510)and Hausdorff distance(oesophagus-0.2541,heart-0.1514,trachea-0.1722,aorta-0.1114)and significantly outperforms the *** current approach is demonstrated to be viable for improving the quality of OAR segmentation for radiotherapy planning.

关键词： 3‐D computer vision deep learning deep neural networks image segmentation medical image processing object segmentation

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Feeding on clean food?Potential effects of electric organ discharges by Torpedo spp.(Torpediniformes:Torpedinidae)on their trophically transmitted parasites

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Integrative Zoology 2022年第2期17卷 234-245页

作者： Jaime PENADÉS-SUAY Tania REGACHO Francisco javier AZNAR Marine Zoology Unit Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValènciaSpain LAMNA Association for the study of elasmobranchs from the Valencian Community ValènciaSpain

Members of the Torpedinidae(torpedoes)and Hypnidae(coffin ray)use electric organ discharges(EOD)to stun or kill their prey before *** investigated whether EOD could also negatively affect the helminth larvae infecting these preys through a surrogate model:we applied electric discharges to individuals of blue whiting,Micromesistius poutassou,that harbored live larvae of *** mortality throughout a 6-h period was significantly higher in the treatment group,suggesting that EODs could significantly hamper helminth *** then tested whether torpedinids and hypnids(“strong-EOD”families)harbored species-poor helminth(cestode)assemblages compared with“weak-EOD”Torpediniformes(Narcidae and Narkidae)and other *** on comparisons on estimated species diversity and mean species richness of tapeworms at host individual level we found that(i)Torpediniformes had the lowest tapeworm diversity of all Batoidea orders;(ii)Torpedo *** had the lowest mean cestode richness at host individual level,and this could not be related to other host factors influencing cestode diversity in chondrichthyans,that is body size,trophic level or dietary ***,a preliminary comparison between“strong-EOD”and“weak-EOD”Torpediniformes did not detect clear differences of cestode ***,evidence supporting an unambiguous contribution of EODs to depauperate cestode assemblages requires further research.

关键词： Anisakis Batoidea cestode EOD behavior Torpediniform Torpedo

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Simulated predation pressure in Pelobates Cultripes tadpoles modulates morphology at the metamorphic stage

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Current Zoology 2019年第6期65卷 651-656页

作者： Francisco javier ZAMORA-CAMACHO Susana Cortes-MANZANEOUE Pedro ARAGON Museo Nacional de Ciencias Naturales(MNCN-CSIC) MadridSpain

Studies on the impacts of variation of biotic interactions at key life cycle stages are crucial to understand the interface between ecological and developmental *** exert a major impact on prey *** direct consumption entails the greatest effect,predators can affect prey by means of other *** instance,injuries inflicted by failed predation attempts can jeopardize prey fitness,even beyond the *** anuran tadpoles,failed predation typically results in partial tail loss,which is known to reduce swimming ***,the potential consequences of tadpole partial tail loss after metamorphosis remain *** tail materials could be important in conforming metamorph body,we assess the effects of tadpole partial tail loss on metamorph body size in Iberian spadefoot toads Pelobates *** clipped 55%tail length of pre-tail-resorption stage anesthetized tadpoles,and compared their body size as metamorphs with anesthetized and non-anesthetized non-tail-clipped ***,we tested whether tail length correlated with metamorph body size of individuals of the control *** tadpoles produced smaller metamorphs than both controls(the bdy size of metamorphs from both controls was similar),which could incur costs in mid-term survival or time to first *** effect could be particularly important in areas with introduced predators,if autochthonous tadpoles lack defenses against *** suggest that materials resorbed from tadpole tail tissues might be reallocated into metamorph body,according to the negative effect of shorter tails in a correlational analysis,and clipped tails in an experimental test,on metamorph body size.

关键词： amphibian anuran body condition body size failed predation partial tail loss

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Analysis of the cryptocurrency market using different prototype-based clustering techniques

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Financial Innovation 2022年第1期8卷 141-186页

作者： Luis Lorenzo javier Arroyo Un iversidad Complute nse de Madrid Facultad de Estudios Estadisticos Madrid MadridSpain

Since the emergence of Bitcoin,cryptocurrencies have grown significantly,not only in terms of capitalization but also in ***,the cryptocurrency market can be a conducive arena for investors,as it offers many ***,it is difficult to *** study aims to describe,summarize,and segment the main trends of the entire cryptocurrency market in 2018,using data analysis ***-ingly,we propose a new clustering-based methodology that provides complementary views of the financial behavior of cryptocurrencies,and one that looks for associations between the clustering results,and other factors that are not involved in ***,the methodology involves applying three different partitional clustering algorithms,where each of them use a different representation for cryptocurrencies,namely,yearly mean,and standard deviation of the returns,distribution of returns that have not been applied to financial markets previously,and the time series of *** each representation provides a different outlook of the market,we also examine the integration of the three clustering results,to obtain a fine-grained analysis of the main trends of the *** conclusion,we analyze the association of the clustering results with other descriptive features of cryptocurrencies,including the age,technological attributes,and financial ratios derived from *** will help to enhance the profiling of the clusters with additional descriptive insights,and to find associations with other ***,this study describes the whole market based on graphical information,and a scalable methodology that can be reproduced by investors who want to understand the main trends in the market quickly,and those that look for cryptocurrencies with different financial *** our analysis of the 2018 and 2019 for extended period,we found that the market can be typically segmented in few clusters(five or less),and even considering the

关键词： Fintech Unsupervised machine learning Cryptocurrency Electronic market Clustering Investment portfolios

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