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RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING

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Acta Metallurgica Sinica(English Letters) 2000年第2期13卷 439-445页

作者： D.N.He X.F.yin H.Z.Thao D.Lv X.y.Ruan j.L.Cheng j.y.jiang Shanghai jiao Tong University National Die&Mold CAD E.R.CShanghai 200030China Shanghai Vopkswagen Automotive Company Ltd. Shanghai 201805China

The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail.

关键词： deep drawing probe test method friction and lubrication evaluation method

A STUDy OF SUPERCONDUCTIVITy IN y-Ba-Cu-F-0 SySTEM

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Chinese Physics Letters 1988年第2期5卷 57-60页

作者： j.H.jia j.y.jiang G.R.Liu y.M.Gao Q.Q.Zheng j.j.Du W.G.yao Institute of Solid Sta te Phsics Academia SinicaHefei

High temperature superconductivity,up to 258K,was observed in the y_(1)Ba_(2)Cu_(3)F_(2x)O_(7-x-δ)(0.2≤x≤1)bulk materials prepared by means of conventional ceramic-technique.X-ray diffraction analysis shows that these materials are *** is believed that to obtain a high Tc superconducting material with Tc near room temperature is possible,though the high Tc state of samples is now very unstable.

关键词： technique ceramic SUPER

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong jiang-Shan Huang Fei-Long Guo jing-yu Wu Mao-Xiu yuan jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-yang Zhang jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from january 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

Motion of the moonlet in the binary system 243 Ida

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Acta Mechanica Sinica 2018年第1期34卷 214-224页

作者： L.Lan y.Ni y.jiang j.Li School of Aerospace Engineering Tsinghua University State Key Laboratory of Astronautic Dynamic Xi'an Satellite Control Center

The motion of the moonlet Dactyl in the binary system 243 Ida is investigated in this paper. First, periodic orbits in the vicinity of the primary are calculated, including the orbits around the equilibrium points and large-scale orbits. The Floquet multipliers’ topological cases of periodic orbits are calculated to study the orbits’ stabilities. During the continuation of the retrograde near-circular orbits near the equatorial plane, two period-doubling bifurcations and one Neimark–Sacker bifurcation occur one by one, leading to two stable regions and two unstable regions. Bifurcations occur at the boundaries of these regions. Periodic orbits in the stable regions are all stable, but in the unstable regions are all unstable. Moreover, many quasi-periodic orbits exist near the equatorial plane. Long-term integration indicates that a particle in a quasi-periodic orbit runs in a space like a tire. Quasi-periodic orbits in different regions have different styles of motion indicated by the Poincare sections. There is the possibility that moonlet Dactyl is in a quasi-periodic orbit near the stable region I, which is enlightening for the stability of the binary system.

关键词： Binary system Bifurcation Periodic orbits Quasi-periodic orbits

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-yi yan Ke-Hui Zhang Di Zhang Xi-Mao Cui Xiao-Hua jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

EFFECT OF CARBON MIGRATION ON CREEP PROPERTIES OF Cr5Mo DISSIMILAR WELDED jOINTS WITH Ni-BASED AND AUSTENITIC WELD METAL

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Acta Metallurgica Sinica(English Letters) 2004年第4期17卷 560-568页

作者： j.M.Gong y.jiang S.T.Tu Nanjing University of Technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 China East China University of Science and Technology Shanghai 200237 China

In this paper, the effect of carbon migration on creep properties of Cr5Mo dissimilar welded joints with Ni-based (Inconel 182) and Cr23Nil3 (A302) austenitic weld metal was investigated. Carbon migration near the weld metal/ferritic steel interface of Cr5Mo dissimilar welded joints was analyzed by aging method. Local creep deformations of the dissimilar welded joints were measured by a long-term local creep deformation measuring technique. The creep rupture testing was performed for Cr5Mo dissimilar welded joints with Inconel 182 and A302 weld metal. The research results show that the maximum creep strain rate occurs in the decarburized zone located on heat affect zone (HAZ) of Cr5Mo ferritic steel. The creep rupture life of Cr5Mo dissimilar welded joints with A 302 weld metal decreases due to carbon migration and is about 50% of that welded with Inconel 182 weld metal.

关键词： dissimilar welded joint carbon migration creep rupture localized deformation

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： yiyang Qin Wenzhen Zhu Tingting Guo yiran Zhang Tingting Xing Peng yin Shihua Li Xiao-jiang Li Su yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Training β relaxation to rejuvenate metallic glasses

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journal of Materials Science & Technology 2023年第27期158卷 53-62页

作者： L.T.Zhang yun-jiang Wang y.yang j.C.Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong Kong SARChina Department of Materials Science and Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong Kong SARChina Innovation Center NPU-ChongqingChongqing 401135China

In the current work,we demonstrated that the rejuvenation of metallic glasses can be achieved through training theβrelaxation *** the increase in the training frequency,a transition from structural relaxation to rejuvenation can be *** rejuvenation treatment is unexpected due to it occurs at a relatively small cyclic strain of 0.2%.Rejuvenation is beneficial to increase the relaxation enthalpy and promotes the decoupling of theβrelaxation process andαrelaxation process.A cluster ofβrelaxation time curves are formulated to describe any energetic state between ultrastable and ultimately rejuvenated metallic *** addition,rejuvenation expands the distribution ofβrelaxation process,anelastic and viscoplastic components during the deformation process.

关键词： Metallic glass βrelaxation Rejuvenation Structural heterogeneity