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Multi-Institutional US Experience of the Occlutech AFR Device in Congenital and Acquired Heart Disease

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Congenital Heart Disease 2022年第1期17卷 107-116页

作者： Barry O’Callaghan jenny Zablah joseph Vettukattil Daniel Levi Morris Salem Allison Cabalka jason Anderson Makram Ebeid Ryan Alexy Gareth j.morgan The Heart Institute Children’s Hospital ColoradoAuroraUSA Pediatric Cardiology Helen DeVos Children’s HospitalGrand RapidsUSA Pediatric Cardiology UCLA HealthMattel Children’s HospitalLos AngelesUSA Pediatric Cardiology UCLA Medical CentreLos AngelesUSA Pediatric Cardiology Mayo ClinicRochesterUSA Pediatric Cardiology University of Mississippi Medical CenterJacksonUSA Pediatric Cardiology Riley Hospital for Children at Indiana University HealthIndianapolisUSA

Objectives:To detail the US multi-institutional experience with the Occlutech©(Occlutech International AB,Helsingborg,Sweden)atrial flow regulator(AFR)in children and adults with acquired or congenital heart ***:The creation of a long-term atrial communication is desirable in several cardiovascular disease phenotypes,most notably pulmonary arterial hypertension,disorders of increased left ventricular filling and increased cavopulmonary pressures in patients with a Fontan type ***:Patients were identified for inclusion from the AFR device manufacturer *** was collected using a RedCap database following IRB approval.8 weeks of follow up data was sought for each patient based on available *** was analyzed and summarized using ***:We report the experience of 6 US centers in the implantation of AFR devices in 15 patients,across a wide age range,with different disease phenotypes and a variety of *** was technically successful in all patients and improvement was noted in both clinical and hemodynamic *** were no immediate or intermediate term complications reported.3 patients died remote from *** deaths were not felt to be related to the AFR device or related procedural ***:Compassionate use of the AFR device in children and adults with congenital&acquired heart disease is technically feasible and produces beneficial short term hemodynamic and symptomatic *** uptake of this technique and treatment at specialist centers has the potential to provide significant benefits to a variety of complex patients with currently limited treatment options and indeterminate prognosis.

关键词： Congenital heart disease pulmonary hypertension left atrial hypertension single ventricle palliation diastolic heart failure

Sleep Disordered Breathing Asian ***

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Cold adaptation does not alter ATP homeostasis during cold exposure in Drosophila melanogaster

华东地区睡眠医学新进展高级研修班

作者： Edward j.morgan Hawaii School of Sleep Medicine and Technology September 2002

＜正＞Evidence-Based Medicine Residents are not correct unless there is evidence Attendings are not correct unless there is evidence Professors are not correct unless there iS evidence

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Integrative Zoology 2018年第4期13卷 471-481页

作者： Caroline M.WILLIAMS james R.ROCCA Arthur S.EDISON David B.ALLISON Theodore j.morgan Daniel A.HAHN Department of Integrative Biology University of CaliforniaBerkeleyCaliforniaUSA Departments of Entomology and Nematology University of FloridaGainesvilleFloridaUSA Biochemistry University of FloridaGainesvilleFloridaUSA Advanced Magnetic Resonance Imaging and Spectroscopy Facility McKnight Brain InstituteUniversity of FloridaGainesvilleFloridaUSA Departments of Genetics and Biochemistry Complex Carbohydrate Research CenterUniversity of GeorgiaAthensGeorgiaUSA Department of Epidemiology and Biostatistics School of Public HealthIndiana University BloomingtonBloomingtonIndianaUSA Division of Biology Kansas State UniversityManhattanKansasUSA

In insects and other ectotherms,cold temperatures cause a coma resulting from loss of neuromuscular function,during which ionic and metabolic homeostasis are progressively *** adaptation improves homeostasis during cold exposure,but the ultimate targets of selection are still an open *** acclimation and adaptation remodels mitochondrial metabolism in insects,suggesting that aerobic energy production during cold exposure could be a target of ***,we test the hypothesis that cold adaptation improves the ability to maintain rates of aerobic energy production during cold exposure by using^(31)P NMR on live *** lines of Drosophila melanogaster artificially selected for fast and slow recovery from a cold coma,we show that cold exposure does not lower ATP levels and that cold adaptation does not alter aerobic ATP production during cold ***-hardy and cold-susceptible lines both experienced a brief transition to anaerobic metabolism during cooling,but this was rapidly reversed during cold exposure,suggesting that oxidative phosphorylation was sufficient to meet energy demands below the critical thermal minimum,even in cold-susceptible *** thus reject the hypothesis that performance under mild low temperatures is set by aerobic ATP supply limitations in ***,excluding oxygen and capacity limitation as a weak link in energy *** work suggests that the modulations to mitochondrial metabolism resulting from cold acclimation or adaptation may arise from selection on a biosynthetic product(s)of those pathways rather than selection on ATP supply during cold exposure.

关键词： chill coma energetics insect oxygen limitation thermal tolerance

The hydrogenation of levulinic acid to γ-valerolactone over Cu–ZrO2 catalysts prepared by a pH-gradient methodology

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journal of Energy Chemistry 2019年第9期28卷 15-24页

作者： Igor Orlowski Mark Douthwaite Sarwat Iqbal james S.Hayward Thomas E.Davies jonathan K.Bartley Peter j.Miedziak jun Hirayama David j.morgan David j.Willock Graham j.Hutchings Cardiff Catalysis Institute School of Chemistry Cardiff University Main Building Park Place Cardiff CF10 3AT UK School of Chemistry Joseph Bank Laboratories Beevor St University of LincolnLincoln LN6 7DL UK School of Applied Sciences University of South WalesPontypridd CF37 4AT UK Institute for Catalysis Hokkaido UniversitySapporo Hokkaido 001-0021 Japan

A novel pH gradient methodology was used to synthesise a series of Cu–ZrO2 catalysts containing different quantities of Cu and *** of the catalysts were highly selective to the desired product,γ-valerolactone, and are considerably more stable than Cu–ZrO2 catalysts prepared by other co-precipitation methods for this *** and further investigation of these catalysts by XRD, BET, SEM and XPS provided insight into the nature of the catalytic active site and the physicochemical properties that lead to catalyst *** consider the active site to be the interface between Cu/CuOxand ZrOx and that lattice Cu species assist with the dispersion of surface Cu through the promotion of a strong metal support *** enhanced understanding of the active site and roles of lattice and surface Cu will assist with future catalyst *** such, we conclude that the activity of Cu–ZrO2 catalysts in this reaction is dictated by the quantity of Cu–Zr interface sites.

关键词： Cu–ZrO2 Hydrogenation Levulinic acid γ-Valerolactone

Use of MRI, metabolomic, and genomic biomarkers to identify mechanisms of chemoresistance in glioma

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Cancer Drug Resistance 2019年第3期2卷 862-876页

作者： Cathy W.Levenson Thomas j.morgan jr.Pamela D.Twigg Timothy M.Logan Victor D.Schepkin Department of Biomedical Sciences Florida State University College of MedicineTallahasseeFL 32306USA Program in Neuroscience Florida State UniversityTallahasseeFL 32306USA Department of Chemistry and Biochemistry and Institute for Molecular Biophysics Florida State UniversityTallahasseeFL 32306USA Current Address:Department of Chemistry University of Alabama in HuntsvilleHuntsvilleAL 35899USA National High Magnetic Field Laboratory Florida State UniversityTallahasseeFL 32306USA.

Gliomas are the most common form of central nervous system tumor. The most prevalent form, glioblastoma multiforme, is also the most deadly with mean survival times that are less than 15 months. Therapies are severely limited by the ability of these tumors to develop resistance to both radiation and chemotherapy. Thus, new tools are needed to identify and monitor chemoresistance before and after the initiation of therapy and to maximize the initial treatment plan by identifying patterns of chemoresistance prior to the start of therapy. Here we show how magnetic resonance imaging, particularly sodium imaging, metabolomics, and genomics have all emerged as potential approaches toward the identification of biomarkers of chemoresistance. This work also illustrates how use of these tools together represents a particularly promising approach to understanding mechanisms of chemoresistance and the development individualized treatment strategies for patients.

关键词： Sodium MRI diffusion genes resistance glycolysis warburg effect

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决策理论导引

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油酸在赤铁矿上的吸附——存在的问题和解决的方法

丛书名：科学图书大库

1979年

作者：（j.morgan jones）黄学亮译

有索引。

ISBN: (纸本)7

有索引。

关键词：社会科学总论管理学

来源：汇雅图书（南通市图书馆... 评论

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国外金属矿选矿 1991年第10期28卷 25-33页

作者： Leslie j.morgan 李志华

在大量的矿物—表面活性剂体系中,浮选回收率和固液界面捕收剂的吸附作用具有良好的对应关系,但在赤铁矿-油酸体系中,未曾得到这种对应关系。本文对赤铁矿-油酸体系的研究结果表明,捕收剂及其复合物的沉淀作用能够导致很高的视在吸附作... 详细信息

在大量的矿物—表面活性剂体系中,浮选回收率和固液界面捕收剂的吸附作用具有良好的对应关系,但在赤铁矿-油酸体系中,未曾得到这种对应关系。本文对赤铁矿-油酸体系的研究结果表明,捕收剂及其复合物的沉淀作用能够导致很高的视在吸附作用(萃取方法—abstraction),因为油酸溶液组分对pH值等变化很敏感,如捕收剂及其复合物的沉积,对取决于矿浆pH的视在吸附作用的影响是非常重要的。在吸附体系中,为了从许多同时发生的复杂现象中得到数据,必须对实验过程倍加注意,本文所得到的结果揭示,在赤铁矿-油酸体系中,与pH值密切相关的浮选回收率和油酸的吸附作用的确是彼此相关的。

关键词：油酸赤铁矿吸附捕收剂浮游选矿

Outcomes of critically ill children with pre-existing mental health conditions

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Pediatric Investigation 2024年第2期8卷 108-116页

作者： Conrad Krawiec morgan Cash Gary Ceneviva Zizhong Tian Shouhao Zhou Neal j.Thomas Department of Pediatrics Pediatric Critical Care MedicinePenn State Hershey Children's HospitalPennsylvaniaUSA Department of Public Health Sciences Division of Biostatistics and BioinformaticsPennsylvania State University College of MedicinePennsylvaniaUSA Department of Public Health_Sciences Pennsylvania State University College of MedicinePennsylvaniaUSA

Importance:Critically ill children with pre-existing mental health conditions may have an increased risk of poor health ***:We aimed to evaluate if pre-existing mental health conditions in critically ill pediatric patients would be associated with worse clinical outcomes,compared to children with no documented mental health ***:This retrospective observational cohort study utilized the TriNetX electronic health record database of critically ill subjects aged 12-18 *** were analyzed for demographics,pre-existing conditions,diagnostic,medication,procedural codes,and ***:From a dataset of 102027 critically ill children,we analyzed 1999 subjects(284[14.2%]with a pre-existing mental health condition and 1715[85.8%]with no pre-existing mental health condition).Multivariable analysis demonstrated that death within one year was associated with the presence of pre-existing mental health conditions(odds ratio 8.97[3.48-23.15],P<0.001),even after controlling for the presence of a complex chronic ***:The present study demonstrates that the presence of pre-existing mental health conditions was associated with higher odds of death within 1 year after receiving critical ***,the confidence interval was wide and hence,the findings are *** studies with a larger sample size may be necessary to evaluate the true long-term impact of children with pre-existing mental health conditions who require critical care services.

关键词： Critical care Psychiatry Psychology Public health

Linking science and decision making to promote an ecology for the city:practices and opportunities

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Ecosystem Health and Sustainability 2016年第9期2卷 18-27页

作者： j.morgan Grove Daniel L.Childers Michael Galvin Sarah Hines Tischa Muñoz-Erickson Erika S.Svendsen Baltimore Field Station USDA Forest ServiceBaltimoreMaryland 21228 USA School of Sustainability Arizona State UniversityTempeArizona 85287 USA Urban Field Station International Institute of Tropical ForestryUSDA Forest ServiceRío PiedrasPuerto Rico 00926-1119 USA New York City Field Station USDA Forest ServiceNew YorkNew York 10007 USA

To promote urban sustainability and resilience,there is an increasing demand for actionable science that links science and decision making based on social-ecological ***,frameworks,and practices for such actionable science are needed and have only begun to *** propose that approaches based on the co-design and co-production of knowledge can play an essential role to meet this *** the antecedents for approaches to the co-design and co-production of knowledge are decades old,the integration of science and practice to advance urban sustainability and resilience that we present is different in several *** differences include the disciplines needed,diversity and number of actors involved,and the technological infrastructures that facilitate local-to global *** this article,we discuss how the new requirements and possibilities for co-design,co-production,and practical use of social-ecological research can be used as an ecology for the city to promote urban sustainability and *** new technologies are part of the solution,traditional approaches also remain *** our urban experiences with long-term,place-based research from several ***-Term Ecological Research sites and *** of Agriculture,Forest Service Urban Field Stations,we describe a dynamic framework for linking research with *** posit that this framework,coupled with a user-defined,theory-based approach to science,is instrumental to advance both practice and ***,cities are ideal places for integrating basic science and decision making,facilitating flows of information through networks,and developing sustainable and resilient solutions and futures.

关键词： Baltimore co-design co-production ecology for cities long-term ecological research New York City Phoenix San juan social-ecological Special Feature:An Ecology in,of,and for the City transdisciplinary urban