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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

A brief review：experimental investigation of zonal flows and geodesic acoustic modes in fusion plasmas

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Plasma Science and Technology 2018年第9期20卷 72-84页

作者： K j ZHAO j q DONG j.q.l. l W YAN Southwestern Institution of Physics Chengdu 610041People＇s Republic of China

Zonal flows self-generated by turbulence play an important role in regulating turbulence,reducing transport level,and thus improve plasma confinement in fusion *** zonal flows and geodesic acoustic modes have been identified in various *** related issues,such as the poloidal and toroidal symmetries,coupling to turbulence,effects on turbulence and transport,nonlinear energy transfer between turbulence and zonal flows,dependence of the plasma parameters,roles in the confinement regime transitions etc are overviewed briefly in this *** interaction between zonal flows and magnetic islands is emphasized.

关键词： zona flow tokamak turbulence fusion plasma

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Fluid-structure interaction in Z-shaped pipe with different supports

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Acta Mechanica Sinica 2020年第2期36卷 513-523页

作者： q.Guo j.X.Zhou X.l.Guan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Highway Science and Technology Research Institute Xinjiang Production and Construction Corpsürümqi 830002China

Fluid-structure interaction(FSI)has a strong relation with layout of fluid delivery *** is liable to cause local ***,FSI analysis is necessary in many cases,especially for flexible pipe *** modeling consists of eight governing equations and then completely solved via the finite volume method(FVM).Friction,Poisson and joint couplings were discussed in detail to reveal the influence of a Z-shaped pipe with different supports and elbows on *** the feasibility of solving FSI by FVM was verified,the different effects of free,fixed and elastic supports on FSI in the commonly used and simplified Z-shaped pipe were further *** indicated that different support stiffness lead to various FSI *** coupling occurs at the elbow and less support is considered,then the pipe has a relatively large amplitude and complex pressure fluctuation.

关键词： Fluid-structure interaction Finite volume method Z-shaped pipe Support stiffness

Effects of Current Stressing on Shear Properties of Sn-3.8Ag-0.7Cu Solder joints

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journal of Materials Science & Technology 2010年第8期26卷 737-742页

作者： X.j. Wang q.l. Zeng q.S. Zhu Z.G. Wang j.K. Shang Shenyang National laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Department of Materials Science and Engineering University of Illinois at Urbana-Champaign Urbana IL 61801 USA

Effects of electromigration on microstructure, shear strength, and fracture behavior of solder joints were investigated by single-ball shear samples of eutectic Sn-3.8Ag-0.7Cu （SAC） joined by Cu plates at two sides. The electromigration tests were conducted at a current density of about 1.1×10^3 A/cm2 and a working temperature of about 83℃. The results showed that the shear strength and flow stress decreased greatly after current stressing. Such a decrease was associated with no significant loss of the fracture strain at short electromigration but a great reduction in the fracture strain after long-term current stressing. The variation of the fracture strain with the electromigration time was shown to result from the shift of the fracture surface from the center of the solder towards the intermetallic compound （IMC） interface at the cathode.

关键词： Strength Fracture strain Voids Solder

Stochastic averaging of quasi integrable and resonant Hamiltonian systems excited by fractional Gaussian noise with Hurst index 1/2

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Acta Mechanica Solida Sinica 2017年第1期30卷 11-19页

作者： q.F.lü M.l.Deng W.q.Zhu Department of Mechanics State Key Laboratory of Fluid Power and Mechatronic SystemsKey Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang University

A stochastic averaging method of quasi integrable and resonant Hamiltonian systems under excitation of fractional Gaussian noise （fGn） with the Hurst index 1/2 〈 H 〈 1 is proposed. First, the definition and the basic property of fGn and related fractional Brownian motion （iBm） are briefly introduced. Then, the averaged fractional stochastic differential equations （SDEs） for the first integrals and combinations of angle variables of the associated Hamiltonian systems are derived. The stationary probability density and statistics of the original systems are then obtained approximately by simulating the averaged SDEs numerically. An example is worked out to illustrate the proposed stochastic averaging method. It is shown that the results obtained by using the proposed stochastic averaging method and those from digital simulation of original system agree well.

关键词： quasi integrable and resonant Hamiltonian system Fractional Brownian motion Fractional Gaussian noise Stochastic averaging method Internal resonant

Viscosity and structure relationship with equimolar substitution of CaO with MgO in the CaO–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang jie Dang jia Guo Hanghang Zhou Xuewei lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for CaO on the viscosity and structure of a high-alumina CaO-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(q^(3))/X_(q^(2))(X_(q^(i))is the molar fraction of q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by CaO and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

EXPERIMENTAl RESEARCH AND NUMERICAl SIMUlATION OF lASER SHOCK FORMING OF TA2 TITANIUM SHEET

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Acta Metallurgica Sinica(English letters) 2006年第5期19卷 347-354页

作者： F. Wang Z. q. Yao j. Hu q.l. Deng School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200030 China

laser shock forming （ISF） was a new technique realized by applying an impulsive pressure generated by laser-induced shock wave on the surface of metal sheet. lSF of metal sheet was investigated with experiments and numerical simulation. The basic theories were introduced; the surface quality and deformation of the processed titanium sample （TA2） were examined; ABAqUS was used to simulate ISF and the central displacement of the shocked region was measured and compared with the simulation. Overlapped ISF treatment was experimentally carried out to produce groove and simulation. The results showed that the surface quality and the microstructure with single laser pulse had no remarkable change, and ablation was observed on the surface of the sample with overlapped pulses. The deformation observed in the numerical simulation agreeed with that observed in the experimental measurement quite well.

关键词： laser shock forming numerical simulation surface quality deformation

Reliability of quasi integrable and non-resonant Hamiltonian systems under fractional Gaussian noise excitation

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Acta Mechanica Sinica 2020年第4期36卷 902-909页

作者： q.F.lu W.q.Zhu M.l.Deng Department of Mechanics State-Key Laboratory of Fluid Power and Mechatronic SystemsZhejiang UniversityHangzhou 310027China

The reliability of quasi integrable and non-resonant Hamiltonian system under fractional Gaussian noise(fGn)excitation is *** rather flat fGn power spectral density(PSD)in most part of frequency band,the fGn is innovatively regarded as a wide-band ***,the stochastic averaging method for quasi integrable Hamiltonian systems under wide-band noise excitation is applied to reduce 2n-dimensional original system into n-dimensional averaged ltd stochastic differential equations(SDEs).Reliability function and mean first passage time are obtained by solving the associated backward Kolmogorov equation and Pontryagin *** validity of the proposed procedure is tested by applying it to an example and comparing the numerical results with those from Monte Carlo simulation.

关键词： Reliability Fkst passage time quasi integrable and non-resonant Hamiltonian systems Fractional Gauss noise