检索结果-南通市图书馆

Impact of high-fat diet on antioxidant status, vascular wall thickening and cardiac function in adult female LDLR<sup>–/–</sup>mice

引用

World journal of Cardiovascular Diseases 2012年第3期2卷 184-192页

作者： Stéphanie Delemasure Carole Richard Ségolène Gambert jean-Claude Guilland Catherine Vergely patrick Dutartre Luc Rochette jean-Louis Connat Biochemistry Department University Hospital Dijon France COHIRO Biotechnology Faculty of Medicine Dijon France Laboratory of Cardio-Metabolic Pathophysiology and Pharmacology Faculty of Medicine University of Burgundy Inserm UMR866 Dijon France

Background: Western diet, rich in saturated fatty acids and cholesterol, is associated with increased cardiovascular risk. We thus investigated in female mice the influence of this diet on plasma antioxidant status, vascular wall thickening and cardiac function. Methods and Results: Adult female C57BL/6j wild type (WT) and LDLR–/– mice were fed a normal diet (ND) or a high-fat diet (HFD) for 17 weeks. HFD induced an increase in plasma lipids and vitamin C (Vit C) levels in both groups but at a much higher level in LDLR–/– and a decrease in plasma ascorbyl free radical levels to Vit C ratio (an endogenous oxidative stress index) in LDLR–/–. We only found a slight decrease in circulating antioxidant status evaluated by the Oxygen Radical Absorbance Capacity (ORAC) assay in WT, but not in LDLR–/–. Echocardiography evidenced an increase in arterial wall thickness in aortic arch at atherosclerosis predilection sites in HFD LDLR–/– as compared to ND LDLR–/– and HFD WT. This result was confirmed by histology. Further-more, histological examination of aortic valves showed an increase in atherosclerotic lesions. Our study, using echocardiography, show that chronic HFD does not induce any major modifications of systolic function in the both mice groups. Conclusions: High-fat intake in mice causes serious disturbances in lipid plasma levels associated to variations of circulating antioxidant status due, at least in part, to an increase in Vit C. At this stage, atherosclerotic lesions, observed in aortic arch and valve, do not impair cardiac function in HFD-fed mice.

关键词： Ascorbyl Free Radical Echocardiography Vitamin C High-Fat Diet Oxygen Radical Absorbance Capacity Oxidant/Antioxidant Status Systolic Function Aortic Arch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

利用旋涂法和喷墨印刷法在室温下沉积银导电层

引用

中国印刷与包装研究 2011年第2期3卷 63-66页

作者： josué j P Valeton Ko Hermans Cees W M Bastiaansen Dirk j Broer jolke Perelaer Ulrich S Schubert Gregory P Crawford patrick j Smith 王晓芳 Department of Chemical Engineering Eindhoven University of TechnologyP O Box 513NL-5600 MB EindhovenThe Netherlands NeoDec BV Raiffeisenstraat 9NL-5611 CH EindhovenThe Netherlands Laboratory of Organic and Macromolecular Chemistry Friedrich-Schiller-University JenaHumboldtstr.1007743 JenaGermany College of Science University of Notre DameNotre DameIndiana46656USA Laboratory for Simulation Albert-Ludwigs-University FreiburgGeorges-Kohler Allee 10279110 FreiburgGermany

以具有低玻璃化温度的聚合物,如PET为基材,采用喷墨印刷法及旋涂法沉积含银金属有机油墨,经UV光固化及对苯二酚溶液处理生成银导电层,此过程在室温下进行,用时不到1min。结果表明银导电层的电导率是纯银的10%。本文也测试了沉积银导电层... 详细信息

以具有低玻璃化温度的聚合物,如PET为基材,采用喷墨印刷法及旋涂法沉积含银金属有机油墨,经UV光固化及对苯二酚溶液处理生成银导电层,此过程在室温下进行,用时不到1min。结果表明银导电层的电导率是纯银的10%。本文也测试了沉积银导电层后PET膜的机械稳定性,发现电阻随着应变的增加呈线性增长,经过12000次变形试验后其电阻不再发生明显变化。

关键词：喷墨印刷导电沉积银利用 PET膜对苯二酚聚合物

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats

引用

World journal of Critical Care Medicine 2019年第7期8卷 106-119页

作者： Andreas janata Ingrid AM Magnet Kristin L Schreiber Caleb D Wilson jason P Stezoski Keri janesko-Feldman patrick M Kochanek Tomas Drabek Safar Center for Resuscitation Research University of Pittsburgh School of MedicinePittsburghPA 15224United States Department of Critical Care Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Emergency Department KA RudolfstiftungVienna 1030Austria Department of Emergency Medicine Vienna General HospitalMedical University of ViennaVienna 1090Austria Department of Anesthesiology and Perioperative Medicine University of Pittsburgh School of MedicinePittsburghPA 15213United States Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Wyoming Otolaryngology Wyoming Medical CenterCasperWY 82604United States

BACKGROUND Prolonged cardiac arrest(CA)produces extensive neuronal death and microglial proliferation and activation resulting in neuro-cognitive *** other potential mechanisms,microglia have been implicated as triggers of neuronal death after hypoxic-ischemic *** is neuroprotective in some brain ischemia models,either by blunting the microglial response or by a direct effect on *** To improve survival,attenuate neurologic deficits,neuroinflammation,and histological damage after ventricular fibrillation(VF)CA in *** Adult male isoflurane-anesthetized rats were subjected to 6 min VF CA followed by 2 min resuscitation including chest compression,epinephrine,bicarbonate,and *** return of spontaneous circulation(ROSC),rats were randomized to two groups:(1)Minocycline 90 mg/kg intraperitoneally(i.p.)at 15 min ROSC,followed by 22.5 mg/kg *** 12 h for 72 h;and(2)Controls,receiving the same volume of vehicle(phosphate-buffered saline).The rats were kept normothermic during the postoperative *** injury was assessed daily using Overall Performance Category(OPC;1=normal,5=dead)and Neurologic Deficit Score(NDS;0%=normal,100%=dead).Rats were sacrificed at 72 *** degeneration(Fluoro-jade C staining)and microglia proliferation(anti-Iba-1 staining)were quantified in four selectively vulnerable brain regions(hippocampus,striatum,cerebellum,cortex)by three independent reviewers masked to the group *** In the minocycline group,8 out of 14 rats survived to 72 h compared to 8 out of 19 rats in the control group(P=0.46).The degree of neurologic deficit at 72 h[median,(interquartile range)]was not different between survivors in minocycline vs controls:OPC 1.5(1-2.75)vs 2(1.25-3),P=0.442;NDS 12(2-20)vs 17(7-51),P=0.328)or between all studied *** number of degenerating neurons(minocycline vs controls,mean±SEM:Hippocampus 58±8 vs 76±8;striatum 121±43 vs 153±32;cerebellum 20±7 vs 22

关键词： Heart arrest/pathology Cardiopulmonary resuscitation Survival rate Neurons/drug effects Microglia/drug effects Minocycline/pharmacology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Introducing the Open Energy Ontology: Enhancing data interpretation and interfacing in energy systems analysis

引用

能源与人工智能(英文) 2021年第3期5卷 53-66页

作者： Meisam Booshehri Lukas Emele Simon Flügel Hannah Förster johannes Frey Ulrich Frey Martin Glauer janna Hastings Christian Hofmann Carsten Hoyer-Klick Ludwig Hülk Anna Kleinau Kevin Knosala Leander Kotzur patrick Kuckertz Till Mossakowski Christoph Muschner Fabian Neuhaus Michaja Pehl Martin Robinius Vera Sehn Mirjam Stappel Institute for Applied Ecology BerlinGermany Institute for Applied Informatics(InfAI)/Leipzig University Germany Department of Energy Systems Analysis Institute of Networked Energy SystemsGerman Aerospace Center(DLR)StuttgartGermany Faculty of Computer Science Otto-von-Guericke-Universität MagdeburgGermany Reiner Lemoine Institut BerlinGermany Institute of Techno-economic Systems Analysis(IEK-3) Forschungszentrum JülichJülichGermany Institute of Energy Economics and Rational Energy Use University of StuttgartGermany Potsdam Institute for Climate Impact Research PotsdamGermany Fraunhofer Institute for Energy Economics and Energy System Technology KasselGermany

Heterogeneous data,different definitions and incompatible models are a huge problem in many domains,with no exception for the field of energy systems ***,it is hard to re-use results,compare model results or couple models at *** provide a precisely defined vocabulary to build a common and shared conceptu-alisation of the energy ***,we present the Open Energy Ontology(OEO)developed for the domain of energy systems *** the OEO provides several benefits for the ***,it enables consistent annotation of large amounts of data from various research *** example is the Open Energy Platform(OEP).Adding such annotations makes data semantically searchable,exchangeable,re-usable and ***,computational model coupling becomes much *** advantages of using an ontology such as the OEO are demonstrated with three use cases:data representation,data annotation and interface *** also describe how the ontology can be used for linked open data(LOD).

关键词： Collaborative ontology development Linked open data Metadata annotation Energy systems analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic pancreatitis:A surgical disease?Role of the Frey procedure

引用

World journal of Gastrointestinal Surgery 2014年第7期6卷 129-135页

作者： Alexra Roch jérome Teyssedou Didier Mutter jacques Marescaux patrick Pessaux Digestive and Endocrine Surgery Nouvel Hopital CivilUniversity of Strasbourg67000 StrabourgFrance Institut de recherche en cancéro-logie de l’appareil digestif(IRCAD) 67000 StrasbourgFrance IHU-Strasbourg Minimally-Inva-sive Image-Guided Surgical InstituteUniversity of Strasbourg67000 StrabourgFrance

Although medical treatment and endoscopic interven-tions are primarily offered to patients with chronic pancreatitis, approximately 40% to 75% will ultimately require surgery during the course of their disease. Al-though pancreaticoduodenectomy has been considered the standard surgical procedure because of its favorable results on pain control, its high postoperative complica-tion and pancreatic exocrine or/and endocrine dysfunc-tion rates have led to a growing enthusiasm for duodenal preserving pancreatic head resection. The aim of this review is to better understand the rationale underlying of the Frey procedure in chronic pancreatitis and to ana-lyze its outcome. Because of its hybrid nature, combin-ing both resection and drainage, the Frey procedure has been conceptualized based on the pathophysiology of chronic pancreatitis. The short and long-term outcome, especially pain relief and quality of life, are better after the Frey procedure than after any other surgical proce-dure performed for chronic pancreatitis.

关键词： Chronic pancreatitis Frey procedure Surgery Complication Outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

***-oxidation of N-retinylidene-N-retinylethanolamine in vitro by high-energy visible light

引用

Annals of Eye Science 2018年第1期 430-430页

作者： Marie-Christine Lambert Mathieu Ouellette Élodie Boisselier patrick j.Rochette Centre Universitaire d’Ophtalmologie Hôpital du Saint-SacrementCHU de QuébecCanada Axe Médecine Régénératrice Centre de recherche du CHU de QuébecHôpital du Saint-SacrementCHU de QuébecCanada Département d’ophtalmologie et d’ORL-CCF Facultéde médecineUniversitéLavalQuébecCanada

Background:Age-related macular degeneration(AMD)is the second Canadian cause in visual *** is characterized by the death of photoreceptors and retinal pigmented epithelium(RPE)in the macular region of the retina,leading to the loss of central *** studies suggest an association between lifetime sun exposure and the probability to develop AMD even though mechanisms are *** is made of about 30%of high-energy visible(HEV)light(blue light),the most energetic wavelength reaching the *** wavelengths can be absorbed by lipofuscin,an age pigment accumulating in RPE *** principal component is N-retinylidene-N-retinylethanolamine(A2E).Many research teams showed that absorption of HEV light by A2E in RPE cells at non-physiological doses produces free radicals and leads to cell *** earlier work shows that when A2E-loaded RPE cells are irradiated with HEV light at physiological doses,the same light does not lead to oxidative stress as measured by telomere and mitochondrial *** hypothesis is that HEV light,at physiological doses,modify or convert A2E in derived produces,inhibiting its photo-oxidant ***:In vitro,we irradiated A2E with HEV light with or without antioxidants and with varying irradiation regimen to observe the UV-Visible spectrum of *** cellulo,we loaded ARPE-19 cells with A2E and irradiated cells at physiological levels for 4 consecutive *** then observed A2E fluorescence using a fluorescence microscope with nucleus counterstaining with ***:HEV light leads to the disappearance of A2E characteristic UV-Visible spectrum and the apparition of a new product suggesting that HEV light modifies *** oxidation and irradiation regimen seem to have an impact in A2E’s conversion by HEV *** observed and progressive diminution of A2E fluorescence in cellulo during physiological ***:The loss of A2E photo-oxidation capacities by HEV light seems to

关键词： Age-related macular degeneration(AMD) A2E degradation blue light retinal pigmented epithelium(RPE) cellular toxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

诊断性试验和策略的证据质量和推荐强度的分级

引用

中国循证医学杂志 2009年第5期9卷 503-508页

作者： Holger j Schünemann Andrew D Oxman jan Brozek Paul Glasziou Roman jaeschke Gunn E Vist john W Williams jr Regina Kunz jonathan Craig Victor M Montori patrick Bossuyt Gordon H Guyatt 李晓黄程陈耀龙李幼平代表GRADE工作组

GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局，

关键词：诊断性试验证据质量强度 E系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

奥斯卡·冯·米勒中心

引用

城市环境设计 2016年第3期 64-73页

作者： Thomas Herzog Hanns j?rg Schrade Roland Schneider Yann Friedl Martin Schumacher Tina Bayerl patrick Brll Kirsten Braun Christoph Rehbach Rainer Wittenborn j?rg Koopmann Verena Herzog-Loibl Herzog+Partner

这座国际交流中心坐落于慕尼黑市中心老城区与大学以及博物馆片区交会的地方。兴建该中心的目的是促进慕尼黑工业大学对优秀建筑工程师的教育培养。该项目的赞助商是巴伐利亚建筑贸易基金会。项目的设计严格遵守了开发计划中紧凑的用地... 详细信息

这座国际交流中心坐落于慕尼黑市中心老城区与大学以及博物馆片区交会的地方。兴建该中心的目的是促进慕尼黑工业大学对优秀建筑工程师的教育培养。该项目的赞助商是巴伐利亚建筑贸易基金会。项目的设计严格遵守了开发计划中紧凑的用地参数和

关键词：图书馆建筑立面建筑物百叶窗大堂客座教师排风慕尼黑德国遮阳

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Knowledge and Practice in Emergency Obstetric and Neonatal Care (EmONC) Providers in Kinshasa, Democratic Republic of Congo

引用

Open journal of Obstetrics and Gynecology 2022年第9期12卷 979-992页

作者： joëlle Ambis Lumaya Roger Mwimba Mbungu Andy Muela Mbangama patrick Muyayalo Kahindo Berry Nsiangangu Kinkenda Guillaume Bisinkam Malingisi Anselme Mulaila Mbungu jean Tshitadi Mukendi Freddy Nkongolo Muamba jésual Banza Lotoy Bienvenu Nkashama Kazadi Adrien Umba Tandu Christian Otem Ndesanzim Gérard Mubengabantu Kabatantshi Department of Obstetrics and Gynaecology University Clinics Kinshasa Democratic Republic of Congo

Context: Maternal and newborn mortality remains a public health concern worldwide. Although its ratio decreased by around 44% from 1990 to 2015, this rate remains high in developing regions, particularly in sub-Saharan Africa. Objectives: To evaluate the level of knowledge and practice of Emergency Obstetric and Neonatal Care (EmONC) of health providers in maternity hospitals in Kinshasa and to identify the causes of the non-practice of EmONC. Methods: A descriptive study was conducted from September 1, 2016 to january 31, 2017 in 21 medical facilities drawn from the 6 health districts of the city of Kinshasa. We analyzed data obtained by interviewing 675 healthcare providers from different professional categories working in gynecology departments and in delivery rooms. The 50% acceptability criterion was set to assess their knowledge and practice. Results: Among the providers, 385 of them (57%) had already heard of EmONC and most of them were general practitioners with a rate of 55.8% of all participants, but specialists were the ones who defined them well. Supervision by trained colleagues was the main source of information on EmONC with 32.5%, while structured training only concerned 24% of our providers and 43% of providers had no training in EmONC. The level of knowledge was deemed satisfactory with 56.4% for the whole population but below the average for general practitioners. 32.2% of our sample did not practice the EmONC and the lack of training was the main reason for this non-practice. Conclusion: EmONC as a strategy in the fight against maternal mortality is not known. Its functions are known within the framework of basic training and current practice. Structured training only concerned 24% of our service providers and 43% of them had no training in EmONC.

关键词： Obstetric and Neonatal Care Emergency Maternity Kinshasa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AOCS专场研讨会精彩回放——国际表面活性剂和洗涤剂技术发展趋势

引用

中国洗涤用品工业 2014年第4期 18-29页

作者： patrick j.Donnelly 胡征宇 GillesMur 中村浩一沈俊 Hans juergen Scholz Mark Smerznak Robert D.Faber 美国油脂化学家学会纳爱斯集团有限公司杜邦工业应用生物科技部花王全球研发战略与计划部联合利华家居护理北亚区科莱恩洗涤剂及中间体业务部宝洁织物与家居护理战略创新与技术部安利家居

2013年11月8日下午,在第33届(2013)中国洗涤用品行业年会上,中国洗涤用品工业协会与美国油脂化学家学会(AOCS)联手,首次举办AOCS专场研讨会。这是中国洗协创新会议形式、提升办会效果的一次成功尝试。报告内容均由AOCS负责组织,充分体现... 详细信息

2013年11月8日下午,在第33届(2013)中国洗涤用品行业年会上,中国洗涤用品工业协会与美国油脂化学家学会(AOCS)联手,首次举办AOCS专场研讨会。这是中国洗协创新会议形式、提升办会效果的一次成功尝试。报告内容均由AOCS负责组织,充分体现了AOCS会议的专业性和一流水准。本文根据会场速记稿整理,以飨读者。

关键词： AOCS 技术发展趋势表面活性剂洗涤剂国际回放洗涤用品行业洗涤用品工业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：