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AgBrT 颗粒横向生长动力学

感光材料 1989年第5期 14-20,25页

作者： P.H.Karpinski j.s.wey 胡家源

引言在 AgBr 颗粒生长阶段,过量 Br^-离子的存在,将极大影响最终的颗粒晶形。当溴余量足够大时,可以得到较大的平均粒径与粒厚之比,亦即具有高形态比的 AgBr 晶体。这种晶型的颗粒通常被称为 T-颗粒。由于T 颗粒的一些特性,如在同等含... 详细信息

引言在 AgBr 颗粒生长阶段,过量 Br^-离子的存在,将极大影响最终的颗粒晶形。当溴余量足够大时,可以得到较大的平均粒径与粒厚之比,亦即具有高形态比的 AgBr 晶体。这种晶型的颗粒通常被称为 T-颗粒。由于T 颗粒的一些特性,如在同等含银量下,其较大的表面积和特殊的光学性能,已使它在感光材料乳剂技术中成为一种很有用的晶型。

关键词：溴化银颗粒生长动力学乳剂

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Pathologic tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 373-378页

作者： june s Peng jane wey sricharan Chalikonda Daniela s Allende R Matthew Walsh Gareth Morris-stiff Department of General surgery Digestive Disease and Surgery InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA Department of Pathology Pathology and Laboratory Medicine InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA

Background:Previous studies have demonstrated the prognostic significance of pathologic tumor response in pancreatic adenocarcinoma following neoadjuvant therapy(NAT).The aim of this study was to determine the incidence of significant pathologic response to NAT in borderline resectable pancreatic cancer(BRPC),and association of NAT regimen and other clinico-pathologic characteristics with pathologic ***:Patients with BRPC who underwent NAT and pancreatic resection between january 2012 and june 2017 were *** response was assessed on a qualitative scale based on the College of American Pathologists grading *** and baseline characteristics,oncologic treatment,pathology,and survival outcomes were ***:seventy-one patients were included for *** patients had complete pathologic responses(tumor regression score 0),12 patients had marked responses(score 1),42 had moderate responses(score 2),and 13 had minimal responses(score 3).Patients with complete or marked responses were more likely to have received neoadjuvant gemcitabine chemoradiation(62.5%,38.1%,and 23.1%of the complete/marked,moderate,and minimal response groups,respectively;P=0.04).Of the complete/marked,moderate,and minimal response groups,margins were negative in 75.0%,78.6%,and 46.2%(P=0.16);node negative disease was observed in 87.5%,54.8%,and 15.4%(Psurvival was 50.0 months,31.7 months,and 23.2 months(P=0.563).Of the four patients with pathologic complete responses,three were disease-free at 66.1,41.7 and 31.4 months,and one was deceased with metastatic liver disease at 16.9 ***:A more pronounced pathologic tumor response to NAT in BRPC is correlated with node negative disease,but was not associated with a statistically significant survival benefit in this study.

关键词： Pancreatic cancer Borderline resectable Neoadjuvant therapy Pathologic response

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Neoadjuvant chemoradiation is associated with decreased lymph node ratio in borderline resectable pancreatic cancer:A propensity score matched analysis

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 74-79页

作者： june s Peng Gareth Morris-stiff Noaman s Ali jane wey sricharan Chalikonda Kevin M El-Hayek R Matthew Walsh Department of surgery The Pennsylvania State UniversityCollege of MedicineHersheyPA 17033-0850USA Department of General surgery Digestive Disease and Surgery InstituteCleveland Clinic FoundationClevelandOH 44195-0001USA

Background:Lymph node ratio(LNR)and margin status have prognostic significance in pancreatic *** we examined the pathologic and clinical outcomes in patients with borderline resectable pancreatic cancer(BRPC)following neoadjuvant therapy(NAT)and ***:Patients who underwent treatment between january 1,2012 and june 30,2017 were *** patients in the BRPC group were compared to a propensity score matched cohort of patients with radiographically resectable pancreatic cancer who underwent upfront surgical *** BRPC group was also compared to sequential patients with radiographically resectable pancreatic cancer who required vein resection(VR)during upfront ***:There were 50 patients in the BRPC group,50 patients in the matched control group,and 38 patients in the VR *** margins(R0)were seen in 72%,64%,and 34%of the BRPC,control,and VR groups,respectively(P=0.521 for BRPC ***;P=0.002 for BRPC ***),with 24%of the BRPC group requiring a vascular *** stage was N0 in 64%,20%,and 18%of the BRPC,control,and VR groups,respectively(Pstatus was stratified into four groups(N0,or LNR≤0.2,0.2–0.4,≥0.4),the BRPC group had a more favorable distribution(Psurvival were 28.8,38.6,and 19.0 months for the BRPC,control,and VR groups,respectively(log-rank P=0.096).Conclusions:NAT in BRPC was associated with more R0 and N0 resections and lower LNR compared to patients undergoing upfront resection for resectable disease.

关键词： Neoadjuvant therapy Lymph node ratio Pancreatic cancer Borderline resectable Vein resection

Refuge size variation and potential for sperm competition in Wellington tree weta

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Current Zoology 2019年第3期65卷 213-223页

作者： Tina W.wey Clint D. KELLY Departement des sciences Biologiques Universite du Quebec a Montreal Montreal Quebec H3C 3P8 Canada Departement de Medecine de Famille et de Medecine D'urgence Faculte de Medecine et des Sciences de la Sante Universite de Sherbrooke Quebec J1H 5N4 Canada

Ecological variation in resources can in flue nee the distributi on and en counter rates of potential mates and competitors and, con sequently, the opport unity for sexual selection. Factors that influence the likelihood that females mate multiply could also affect the potential for sperm competition. In Wellington tree weta (Hemideina crassidens, plural "weta"), the size of tree cavities (called galleries) used as refuges affects weta distribution and thus the opport unity for sexual selection and selection on male weaponry size. We examined the predicted effects of gallery size and male weap onry size on the potential for sperm competition. We asked if gallery size in flue need the potential for multiple mating by females and potential for sperm competition, if male weaponry size was associated with relative expected sperm competition intensity (sCI), and if estimated male mating success was correlated with pote ntial sCI. To qua ntify relative competitive envir on merits of males, we created and analyzed networks of potential competitors based on which males could have mated with the same females. We found that small galleries had higher potential for female multiple mating and higher potential for sperm competition. size of male weaponry was not associated with expected relative sCI. Regardless of gallery size, males with more potential mates were expected to face lower expected relative sperm competition. Thus, in this system, variation in the size of available refuges is likely to in flue nee the pote ntial for sperm competiti on, in a way that we might expect to in crease variation in overall reproductive success.

关键词： ecological variation mating dynamics opportunity for sperm competition polyandry sexual selection