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Optimization of performance of the KM2A full array using the Crab Nebula

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Chinese Physics C 2024年第6期48卷 169-178页

作者：曹臻 F.Aharonian 安琪阿西克古白云翔包逸炜 D.Bastieri 毕效军毕玉江蔡金庭曹晴曹文羽曹喆常进常劲帆陈尚明陈恩生陈亮陈林陈龙陈明君陈玛丽陈起辉陈素弘陈天禄陈阳程宁程耀东崔明阳崔树旺崔晓红崔昱东戴本忠代洪亮戴子高单增罗布 D.della Volpe 董绪强段凯凯樊军辉范一中方军方堃冯存峰封莉冯少辉丰晓婷冯有亮 S.Gabici 高博高川东高林青高启高卫高伟康葛茂茂耿利斯 G.Giacinti 龚光华苟全补顾旻皓郭福来郭晓磊郭义庆郭莹莹韩毅昂何会海贺昊宁何佳银何新波何钰 M.Heller 贺远强侯博文侯超侯贤胡红波胡铨胡世聪黄代绘黄天奇黄文俊黄性涛黄晓渊黄勇黄志成季筱璐贾焕玉贾康江琨姜晓巍姜泽军金敏康明铭柯通 D.Kuleshov.K.Kurinov 李兵兵李澄李骢李丹李飞李海波李会财李华阳李军李剑李捷李凯李文龙李文莲李秀荣李昕李一卓李哲黎卓梁恩维梁云峰林苏杰刘冰刘成刘栋刘虎刘海东刘佳刘江来刘金艳刘茂元柳若愚刘四明刘伟刘怡刘以农鲁睿罗晴吕洪魁马伯强马玲玲马欣华毛基荣闵振 W.Mitthumsiri 穆慧君南云程 A.Neronov 区子维庞彬宇 P.Pattarakijwanich 裴致远齐孟尧祁业情乔冰强秦家军 D.Ruffolo A.Sáiz D.Semikoz 邵澄宇邵琅 O.Shchegolev 盛祥东舒富文宋慧超 Yu.V.Stenkin V.Stepanov 苏扬孙秦宁孙晓娜孙志斌谭柏轩唐庆文唐泽波田文武王超王昌贝王广威王洪光王惠惠王建成汪凯王利苹王玲玉王培汉王冉王为王祥高王祥玉王阳王玉东王岩谨王忠海王仲翔王振王铮韦大明魏俊杰魏永健文韬吴超勇吴含荣武莎吴雪峰吴雨生席邵强夏捷夏君集项光漫肖迪泫肖刚辛广广辛玉良邢祎熊峥徐东莲徐仁峰徐仁新徐伟立薛良闫大海颜景志颜田杨朝文杨帆杨冯帆杨何文杨佳盈杨莉莉杨明洁杨睿智杨深邦姚玉华姚志国叶一锰尹丽巧尹娜游晓浩游智勇于艳红袁强岳华曾厚敦曾婷轩曾玮查敏张彬彬张丰张海明张恒英张建立张丽霞张力张鹏飞张佩佩张瑞张少博张少如张寿山张潇张笑鹏张云峰张毅张勇赵兵赵静赵雷赵立志赵世平郑福周斌周浩周佳能周猛周平周荣周勋秀祝成光祝凤荣朱辉朱科军左雄 LHAASO Collaboration Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China Dublin Institute for Advanced Studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 10398069029 HeidelbergGermany State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China Hefei 230026China School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Hebei Normal University Shijiazhuang 050024China Key Laboratory of Dark Matter and Space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000TibetChina National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Physics and Astronomy(Zhuhai)&School of Physics(Guangzhou)&Sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275China School of Physics and Astronomy Yunnan UniversityKunming 650091China Département de Physique Nucléaire et Corpusculaire Facultéde SciencesUniversitéde Genève24 Quai Ernest Ansermet1211 GenevaSwitzerland Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China APC Universit'e Paris Cit'eCNRS/IN2P3CEA/IRFUObservat

The full array of the Large High Altitude Air Shower Observatory(LHAASO)has been in operation since july *** its kilometer-square array(KM2A),we optimized the selection criteria for very high and ultrahigh energyγ-rays using data collected from August 2021 to August 2022,resulting in an improvement in significance of the detection in the Crab Nebula of approximately 15%,compared with that of previous *** the implementation of these new selection criteria,the angular resolution was also significantly improved by approximately 10%at tens of *** aspects of the full KM2A array performance,such as the pointing error,were also calibrated using the Crab *** resulting energy spectrum of the Crab Nebula in the energy range of 10-1000 TeV are well fitted by a log-parabola model,which is consistent with the previous results from LHAASO and other experiments.

关键词： γ-ray Crab Nebula significance

垂向振动对电弧增材制造碳钢的形貌、组织及性能的影响

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机械工程学报 2024年第11期60卷 342-352页

作者：石学智蔡成恒李振华浙江海洋大学海洋工程装备学院舟山316022

为探究电弧增材制造技术上舰制造的可行性,将电弧增材制造设备置于振动平台上,并利用正弦振动模拟舰船振动环境,进行ER50-6碳钢沉积实验,研究大型舰船常见的振动范围(频率为5~25 Hz)内,垂向振动对电弧增材制造设备振动特性及成形件形貌... 详细信息

为探究电弧增材制造技术上舰制造的可行性,将电弧增材制造设备置于振动平台上,并利用正弦振动模拟舰船振动环境,进行ER50-6碳钢沉积实验,研究大型舰船常见的振动范围(频率为5~25 Hz)内,垂向振动对电弧增材制造设备振动特性及成形件形貌、组织和性能的影响。研究结果表明,受到外部垂向振动的影响,电弧增材制造设备的焊枪和基板会发生差异性地振动,从而导致成形过程中电弧和熔池不稳定、熔滴发生偏离、传热凝固行为改变,使得电弧增材制造成形件的形貌、组织和性能发生变化。无振动成形试样平均晶粒尺寸为7.46μm,抗拉强度、下屈服强度和延伸率分别为495 MPa、370 MPa和29.87%;与之相比,不同振动工况下成形试样的平均晶粒尺寸在5.71μm到8.53μm之间,抗拉强度490~500 MPa,屈服强度370~385 MPa,延伸率29.17%~34.57%,所有顺利成形的试样均能满足性能要求;但有些振动会导致成形件外观形貌恶化甚至无法顺利成形,从而达不到生产制造要求,这是未来实现电弧增材制造上舰制造需解决的最大难题。

关键词：舰船电弧增材制造振动碳钢形貌性能

THE REINFORCING MECHANISM OF TiB2 IN TiB2/A357 COMPOSITE

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Acta Metallurgica Sinica(English Letters) 2003年第5期16卷 375-378页

作者： B.Yu Y.j.Zhang Z.x.Zhao~ F.x.Zhao: Q.K.cai C.S.Liu ShenyangResearchInstituteofFoundry TheChineseAcademyofMachinerySciencesShenyang110022China EastChinaUniversityofScienceandTechnology Shanghai200237China SchoolofMaterials&Metallurgy NortheasternUniversityShenyang110004China

Mechanical properties were tested for in situ TiB2/A357 composite fabricated by LSM (mixed salts reaction) method. Micro structures of as cast and plastic deformed TiB2/A357 were investigated. The results show that there is a low misfit between (200) Al and (101)TiB2 with [011]//Al [101]TiB2. There is a change from fully dendritic structure of the α-Al of A357 to a rosette-type structure of TiB2/A357. Significant increases in proof stress and Young's modulus can be obtained at low TiB2 additions. There exist dislocation loops around neighboring TiB2 particles with about 0.1μm in diameter and dislocation multiplication near TiB2 particles.

关键词： TiB2/Al in situ composite reinforcing mechanism

Role of mitophagy in head and neck squamous cell carcinoma:Prognosis and immune insights

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Radiation Medicine and Protection 2024年第2期5卷 100-112页

作者： Qin Ding Wei Liu junping Pan Lihua Wang Wenquan Hong Sunqin cai xin Chen Duanyu Lin Sufang Qiu Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China Fujian Provincial Key Laboratory of Translational Cancer Medicine Fuzhou 350014China Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China

Objective:To explore the correlation between mitophagy and the tumor microenvironment(TME)in patients with head and neck squamous cell carcinoma(HNSCC),with an aim to enhance therapeutic efficacy for ***:A machine learning-based multigene prognostic signature was developed based on mitophagy-related differentially expressed genes(MRGs)identified in The Cancer Genome Atlas *** signature was correlated with the TME using gene set enrichment *** association between this prognostic signature and various immunological features of the TME was explored,including status of tumor-infiltrating immune cells,expression of immune checkpoint molecules,and the *** validated the expression of hub gene CSNK2A2 and assessed its relationship with immunomarker *** PCR validated CSNK2A2 knockdown in HNSCC cell *** experiments including Transwell assays to determine cell migration and invasion,Cell Counting Kit 8 assay,and 5-ethynyl-2-deoxyuridine assay were performed to confirm the role of CSNK2A2 in ***,a subcutaneous xenograft model was generated in C3H mice to validate our ***:The MRG-based prognostic signature showed excellent predictive ***-risk patients had significantly shorter progression-free and overall survival(Pxpressed and strongly correlated with CD8 and PD-L1 based on immunohistochemistry of the HNSCC tissue ***2A2 knockdown reduced cell migration,invasion,and proliferation,and arrested cells in G1 *** vivo,it led to slower tumor growth and smaller tumor ***:We established a potential prognostic signature that could impr

关键词： Head and neck squamous cell carcinoma Mitophagy Tumor microenvironment CSNK2A2 Prognostic model

2000-2021年新疆植被覆盖度变化及驱动力

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水土保持研究 2024年第1期31卷 385-394页

作者：马楠白涛蔡朝朝新疆农业大学计算机与信息工程学院乌鲁木齐830052 新疆农业信息化工程技术研究中心乌鲁木齐830052

[目的]探讨2000—2021年新疆植被覆盖变化及其驱动力的分析,为新疆地区环境监测提供理论依据。[方法]借助GEE平台获取由NASA提供的NDVI数据,利用趋势分析、Hurst指数法对新疆地区2000—2021年植被覆盖变化进行动态分析,结合气象等数据,... 详细信息

[目的]探讨2000—2021年新疆植被覆盖变化及其驱动力的分析,为新疆地区环境监测提供理论依据。[方法]借助GEE平台获取由NASA提供的NDVI数据,利用趋势分析、Hurst指数法对新疆地区2000—2021年植被覆盖变化进行动态分析,结合气象等数据,采用Mann-Kendall、偏相关分析法等对植被覆盖变化与气候、地表因素的响应进行分析。[结果](1)2000—2021年新疆地区NDVI年际变化总体以0.0014/a的速率波动式增长;年内变化总体呈倒U型,草甸植被的NDVI月均值波动最大。(2)2000—2021年新疆地区NDVI年均值77.9%在0~0.3波动,在空间分布表现为北部和西北部高,南部和东南部低。(3)2000—2021年新疆地区总体slope值在-0.036~0.052波动,主要变化趋势为基本不变和轻微改善,结合Hurst指数,新疆植被主要未来趋势变化为改善到退化。(4)22年间新疆地区的气温总体呈上升趋势,降水、土壤湿度和径流总体呈下降趋势。NDVI年均值与气温、降水、土壤湿度和径流呈显著负相关性的像元数占比均大于正相关性的像元数占比,且存在明显的空间地域特征。[结论]新疆植被覆盖变化总体呈上升趋势,但未来趋势不容乐观,需要重点关注新疆地区的环境监测等保护措施。

关键词：植被类型 NDVI 趋势变化气温降水土壤湿度径流

平台“独家交易”的社会福利效应:基于霍特林模型的分析

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经济理论与经济管理 2024年第3期44卷 117-134页

作者：顾雨辰蔡跃洲福州外语外贸学院中国社会科学院数量经济与技术经济研究所 100732 中国社会科学院经济大数据与政策评估实验室 100732

本文采用霍特林模型和数值模拟方法,揭示了不同竞争环境下平台实行“独家交易”的动机和底层逻辑,以分析其对社会福利和市场竞争格局的影响。研究发现:(1)在高速成长阶段,平台出于扩大规模、扭亏为盈的考虑,一般不会实行“独家交易”。... 详细信息

本文采用霍特林模型和数值模拟方法,揭示了不同竞争环境下平台实行“独家交易”的动机和底层逻辑,以分析其对社会福利和市场竞争格局的影响。研究发现:(1)在高速成长阶段,平台出于扩大规模、扭亏为盈的考虑,一般不会实行“独家交易”。(2)在平稳成熟阶段,优势平台出于提升收益或扩大相对商户规模的目的,有动力单方面实行“独家交易”;而劣势平台出于持续盈利、平稳发展以及维持商户规模(或相对商户规模)的考虑,一般不会主动实行“独家交易”。(3)“独家交易”会损害消费者、商户的福利及社会总福利,并在竞争相对激烈时使劣势平台面临更高比例的商户流失并降低其收益。(4)在竞争相对缓和时,“独家交易”也可能在提升优势平台收益的同时,增加劣势平台收益和商户数量,防止市场格局由“垄断竞争”演变成“完全垄断”。监管部门应考察不同竞争环境下平台“独家交易”对社会福利的差异化影响,并据此完善监管理念、优化监管措施。

关键词：平台经济独家交易福利分析网络外部性市场支配力

基于轮轨黏着大滑移机理的防滑黏着利用控制策略研究

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铁道学报 2024年第5期46卷 30-37页

作者：张波周军蔡田常崇义齐政亮动车组和机车牵引与控制国家重点实验室北京100081 中国铁道科学研究院集团有限公司机车车辆研究所北京100081 北京纵横机电科技有限公司北京100094 高速铁路与城轨交通系统技术国家工程研究中心轮轨关系实验室北京100081

随着列车运行速度的提高,轮轨界面湿滑条件下存在制动黏着利用需求与黏着系数下降的矛盾,因此急需突破制动防滑及黏着利用关键技术瓶颈。在深入分析高速制动黏着-滑移特性规律以及黏着再上升影响因素的基础上,提出一种基于分层滑动速度... 详细信息

随着列车运行速度的提高,轮轨界面湿滑条件下存在制动黏着利用需求与黏着系数下降的矛盾,因此急需突破制动防滑及黏着利用关键技术瓶颈。在深入分析高速制动黏着-滑移特性规律以及黏着再上升影响因素的基础上,提出一种基于分层滑动速度判据的黏着大滑移机理的防滑黏着利用控制策略。该策略通过维持一定的滑动速度获得滑动能量进而改善轮轨黏着系数,并根据测量的轮轨接触点切向力和防滑阀下游的制动缸压力实时计算滑行过程的轮轨可用黏着系数判断轮轨黏着改善程度。在此基础上,进行基于1∶1高速轮轨关系试验台的不同黏着条件下的高速防滑模拟试验,结果表明:该控制策略可自适应地追踪不同轮轨黏着条件下(水、防冻液)的可用黏着,提高了防滑控制系统对铁路复杂运用环境和轮轨黏着特性的适应性。

关键词：黏着利用大滑移分层滑动速度滑动能量可用黏着系数

jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan Wang xiang-Yang Zhai Zheng Wang Chun-Ling Gao Sui-cai Mi Wen-Li Tang xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-Fei Li Sheng-Yan xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces

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Magnetic Resonance Letters 2023年第2期3卷 90-107,I0003页

作者： Nathan H.Williamson Velencia j.Witherspoon Teddy x.cai Rea Ravin Ferenc Horkay Peter j.Basser Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of HealthBethesdaMD20892USA Wellcme Centre for Igative Neuromging FMRIBNuffeld Department of Clinical NeurosciencesUiversity of Oxford Oxford OX39DUUK Celoptics RockvilleMD20850USA

Nuclear magnetic resonance(NMR)measurements of water diffusion have been extensively used to probe microstructure in porous materials,such as biological tissue,however primarily using pulsed gradient spin echo(PGSE)***-field single-sided NMR systems have built-in static gradients(SG)much stronger than typical PGSE maximum gradient strengths,which allows for the signal attenuation at extremely high b-values to be ***,we perform SG spin echo(SGSE)and SG stimulated echo(SGSTE)diffusion measurements on biological cells,tissues,and *** on fixed and live neonatal mouse spinal cord,lobster ventral nerve cord,and starved yeast cells all show multiexponential signal attenuation on a scale of b with significant signal fractions observed at b×Do>1 with b as high as 400 ms/*** persistent signal fractions trend with surface-to-volume ratios for these systems,as expected from porous media *** exception found for the case of fixed *** spinal cords was attributed to faster exchange or permeability in live spinal cords than in fixed spinal cords on the millisecond *** suggests the existence of multiple exchange processes in neural tissue,which may be relevant to the modeling of time-dependent diffusion in gray *** observed multi-exponential attenuation is from protons on water and not macromolecules because it remains proportional to the normalized signal when a specimen is washed with *** signal that persists to b×Do>1 is also drastically reduced after delipidation,indicating that it originates from lipid membranes that restrict water *** multiexponential or stretched exponential character of the signal attenuation at b×Do>1 appears mono-exponential when viewed on a scale of(b×Do)/3,suggesting it may originate from localization or motional averaging of water near membranes on sub-micron length *** try to disambiguate these two contributions,signal attenuation curves were compared at varying temper

关键词： Magnetic resonance in porous media Single-sided NMR-MOUSE Microstructure High b-values Short diffusion time Stretched exponential Diffusion MRI contrast mechanisms