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Phylogeny,ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae(Onygenales):Blastomyces,Emergomyces,Emmonsia,Emmonsiellopsis

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Fungal Diversity 2018年第3期90卷 245-291页

作者： Yanping jiang Karolina Dukik jose F.munoz Lynne sigler Ilan s.schwartz Nelesh P.Govender Chris Kenyon Peiying Feng Bert Gerrits van den Ende j.Benjamin stielow Alberto M.stchigel Hongguang Lu sybren de Hoog Department of Dermatology The Affiliated HospitalGuizhou Medical UniversityGuiyangChina Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands Center of Expertise in Mycology of RadboudUMC/Canisius Wilhelmina Hospital NijmegenThe Netherlands Institute of Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Broad Institute of MIT and Harvard CambridgeMAUSA and Biological sciences EdmontonABCanada Division of Infectious Diseases Department of MedicineFaculty of Medicine and DentistryUniversity of AlbertaEdmontonABCanada Global Health Institute Faculty of Medicine and Health SciencesUniversity of AntwerpAntwerpBelgium A Division of the National Health Laboratory ServiceJohannesburgSouth Africa sexually Transmitted Infection Unit Institute of Tropical MedicineAntwerpBelgium Third Affiliated Hospital Sun Yat-Sen UniversityGuangzhouChina Thermo Fisher scientific LandsmeerThe Netherlands Mycology Unit and IIsPV University Rovira i VirgiliReusTarragonaSpain

The family Ajellomycetaceae(Onygenales)includes mammal-associated pathogens within the genera Blastomyces,Emmonsia,Histoplasma and Paracoccidioides,as well as the recently described genera,Emergomyces that causes disease in immunocompromised hosts,and Emmonsiellopsis,known only from *** further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species,we sequenced and analyzed the DNA-directed RNA polymerase II(rPB2),translation elongation factor 3-a(TEF3),b-tubulin(TUB2),28s large subunit rDNA(LsU)and the internal transcribed spacer regions(ITs)in 68 strains,in addition to morphological and physiological *** better understand the thermal dimorphism among these fungi,the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures(6–42C).Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus ***,typified by Emmonsia parva,is a synonym of Blastomyces that also accommodates Blastomyces helicus(formerly Emmonsia helica).Emmonsia crescens is phylogenetically distinct,and found closely related to a single strain from soil without known *** silverae,Emergomyces canadensis,Emergomyces europaeus and Emmonsia sola are newly *** all of the taxa are associated with human and animal *** crescens,*** and *** are prevalently associated with pulmonary disease in humans or *** helicus,***,Emergomyces africanus,***,***,*** and ***(formerly Emmonsia pasteuriana)are predominantly found in human hosts with immune disorders;no animal hosts are known for these species except ***.

关键词： Ajellomycetaceae Onygenales Phylogeny Ecology Thermal dimorphism systemic infection Taxonomy

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MicroRNAs in biliary diseases

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World journal of Gastroenterology 2012年第43期18卷 6189-6196页

作者： Patricia munoz-Garrido Maite García-Fernández de Barrena Elizabeth Hijona Miguel Carracedo joséj G Marín Luis Bujanda jesús M Banales Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpain Division of Oncology Research Schulze Center for Novel TherapeuticsMayo ClinicRochesterMN 55905United States Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpains Department of Liver and Gastrointestinal Diseases National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehdfunded by the Spanish CarlosⅢInstitute)08036 BarcelonaSpain Department of Physiology and Pharmacology Experimental Hepatology and Drug Targeting(HEVEFARM)Biomedical Research Institute of Salamanca(IBSAL)University of Salamanca37008 SalamancaSpain Ikerbasque Basque Foundation for Science48011 BilbaoSpain

Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.

关键词： miRNAs Cholangiopathies Cholangiocarcinoma Polycystic liver diseases Primary biliary cirrhosis

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Investigation of pore geometry influence on fluid flow in heterogeneous porous media:A pore-scale study

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Energy Geoscience 2024年第1期5卷 72-88页

作者： Ramin soltanmohammadi shohreh Iraji Tales Rodrigues de Almeida Mateus Basso Eddy Ruidiaz munoz Alexandre Campane Vidal Ingram school of Engineering Texas State UniversitySan MarcosTX78666USA Department of Mechanical Engineering(FEM) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Department of Geology and Natural Resources Geosciences Institute(IG)State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Center of Energy and Petroleum study(CEPETRO) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil

Brazilian pre-salt reservoirs are renowned for their intricate pore networks and vuggy nature,posing significant challenges in modeling and simulating fluid flow within these carbonate *** possessing excellent petrophysical properties,such as high porosity and permeability,these reservoirs typically exhibit a notably low recovery factor,sometimes falling below 10%.Previous research has indicated that various enhanced oil recovery(EOR)methods,such as water alternating gas(WAG),can substantially augment the recovery factor in pre-salt reservoirs,resulting in improvements of up to 20%.Nevertheless,the fluid flow mechanism within Brazilian carbonate reservoirs,characterized by complex pore geometry,remains *** study examines the behavior of fluid flow in a similar heterogeneous porous material,utilizing a plug sample obtained from a vugular segment of a Brazilian stromatolite outcrop,known to share analogies with certain pre-salt *** conducted single-phase and multi-phase core flooding experiments,complemented by medical-CT scanning,to generate flow streamlines and evaluate the efficiency of water ***,micro-CT scanning of the core sample was performed,and two cross-sections from horizontal and vertical plates were *** cross-sections were then employed as geometries in a numerical simulator,enabling us to investigate the impact of pore geometry on fluid *** of the pore-scale modeling and experimental data unveiled that the presence of dead-end pores and vugs results in a significant portion of the fluid remaining stagnant within these ***,the injected fluid exhibits channeling-like behavior,leading to rapid breakthrough and low areal swept ***,the numerical simulation results demonstrated that,irrespective of the size of the dead-end regions,the pressure variation within the dead-end vugs and pores is *** the stromatolite's favorable petrophysica

关键词： Pore-scale modeling Pore geometry Flow streamlines Computational modeling Digital rock analysis

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Hopf Bifurcation Control in a Lorenz Type system

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journal of Applied Mathematics and Physics 2018年第8期6卷 1704-1719页

作者： P. E. Calderon-saavedra E. munoz-Aguirre j. Alvarez-Mena s. Gomez-Perez Universidad del Tolima Ibagué Colombia Universidad Veracruzana Veracruz Mexico

In this paper Hopf bifurcation control is implemented in order to change the bifurcation from supercritical to subcritical in a differential equations system of Lorenz type. To achieve this purpose: first, a region of parameters is identified where the system has a supercritical Hopf bifurcation;second, a class of non-linear feedback control laws is proposed;finally, it is shown that there are control laws which the disturbed system undergoes subcritical Hopf bifurcation.

关键词： Lorenz Type systems Bifurcation Control Hopf Bifurcation Control subcritical and supercritical Hopf Bifurcation

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Mechanical valve obstruction:Review of diagnostic and treatment strategies

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World journal of Cardiology 2015年第12期7卷 875-881页

作者： jason salamon jerson munoz--Mendoza jared j Liebelt Cynthia C Taub Department of Cardiology Montefiore Medical CenterBronx Department of Medicine Jacobi Medical CenterAlbert Einstein College of Medicine

Prosthetic valve obstruction(PVO) is a rare but feared complication of mechanical valve replacement. Diagno-stic evaluation should focus on differentiating prosthetic valve thrombosis(PVT) from pannus formation,as their treatment options differ. History of sub-optimal anti-coagulation and post-op time course to development of PVO are useful clinical characteristics in differentiating thrombus from pannus formation. Treatment of PVT is influenced by the patient's symptoms,valve location,degree of obstruction and thrombus size and may include thrombolysis or surgical intervention. Alternatively,pannus formation requires surgical intervention. The purpose of this article is to review the pathophysiology,epidemiology,diagnostic approach and treatment options for aortic and mitral valve PVO.

关键词： Prosthetic valve thrombosis Pannus overgrowth Thrombolysis Prosthetic valve obstruction Echocardiography

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Effects of 12 weeks of barefoot running on foot strike patterns,inversion-eversion and foot rotation in long-distance runners

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journal of sport and Health science 2019年第6期8卷 579-584页

作者： Pedro ALatorre-Román Felipe García-Pinillos Víctor M.soto-Hermoso Marcos munoz-jiménez Department of Didactics of Corporal Expression University of JaénJaen 23071Spain Department of sports sciences University of GranadaGranada 18071Spain

Purpose:The purpose of this study was to determine the effects of 12 weeks of barefoot running on foot strike patterns,inversion-eversion and foot rotation in long-distance ***:Thirty-one endurance runners with no experience in barefoot running were randomized into a control group and an experimental group who received barefoot *** pre-test and post-test,all subjects ran at low and high self-selected speeds on a *** were collected by systematic observation of lateral and back recordings at 240 ***:McNemar’s test indicated significant changes(p speed running in foot strike patterns,reducing the percentage of high rearfoot strikers and increasing the number of midfoot strikers.A significant increase(p se of inversion occurred at comfortable speed in the experimental ***:Twelve weeks of barefoot running,applied progressively,causes significant changes in foot strike pattern with a tendency toward midfoot or forefoot strikes,regardless of running speed and significant changes in foot rotation at low speed,while the inversion was reduced in left foot at low speed with a tendency toward centered strike.

关键词： Endurance Footwear Kinematics Training Unshod

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Potential Areas for Commercial Timber Plantations of Tabebuia rosea(Bertol.)*** Michoacan,Mexico

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Open journal of Forestry 2017年第1期7卷 48-57页

作者： Hipolito jesus munoz-Flores David Castillo-Quiroz Francisco Castillo-Reyes j.Trinidad sáenz-Reyes Diana Avila-Flores Agustín Rueda-sánchez National Institute of Forestry Agriculture and Livestock Research(INIFAP)-Experimental Station UruapanUruapanMéxico National Institute of Forestry Agriculture and Livestock Research(INIFAP)-Experimental Station SaltilloSaltilloMéxico

The targeted area for plant reforestation in the state of Michoacan is made up of eroded areas and pasture induced areas, both adding to 525,260 ha and representing 10.9% of the total surface of the state. The regions with the largest areas in need of reforestation are the Costa with 185,396 ha (29%), Oriente with 106,836 (17%) and Tierra Caliente with 96,284 (15%). Commercial forest plantations are an alternative for reducing the pressure on natural forests and creating options for sustainable and diversified development, changing the land use from fragmented agricultur and livestock purposes to forestry. The object of this study was to determine potential areas for the establishment of commercial forest plantations of Tabebuia rosea (Bertol.) DC. in the state of Michoacan, Mexico, by using geographic information systems. The outlining of potential areas was performed with the IDRIsI 32 and ArcView programs, according to the environmental requirements of T. rosea. These environmental requirements include precipitation, temperature, soil, altitude, land use and slope. The analysis resulted in two maps where the potential areas for the establishment of commercial forest plantations with this species were shown, which turned out a total potential area of 54,320 ha, distributed in 47,566 ha considering a slope of 0% - 15% for non-manual forest plantations, and 6754 ha considering a slope of 15% - 30% for manual forest plantations. The ecologic conditions in Michoacan are favorable for successful establishment and development of commercial forest plantations of T. rosea.

关键词： Potential Areas Michoacan Commercial Forest Plantations Tabebuia rosea Geographic Information system

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Mucosal schwann Cell Hamartoma—Colonic Lesion susceptible to an Interesting Differential Diagnosis

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Open journal of Pathology 2018年第3期8卷 101-105页

作者： j.Ortiz L.Chinchilla E.munoz Md Ludena Department of Pathological Anatomy of the University Hospital of salamanca SalamancaSpain

We present a mucosal schwann cell hamartoma that was observed in a 63-year-old woman with no personal or family history of interest who underwent a screening colonoscopy for early detection of colon cancer. During colonoscopy, a small polyp with a maximum diameter of 0.8 cm was detected at the rectosigmoid level. Histologically, a benign lesion of neuroid aspect was observed, consisting of multiple spindle cell fascicles that was positive for s-100 and negative for enolase, synaptophysin, CD34, CD117, actin, desmin, Dog1, EMA, and neurofilaments. These findings, supported by the family and personal history of the patient, allowed us to make a diagnosis, discarding other entities.

关键词： schwann Cell Hamartoma Immunohistochemistry

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secondary male hypogonadism： a prevalent but overlooked comorbidity of obesity

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Asian journal of Andrology 2018年第6期20卷 531-538页

作者： Maria Molina-Vega Araceli Mufioz-Garach Miguel Damas-Fuentes josO Carlos Fernfindez-Garcia Francisco j inahones Department of Endocrinology and Nutrition Virgen de la Victoria Universitary HospitalMalaga 29010Spain Institute of Biomedical Research in Malaga（IBIMA） Virgen de la Victoria Universitary HospitalMalaga 29010Spain CIBER Pathophysiology of Obesity and Nutrition（CB06/003） Institute of Health Carlos III（ISClII）Madrid 28029Spain.

Male hypogonadism associated with obesity is a very prevalent condition and is increasing in parallel with the epidemic prevalence of obesity. Low testosterone levels promote higher fat mass with reduced lean mass. Male hypogonadism is related to an increase in associated cardiometabolic complications, such as hypertension, type 2 diabetes mellitus, the metabolic syndrome, and cardiovascular disease. Its influence as a comorbidity of obesity is becoming more evident and should be evaluated and treated in at-risk patients. Mechanisms involved in this relationship include body composition changes, the presence of adipokines, insulin resistance, and other factors, some of which are still unknown. Weight loss and treatment to replace testosterone levels improve the metabolic profile and quality of life in patients with obesity and hypogonadism; these beneficial effects depend on treatment modality and duration of therapy. The use of testosterone replacement therapy may be indicated, as it has not been shown to increase cardiovascular risk, and retrospective studies suggest a reduction in events in men with metabolic syndrome and type 2 diabetes.

关键词： adipose tissue male hypogonadism obesity testosterone

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Primary Analysis of Oceanic Mesoscale Eddies Observation Abilities by sentinel-3A sRAL

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journal of Geodesy and Geoinformation science 2021年第1期4卷 56-62页

作者： jungang YANG jie ZHANG Wei CUI munoz MAITE Makhoul EDUARD First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China IsardsAT s.L. Barcelona 08007Spain

In this study,the north-western Pacific Ocean of Kuroshio region is selected as the experimental area to analyze the mesoscale eddies observation abilities of sentinel-3 A sRAL,including the independent detection abilities of sentinel-3 A sRAL and the improvement of mesoscale eddies detection abilities by data fusion with other satellite altimetry *** sentinel-3 A sRAL data are mapped by the spatial-temporal objective analysis method to the sea level anomaly grid *** mapping errors are analyzed by the comparisons between the grid data of different combinations and along the ground track of jason-2/*** independent detection abilities of sentinel-3 A sRAL are analyzed by the comparison between the grid data and the AVIsO MsLA *** the other hand,through the multi-satellite data fusion of different combinations of sentinel-3 A altimeter and other satellite altimeters such as jason-2/3,the mesoscale eddies detection was performed based on the merged sea level anomaly data and the addition of sentinel-3 A sRAL data for the improvements of mesoscale eddies detection abilities by multi-satellite altimeters are *** is concluded that sentinel-3 A sRAL has good abilities of mesoscale eddies detection as the combination of jason-2 and jason-3,and it is better than that of single altimeter of jason-2 or jason-3.

关键词： sentinel-3 altimeter mesoscale eddy

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