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Clinical heterogeneity of NLrP12-associated autoinflammatory diseases

Genes & Diseases 2023年第3期10卷 1090-1100页

作者： Yue Li Mengyue Deng Yulu Li Xiaolan mao Shi Yan Xuemei Tang Huawei mao Department of rheumatology and Immunology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Infection and ImmunityChongqing 400014China Department of rheumatology and Immunology Children's Hospital of Chongqing Medical UniversityChongqing 400014China

Nod-like receptor family pyrin domain-containing protein 12 (NLrP12) is one of the critical pattern recognition receptors which participates in the regulation of multiple inflammatory responses. Mutations in NLrP12 cause exceptionally rare NLrP12-associated autoinflammatory disease (NLrP12-AID). So far, very few patients with NLrP12-AID have been identified worldwide;therefore, data on the clinical phenotype and genetic profile are limited. In this study, we reported 10 patients who presented mainly with periodic fever syndrome or arthritis. Next-generation sequencing (NGS) identified 6 heterozygous mutations of NLrP12, including 2 novel null mutations. Of the patients, some with same mutations showed different clinical features. Compared to healthy controls, the increased levels of cytokines were revealed in the patients' plasmas, as well as in the supernatants of patients’ cells stimulated with lipopolysaccharide (LPS) or tumor necrosis factor-α (TNF-α). The missense mutations did not change the protein expression;but decreased level of NLrP12 protein was shown in the null mutations. And in vitro expression assay demonstrated a truncating protein induced by the frameshift mutation. Further functional studies revealed the deleterious effect of mutations on nuclear factor-kappa B (NF-κB) signaling. Both the null and missense mutations impaired their inhibition of NF-κB activation induced by p65. Collectively, this study reported a relatively large NLrP12-AID case series. Our findings expand the clinical spectrum, and reinforce the diversity of genetic mutations and clinical phenotypes. The NLrP12-associated disorder should be considered when autoinflammatory diseases are encountered in the clinical practice, especially for patients presenting with periodic fever but no other genetic cause identified.

关键词： Autoinflammatory diseases Fanilial cold autoinflammatory syndr ome type 2(FCAS2) NLrP12-Associated autoinflammatory disease(NLrP12-AID) Nod-like receptor family pyrin domain-containing protein 12(NLrP12) Nuclear factor-Kappa B(NF-kB)

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A survey of free space optical networks

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Digital Communications and Networks 2017年第2期3卷 67-77页

作者： In Keun Son Shiwen mao Department of Electrical and Computer Engineering Auburn University Auburn AL USA Defense Acquisition Program Administration (DAPA) Republie of Korea

Free Space Optical （FSO） networks, also known as optical wireless networks, have emerged as viable candidates for broadband wireless communications in the near future. The range of the potential application of FSO networks is extensive, from home to satellite. However, FSO networks have not been popularized because of insufficient availability and reliability. researchers have focused on the problems in the physical layer in order to exploit the properties of wireless optical channels. However, recent technological developments with successful results make it practical to explore the advantages of the high bandwidth. Some researchers have begun to focus on the problems of network and upper layers in FSO networks. In this survey, we classify prospective global FSO networks into three subnetworks and give an account of them. We also present state-of- the-art research and discuss what kinds of challenges exist.

关键词： Wireless access networks Free space optical networks Free space optical communications Network architecture Optical wireless networks Satellite networks

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Chen jiayong:Pioneer in hydrometallurgy and chemical engineering disciplines

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Chinese journal of Chemical Engineering 2022年第1期35卷 2-5页

作者： Zai-Sha mao Huizhou Liu Chao Yang Institue of Process Engineering Chinese Academy of SciencesBeijing 100190China

*** jiayong(Chia-Yung)was born on Feb.17,1922 in a prestigous intellectual clan at jintang County,Sichuan Province,*** receiving early education at the Chengdu County Middle School(now Chengdu 7th School),he was admitted as an undergraduate student to the Department of Chemical Engineering,the National Central University at the city of Chongqing from 1939 through 1943 during the Anti-japanese *** graduation,he continued to work as a teaching assistant for both the inorganic and organic chemistry courses.

关键词： Chongqing Pioneer admitted

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Dynamic pore wetting and its effects on porous particle flotation:A review

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International journal of Mining Science and Technology 2022年第6期32卷 1365-1378页

作者： Yuqiang mao Wencheng Xia Yaoli Peng Guangyuan Xie Key Laboratory of Coal Processing and Efficient Utilization of Ministry of Education School of Chemical Engineering and TechnologyChina University of Mining and TechnologyXuzhou 221116China

The dynamic pore wetting plays an important role in the flotation of porous particle,such as coal,fly ash,gasification slag,*** phase get into the pores and crevices on the surface and inside of the particles,creating a dense water layer that covers their surface and decreases their *** is important to reduce the adverse impact of dynamic pore wetting on the flotation performance of porous ***,this review is to highlight the dynamic pore wetting behavior,and its role in the porous particle flotation as well as the proposed regulation methods to weaken the pore *** characterization approaches of the dynamic pore wetting are discussed including the optical method for the capillary and the nuclear magnetic resonance(NMr)method for porous *** surface tension and viscosity of liquid significantly affect the pore wetting degree of porous particles during the 60 min wetting ***-wetting time adjustment,pore compression,pore filling,and hydrophobic modifications are introduced to decrease the wetting percentage of pores in porous particles and further improve their flotation *** critical review will provide some guidance for studying the dynamic wetting behavior of pores and enhancing the floatability of porous particles.

关键词： Pore wetting Porous particles NMr Floatability regulation

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An optimized time-adaptive aerothermal coupling calculation method for aerothermal analysis of disc cavity system

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Chinese journal of Aeronautics 2024年第9期37卷 164-177页

作者： Shuai BI junkui mao Lei WANG Feng HAN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 20016China AECC Aeroengine Control System Institute Wuxi 214063China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In order to further achieve the balance between the calculation accuracy and efficiency of the transient analysis of the aero-engine disc cavity system,an Optimized Time-adaptive Aerother-mal Coupling calculation(OTAC)method has been *** combines one-dimensional tran-sient calculation of air system,Conventional Sequence Staggered(CSS)method,Time-adaptive Aerothermal Coupling calculation(TAC)method and differential evolution optimization algorithm to obtain an efficient and high-precision aerothermal coupling calculation method of air *** both the heat conduction in the solid domain and the flow in the fluid domain as unsteady states in the OTAC,the interaction of fluid-solid information within a single coupling time step size was implemented based on the CSS ***,the coupling time step size was automatically adjusted with the number of iterations by using the Proportional-Integral-Deri vative(PID)*** show that when compared with the traditional loosely coupling method with a fixed time step size,the computational accuracy and efficiency of the OTAC method are improved by 8.9%and 30%,*** with the tight coupling calculation,the OTAC method can achieve a speedup of 1 to 2 orders of magnitude,while the calculation error is maintained within 6.1%.

关键词： Air system 1D-3D coupling Conjugate heat transfer Transient calculation Adaptive time step size

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Unsteady analysis of jet impingement under vibration conditions

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Chinese journal of Aeronautics 2022年第5期35卷 291-308页

作者： Yue YANG junkui mao Feilong WANG Xingsi HAN jiangsu Province Key Laboratory of Aerospace Power System Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The vibration of thermodynamic machinery will affect its cooling *** this research,a high-resolution simulation of jet impingement was performed to quantify the unsteady turbulent convection under vibration conditions.A newly developed Self-Adaptive Turbulence Eddy Simulation(SATES)method was *** reynolds number was re=23000,the jet-towall distance was fixed at H/D=2,and the vibrating frequency of the impinging wall f varied from 0 to 200 *** with the static wall case,the maximum enhancement of the stagnation point and area averaged Nusselt number within r/D=1 could reach up to 5%due to the larger primary vortices,whereas it could reduce the heat transfer by 10%beyond r/D=3 due to the suppression of the wall vortices *** on the unsteady analysis and Proper Orthogonal Decomposition(POD)pattern,the modes controlled by vibration were recognized and their contributions to the heat transfer performance were also *** introduction of the vibration promoted the development of the primary vortices and changed the radial alternating motion to a vertical alternating motion at the wall jet *** former was beneficial for the heat transfer,while the latter was unfavorable.

关键词： Impinging jet Proper orthogonal decomposition Self-Adaptive Turbulence Eddy Simulation(SATES) Unsteady turbulent convection Vibration

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Modeling and analysis of air combustion and steam regeneration in methanol to olefins processes

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Chinese journal of Chemical Engineering 2024年第2期66卷 94-103页

作者： jinqiang Liang Danzhu Liu Shuliang Xu mao Ye Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China National Engineering research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116021China University of Chinese Academy of Sciences Beijing 100049China

Light olefins is the incredibly important materials in chemical *** to olefins(MTO),which provides a non-oil route for light olefins production,received considerable attention in the past ***,the catalyst deactivation is an inevitable feature in MTO processes,and regeneration,therefore,is one of the key steps in industrial MTO *** the MTO catalyst is regenerated by removing the deposited coke via air combustion,which unavoidably transforms coke into carbon dioxide and reduces the carbon utilization *** study shows that the coke species over MTO catalyst can be regenerated via steam,which can promote the light olefins yield as the deactivated coke species can be essentially transferred to industrially useful synthesis gas,is a promising pathway for further MTO processes *** this work,we modelled and analyzed these two MTO regeneration methods in terms of carbon utilization efficiency and technology *** shown,the steam regeneration could achieve a carbon utilization efficiency of 84.31%,compared to 74.74%for air combustion *** MTO processes using steam regeneration can essentially achieve the near-zero carbon *** addition,light olefins production of the MTO processes using steam regeneration is 12.81%higher than that using air combustion *** this regard,steam regeneration could be considered as a potential yet promising regeneration method for further MTO processes,showing not only great environmental benefits but also competitive economic performance.

关键词： Model Methanol to olefins regeneration Greenhouse gas Processes simulation

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Machine learning of materials design and state prediction for lithium ion batteries

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Chinese journal of Chemical Engineering 2021年第9期34卷 1-11页

作者： jiale mao jiazhi Miao Yingying Lu Zheming Tong State Key Laboratory of Chemical Engineering Institute of Pharmaceutical EngineeringCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

With the widespread use of lithium ion batteries in portable electronics and electric vehicles,further improvements in the performance of lithium ion battery materials and accurate prediction of battery state are of increasing interest to battery *** learning,one of the core technologies of artificial intelligence,is rapidly changing many fields with its ability to learn from historical data and solve complex tasks,and it has emerged as a new technique for solving current research problems in the field of lithium ion *** review begins with the introduction of the conceptual framework of machine learning and the general process of its application,then reviews some of the progress made by machine learning in both improving battery materials design and accurate prediction of battery state,and finally points out the current application problems of machine learning and future research *** is believed that the use of machine learning will further promote the large-scale application and improvement of lithium-ion batteries.

关键词： Lithium ion batteries Machine learning Materials design State prediction

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Multicolor luminescence of hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals with tunable morphology under 940 nm excitation for temperature-responsive anti-counterfeiting

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journal of rare Earths 2022年第3期40卷 406-414,I0002页

作者： Lingna Xu Hongyan Zheng Tao Pang junwen mao College of Science Huzhou UniversityHuzhou 313000China

In this study,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) microcrystals were synthesized controllably,and upconversion luminescence excited at 940 nm and its application in temperature-responsive anti-counterfeiting are *** is clarified that the Ln^(3+)(Ln=Y+Yb+Ho+Ce)density ratio of bottom plane to side plane in the unit cell can be regulated by Ce^(3+) *** is also proved that the energy transfer of Yb^(3+) to Ho^(3+) is responsible for the activation of Ho^(3+)under 940 nm excitation,while the cross relaxation between Ho^(3+)and Ce^(3+)participates in the redistribution of electron population of^(5)S_(2)/^(5)F_(4)and^(5)F_(5)*** theory and experiment confirm that the intensity ratio of red to green emission(I_(r)/I_(G))as a function of temperature as an independent variable has good linear characteristics in the temperature range of 300-500 *** to the good responsiveness of multicolor luminescence to temperature,the hexagonal NaYF_(4):Yb^(3+)/Ho^(3+)/Ce^(3+) with tunable morphology is a promising candidate for advanced temperature-responsive upconversion *** results provide a new pathway for the controllable synthesis of hexagonal NaYF_(4)microcrystals as well as the regulation of upconversion luminescence that is excited by wavelengths other than 980 nm and its application in anti-counterfeiting.

关键词： Upconversion luminescence Color regulation Anti-counterfeiting rare earths

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Adversarial attacks and defenses for digital communication signals identification

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Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao Tian Sicheng Zhang Shiwen mao Yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China Department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

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