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Episodes 2005年第3期28卷 177-186页

作者： j. Brilha C. Andrade A. Azeredo F.j.A.S. Barriga m. Cachāo2 H. Couto P.P. Cunha j.A. Crispim P. Dantas L. V. Duarte m. C Freitas H.m. Granja m.H. Henriques P. Henriques L. Lopes j. madeira j.m.x. matos F. Noronha j. Pais j. Pifarra m.m. Ramalho j.m.R.S. Relvas A. Ribeiro A. Santos V.F.Santos P. Terrinha University of minho University of Lisbon National Natural History museum University of Porto University of Coimbra Portuguese Speleological Society INETInovacāo University of évora New University of Lisbon League for Nature Protection University of Algarve

This work constitutes the first contribution for the systematisation of geological heritage knowledge in Portugal, following the international recommendations for the characterisation of geological heritage （IUGS, ProGEO）. The application of the ProGEO methodology has resulted in the creation of fourteen frameworks with international relevance, established by consensus among the Portuguese geological community. The description of each category in this paper is not exhaustive and only the most relevant scientific settings are presented. The following are the three key outcomes of this work： i） At a national level, the most important geosites are identified, indicating where geoconservation efforts should be prioritised based on scientific justification; ii） At a regional level, conditions have been developed to foster dialogue with Spanish colleagues in order to create Iberian frameworks; iii） At an international level, it is now possible to integrate Portuguese geosites into the global inventories promoted by IUGS, UNESCO, and ProGEO.

关键词：葡萄牙欧洲地质条件地质图地形特征

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Processing, microstructure and mechanical Properties of Ti6Al4V Particles-Reinforced mg matrix Composites

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Acta metallurgica Sinica(English Letters) 2016年第10期29卷 940-950页

作者： x.m.Wang x.j.Wang x.S.Hu K.Wu m.Y.Zheng School of materials Science and Engineering Harbin Institute of Technology

Novel Ti6Al4V particles-reinforced AZ91 mg matrix composites were successfully fabricated by stir casting method. The stirring time in semisolid condition directly affected the particle distribution and the quality of the ingots. Furthermore, the optimal speed of the heating and the liquid stirring could overcome particle settlement caused by the density difference between the matrix and the particles. Ti6Al4V particles distributed uniformly in the composites with different particle contents. The average grain size decreased with the increase in the particle contents. The Ti6A14V particles bonded pretty well with the alloy matrix. In addition, there were some interfacial reactions in the composites. There were rod-like A13Ti phases at the interface. The precipitates extended from the particle surface to the matrix, and they might improve the interfacial bonding strength. The ultimate tensile strength, yield strength and elastic modulus were enhanced as the particle contents increased, and the elongation was much better than that of the same matrix material reinforced with SiC particles. Thus, the novel composites exhibit better comprehensive mechanical properties.

关键词： magnesium matrix composites Ti6Al4V particles Stir casting microstructure mechanicalproperties

machine learning guided automatic recognition of crystal boundaries in bainitic/martensitic alloy and relationship between boundary types and ductile-to-brittle transition behavior

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journal of materials Science & Technology 2021年第25期84卷 49-58页

作者： x.C.Li j.x.Zhao j.H.Cong R.D.K.misra x.m.Wang x.L.Wang C.j.Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Department of metallurgical Materials and Biomedical EngineeringUniversity of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

Gradient boosting decision tree(GBDT)machine learning(mL)method was adopted for the first time to automatically recognize and conduct quantitative statistical analysis of boundaries in bainitic microstructure using electron back-scatter diffraction(EBSD)*** spite of lack of large sets of EBSD data,we were successful in achieving the desired accuracy and accomplishing the objective of recognizing the *** with a low model accuracy ofxis-angle pair as characteristic features,the accuracy of the model was significantly enhanced to about 88%when the Euler angle was converted to overall misorientation angle(OmA)and specific misorientation angle(SmA)and considered as important *** this model,the recall score of prior austenite grain(PAG)boundary was~93%,high angle packet boundary(OmA>40°)was~97%,and block boundary was~96%.The derived outcomes of mL were used to obtain insights into the ductile-to-brittle transition(DBTT)***,mL modeling approach suggested that DBTT was not determined by the density of high angle grain boundaries,but significantly influenced by the density of PAG and packet *** study underscores that mL has a great potential in detailed recognition of complex multi-hierarchical microstructure such as bainite and martensite and relates to material performance.

关键词： machine learning Feature engineering Automatic recognition Lath structure Crystallography

Guided Waves in the multilayered One-Dimensional Hexagonal Quasi-crystal Plates

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Acta mechanica Solida Sinica 2021年第1期34卷 91-103页

作者： B.Zhang j.G.Yu x.m.Zhang x.H.Wang School of mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo454003China

Guided waves in the multilayered one-dimensional quasi-crystal plates are,respectively,investigated in the context of the Bak and elasto-hydrodynamic *** curves and phonon and phason displacements are calculated using the Legendre polynomial *** characteristics in the context of these two models are analyzed in *** show that the phonon-phason coupling effects on the first two layers are the same at low frequencies;but,they are more significant on the first layer than those on the second layer at high *** obtained results lay the theoretical basis of guided-wave nondestructive test on multilayered quasi-crystal plates.

关键词： multilayered structures Quasi-crystal plate Guided wave Phonon-phason coupling effect

Phase Selection in Solidi?cation of Undercooled Co–B Alloys

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journal of materials Science & Technology 2017年第4期33卷 352-358页

作者： x.x.Wei W.xu j.L.Kang m.Ferry j.F.Li State Key Laboratory of metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240.China Australian Research Council Centre of Excellence for Design in Light metals School of Materials Science and EngineeringThe University of New South WalesSydneyNSW 2052Australia

A series Co-（18.5–20.7） at.% B melts encompassing the eutectic composition（Co81.5B18.5） were solidified at different degrees of undercooling. It is found that the metastable Co23B6 phase solidifies as a substitute for the stable Co3 B phase in the alloy melts undercooled above a critical undercooling value of -60 *** Co23B6 and α-Co phases make up a metastable eutectic. The corresponding eutectic composition and temperature are Co80.4B19.6 and 1343 K, respectively. On exposure of the metastable Co23B6 phase at a given temperature above 1208 K, it does not decompose even after several hours. But it transforms by a eutectoid reaction to α-Co ＋ Co3 B at lower temperature.

关键词： Undercooling Rapid solidi?cation metastable phase diagram Structure evolution

Effect of Grain Boundary Engineering on the Work Hardening Behavior of AL6xN Super‑Austenitic Stainless Steel

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Acta metallurgica Sinica(English Letters) 2023年第4期36卷 681-693页

作者： x.j.Guan Z.P.jia m.A.Nozzari Varkani x.W.Li Department of materials Physics and Chemistry School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of materials Ministry of EducationNortheastern UniversityShenyang 110819China

To examine the influence of grain boundary engineering(GBE)on the work hardening behavior,the tensile tests were carried out on the non-GBE and GBE AL6xN super-austenitic stainless steel(ASS)samples with a comparable grain size at two strain rates of 10^(-2)s^(-1)and 10^(-4)s^(-1).The evolution of deformation microstructures was revealed by transmission electron microscopy(TEm)and quasi-in situ electron backscatter diffraction(EBSD)*** results show that the influence of GBE on the mechanical properties of AL6xN super-ASS is mainly manifested in the change of work hardening *** the early stage of plastic deformation,GBE samples show a slightly lowered work hardening rate,since the special grain boundaries(SBs)of a high fraction induce a higher dislocation free path and a weaker back stress;however,with increasing plastic deformation amount,the work hardening rate of GBE samples gradually surpasses that of non-GBE samples due to the better capacity of maintainable work hardening that is profited from the inhibited dislocation annihilation by *** a word,the enhanced capacity of sustained work hardening effectively postpones the appearance of necking point and thus efficaciously ameliorates the ductility of GBE samples under the premise of little changes in yield strength and ultimate tensile strength.

关键词： AL6xN super-austenitic stainless steel Grain boundary engineering Work hardening behavior Quasi-in situ observation Ductility

ON THE mONTE CARLO SImULATION OF NORmAL GRAIN GROWTH

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Acta metallurgica Sinica(English Letters) 2008年第4期21卷 282-288页

作者： Y.T. Liu x.j. Guan x.m. Shen x.F. ma L.j. Wang School of materials Science and Engineering Shandong University Jinan 250061 China

The microstructures and their kinetics of normal grain growth are simulated using different monte Carlo （mC） algorithms. Compared with the relative figures and the theoretical normal grain growth exponents of n =0.5, the effects of some factors of mC algorithm, i.e. the lattice types, the methods of selecting lattice sites, and the neighbors selection for energy calculations, on the simulation results of grain growth are studied. Two methods of regression were compared, and the three-parameter nonlinear regression is much more suitable for fitting the grain growth kinetics. A better model with appropriate factors included triangular lattice, the attempted site randomly selected, and the first and second nearest neighbors for energy calculations is obtained.

关键词： Grain growth microstructure monte Carlo method Computer simulation Grain growth kinetics Nonlinear regression