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Acta Pharmaceutica Sinica B 2016年第3期6卷 253-258页

作者： Sonal sharma Neeta Shrivastava B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Sarkhej-Gandhinagar Highway Nirma University

Shankhpushpi is a reputed drug from an Indian system of medicine for treating mental disorders and enhancing memory. Two herbs, namely Convolvulus prostratus Forssk. and Evolvulus alsinoides(L.) L., are commonly known as Shankhpushpi. Ambiguous vernacular identity can affect the scientific validity of the Shankpushpi-based herbal drug therapy. In the present investigation, a novel and sensitive multiplex PCR method based on polymorphism in the internal transcribed spacer(ITS) region was developed to establish the molecular identity of C. prostratus and E. alsinoides. DNA was isolated and the ITS region was amplified, sequenced and assembled. Sequences were aligned to identify variable nucleotides in order to develop plant-specific primers. Primers were validated in singleplex reactions and eventually a multiplex assay was developed. This assay was tested for sensitivity and validated by amplifying DNA isolated from the simulated blended powdered plant material. Primers developed for C. prostratus resulted into a 200 bp amplicon and 596 bp for E. alsinoides. The assay was found to be sensitive enough for amplification of low quantities of DNA. The method can detect 10% of the mixing of plants with each other in blended material. This PCR assay can be used for rapid botanical identification of Shankhpushpi plant materials and will improve evidence-based herbal drug therapy.

关键词： PCR Internal transcribed spacers Shankhpushpi Botanical identification Adulteration Substitution Herbal drugs DNA barcoding

Gas Chromatography Analysis of Resin and Fatty Acids from Laboratory Generated Bleach Plant Effluents

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中国造纸 2007年第5期26卷 29-33页

作者： Chhaya sharma S. Mohanty S. Kumar N.j. Rao Department of Paper Technology llT-Roorkeelndia Gas Authority of India Ltd. Calcutta India jP Institute Gunna India

Laboratory generated spent bleached liquor from the chlorination, caustic extraction stage of mixed wood kraft pulp processing has been analyzed both qualitatively and quantitatively for various resin & fatty acids by using GC. A number of resin acids, saturated and unsaturated fatty acids, chloro fatty and resin acid have been detected and their concentrations are estimated. The results are compared with results on different agriculture residue/hardwood pulps, which were reported earlier. The concentrations of various compounds detected have also been compared with their reported LC50 values.

关键词：气相色谱分析脂肪酸树脂酸漂白废液

Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

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World journal of Gastroenterology 2011年第7期17卷 867-897页

作者： Chakshu sharma Karim M Eltawil Paul D Renfrew Mark j Walsh Michele Molinari Department of Surgery Queen Eliz-abeth Ⅱ Health Sciences Center Dalhousie University

Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic.

关键词： Diagnosis Epidemiology Palliation Pancreatic cancer Therapy

Effects of L-arginine and L-citrulline supplementation in reduced protein diets for broilers under normal and cyclic warm temperature

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Animal Nutrition 2021年第4期7卷 927-938页

作者： Hiep Thi Dao Nishchal K.sharma Emma j.Bradbury Robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New EnglandArmidaleAustralia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoiViet Nam Ridley AgriProducts MelbourneVictoriaAustralia

Heat stress causes significant economic losses in the broiler *** supplementation of arginine(Arg)and citrulline(Cit)might increase the performance of broilers raised under warm temperature due to vasodilation *** study investigated the effects of L-Arg or L-Cit supplementation in broilers fed a reduced protein wheat-based diet deficient in Arg under thermoneutral(NT)and cyclic warm temperature(WT).Ross 308 cockerels(n=720)were randomly allocated to 4 dietary treatments with 12 replicates of 15 birds per pen from d 7 to *** 4 treatments were:normal protein(NP),i.e.,22.3%and 20.9%crude protein in grower and finisher,respectively;reduced protein(RP),i.e.,2.5%lower protein and deficient in Arg;and RP supplemented with 0.28%Arg(RP-Arg)or 0.28%Cit(RP-Cit).A factorial arrangement of treatments was applied during the finisher phase(21 to 35 d).Factors were:diet(4 diets above);and temperature,NT(24℃)or cyclic WT(33±1℃for 6 h per day)with 6 replicate pens per *** 7 to 35 d and 21 to 35 d,the birds fed the RP diet had lower body weight gain(BWG)and higher FCR compared to the NP diet(P0.05)compared to birds exposed to *** by temperature interactions were not observed for performance parameters during the period of WT(P>0.05).On d 35,the RP-fed birds had a lower yield of thigh and drumstick,higher fat pad,lower femur ash,and breaking strength but similar serum uric acid level and higher nitrogen digestibility on d 21 compared to those offered NP(P<0.05).Supplementation of Arg or Cit to RP resulted in increased femur ash on d 35(P<0.05).Thus,feeding the NP diets is necessary to maintain growth performance in broilers regardless of the temperature conditions.

关键词： Arginine Citrulline Meat chickens Low protein Heat stress

Response of laying hens to L-arginine,L-citrulline and guanidinoacetic acid supplementation in reduced protein diet

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Animal Nutrition 2021年第2期7卷 460-471页

作者： Hiep Thi Dao Nishchal K.sharma Emma j.Bradbury Robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New England2351New South WalesAustralia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoiViet Nam Ridley AgriProducts Level 4565 Bourke StreetMelbourneVICAustralia

A study was conducted with Hy-Line Brown laying hens to examine the effects of reduced protein diet,deficiency of arginine(Arg),and addition of crystalline Arg,citrulline(Cit)and guanidinoacetic acid(GAA)as substitutes for *** performance,egg quality,serum uric acid,liver and reproductive organ weights,and energy and protein digestibility were measured using a completely randomized design with 5 *** were a standard diet(17%protein diet;SP),a reduced diet(13%protein diet deficient in Arg;RP)and RP with added Arg(0.35%,RP-Arg),GAA(0.46%equivalent to 0.35%Arg,RP-GAA)or Cit(0.35%,RP-Cit)to the level of *** was hypothesized that performance would decrease with Arg deficient RP diet and the addition of GAA or Cit in RP would allow birds to perform similar or greater than Arg-added RP *** experiment was conducted from 20 to 39 wk of age but the treatment effect was seen only after 29 wk of *** birds offered RP had reduced egg and albumin weights(P0.05).The birds offered RP-GAA decreased FI and egg production(P0.05).However,birds offered the RP-Cit diet tended to have higher Haugh unit(P=0.095)and lower shell breaking strength(P=0.088)compared to all other treatments while those offered RP-GAA had higher energy digestibility(P<0.05)than all other groups but *** limited performance response of hens fed RP with added Arg,GAA,or Cit may be due to deficiency of some other nutrients in RP such as phenylalanine,potassium or non-essential amino acids and other components of soybean meal in the diet.

关键词： Arginine Citrulline Guanidinoacetic acid Laying hen Reduced protein

Synthesis of novel 3,5-disubstituted-dihydroisoxazoles from methyl undec-10-enoate and isoxazoles,triazole and tetrazolo-triazole from methyl undec-10-ynoate

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Chinese Chemical Letters 2009年第10期20卷 1145-1149页

作者： Shweta sharma Abdul Rauf Department of Chemistry Aligarh Muslim UniversityAligarh 202002 India

The efficient cycloaddition reactions were carried out to afford the novel 3,5-disubstituted-dihydroisoxazoles from methyl undec-10-enoate and isoxazoles, triazole and tetrazolo-triazole from methyl undec-10-ynoate. T... 详细信息

关键词： 3,5-Disubstituted-dihydroisoxazoles Triazole Methyl undec-10-enoate and undec-10-ynoate

Turbulence characteristics of flow past submerged vanes

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International journal of Sediment Research 2020年第1期35卷 42-56页

作者： Himanshu sharma Zulfequar Ahmad Department of Civil Engineering Institute of Infrastructure Technology Research and Management Department of Civil Engineering IIT Roorkee

Submerged vanes are hydrofoils utilized to manage the sediment transport through the river by generating the turbulence in the flow in the form of helical *** vanes are placed in the flow with respect to its direction at angle of 10°to 40°.In the current study,an attempt has been made to study the effect of the introduction of vanes in form of rows on parameters like turbulence intensities,Reynolds stresses,turbulent kinetic energy,anisotropy index,and the velocity profile of the *** is observed that the profile of variation of turbulence intensities,turbulent kinetic energy,vertical Reynolds stress and velocity over three different marked verticals on a transect are nearly identical whereas a large scatter is observed in the variation of transverse Reynolds stress over the vertical of the aforementioned vertical *** observation suggests that flow turbulence is homogeneous over the vertical while scattering in the variation of the transverse Reynolds stress component may be attributed to the presence of secondary currents in the *** introducing rows of submerged vanes,the bed turbulence is reduced,hence,helping reduce many scour related *** is also observed that a vortex occurred at 0.85 times the height of the vane and the variation of turbulence quantities in the presence of vanes shows the existence of a peak in these *** is observed that as flow moves away from the vane rows,due to the interaction of vortices and the action of vorticity,vortices dampens down and the flow regains *** the introduction of submerged vane rows,bed shear stress reduces as fluid from the surface replaces the slow-moving fluid near the bed due to the secondary currents generated by the vanes leading to reduction in the magnitude of turbulence intensities,Reynolds stresses,and turbulent kinetic energy near the *** anisotropy index is observed to increase near the bed as induced secondary currents enhanced the turbulence

关键词： Turbulence Anisotropy Submerged vanes Secondary currents Turbulence parameters

Effect of organic component(tartrate) addition on cerium nitrate's ability to inhibit corrosion of mild steel in NaCl solution

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journal of Rare Earths 2024年第10期42卷 1995-2002页

作者： Minakshi Koundal Chhaya sharma A.K.Singh Department of Applied Science and Engineering Indian Institute of Technology RoorkeeSaharanpur CampusSaharanpurU.247001India Department of Pulp and Paper Technology Indian Institute of Technology Roorke Saharanpur CampusSaharanpurU.p247001India

Cerium tartrate(CeTar),produced in this study by precipitating cerium nitrate with potassium sodium tartrate(KNaTar),was examined as a corrosion *** loss tests show inhibition efficiency of 71.7% with Ce(NO_(3))_(3) and 88.7% with CeTar inhibitor for one-month exposure to mild steel in 7 g/L NaCl *** inhibition efficiency drops to 28.6% with the fo rmer and remains around 8 7% with the latter inhibitor after six months of *** results from electrochemical testing indicate that the inhibition efficiency decreases by adding cerium ***,the cerium tartrate inhibitor demonstrates a nearly constant inhibition efficiency for up to 30 d,i.e.,≈90%.Electrochemical impedance spectroscopy(EIS) performed in these cases shows the following results:(ⅰ) with cerium nitrate,a film of iron and cerium oxide,which on prolonged exposure diminishes,and(ⅱ) with cerium tartrate,the formation of a bimetallic film(Fe-tartrate-Ce) and a mixture of cerium hydroxide and iro n oxide that protects steel for a longer *** inferences are based on the analyses of scanning electron microscopy/energydispersive X-ray analysis(SEM/EDAX),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron(XPS),and Raman spectroscopy results.

关键词： Cerium tartrate Cerium nitrate Corrosion inhibition Mild steel Inhibitor film characterization Rare earths

Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant sharma jenny Serra-Vinardell Wendy j.Introne May Christine V.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

Concentration,sources and wet deposition of dissolved nitrogen and organic carbon in the Northern Indo-Gangetic Plain during monsoon

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journal of Environmental Sciences 2021年第4期33卷 37-52页

作者： Hemraj Bhattarai Lekhendra Tripathee Shichang Kang Chhatra Mani sharma Pengfei Chen junming Guo Prakriti sharma Ghimire Earth System Science Programme and Graduate Division of Earth and Atmospheric Sciences The Chinese University of Hong KongHong KongChina State Key Laboratory of Cryospheric Science Northwest Institute of Eco-environment and ResourcesChinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchCASBeijing 100101China Chinese Academy of Sciences(CAS)Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100085China Himalayan Environment Research Institute(HERI) KathmanduNepal Central Department of Environmental Science Tribhuvan UniversityKathmanduNepal Kathmandu Center for Research and Education(KCRE) KathmanduNepal

Precipitation represents an important phenomenon for carbon and nitrogen ***,the concentrations and fluxes of dissolved organic carbon(DOC)and total dissolved nitrogen(TDN)with their potential sources were analyzed in wet precipitation during summer monsoon from the Northern Indo-Gangetic Plain(IGP),important but neglected *** volume-weighted mean(VWM)concentration of DOC and TDN were 687.04 and 1210.23μg/L,***,the VWM concentration of major ions were in a sequence of NH_(4)^(+)>Ca^(2+)>SO_(4)^(2-)>Na^(+)>K^(+)>NO_(3)~->Cl~->Mg^(2+)>F~->NO_(2)~-,suggesting NH_(4)^(+)and Ca^(2+)from agricultural activities and crustal dust played a vital role in precipitation ***,the wet deposition flux of DOC and TDN were 9.95 and 17.06 kg/(ha year),*** wet deposition flux of inorganic nitrogen species such as NH_(4)^(+)-N and NO_(3)^(-)-N were 14.31 and 0.47 kg/(ha year),respectively,demonstrating the strong influence of emission sources and precipitation *** attribution from different analysis suggested the influence of biomass burning on DOC and anthropogenic activities(agriculture,animal husbandry)on nitrogenous *** air-mass back trajectory analysis indicated the influence of air masses originating from the Bay of Bengal,which possibly carried marine and anthropogenic pollutants along with the biomass burning emissions to the sampling *** study bridges the data gap in the less studied part of the northern IGP region and provides new information for policy makers to deal with pollution control.

关键词： Precipitation chemistry Dissolved organic carbon Total dissolved nitrogen Major ions Indo-Gangetic Plain