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A Light-Independent Allele of Phytochrome B Faithfully Recapitulates Photomorphogenic Transcriptional Networks

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Molecular Plant 2009年第1期2卷 166-182页

作者： wei hu Yi-Shin Su j. Clark Lagarias Department of Molecular and Cellular Biology College of Biological Sciences University of California Davis CA 95616 USA Present address: Carnegie Institution of washington -Department of Plant Biology Stanford CA 94305 USA

Dominant gain-of-function alleles of Arabidopsis phytochrome B were recently shown to confer lightindependent, constitutive photomorphogenic （cop） phenotypes to transgenic plants （Su and Lagarias, 2007）. In the present study, comparative transcription profiling experiments were performed to assess whether the pattern of gene expression regulated by these alleles accurately reflects the process of photomorphogenesis in wild-type Arabidopsis. whole- genome transcription profiles of dark-grown phyAphyB seedlings expressing the Y^276H mutant of phyB （YHB） revealed that YHB reprograms about 13% of the Arabidopsis transcriptome in a light-independent manner. The YHB-regulated transcriptome proved qualitatively similar to but quantitatively greater than those of wild-type seedlings grown under 15 or 50 μmol m^-2 m^-1 continuous red light （Rc）. Among the 2977 genes statistically significant two-fold （SSTF） regulated by YHB in the absence of light include those encoding components of the photosynthetic apparatus, tetrapyrrole/pigment biosynthetic pathways, and early light-responsive signaling factors. Approximately 80% of genes SSTF regulated by Rc were also YHB-regulated. Expression of a notable subset of 346 YHB-regulated genes proved to be strongly attenuated by Rc, indicating compensating regulation by phyC-E and/or other Rc-dependent processes. Since the majority of these 346 genes are regulated by the circadian clock, these results suggest that phyA- and phyB-independent light signaling pathway（s） strongly influence clock output. Together with the unique plastid morphology of dark-grown YHB seedlings, these analyses indicate that the YHB mutant induces constitutive photomorphogenesis via faithful reconstruction of phyB signaling pathways in a light-independent fashion.

关键词： light signaling signal transduction transcriptome analysis photomorphogenesis Arabidopsis phytochrome.

Ellipsometric Spectra and Optical Properties of Anisotropic SrBi2Ta2O9 Films

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Chinese Physics Letters 2004年第2期21卷 266-268页

作者：莫党刘毅 G.D.hu j.B.Xu StateKeyLaboratoryofOptoelectronicMaterialsandTechnologiesandDepartmentofPhysics ZhongshanUniversityGuangzhou510275 NormalCollege ShenzhenUniversityShenzhen518060 DepartmentofElectronicEngineeringandMaterialScienceandTechnologyResearchCenter TheChineseUniversityofHongKongHongKong

Ellipsometric spectra of the SrBi2Ta2O9 (SBT) films of (200) and (0010) predominant orientation are measured and analysed in the range of photon energy from 2 to 5eV. The results show that the oriented SBT films appear to be strongly anisotropic. The ellipsometric spectra of the (200)-predominant SBT films are different from those of the (0010)-predominant films. we suggest an analysis model for these oriented films and perform the fitting of the anisotropic ellipsometric spectra. The refractive index and the extinction coefficient of the ordinary ray and the extraordinary ray for these oriented SBT films are obtained. The ordinary refractive index is larger than the extraordinary one.

关键词： Anisotropy

Tailoring grain growth and solid solution strengthening of single-phase CrCoNi medium-entropy alloys by solute selection

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journal of Materials Science & Technology 2020年第19期54卷 196-205页

作者： G.w.hu L.C.Zeng H.Du X.w.Liu Y.wu P.Gong Z.T.Fan Q.hu E.P.George Key Laboratory of Metallurgical Equipment and Control Technology Ministry of EducationWuhan University of Science and TechnologyWuhan 430081China hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Institute of Applied Physics Jiangxi Academy of SciencesNanchang 330029China Oak Ridge National Laboratory Materials Science and Technology DivisionOak RidgeTN37831USA Department of Materials Science and Engineering University of TennesseeKnoxvilleTN37996USA

In the present study,we selected solutes to be added to the Cr Co Ni medium-entropy alloy(MEA)based on the mismatch of self-diffusion activation energy(SDQ)between the alloying elements and constituent elements of the matrix,and then investigated their grain growth behavior and mechanical *** and Al were selected as the solutes for investigation primarily because they have higher and lower SDQ,respectively,than those of the matrix elements;a secondary factor was their higher and lower shear *** concentrations were fixed at 3 at.%each because previous work had shown these compositions to be single-phase solid solutions with the face-centered cubic *** alloys were produced by arc melting,casting,homogenizing,cold rolling and annealing at various temperatures and times to produce samples with different grain *** were(a)the base alloy Cr Co Ni,(b)the base alloy plus 3 at.%Mo,and(c)the base alloy plus 3 at.%*** activation energies for grain growth of the Cr Co Ni,Cr Co Ni-3Mo and CrCo Ni-3Al MEAs were found to be^251,~368 and^219 k j/mol,respectively,consistent with the notion that elements with higher SDQ(in this study Mo)retard grain growth(likely by a solute-drag effect),whereas those with lower values(Al)accelerate grain *** roomtemperature tensile properties show that Mo increases the yield strength by^40%but Al addition has a smaller strengthening effect consistent with their relative shear *** yield strength as a function of grain size for the three single-phase MEAs follows the classical Hall-Petch relationship with much higher slopes(>600 MPaμm-0.5)than traditional solid *** work shows that the grain growth kinetics and solid solution strengthening of the Cr Co Ni MEA can be tuned by selecting solute elements that have appropriate diffusion and physical properties.

关键词： Medium and high entropy alloys Solute-drag effect Microstructure Grain growth kinetics Solid solution strengthening

PhaseⅠ/Ⅱtrial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

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Chinese journal of Cancer 2016年第12期35卷 743-753页

作者： Lin Kong jing Gao jiyi hu weixu hu Xiyin Guan Rong Lu jiade j.Lu Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterFudan University Shanghai Cancer HospitalShanghai 200321P.R.China. Department of Radiation Oncology Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. Department of Outpatient Clinic Shanghai Proton and Heavy Ion CenterShanghai 200321P.R.China. Shanghai Proton and Heavy Ion Center 4365 Kangxin RoadPudongShanghai 201315P.R.China.

Background: After deinitive chemoradiotherapy for non-metastatic nasopharyngeal carcinoma(NPC), more than 10% of patients will experience a local recurrence. Salvage treatments present signiicant challenges for locally recurrent NPC. Surgery, stereotactic ablative body radiotherapy, and brachytherapy have been used to treat locally recurrent NPC. However, only patients with small-volume tumors can beneit from these treatments. Re-irradiation with X-ray—based intensity-modulated radiotherapy(IMXT) has been more widely used for salvage treatment of locally recurrent NPC with a large tumor burden, but over-irradiation to the surrounding normal tissues has been shown to cause frequent and severe toxicities. Furthermore, locally recurrent NPC represents a clinical entity that is more radioresistant than its primary counterpart. Due to the inherent physical advantages of heavy-particle therapy, precise dose delivery to the target volume(s), without exposing the surrounding organs at risk to extra doses, is highly feasible with carbon-ion radiotherapy(CIRT). In addition, CIRT is a high linear energy transfer(LET) radiation and provides an increased relative biological efectiveness compared with photon and proton radiotherapy. Our prior work showed that CIRT alone to 57.5 Gy E(gray equivalent), at 2.5 Gy E per daily fraction, was well tolerated in patients who were previously treated for NPC with a deinitive dose of IMXT. The short-term response rates at 3–6 months were also acceptable. However, no patients were treated with concurrent chemotherapy. whether the addition of concurrent chemotherapy to CIRT can beneit locally recurrent NPC patients over CIRT alone has never been addressed. It is possible that the beneits of high-LET CIRT may make radiosensitizing chemotherapy unnecessary. we therefore implemented a phase I/II clinical trial to address these questions and present our methodology and *** and design: The maximal tolerated dose(MTD) of re-treatment usi

关键词： Recurrent nasopharyngeal cancer Carbon ion radiotherapy Re-irradiation Salvage therapy Chemotherapy

信息化时代基于微课的翻转课堂在研究生英语教学中的应用研究

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科教文汇 2025年第1期 124-128页

作者：胡奇军江西中医药大学人文学院江西南昌330004

研究生教育对学生的英语能力要求较高,传统的学习方式难以满足学生的学习需求,互联网的普及和信息技术的发展为研究生英语教学改革指明了新的方向。基于微课的翻转课堂深度学习模式实现了以信息化带动教育现代化,引导学生主动探索学习... 详细信息

研究生教育对学生的英语能力要求较高,传统的学习方式难以满足学生的学习需求,互联网的普及和信息技术的发展为研究生英语教学改革指明了新的方向。基于微课的翻转课堂深度学习模式实现了以信息化带动教育现代化,引导学生主动探索学习中的问题,让学生更多地参与深入思考,提高研究生的自主学习能力和英语综合应用能力,提升研究生教育的整体质量。

关键词：信息技术研究生英语翻转课堂微课应用研究

ON THE ZEROS OF QUOTIENTS OF BESSEL FUNCTIONS

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Chinese Annals of Mathematics,Series B 2000年第3期21卷 285-296页

作者： A.FRIEDMAN B.hu j.j.L.VELAZQUEZ DepartmentofMathematics UniversityofMinnesotaMinneapolisMN55455USA. DepartmentofMathematics UniversityofNotreDameNotreDameIN46556USA. DepartamentodeMatematicaAplicada FacultaddeMatematicasUniversidadComplutense28040MadridSpain.

The paper studies the zeros of 2mIm/Im-1- (m+1)I1 /I0, where Im are the Bessel functions.

关键词： Zeros Quotient Bessel function

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小煤柱沿空掘进瓦斯综合防治技术研究

煤炭技术 2025年第1期44卷 198-201页

作者：胡乐天山西保利平山煤业股份有限公司山西沁水048200

以某矿31018回风顺槽小煤柱沿空掘进为工程背景,对采空区侧煤体卸压范围考察,确定采空区侧煤体卸压范围,并在卸压范围进行残余瓦斯含量测试,划定无突出危险性范围;采用对小煤柱进行注浆加固和巷道全断面喷浆措施防止采空区瓦斯溢出;使... 详细信息

以某矿31018回风顺槽小煤柱沿空掘进为工程背景,对采空区侧煤体卸压范围考察,确定采空区侧煤体卸压范围,并在卸压范围进行残余瓦斯含量测试,划定无突出危险性范围;采用对小煤柱进行注浆加固和巷道全断面喷浆措施防止采空区瓦斯溢出;使用钻屑指标法对掘进工作面进行预测和验证。统计表明:31018回风顺槽小煤柱沿空掘巷过程中,预测指标K_(1max)=0.24,S_(max)=3.4,平均进尺5.8 m/d,回风流平均瓦斯浓度为0.15%,单日绝对瓦斯涌出量平均为1.04 m^(3)/min,实现了巷道安全掘进。

关键词：沿空掘进瓦斯治理小煤柱卸压范围注浆加固

Diabetes exacerbates inflammatory bowel disease in mice with dietinduced obesity

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world journal of Gastroenterology 2023年第33期29卷 4991-5004页

作者： Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon j hu Cody A Krutzsch Gregory j Morton Michael w Schwartz jarrad M Scarlett Department of Pediatric Gastroenterology and Hepatology Seattle Children’s HospitalSeattleWA 98105United States 不详 Department of Medicinal Chemistry University of WashingtonSeattleWA 98195United States Department of Laboratory Medicine and Pathology Seattle Children's HospitalSeattleWA 98105United States

BACKGROUND The increased prevalence of inflammatory bowel disease(IBD)among patients with obesity and type 2 diabetes suggests a causal link between these diseases,potentially involving the effect of hyperglycemia to disrupt intestinal barrier *** To investigate whether the deleterious impact of diabetes on the intestinal barrier is associated with increased IBD severity in a murine model of colitis in mice with and without diet-induced *** Mice were fed chow or a high-fat diet and subsequently received streptozotocin to induce diabetic-range *** weeks later,dextran sodium sulfate was given to induce *** select experiments,a subset of diabetic mice was treated with the antidiabetic drug dapagliflozin prior to colitis *** included both clinical and histological measures of colitis activity as well as histochemical markers of colonic epithelial barrier *** In mice given a high-fat diet,but not chow-fed animals,diabetes was associated with significantly increased clinical colitis activity and histopathologic markers of disease *** was also associated with a decrease in key components that regulate colonic epithelial barrier integrity(colonic mucin layer content and epithelial tight junction proteins)in diet-induced obese *** of these effects of diabetes in diet-induced obese mice was ameliorated by restoring *** In obese mice,diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of ***-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis *** findings suggest that effective diabetes management may decrease the clinical severity of IBD.

关键词： Inflammatory bowel disease Type 2 diabetes Obesity Intestinal barrier Hyperglycemia Colitis in mice Tight junction proteins

Predicting the strut forces of the steel supporting structure of deep excavation considering various factors by machine learning methods

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Underground Space 2024年第5期18卷 114-129页

作者： Haibo hu Xunjian hu Xiaonan Gong Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou 310058China

The application of steel strut force servo systems in deep excavation engineering is not widespread,and there is a notable scarcity of in-situ measured *** presents a significant research gap in the *** this,our study introduces a valuable dataset and application scenarios,serving as a reference point for future *** main objective of this study is to use machine learning(ML)methods for accurately predicting strut forces in steel supporting structures,a crucial aspect for the safety and stability of deep excavation *** employed five different ML methods:radial basis function neural network(RBFNN),back propagation neural network(BPNN),K-Nearest Neighbor(KNN),support vector machine(SVM),and random forest(RF),utilizing a dataset of 2208 measured *** points included one output parameter(strut forces)and seven input parameters(vertical position of strut,plane position of strut,time,temperature,unit weight,cohesion,and internal frictional angle).The effectiveness of these methods was assessed using root mean square error(RMSE),correlation coefficient(R),and mean absolute error(MAE).Our findings indicate that the BPNN method outperforms others,with RMSE,R,and MAE values of 72.1 kN,0.9931,and 57.4 kN,respectively,on the testing *** study underscores the potential of ML methods in precisely predicting strut forces in deep excavation engineering,contributing to enhanced safety measures and project planning.

关键词： Deep excavation Steel supporting structure Strut forces Machine learning Time Temperature