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Simulation of Fusion Plasmas:Current Status and Future Direction

Plasma Science and Technology 2007年第3期9卷 312-387页

作者： D.A.Batchelor M.Beck A.Becoulet R.V.Budny C.S.Chang P.H.Diamond j.Q.Dong G.Y.FU A.Fukuyama T.S.Hahm D.E.Keyes Y.Kishimoto S.Klasky L.L.Lao K.Li Z.Lin B.Ludaescher j.manickam N.Nakajima T.Ozeki N.Podhorszki W.M.Tang M.A.Vouk R.E.Waltz S.j.Wang H.R.Wilson X.Q.Xu M.Yagi F.Zonca Oak Ridge National Laboratory Oak RidgeTN 37831USA 1122 Volunteer Blvd Suite 203KnoxvilleTN 37996-3450USA AssociationEURATOM-CEA sur la Fusio n Contr■lée CEA Cadarache13108 Saint Paul lez Durance CedexFrance Princeton Plasma Physics Laboratory Princeton UniversityPrincetonNJ 08543USA Courant Institute of Mathematical Sciences New York University251 Mercer StreetNew YorkNY 10012USA University of California at San Diego Dept.of Physics and Center for Astrophysics and Space SciencesLa JollaCA 92093USA Southwestern Institute of Physics Chengdu 610041China Department of Nuclear Engineering Kyoto UniversityKyoto 606-8501Japan Columbia University Department of Applied Physics and Applied MathematicsMC 4701New YorkNY 10027USA Department of Fundamental Energy Science Graduate School of Energy ScienceKyoto UniversityGokashoUjiKyoto 611-0011Japan General Atomics P.O.Box 85608San DiegoCA 92186USA Department of Computer Science Princeton University PrincetonNJ 08544USA Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Department of Computer Science University of California DavisCA95616USA National Institute for Fusion Science TokiGifu 509-5292Japan japan Atomic Energy Agency Naka Fusion Research EstablishmentNaka-machiIbaraki-kenJapan Department of Computer Science North Carolina State UniversityRaleighNC 27695USA Department of Physics Fudan University200433 ShanghaiChina Department of Physics University of YorkHeslingtonYork YO10 5DD UK Lawrence Livermore National Laboratory LivermoreCA 94550USA Research Institute for Applied Mechanics Kyushu UniversityKasuga 816-8580Japan Associazione Euratom-ENEA sulla fusione CR FrascatiCasella Postale 65-00044FrascatiItaly

I. Introduction (Z. Lin, G. Y. Fu, j. Q. Dong) II. Role of theory and simulation in fusion sciences 1. The Impact of theory and simulation on tokomak experiments (H. R. Wilson, T.S. Hahm and F. Zonca) 2. Tokomak Transport Physics for the Era of ITER: Issues for Simulations (P.H. Diamond and T.S. Hahm) III. Status of fusion simulation and modeling 1. Nonlinear Governing Equations for Plasma Simulations (T. S. Hahm) 2. Equilibrium and stability (L.L. Lao, j. manickam) 3. Transport modeling (R.E. Waltz) 4. Nonlinear MHD (G.Y. Fu) 5. Turbulence (Z. Lin and R.E. Waltz) 6. RF heating and current drive (D.A. Batchelor) 7. Edge physics Simulations (X.Q. Xu and C.S. Chang) 8. Energetic particle physics (F. Zonca, G.Y. Fu and S.j. Wang) 9. Time-dependent Integrated Modeling (R.V. Budny) 10. Validation and verification (j. manickam) IV. Major initiatives on fusion simulation 1. US Scientific Discovery through Advanced Computing (SciDAC) Program & Fusion Energy Science (W. Tang) 2. EU Integrated Tokamak Modelling (ITM) Task Force (A. Becoulet) 3. Fusion Simulations Activities in japan (A. Fukuyama, N. Nakajima, Y. Kishimoto, T. Ozeki, and M. Yagi) V. Cross-disciplinary research in fusion simulation 1. Applied mathematics: Models, Discretizations, and Solvers (D.E. Keyes) 2. Computational Science (K. Li) 3. Scientific Data and Workflow Management (S. Klasky, M. Beck, B. Ludaescher, N. Podhorszki, M.A. Vouk) 4. Collaborative tools (j. manickam)

关键词： mode ITER

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Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Evaluation of Zero and Sub-zero Temperature Tensile and Impact Properties of Quenched and Tempered Steel Weldments

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journal of Iron and Steel Research International 2016年第11期23卷 1177-1187页

作者： M.BALAKRISHNAN V.BALASUBRAMANIAN M.A.MUTHU manickam Department of Mechanical Engineering M.Kumarasamy College of Engineering(Autonomous)ThalavapalayamKarur 639113Tamil NaduIndia Center for Materials joining&Research(CEMAjOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalainagar 608002Tamil NaduIndia Combat Vehicles Research and Development Establishment(CVRDE) AvadiChennai 600054Tamil NaduIndia

Combat vehicles using armour grade quenched and tempered （Q＆T） steel are needed to be operated under different climatic conditions. However, the properties meeting the room temperature test conditions may not neces-sarily be required to meet the low temperature operating conditions. The influences of shielded metal arc welding （SMAW） process, flux cored arc welding （FCAW） processes and test temperatures below room temperature up to 60℃ on tensile and impact toughness properties of armour grade Q＆T steel welds were reported. The tensile and impact properties of the joints showed incremental trend with respect to the decrement in test temperature up to -40℃ irrespective of the welding processes used. The increment in tensile and impact properties of SMAW and FCAW joints subjected to the low temperature environment is due to plastic strain-induced phase transformation of retained austenite into martensite phase. Among the two processes, SMAW process welded joint showed better tensile and impact properties than its FCAW counterpart joints.

关键词： shielded metal arc welding flux cored arc welding low temperature property microstrncture: hardness

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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The Impact of Heat Treatment and Surface Treatment on Thermal Conductivity of Heat Sinks Made of Aluminium Die Casting Alloys

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journal of Harbin Institute of Technology(New Series) 2024年第4期31卷 34-41页

作者： Rajesh Kumar manickam Dilip Raja Narayana Department of Mechanical Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600001Tamil NaduIndia

This research contributes to understand the thermal management capabilities of Plate Fin Heat Sinks(PFHS)fabricated from *** uniqueness in this study is that the heat sinks were exposed to abrasive blasting,heat treatment,and graphene coating,and a full evaluation of the influence of the aforementioned treatments on the thermal management capacities of PFHS was *** PFHS is compared with 1)abrasive blasted and graphene coated heat sink,and 2)heat treated and graphene coated heat *** assess the thermal efficiency of the PFHS variants,a dedicated experimental set up was meticulously *** is noteworthy that a junction temperature of 60℃was assumed as the reference point for the *** results revealed that the charging cycle time which denotes the time required attaining the junction temperature,increased 1.3 times for the sample being abrasive-blasted at 0.5 MPa pressure and graphene-coated for 0.5 mm when the maximum heat input of 45 W is *** low heat input of 15 W is evaluated,the results revealed that there is no significant difference in charging cycle when compared to the untreated heat *** charging cycle time increased 2 times for the sample which is heat-treated at 450℃and graphene-coated for 0.5 mm at heat input of 15 *** finding unequivocally underscores the heightened capacity of the heat treated and graphene coated PFHS made of AlSi10Mg to withstand elevated junction temperatures.

关键词： PFHS abrasive blasting heat treatment graphene

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Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG Steven A.BINNIE Sheng XU Cong-Qiang LIU Tibor j.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira M.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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