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Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Mental health in the virtual world:Challenges and opportunities in the metaverse era

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World Journal of Clinical Cases 2024年第17期12卷 2939-2945页

作者： Yolanda López del Hoyo Matilde Elices javier garcia-Campayo Department of Psychology and Sociology University of ZaragozaZaragoza 50009Spain Mental Health Research Group Hospital del Mar Medical Research InstituteBarcelona 08003Spain Department of Psychiatry Miguel Servet HospitalAragon Institute for Health ResearchUniversity of ZaragozaZaragoza 50009Spain

Current rates of mental illness are *** illness mainly affects females and younger age *** use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the *** intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the *** will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health *** this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.

关键词： Metaverse Virtual world Artificial intelligence Mental health Virtual reality Augmented reality Technology

A Sustained Force for Economic Growth

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Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma

CHINA TODAY 2024年第5期 42页

作者： javier garcia

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Cancer Drug Resistance 2022年第1期5卷 184-198页

作者： Camille Jubelin javier Munoz-garcia Denis Cochonneau Emilie Moranton Marie-Francoise Heymann Dominique Heymann CNRS US2BUMR 6286Nantes UniversiteBiological Sciences and Biotechnologies unitNantes 44000France Institut de Cancerologie de l’Ouest “Tumor Heterogeneity and Precision Medicine”LaboratorySaint-Herblain 44805France Atlantic Bone Screen Saint-Herblain 44800France Department of Oncology and Metabolism University of SheffieldMedical SchoolSheffield S102RXUK

Sarcomas are a large family of cancers originating in the *** of more than 100 histological subtypes,soft tissue and bone sarcomas remain clinically challenging,particularly in children and adolescents in whom sarcomas are the second most common malignant *** is the main primary bone tumor in adolescents and young adults and is characterized by a high propensity to induce distant metastatic foci and become multi-drug *** innate and acquired resistance of osteosarcoma can be explained by high histological heterogeneity and genetic/molecular *** the last decade,the notion of cancer stem-like cells(CSCs)has *** subset of cancer cells has been linked to drug resistance properties,recurrence of the disease,and therapeutic *** CSCs remain controversial,many elements are in favor of them playing a role in the development of the drug resistance *** present review gives a brief overview of the most recent biological evidence of the presence of CSCs in osteosarcomas and their role in the drug resistance profile of these rare oncological *** use as promising therapeutic targets is discussed.

关键词： Cancer stem cells bone sarcoma soft tissue sarcoma drug resistance tumor microenvironment recurrent disease residual disease

Atrial fibrillation in the elderly： predisposing factors and management

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Journal of Geriatric Cardiology 2017年第3期14卷 185-194页

作者： Juan Lacalzada-Almeida javier garcia-Niebla Department of Cardiology Hospztal Umversitarlo de Canarias Tenerife Spain Servicios Sanitarios del Area de Salud de El Hierro Valle del Golfo Health Center El Hierro Spain

In the last twenty years, new imaging techniques to assess atrial function and to predict the risk of recurrence of atrial fibrillation after treatment have been developed. The present review deals with the role of these techniques in the detection of structural and functional changes of the atrium and diagnosis of atrial remodeling, particularly atrial fibrosis. Echocardiography allows the detection of anatomical, functional changes and deformation of the atrial wall during the phases of the cardiac cycle. For this, adequate acquisition of atrial images is necessary using speckle tracking imaging and interpretation of the resulting strain and strain rate curves. This allows to predict new-onset atrial fibrillation and recurrences. Its main limitations are inter-observer variability, the existence of different software manufacturers, and the fact that the software used were originally developed for the evaluation of the ventricular function and are now applied to the atria. Cardiac magnetic resonance, using contrast enhancement with gadolinium, plays a key role in the visualization and quantification of atrial fibrosis. This is the established method for visualization of myocardial fibrotic tissue. The non-invasive evaluation of atrial fibrosis is associated with the risk of recurrence of atrial fibrillation and with electro-anatomical endocardial mapping. We discuss the limitations of these techniques, derived from the difficulty of demonstrating the correlation between fibrosis imaging and histology, and poor intra- and inter-observer reproducibility. The sources of discordance are described, mainly due to image acquisition and processing, and the challenges ahead in an attempt to eliminate differences between operators.

关键词：心房诱发因素老年人心肌纤维化可视化方法成像技术颤动超声心动图

Data model extension for security event notification with dynamic risk assessment purpose

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Science China(Information Sciences) 2013年第11期56卷 36-44页

作者： David LOPEZ Oscar PASTOR Luis javier garcia VILLALBA Group of Analysis Security and Systems (GASS) Department of Software Engineering and Artificial Intelligence (DISIA) School of Computer Science Universidad Complutense Madrid 28040 Spain

Dynamic risk assessment refers to a risk management framework where frequent updates of risk evaluation information are used to evaluate risk exposure,as close as possible to *** this paper,we present the incident object description exchange format extended model for dynamic risk *** format attempts to overcome the absence of integration and real-time communication between security systems and risk assessment *** model is based on the incident object definition exchange format,which is commonly used in the computer security incident response teams *** data model aims to facilitate a global vision of information systems risk by supplying real-time security events data to risk assessment tools based on renowned *** present a proof-of-concept scenario to demonstrate the usefulness of this integration and the proposed data model,and discuss the expected improvements.

关键词： dynamic risk assessment risk management DRA IODEF-DRA IODEF.

Assessment of Technical and Economic Impacts of EV User Behavior on EV Aggregator Smart Charging

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 356-366页

作者： Jean-Michel Clairand javier Rodriguez-garcia Carlosalvarez-Bel the Facultad de Ingenieria y Ciencias Agropecuarias Universidad de las Americas-Ecuador170122 QuitoEcuador the Institute for Energy Engineering Universitat Politecnica de Valencia46022 ValenciaSpain

The increase in global electricity consumption has made energy efficiency a priority for ***,there has been a focus on the efficient integration of a massive penetration of electric vehicles(EVs)into energy *** study presents an assessment of various strategies for EV *** this analysis,the smart charging methodology proposed in a previous study is *** smart charging technique employs charging power rate modulation and considers user *** adopt several strategies,this study simulates the effect of these actions in a case study of a distribution system from the city of Quito,*** actions are simulated,and the EV aggregator costs and technical conditions are evaluated.

关键词： Electric vehicle(EV) smart grid aggregator smart charging charging power modulation charging strategies

Quantum nonlocal effects in individual and interacting graphene nanoribbons

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Light(Science & Applications) 2015年第1期4卷 513-517页

作者： Ivan Silveiro Juan Manuel Plaza Ortega F javier garcia de Abajo ICFO-Institut de Ciencies Fotoniques Mediterranean Technology Park08860 Castelldefels(Barcelona)Spain ICREA-Institucio Catalana de Recerca i Estudis Avanc¸ats Passeig Lluis Companys 2308010 BarcelonaSpain

We show that highly doped graphene ribbons can support surface plasmons at near-infrared frequencies when their width is in the nanometer range,leading to important nonlocal and finite quantum-size corrections,such as sizable *** magnitude of these effects is assessed by comparing classical and quantum-mechanical models to describe graphene *** precisely,we examine individual and interacting 6–8 nm wide zigzag and armchair ribbons doped to 0.4–1.5 eV Fermi *** find a strong influence of nonlocal effects on the orientation of graphene edges,with plasmons in zigzag ribbons undergoing strong quenching when their energy is below the Fermi *** is also affecting the hybridization between ribbon plasmons in dimers and arrays for separations below a few ***,the removal of a single row of atomic bonds in a ribbon produces a strong plasmon frequency shift,whereas the removal of bonds along an array of rows separated by several nanometers in an extended sheet causes a dramatic increase in the *** the fundamental interest of these results,our work supports the use of narrow ribbons to achieve electro-optical modulation in the near infrared.

关键词： graphene graphene plasmons graphene ribbons metamaterials plasmonics

Thermal manipulation of plasmons in atomically thin films

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Light(Science & Applications) 2020年第1期9卷 1179-1189页

作者： Eduardo J.C.Dias Renwen Yu F.javier garcia de Abajo ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860 Castelldefels(Barcelona)Spain ICREA-Institucio Catalana de Recerca i Estudis Avançats Passeig Lluis Companys 2308010 BarcelonaSpain

Nanoscale photothermal effects enable important applications in cancer therapy,imaging and *** effects also induce substantial changes in the optical response experienced by the probing light,thus suggesting their application in all-optical ***,we demonstrate the ability of graphene,thin metal films,and graphene/metal hybrid systems to undergo photothermal optical modulation with depths as large as>70%over a wide spectral range extending from the visible to the terahertz frequency *** envision the use of ultrafast pump laser pulses to raise the electron temperature of graphene during a picosecond timescale in which its mid-infrared plasmon resonances undergo dramatic shifts and broadenings,while visible and near-infrared plasmons in the neighboring metal films are severely attenuated by the presence of hot graphene *** study opens a promising avenue toward the active photothermal manipulation of the optical response in atomically thin materials with potential applications in ultrafast light modulation.

关键词： pump visible films