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Structure-based protein-protein interaction networks and drug design

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Frontiers of Electrical and Electronic Engineering in China 2013年第3期8卷 183-191页

作者： Hammad Naveed jingdong j. Han Chinese Academy of Sciences Key Laboratory of Computational Biology Chinese Academy of Sciences-Max Planck PartnerInstitute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai200031 China

Proteins carry out their functions by interacting with other proteins and small molecules, forming a complex interaction network. In this review, we briefly introduce classical graph theory based protein-protein interaction networks. We also describe the commonly used experimental methods to construct these networks, and the insights that can be gained from these networks. We then discuss the recent transition from graph theory based networks to structure based protein-protein interaction networks and the advantages of the latter over the former, using two networks as examples. We further discuss the usefulness of structure based protein-protein interaction networks for drug discovery, with a special emphasis on drug repositioning.

关键词： protein-protein interaction network structure-based drug design drug reposition

A new way to construct topological invariants of non-Hermitian systems with the non-Hermitian skin effect

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Chinese Physics B 2020年第1期29卷 119-123页

作者： j S Liu Y Z Han C S Liu Hebei Key Laboratory of Microstructural Material Physics School of ScienceYanshan UniversityQinhuangdao 066004China

The non-Hermitian skin effect breaks the conventional bulk–boundary correspondence and leads to non-Bloch topological *** by the fact that the topological protected zero modes are immune to perturbations,we construct a partner of a non-Hermitian system by getting rid of the non-Hermitian skin *** adjusting the imbalance hopping,we find that the existence of zero-energy boundary states still dictate the bulk topological invariants based on the band-theory *** non-Hermitian Su–Schrieffer–Heeger(SSH)models are used to illuminate the ***,we obtain the winding numbers in analytical form without the introduction of the generalized Brillouin *** work gives an alternative method to calculate the topological invariants of non-Hermitian systems.

关键词： non-Hermitian skin effect Su–Schrieffer–Heeger(SSH)model bulk–boundary correspondence topological invariant

Cystic fibrosis associated liver disease in children

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World journal of Hepatology 2021年第11期13卷 1727-1742页

作者： joseph j Valamparampil Girish L Gupte Liver Unit Birmingham Children’s HospitalBirmingham B46NHUnited Kingdom

Cystic fibrosis(CF)is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator *** liver disease develops in 5%-10%of patients with CF and is the third leading cause of death among patients with CF after pulmonary disease or lung transplant *** review the pathogenesis,clinical presentations,complications,diagnostic evaluation,effect of medical therapies especially CF transmembrane conductance regulator modulators and liver transplantation in CF associated liver disease.

关键词： Cystic fibrosis liver disease Portal hypertension Cirrhosis Liver transplantation Cystic fibrosis transmembrane conductance regulator modulators Distal intestinal obstructive syndrome

Cuticular hydrocarbon profiles differ between ant body parts:implications for communication and our understanding of CHC diffusion

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Current Zoology 2021年第5期67卷 531-540页

作者： Philipp P.SPRENGER Lisa j.GERBES jacqueline SAHM Florian MENZEL Institute of Organismic and Molecular Evolution(iomE) Johannes Gutenberg-University MainzHanns-Dieter Husch-Weg 15Mainz55128Germany Department of Evolutionary Animal Ecology University of BayreuthUniversitatsstraße 30Bayreuth95477Germany Senckenberg Research Institute Senckenberganlage 2560325 Frankfurt am MainGermany

Insect cuticular hydrocarbons(CHCs)serve as communication signals and protect against *** form complex blends of up to 150 different *** to differences in molecular packing,CHC classes differ in melting *** is especially important in social insects like ants,which use CHCs to communicate within the colony and to recognize *** recognition models often assume a homogenous colony odor,where CHCs are collected,mixed,and redistributed in the postpharyngeal gland(PPG).Via diffusion,recognition cues should evenly spread over the body ***,CHC composition should be similar across body parts and in the *** test this,we compared CHC composition among whole-body extracts,PPG,legs,thorax,and gaster,across 17 ant species from 3 *** CHC composition differed between body parts,with consistent patterns across species and CHC ***-melting CHC classes were most abundant in the *** contrast,whole body,gaster,thorax,and legs had increasing proportions of CHC classes with higher melting *** CHC variation was highest for rather solid,late-melting CHC classes,suggesting that CHCs differ in their diffusion rates across the body *** results show that body parts strongly differ in CHC composition,either being rich in rather solid,late-melting,or rather liquid,early-melting *** implies that recognition cues are not homogenously present across the insect ***,the unequal diffusion of different CHCs represents a biophysical mechanism that enables caste differences despite continuous CHC exchange among colony members.

关键词： nestmate recognition Formicidae eusocial insects melting temperature cuticle regionalization pheromones

EDGE LOCALIZATION BY MULTIPLE OF GAUSSIANs THEORY

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journal of Electronics(China) 1995年第4期12卷 367-373页

作者：高峰 Lucas j. van Vliet Xi'an Institute of Optics & Precision Mechanics Academia Sinica Xi'an 710068 Faculty of Applied Physics Delft University of Technology 2600 GA Delft The Netherlans

Zero-crossing of a derivative of Gaussian filter is a well-known edge location criterion. Examples are the Laplacian, the second derivative in the gradient direction (SDGD) and the sum of the Laplacian and SDGD (PLUS). Derivative operators can easily be implemented by convoluting the primitive image with a derivative of a Gaussian. Gaussian filter displaces the equipotential of half height inwards for convex edge and outwards for concave edges. A Difference-of-Gaussian (DoG) filter is similar to the Laplacian-of-Gaussian but with opposite sign and causes a convex edge shift inwards. This paper introduces the Multiple-of-Gaussian niters to reduce curvature-based location error. Using a linear combination of N Gaussians(N>2) with proper weights, the edge shifts can be reduced to 1/(2N-3) of the ones produced by a similar Laplacian-of-Gaussian filter.

关键词： Edge location Multiple-of-Gaussians Pseudo-second-derivative filter Zero-crossing

Synthesis of Ni-CeO_2 catalyst for the partial oxidation of methane using RF thermal plasma

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Chinese journal of Catalysis 2016年第5期37卷 743-749页

作者： M.Y.Lee j.S.Nam j.H.Seo 韩国全北国立大学应用等离子体工程系韩国全北国立大学量子系统工程系

Ni‐CeO2 catalysts with a nickel content of 50 mol% were prepared using RF thermal plasma, and their catalytic activities for methane partial oxidation were characterized. For the synthesis of Ni‐CeO2 catalysts, a precursor containing Ni（～5‐μm diameter） and CeO2（～200‐nm diameter）powders were heated simultaneously using an RF plasma at a power level of ～52 kVA and a powder feeding rate of ～120 g/h. From the X‐ray diffraction data and transmission electron microscopy images, the precursor formed into high crystalline CeO2 supports with nanosized Ni particles（ 50‐nm diameter） on their surfaces. The catalytic performance was evaluated under atmospheric pressure at 500 °C and a CH4：O2 molar ratio of 2：1 with Ar diluent. Although the Ni content was high（～50 mol%）, the experimental results reveal a methane conversion rate of 70%, selectivities of CO and H2 greater than 90% and slight carbon coking during an on‐stream test at 550 °C for 24 ***, at 750 °C, the on‐stream test revealed the formation of filament‐like carbons with an increased methane conversion rate over 90%.

关键词： RF thermal plasma Methane Partial oxidation Nickel catalyst Ceria Carbon deposition

G.j.沃瑟伯格教授生平简介(一)--从童年到加州理工

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矿物岩石地球化学通报 2017年第1期36卷 179-182页

作者： G j Wasserburg 周新华不详中国科学院地质与地球物理研究所

一、青少年时代沃瑟伯格教授于1927年3月25日生于美国新泽西州New Brunswick一个商人家庭,其外祖父是一成功的涂料和房地产经营者,家境优厚。自幼学习成绩优秀,经常跳级,并深受生物老师等及课余活动矿物学老师有关矿物、晶体、对称等自... 详细信息

一、青少年时代沃瑟伯格教授于1927年3月25日生于美国新泽西州New Brunswick一个商人家庭,其外祖父是一成功的涂料和房地产经营者,家境优厚。自幼学习成绩优秀,经常跳级,并深受生物老师等及课余活动矿物学老师有关矿物、晶体、对称等自然现象的启蒙,野外采集和1939年纽约世界博览会矿物晶体展品的影响,大大激发及培养了对自然界热爱及科学的兴趣和追求。

关键词：瑟伯 G.j 生平简介世界博览会矿物晶体野外采集课余活动房地产经营芝加哥大学森伯

Integrating flood depth and plant resistance with chlorantraniliprole seed treatments for management of rice water weevil, Lissorhoptrus oryzophilus （Coleoptera： Curculionidae）

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Insect Science 2015年第5期22卷 679-687页

作者： Srinivas K. Lanka David C. Blouin Michael j. Stout Department of Entomology Louisiana State University Agricultural Center Baton Rouge LA 70803 USA

Chlorantraniliprole seed treatments in rice provide effective suppression of rice water weevil populations in the United States; however, heavy reliance on prophylac- tic insecticide treatments as a sole strategy could destabilize management programs for this insect. The present research evaluated the compatibility of seed treatments with two other potential management tactics--plant resistance and shallow flooding-by conducting two split-plot experiments in 2009 and 2011. In both experiments, no substantial antago- nism was found among the 3 different tactics. Statistical interactions in these experiments arose from the strong and persistent effects of chlorantraniliprole on larval densities rather than incompatibility of tactics. In 2009, weevil densities differed among varieties and were significantly lower on the cultivar ＂jefferson.＂ In 2011, weevil densities were reduced sig- nificantly in shallow-flooded plots compared to deep-flooded plots. Significant reductions in weevil numbers by chlorantraniliprole seed treatments, even at application rates 5 fold lower than commercially recommended rates, demonstrated the potential to reduce appli- cation rates of this highly potent larvicide. These latter results suggest that future studies on the relationship between chlorantraniliprole seed treatment rate and weevil fitness are warranted.

关键词： chlorantraniliprole compatibility integrated management plant resistance rice water weevil seed treatments

What happens in the smooth muscle cell for lower vasoreactivity in severe shock

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中国病理生理杂志 2001年第8期 66-67页

作者： Zhao KS Liu j Yang GY Department of Pathophysiology First Military Medical University Guangzhou 510515 China

It is very difficult for doctor to treat patient with persistent hypotension in the late stage of shock. The aim of present study was to elucidate the reason for lower vasoreactivity in severe shock. Irreversible hemorrhagic shock of rat was reproduced and the vasoreactivity of arteriole in spinotrapezius muscle to norepinephrine (NE) was measured. The resting membrane potential of isolated arterial strips was detected with a microelectrode. The effect of NO on the membrane potential and intracellular ［Ca2＋］i level in isolated arteriolar smooth muscle cells (ASMCs) was determined with fluorescent probes under confocal microscope. KATP channel of ASMCs was measured with patch clamp method. It was shown that membrane hyperpolarization appeared in arteroles 2 h post hemorrhage, while the resting potential was increased from (-36.9±6.3) mV of control value to (-51.0±9.1) mV with the NE threshold increased to 15 times more than preshock value. The hyperpolarization of ASMCs was closely related to vascular hyporeactivity (correlation coefficient 0.96, P＜0.01). The hyperpolarization was enhanced by lack of ATP, increase in H＋，and OONO- in ASMCs. Single KATP channel conducatance, mean open time and open probability was increased in ASMCs, and the increased ［Ca2＋］i level of ASMCs stimulated by NE was reduced to 50% of normal value. The vasoreactivity, blood pressure and survival rate could be improved by the treatment of glybenclamide and NaHCO3. The study indicates that hyperpolarization of ASMCs is a major reason for lower vasoreactivity in severe shock, since it inhibits the voltage dependent Ca2＋ channel (POC) with the reduction of NE stimulated ［Ca2＋］i increase. The decrease in ATP and increase in H+, and OONO- in ASMCs involves in the activation of KATP channel, leading to the ASMCs hyperpolarization.

关键词： cell