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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Spatiotemporal variation in the adult sex ratio,male aggregation,and movement of two tropical cloud forest dung beetles

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Current Zoology 2022年第6期68卷 635-644页

作者： julliana BARRETTO martha L.BAENA Israel Huesca domınguez Federico ESCOBAR Red de Ecoetologıa Instituto de EcologıaXalapaC.P.91073Mexico Instituto de Investigaciones Biologicas Universidad Veracruzana.Av.Luis Castelazo Ayala s/n Col.IndustrialAnimasXalapaC.P.91190Mexico

While theory suggests that at conception the sex ratio should be balanced(1:1),this can be variable across space and time in wild ***,studies of the environmental factors that regulate adult sex ratio(ASR)in species with different life history traits are *** capture–recapture over a year,we analyzed the influence of habitat type(forest and nonforest)and season(rainy and dry)on variation in ASR,male aggregation and the trajectory movement of 2 dung beetle species with different life history traits:Deltochilum mexicanum(a hornless roller species)and Dichotomius satanas(a tunneler species with horns on its head and thorax).We found opposite *** *** population tends to be female-biased,but the population of *** tends to be predominantly male,and observed values were not related to habitat type or ***,the 95%confidence intervals estimated were highly variable between seasons depending on *** examining the monthly variation in ASR for both habitats,we found that it depends on the *** addition,male aggregation differed between species depending on habitat type and season,and species movement patterns were closely related to their habitat *** on our results,we argue that comparative population studies of species with different life history traits are necessary to understand the variation in demographic parameters as well as its ecological and evolutionary implications in the face of spatial and climatic environmental variation.

关键词： habitat preference mark-recapture mean crowding seasonality Scarabaeinae sex proportion

Rapid on-site evaluation of endoscopic-ultrasound-guided fine-needle aspiration diagnosis of pancreatic masses

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World journal of Gastroenterology 2014年第28期20卷 9451-9457页

作者： julio Iglesias-Garcia jose Lario-Noia Ihab Abdulkader j Enrique domínguez-muoz Department of Gastroenterology and Hepatology Foundation for Research in Digestive DiseasesUniversity Hospital of Santiago de Compostela Department of Pathology University Hospital of Santiago de Compostela

Endoscopic ultrasound (EUS) has become an essential tool for the study of pancreatic diseases. Specifically, EUS plays a pivotal role evaluating patients with a known or suspected pancreatic mass. In this setting, differential diagnosis remains a clinical challenge. EUS-guided fine-needle aspiration (FNA) and fine-needle biopsy (FNB) have been proven to be safe and useful tools in this setting. EUS-guided FNA and FNB, by obtaining cytological and/or histological samples, are able to diagnose pancreatic lesions with high sensitivity and specificity. In this context, several methodological features, trying to increase the diagnostic yield of EUS-guided FNA and FNB, have been evaluated. In this review, we focus on the role of rapid on-site evaluation (ROSE). From data reported in the literature, ROSE may increase diagnostic yield of EUS-FNA specimens by 10%-30%, and thus, diagnostic accuracy. However, we should point out that many recent studies have reported adequacy rates of > 90% without ROSE, indicating that, perhaps, at high-volume centers, ROSE may not be indispensable to achieve excellent results. The use of ROSE can be considered important during the learning curve of EUS-FNA, and also in hospital with diagnostic accuracy rates < 90%.

关键词： Endoscopic-ultrasound-guided fine-needle aspiration Rapid on-site evaluation Solid pancreatic tumors Diagnostic accuracy

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Nanoscale mapping of optically inaccessible bound-states-in-the-continuum

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Light(Science & Applications) 2022年第2期11卷 188-196页

作者： Zhaogang Dong Zackaria mahfoud Ramón Paniagua-domínguez Hongtao Wang Antonio I.Fernández-domínguez Sergey Gorelik Son Tung Ha Febiana Tjiptoharsono Arseniy I.Kuznetsov michel Bosman joel K.W.Yang Institute of materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis Way#08-03 Innovis138634 SingaporeSingapore Department of materials Science and Engineering National University of Singapore9 Engineering Drive 1117575 SingaporeSingapore Singapore University of Technology and Design 8 Somapah Road487372 SingaporeSingapore Departamento de Física Teórica de la materia Condensada and Condensed matter Physics Center Universidad Autónoma de Madrid28049 MadridSpain Singapore Institute of Food and Biotechnology Innovation A*STAR(Agency for ScienceTechnology and Research)31 Biopolis Way#01-02 Nanos138669 SingaporeSingapore

Bound-states-in-the-continuum(BIC)is an emerging concept in nanophotonics with potential impact in applications,such as hyperspectral imaging,mirror-less lasing,and nonlinear harmonic *** true BIC modes are nonradiative,they cannot be excited by using propagating light to investigate their optical *** this paper,for the 1st time,we map out the strong near-field localization of the true BIC resonance on arrays of silicon nanoantennas,via electron energy loss spectroscopy with a sub-1-nm electron *** systematically breaking the designed antenna symmetry,emissive quasi-BIC resonances become *** gives a unique experimental tool to determine the coherent interaction length,which we show to require at least six neighboring antenna *** importantly,we demonstrate that quasi-BIC resonances are able to enhance localized light emission via the Purcell effect by at least 60 times,as compared to unpatterned *** work is expected to enable practical applications of designed,ultra-compact BIC antennas such as for the controlled,localized excitation of quantum emitters.

关键词： antenna states mapping

Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World journal of Emergency medicine 2024年第1期15卷 56-58页

作者： Salvador Gomez-Carro Ruben R.Lozano-Salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer Nina méndez-domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico National Institute of Perinatology.mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver *** identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane

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Food Bioscience 2023年第1期51卷 413-419页

作者： Paola Sanchez-Bravo Angel Abellan Pedro jZapata Cristina García-Viguera Raúl domínguez-Perles maría jose Gimenez Lab.Fitoquímica y Alimentos saludables(LabFAS) Centro de Edafología y Biología Apliada del Segura(CEBAS)-CSICUniversity Campus-2530100EspinardoMurciaSpain Department of Food Technology EPSOUniveristy Miguel HernandezCtra Beniel km 3.203312OrihuelaAlicanteSpain

Broccoli is a highly consumed vegetable due to its content of bioactive nutrients and non-nutrients,including glucosinolates and ***,the consumption of craft beer has been boosted by the seek for enhanced sensory and functional *** this frame,broccoli have been proven as an ingredient to develop healthy *** objective of the work was to evaluate alternative broccoli materials(sprouts and byproducts powder)to go further from previous results,in a way contributing to the sustainability and circularity of the agro-food chain using underexploited material to supplement beers,which could be a sustainable dietary source of bioactive sulforaphane(SFN).The results showed high concentrations of SFN in beers supplemented with broccoli sprouts and powder(5.00 and 2.54 mg/L,respectively,previous to bottling).These concentrations remained stable until bottling,where they were reduced by>50%.After 150 storage days,the concentrations of SFN were 1.08 and 0.30 mg/L in beers supplemented with sprouts and powder,*** sensory analysis revealed the positive attributes(colour,floral,fruity,and aftertaste as a result of the profile of volatile compounds)of beers developed using sprouts,and significant values of cooked vegetables,alcoholic,and earthy leather,which could be considered negative in *** latter negative tips are the ones offering sensory traits associated to ITC to broccoli-based ***,the addition of broccoli in the format of fresh sprouts is more appropriate according to the SFN content and sensory features,providing a functional alternative that could be appreciated by consumers.

关键词： Healthy foods Beverages Brassica Isothiocyanates UHPLC-ESI-mS/mS Sensory properties