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Lycorine derivative effectively inhibits the replication of coronaviruses both in vitro and in vivo

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hLife 2024年第2期2卷 75-87页

作者： Liang Shen jianzhong Zhao Ying Xia junjie Lu jiali sun jian Tang Hui Xing Lijuan Yin Yang Yang Chunhua Wang Department of Clinical Laboratory Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceHubeiChina Shenzhen Key Laboratory of Pathogen and Immunity National Clinical Research Center for Infectious DiseaseState Key Discipline of Infectious DiseaseShenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyGuangdongChina Department of Clinical Laboratory Xiangyang No.1 People’s HospitalHubei University of MedicineHubeiChina State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyNational and Local United Engineering Lab of Metabolic Control Fermentation TechnologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjinChina

The established and ongoing prevalence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and seasonal human coronaviruses(HCoV)like HCoV-OC43,HCoV-NL63,and HCoV-229E,pose a continuous threat to public ***,it is urgently needed to explore antiviral drugs with broad-spectrum anti-coronavirus *** previous studies have revealed that lycorine is a potent broad-spectrum anti-coronavirus drug,a natural alkaloid extracted from Amaryllidaceae with various pharmacological and microbiological ***,it is unsafe to directly use lycorine as a clinical antiviral drug due to the cytotoxicity and induction of cell *** this study,a series of lycorine derivatives were designed and *** of them,named Ly-8,was found to effectively inhibit the replication of different coronavirus strains in vitro,including ***,Ly-8 was also shown to effectively inhibit HCoVOC43 replication in the central nervous system,and provide effective protection against HCoV-OC43 infection in mice with low drug ***,Ly-8-resistant mutants were not observed during the 30 times sequential passages in cell ***,these findings suggest that Ly-8 may be a potential candidate drug for the future development of broad-spectrum anti-coronavirus drugs.

关键词： broad-spectrum antiviral drug lycorine derivative Ly-8

Design and Pilot Programs of Marine Exposure Station of A Sea-crossing Bridge

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武汉理工大学学报 2010年第17期32卷 131-136页

作者： qIN M q WANG C j TU L q ZHANG G Z sun T X Wuhan Harbour Engineering Design and Research Co. Ltd. Wuhan 430071China Key Lab of Large-span Bridge Construction Technology Ministry of CommunicationsWuhan 430071China Zhejiang Province Zhoushan Island Linking Construction Commanding Department Zhoushan 316032China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

This paper presents the Location,the structural design as well as the anti-corrosion and the pilot programs of the marine exposure station of Zhoushan Archipelago seas sea-crossing bridges. Subjected to the marine environment,the concrete structures in serve with different mixing proportions,cover thickness,additional anti-corrosion measures such as rust-preventing agent,coating,penetration crystalline waterproof material,silicone and permeable fabric were studied. Those results obtained provide important information for the maintenance of marine concrete and the structural design of sea-crossing bridges in the above sea area.

关键词： exposure station sea-crossing bridge marine concrete durability design

Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World journal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong Feng-Di sun Zhen-Ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-qing Tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World j Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

STUDY OF DYNAMIC RECRYSTALLIZATION OF LOW CARBON STEEL IN THIN SLAB CONTINUOUS ROLLING PROCESS

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Acta Metallurgica Sinica(English Letters) 2006年第4期19卷 265-270页

作者： X.K. Liang X.j. sun q.Y. Liu H. Dong State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute Beijing 100081 China

Combined with the technological characteristics of thin slab continuous rolling process （TSCR）, dynamic recrystallization of an extremely coarse austenite of low carbon steel is studied by Thermecmaster-Z hot simulator. By the analysis of true stress-strain curves and the observation of microstructures at different deformation stages, the critical stress and critical strain are determined under different deformation conditions. The effect of Z parameter on dynamic recrystallization of coarse austenite is studied. The microstructure evolution in real production is also discussed.

关键词： TSCR (thin slab continuous rolling process) coarse austenite dynamic recrystallization

A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance

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Acta Pharmaceutica Sinica B 2024年第1期14卷 223-240页

作者： Lei sun Arabella H.Wan Shijia Yan Ruonian Liu jiarui Li Zhuolong Zhou Ruirui Wu Dongshi Chen Xianzhang Bu jingxing Ou Kai Li Xiongbin Lu Guohui Wan Zunfu Ke Department of Pathology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Local joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(Cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Hepatic Surgery and Liver Transplantation Center Third Affiliated HospitalOrgan Transplantation InstituteSun Yat-sen UniversityOrgan Transplantation Research Center of Guangdong ProvinceGuangdong Province Engineering Laboratory for Transplantation MedicineGuangzhou 510630China Guangdong Provincial Key Laboratory of Liver Disease Research Guangzhou 510630China Department of Ultrasound Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Melvin and Bren Simon Comprehensive Cancer Center Indiana UniversityIndianapolisIN 46202USA

Lenvatinib,a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer,facing limitations due to drug ***,we applied a multidimensional,high-throughput screening platform comprising patient-derived resistant liver tumor cells(PDCs),organoids(PDOs),and xenografts(PDXs)to identify drug susceptibilities for conquering lenvatinib resistance in clinically relevant *** and passaging of PDCs and PDOs from resistant patient liver tumors retained functional fidelity to lenvatinib treatment,expediting drug repurposing *** screening identified romidepsin,YM155,apitolisib,NVP-TAE684 and dasatinib as potential antitumor agents in lenvatinib-resistant PDC and PDO ***,romidepsin treatment enhanced antitumor response in syngeneic mouse models by triggering immunogenic tumor cell death and blocking the EGFR signaling pathway.A combination of romidepsin and immunotherapy achieved robust and synergistic antitumor effects against lenvatinib resistance in humanized immunocompetent PDX ***,our findings suggest that patient-derived liver cancer models effectively recapitulate lenvatinib resistance observed in clinical settings and expedite drug discovery for advanced liver cancer,providing a feasible multidimensional platform for personalized medicine.

关键词： Lenvatinib Drug resistance High-throughput screening Drug discovery Patient-derived model Romidepsin EGFR Liver cancer

STUDY ON THE VARIATION MECHANISM OF CARBON CONTENT OF LIqUID IRON IN MELTING GASIFIER

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Acta Metallurgica Sinica(English Letters) 2003年第2期16卷 132-138页

作者： q.Lu L.F sun Y.Xu q.F.Chan Hebei University of Technology Tangshan 063009ChinaHebei University of TechnologyTangshan 063009ChinaHebei University of TechnologyTangshan 063009ChinaHebei Institute of Vocation and TechnologvShiiiazhuang 050031China

This paper studied the changing principles of carbon content in direct reduction iron (DRI) and liquid iron in the COREX melting gasifier. Under the normal working conditions of experimental equipment, liquid nitrogen was poured into the melting gasifier from its tuyere to cool down quickly. And then seven cross sections were made to study the carburization reaction and its characteristics of the solid iron and the liquid iron, and also the reaction of carbon between the slag and the metal. According to the results, the influences of the thickness of the semi-coke layer and the temperature on the carbon content of liquid iron in the COREX melting gasifier were confirmed.

关键词： melting gasifier direct reduction iron (DRI) liquid iron carbon content

A　NEW　DITERPENOID　FROM　COLEUS　SCUTELLARIOIDES

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Chinese Chemical Letters 1996年第5期7卷 441-442页

作者： Mu, q Zhang, Hj Li, CM sun, HD ACAD SINICA KUNMING INST BOTLAB PHYTOCHEMKUNMING 650204PEOPLES R CHINA

Abstract: From the herbs of Coleus sculellarioides, a new diterpenoid was isolated and identified as 2-(2'ξ-methoxypropy)-3-hydroxy-5,7,8-trimethylphenanthrene-1,4--dione,named as scutequinone(1).

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Fabrication of Chemically-Modified Electrode Containing 1:12 Phosphomolybdic Anions by Sol-Gel Technique and Its Electrocatalytic Reduction of BrO₃^-Anions

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Chinese Chemical Letters 1998年第12期9卷 0-0,0-0页

作者： Song W.B. sun C.q. Department of Chemistry Jilin University Changchun 130023 China

A novel chemically-modified electrode containing 1:12 phosphomolybdic anions was achieved on the surface of platinum electrode by the sol-gel technique. The electrode exhibits a high catalytic activity towards the ele... 详细信息

关键词： Chemically-modified electrode Electrocatalysis Polyoxometallates Sol-gel technique

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稀土圆偏振发光材料研究进展

化学学报 2024年第6期82卷 707-730页

作者：李小贞孙庆福福建师范大学海峡柔性电子实验室福州350117 中国科学院福建物质结构研究所结构化学国家重点实验室福州350002

圆偏振光(CPL)是一种特殊而重要的光,在三维显示、有机光电器件、安全油墨、生物和化学探针等方面具有广泛应用前景.发光不对称因子和发光量子产率是衡量圆偏振发光性能的重要指标.受磁跃迁偶极矩较小的影响,大部分手性材料的发光不对... 详细信息

圆偏振光(CPL)是一种特殊而重要的光,在三维显示、有机光电器件、安全油墨、生物和化学探针等方面具有广泛应用前景.发光不对称因子和发光量子产率是衡量圆偏振发光性能的重要指标.受磁跃迁偶极矩较小的影响,大部分手性材料的发光不对称因子较小.稀土金属离子优异的光、电性能和部分磁偶极跃迁允许特性使手性稀土化合物被认为是理想的具有高发光不对称因子和高发光量子产率的圆偏振发光材料.基于此,本综述归纳总结了手性稀土材料在可见光、近红外光和双光子激发圆偏振发光材料等方面的研究进展,探讨了配体、溶剂、阴离子、多级自组装作用和外界刺激等因素对圆偏振发光性能的调控规律,总结了手性稀土圆偏振发光材料在圆偏振有机发光二极管、生物传感、检测、防伪和成像等方面的应用,以及该领域目前面临的主要机遇和挑战.

关键词：稀土手性圆偏振发光自组装发光不对称因子