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Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism

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journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 410-421页

作者： Chong LAI qingling YANG Yunuo ZHANG Renjie GONG Majie WANG jiankang LI Maode LAI qingrong sun Department of Urology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China School of Basic Medical Sciences and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009China Department of Laboratory Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Laboratory of Behavioral Neuroscience Ningbo Kangning HospitalNingbo Institute of Microcirculation and HenbaneSchool of MedicineNingbo UniversityNingbo 315201China Xi'an Key Laboratory of Stem Celland Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi'an 710072China Department of Pathology Research Unit of Intelligence Classification of Tumor Pathology and Precision TherapyChinese Academy of Medical Sciences Key Laboratory of Disease Proteomics of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310058China

Pheochromocytomas and paragangliomas(PPGLs)cause symptoms by altering the circulation levels of catecholamines and peptide ***,the diagnosis of PPGLs relies on diagnostic imaging and the detection of *** this study,we used ultra-performance liquid chromatography(UPLC)/quadrupole time-of-flight mass spectrometry(q-TOF MS)analysis to identify and measure the perioperative differential metabolites in the plasma of adrenal pheochromocytoma *** identified differentially expressed genes by comparing the transcriptomic data of pheochromocytoma with the normal adrenal *** conducting two steps of metabolomics analysis,we identified 111 differential metabolites between the healthy group and the patient group,among which 53 metabolites were *** integrating the information of differential metabolites and differentially expressed genes,we inferred that the cysteine-methionine,pyrimidine,and tyrosine metabolism pathways were the three main metabolic pathways altered by the *** analysis of transcription levels revealed that the tyrosine and cysteine-methionine metabolism pathways were downregulated in pheochromocytoma,whereas the pyrimidine pathway showed no significant ***,we developed an optimized diagnostic model of two metabolites,L-dihydroorotic acid and *** results for these metabolites suggest that they may serve as potential clinical biomarkers and can be used to supplement and improve the diagnosis of pheochromocytoma.

关键词： Pheochromocytoma and paraganglioma(PPGL) Metabolomics Gene set variation analysis L-Dihydroorotic acid Vanylglycol

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

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Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi Xu jianhong Yang Yao Xu Xiaofeng Wang Xiang Gao jie sun Chenhui Zhou Yi Huang Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province NingboZhejiang ProvinceChina

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier *** microvascular endothelial cells are a major component of the blood-brain *** mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial *** this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial *** found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial ***,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial *** established an in vitro brain microvascular endothelial cell model of the blood-brain *** found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain *** a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic *** found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic *** findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

Effect of Fe_(2)O_(3)on the Structure,Physical Properties and Crystallization of CaO-Al_(2)O_(3)-SiO_(2)Glass

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journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 954-961页

作者：张峰 XIONG Dehua 谢俊张继红 HAN jianjun CHEN Dequan WEN Zhongquan FAN Zhenhua CHEN Lina sun Tengfei State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Hepu Research Center for Silicate Materials Industry Technology Beihai 536100China Hainan Institute of Wuhan University of Technology Sanya 430079China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China Chongqing Polycomp Inter-national Corporation Chongqing 400400China

The calcium aluminosilicate-based glasses(CaO-Al_(2)O_(3)-SiO_(2),CAS)with different Fe_(2)O_(3)content(0.10wt%,0.50wt%,0.90wt%,and 1.30wt%)were prepared by traditional melt-quenching *** glass network structure,thermal and mechanical properties,and crystallization behavior changes were investigated by nuclear magnetic resonance spectrometer,Fourier-transform infrared spectro-photometer,X-ray diffractometer,differential scanning calorimetry and field emission scanning electron microscope *** change of q^(n)in glass structures reveals the glass network connectivity decreases due to the increasing content of Fe_(2)O_(3)addition,resulting in the increasing of non-bridging number in glass *** glass densities slightly rise from 2.644 to 2.681 g/cm^(3),while Vickers’s hardness increases at first,from 6.469 to 6.901 GPa,then slightly drops to 6.745 GPa,with Fe_(2)O_(3)content *** is almost no thermal expansion coefficient change from different Fe_(2)O_(3)*** glass transmittance in visible range gradually decreases with higher Fe_(2)O_(3)content,resulting from the strong absorption of Fe^(2+)and Fe^(3+)*** calculated activation energy from thermal analysis results first decreases from 282.70 to 231.18 kj/mol,and then increases to 244.02 kj/mol,with the Fe_(2)O_(3)content increasing from 0.10wt%to 1.30wt%.Meanwhile,the maximum Avrami constant of 2.33 means the CAS glasses exhibit two-dimensional *** of the CAS glass-ceramics samples contain main crystal phase of anorthite,the microstructure appears lamellar and columnar crystals.

关键词： calcium aluminosilicate glass network structure physical properties crystallization

Hot Compression Behavior and Tensile Property of a Novel Ni-Co-Based Superalloy Prepared by Electron Beam Smelting Layered Solidification Technology

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 283-292页

作者： Yong-Chao Gai Rui Zhang Chuan-Yong Cui Zi-jian Zhou Yi Tan Yi-Zhou Zhou Xiao-Feng sun Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

The hot compression behavior and tensile strength after compression of a new Ni-Co-based superalloy produced using electron beam smelting layered(EBSL)solidification technology were *** compression tests were performed at temperatures of 1120℃and 1150℃,with strain rates of 1 s^(-1) and 0.01 s^(-1),reaching a true strain of *** strength was evaluated at room *** results revealed that this EBSL technology accelerates dynamic recrystallization(DRX),without compromising the strength of alloy.A significant correlation between the volume fraction of DRX and the strain rate was observed,with higher fractions at lower strain rates,leading to higher tensile ***,at the same strain rate,the specimens compressed at 1120℃exhibited higher tensile strength due to undissolvedγ′*** solution and aging heat treatment,the alloy maintained high tensile *** results suggested that the EBSL Ni-Co-based superalloy offers excellent prospects for practical applications.

关键词： Ni-Co-based superalloy Hot deformation Electron beam smelting Tensile strength

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雷公藤多甙及其活性化合物的遗传学研究

中国男科学杂志 1989年第3期10卷 133-136页

作者：史家芳王薏刘启兰潘丽孙家庆张珠涛胡延忠许烨钱绍祯江苏省计划生育研究所

雷公藤乡甙(GTW)在雄性大鼠及男子均可致不育而无明显毒副作用,从雷公藤提得的新化合物T_4在雄大鼠也有明确的抗生育作用,至于它们是否会产生遗传学后果,是人们关注而迄未报道的问题。本文进行了GTW对大鼠及人某些重要遗传学指标的影响... 详细信息

雷公藤乡甙(GTW)在雄性大鼠及男子均可致不育而无明显毒副作用,从雷公藤提得的新化合物T_4在雄大鼠也有明确的抗生育作用,至于它们是否会产生遗传学后果,是人们关注而迄未报道的问题。本文进行了GTW对大鼠及人某些重要遗传学指标的影响,包括大鼠显性致死突变、胎肝淋巴细胞染色体畸变与微核率、以及人外周淋巴细胞染色体畸变率、姐妹染色单体互换(SCE)率、微核率、细胞分裂指数的研究,也观察了T_4对大鼠外周淋巴细胞微核率的影响。结果表明,从上述指标来看,抗生育剂量的GTW及T_4未见导致明显的遗传学影响。

关键词：雷公藤诱变作用雄性抗生育

Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： j.A.Carter M.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams j.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-j.Hu M.K.james L.juusola K.Kauristie E.A.Kronberg M.Lester j.Manuel j.Matzka I.McCrea Y.Miyoshi j.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.sun M.-T.Walach B.Walsh C.Wang j.Weygand j.Wild j.Yan j.Zhang q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

Acasta片麻杂岩多期次热事件:来自锆石、榍石和磷灰石的原位微区年代学证据

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中国科学：地球科学 2024年第3期54卷 693-707页

作者：梅清风杨进辉孙金凤李秋立吴石头凌潇潇彭澎王浩中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 中国科学院大学地球与行星科学学院北京100049 中国科学院大学计算地球动力学重点实验室北京100049

本文使用激光剥蚀电感耦合等离子体质谱(LA-ICPMS)和二次离子质谱(SIMS)对Acasta片麻杂岩样品碎片(大小约1cm2)中的锆石、磷灰石和榍石进行了原位微区定年,以制约Acasta片麻杂岩的热演化历史.这些样品碎片中的锆石显示多期年龄,反映了... 详细信息

本文使用激光剥蚀电感耦合等离子体质谱(LA-ICPMS)和二次离子质谱(SIMS)对Acasta片麻杂岩样品碎片(大小约1cm2)中的锆石、磷灰石和榍石进行了原位微区定年,以制约Acasta片麻杂岩的热演化历史.这些样品碎片中的锆石显示多期年龄,反映了继承锆石的存在或者锆石结晶后的再生长过程.结合前人研究,本文锆石数据揭示, Acasta片麻杂岩经历的多期岩浆事件发生时间分别为:>3.96、约3.72和约3.57Ga.样品AY199中榍石的PbPb等时线年龄为(2911±22)Ma(95%置信水平, MSWD=1.5),与Acasta片麻杂岩记录的太古宙最后一次岩浆事件年龄一致.样品AC478和AY066中榍石U-Pb年龄分别为(1932±270)Ma(95%置信水平, MSWD=2.3)和(1813±45)Ma(95%置信水平, MSWD=2.3).样品P090803-C中磷灰石的Pb-Pb等时线年龄为(1833±26)Ma(95%置信水平,MSWD=1.4).样品AC478、AY199和AY066中磷灰石U-Pb年龄分别为(1850±20)Ma(95%置信水平, MSWD=1.3)、(1827±100)Ma(95%置信水平, MSWD=6.3)和(1807±58)Ma(95%置信水平, MSWD=3.9).样品AC478和AY066中的榍石U-Pb年龄以及本文所有样品中的磷灰石Pb-Pb或U-Pb年龄相同,均为约1.9~1.8Ga,指示Wopmay造山作用导致的矿物U-Pb体系重置,证明了Wopmay造山作用的峰期温度超过了磷灰石的U-Pb体系封闭温度,并接近或者超过榍石的U-Pb体系封闭温度.

关键词：锆石榍石磷灰石 Acasta片麻杂岩 Wopmay造山带

Thermal comfort in a building with Trombe wall integrated with phase change materials in hot summer and cold winter region without air conditioning

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Energy and Built Environment 2024年第1期5卷 58-69页

作者： jie Li Yuan Zhang Ziyang Zhu jiangtian Zhu jing Luo Fen Peng Xiaoqin sun School of Energy and Power Engineering Changsha University of Science and TechnologyChangshaHunan 410114PR China

Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal ***,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal *** compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with *** on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were *** the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter *** show that the Trombe wall helped PCMs complete the phase change process *** wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,*** with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions.

关键词： Trombe wall Phase change materials Integrated indoor discomfort duration Integrated discomfort degree-hour Liquid fraction

Bacteriophages assisted bacteria to facilitate soil multifunctionality under organochlorine pesticide contamination

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Science China Technological Sciences 2024年第10期67卷 3116-3128页

作者： ZHAO DuoKai CHAO HuiZhen BALCAZAR jose Luis WU ShiMao ZHENG XiaoXuan WU YunLing YUAN Shujian sun MingMing HU Feng Soil Ecology Lab Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization and Jiangsu Key Laboratory for Solid Organic Waste UtilizationNanjing Agriculture University j.F.Blumenbach Institute of Zoology and Anthropology University of G?ttingen Catalan Institute for Water Research (ICRA) University of Girona College of Environmental and Resource Sciences Zhejiang University

As the most abundant living entities in the environment, viruses have been well recognized as crucial members in sustaining biogeochemical cycling. However, the significance of viruses in soil ecosystem multifunctionality remains under-explored. In this study, we used metagenomics and meta-viromics analysis to investigate the role of soil viruses in soil ecosystem functions under heavy, light, and no organochlorine pesticides(OCPs) contamination. In the three types of soil samples collected, lightcontaminated soils supported the highest level of multifunctionality, followed by heavy-contaminated soils and clean ***, our results revealed a positive correlation between bacterial community evenness and multifunctionality index(p <0.05). Dominant bacterial species with biodegradation and stress resistance advantages exhibited higher abundance in OCPaffected soils, potentially playing a core functional supporting role. Furthermore, our results indicated that the species richness and diversity of bacteriophages were positively correlated with multifunctionality(p < 0.05) in OCP-affected soils. Bacteriophages in OCP-affected soils regulate host metabolism and enhance soil ecosystem multifunctionality by infecting functional bacterial hosts and encoding AMGs related to soil element cycling. Our findings emphasize the potential effect of phages on ecosystem multifunctionality in contaminated soil, suggesting that phages may serve as contributors to soil ecology beyond bacteria and other microorganisms. Therefore, in polluted or constrained soils, further research could potentially translate phage communities and related ecological processes into artificial methods for application in soil pollution remediation or ecological restoration.

关键词： soil ecosystem multifunctionality viruses auxiliary metabolic genes organochlorine pesticides contamination

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