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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

A rapid and efficient method for the synthesis of 14H-dibenzo[α.j]xanthenes,aryl-5H-dibenzo[b.i]xanthene-5,7,12,14-(13H)-tetraone and 1,8-dioxooctahydroxanthenes by acidic ionic liquid

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Chinese Chemical Letters 2010年第7期21卷 761-764页

作者： abbas Rahmati Department of Chemistry University of IsfahanP.O.Box 81746-7344IsfahanIran

Various xanthenes have been synthesized by the condensation ofβ-naphthol,2-hydroxynaphthalene-1,4-dione or dimedone with various aldehydes in the presence of trifluoroacetic acid as catalyst in 1,1,3,3-N,N,N′,N′-te... 详细信息

关键词： Ionic liquid 14H-Dibenzo[α.j]xanthenes β-Naphthol 2-Hydroxynaphthalene-1 4-dione Dimedone

Exact solution of Schrdinger equation with q-deformed quantum potentials using Nikiforov–Uvarov method

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Chinese Physics B 2013年第11期22卷 166-173页

作者： Falaye B.j. Oyewumi K.j. abbas m. Theoretical Physics Section Department of Physics University of Ilorin Physics Department Kebbi State University of Science and Technology

In this paper, we present the exact solution of the one-dimensional Schrrdinger equation for the q-deformed quantum potentials via the Nikiforov-Uvarov method. The eigenvalues and eigenfunctions of these potentials are obtained via this method. The energy equations and the corresponding wave functions for some special cases of these potentials are briefly discussed. The PT-symmetry and Hermiticity for these potentials are also discussed.

关键词： Schrōdinger equation q-deformed quantum potential Woods-Saxon potential Nikiforov-Uvarovmethod

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Facile synthesis of samarium and cerium doped double perovskite cobaltite with enhanced dielectric response

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journal of Rare Earths 2024年第7期42卷 1317-1327,I0005页

作者： Yasir abbas m.Kamran m.Anis-ur-Rehman Applied Thermal Physics Laboratory Department of PhysicsCOMSATS University IslamabadIslamabad 45550Pakistan

The investigation of Sm-Ce doping on structure,conduction,and dielectric response of Bi_(2)Ca_(2-2x)Sm_(x)CexCoO_(6)(x=0.000,0.025,0.050,0.075)(BCSCCO)are *** the specimens were synthesized by a facile synthesis technique named the co-precipitation route.X-ray diffraction(XRD)reveals that BCSCCO crystallizes into one phase with space group P21/*** crystallite size,dislocation density,lattice parameters,lattice strain,unit cell volume,and bulk density were determined using XRD *** structural properties of Bi_(2)Ca_(2)CoO_(6)were examined using calculations based on the density functional *** and experimental values discrepancy is less than 1%.A scanning electron microscope was used for performing a microstructural *** SEm images demonstrate the homogeneous distribution of grains with a range of sizes(0.054-0.090μm).The alternating current(ac)conductivity,dielectric permittivity,and tangent loss were also studied as a function of frequency(20 Hz-3 mHz)at different temperatures(100-500℃).All synthesized samples were examined using non-linear Debye's function to determine their spreading factor and relaxation *** specimen with the lowest crystallite size(∼23 nm)exhibits a high dielectric permittivity(∼3.80×10^(6)).The conduction mechanism was examined in the studied samples with the use of jonscher's power *** power law indicates that the BCSCCO(x=0.000,0.025)follows correlated barrier hopping,whereas the x=0.050 and 0.075 compositions follow non-overlapping polaron *** studied specimen Bi_(2)Ca_(1.9)0Sm_(0.05)0Ce_(0.05)_(0)CoO_(6)with the highest density(∼5.65 g/cm^(3))displays a high electrical conductivity(∼46.1 S/cm).These findings correspond to those published for ceramics made from calcium cobaltite using solid-state reactions(5.0-26.0 S/cm).

关键词： Bismuth calcium samarium cerium cobaltite (BCSCCO) Spreading factor Conduction mechanism Rare earths

Structure inversion asymmetry enhanced electronic structure and electrical transport in 2D A3SnO(A=Ca,Sr,and Ba)antiperovskite monolayers

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Nano Research 2023年第1期16卷 1779-1791页

作者： Syed muhammad Alay-e-abbas Ghulam abbas Waqas Zulfiqar muhammad Sajjad Nirpendra Singh j.Andreas Larsson Applied Physics Division of Materials ScienceDepartment of Engineering Sciences and MathematicsLuleåUniversity of Technology97187 LuleåSweden Computational materials modeling Laboratory Department of PhysicsGovernment College UniversityFaisalabad 38040Pakistan Department of Energy Conversion and Storage Technical University of Denmark2800 Kgs.LyngbyDenmark Department of Physics Khalifa University of Science and TechnologyAbu Dhabi-127788United Arab Emirates Center for Catalysis and Separation(CeCaS) Khalifa University of Science and TechnologyAbu Dhabi-127788United Arab Emirates

Anti-perovskites A3SnO(A=Ca,Sr,and Ba)are an important class of materials due to the emergence of Dirac cones and tiny mass gaps in their band structures originating from an intricate interplay of crystal symmetry,spin–orbit coupling,and band *** provides an exciting playground for modulating their electronic properties in the two-dimensional(2D)***,we employ first-principles density functional theory(DFT)calculations by combining dispersion-corrected SCAN+rVV10 and mBj functionals for a comprehensive side-by-side comparison of the structural,thermodynamic,dynamical,mechanical,electronic,and thermoelectric properties of bulk and monolayer(one unit cell thick)A3SnO *** results show that 2D monolayers derived from bulk A3SnO anti-perovskites are structurally and energetically ***,Rashba-type splitting in the electronic structure of Ca3SnO and Sr3SnO monolayers is observed owing to strong spin–orbit coupling and inversion *** the other hand,monolayer Ba3SnO exhibits Dirac cone at the high-symmetryΓpoint due to the domination of band *** on the predicted electronic transport properties,it is shown that inversion asymmetry plays an essential character such that the monolayers Ca3SnO and Sr3SnO outperform thermoelectric performance of their bulk counterparts.

关键词： electrical transport anti-perovskites low-dimensional materials electronic structure mechanical properties

Characteristics of settling of dilute suspension of particles with different density at high Reynolds numbers

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Particuology 2021年第3期19卷 62-74页

作者： Ali abbas Zaidi Department of mechanical and Process Engineering ETH Zurich8092 ZurichSwitzerland

Dilute suspension of particles with same density and size develops clusters when settle at high Reynolds number(≥250).It is due to particles entrapment in the wakes produced by upstream *** this work,this phenomenon is studied for suspension having particles with different densities by numerical *** particle-fluid interactions are modelled using immersed boundary method and inter-particle collisions are modelled using discrete element *** simulations,settling Reynolds number is always kept above 250 and the suspension solid volume fraction is nearly 0.1 *** particle density ratios(*** of heavy particles to lighter particles)equal to 4:1 and 2:1 and particles with same density are *** each density ratio,the percentage volume fraction of each particle density is nearly varied from 0.8 to *** characteristics such as microstructures of settling particle,average settling velocity and velocity fluctuations of settling particles are *** show that for different density particles settling characteristics of suspension is largely dominated by heavy *** the end of paper,the underlying physics is explained for the anomalies observed in simulation.

关键词： Particle clustering at high reynolds number Suspension with different density particles Particle microstructure due to settling Immersed boundary method

Heat transfer analysis in particle-laden flows using the immersed boundary method

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Particuology 2024年第7期90卷 394-403页

作者： Ali abbas Zaidi Department of mechanical Engineering University of Manitoba75A Chancellors CircleWinnipegR3T 5V6Canada

This paper investigates an efficient immersed boundary method(IBm)for multiple-core CPU machines with local grid refinement for the calculation of heat transfer between fluids and finite-sized *** fluid momentum equations are solved by using the fractional step method,while the energy equation is solved by employing the second-order Adams-Bashforth *** efficient load balancing between the CPU cores,the coupling between particles and fluid is obtained by applying the body force in the fluid equations,which depends on the solid volume fraction of particles contained in each grid cell,and then by linearly interpolating the particle temperature and velocity on the fluid grid cell(in place of the delta function commonly used in literature).Several test cases from the literature are studied,and good agreement is observed between the simulation results and the ***,a scaling study on multiple core machines is performed,demonstrating the proposed IBm's capabilities for a significant reduction in processing time.

关键词： Heat transfer Immersed boundary method Particle resolved direct numerical simulations Fluid solid interactions