检索结果-南通市图书馆

Peptide-based strategies for overcoming multidrug-resistance in cancer therapy

Chinese Chemical Letters 2025年第1期36卷 110-118页

作者： Xiaofang Luo Ye Wu Xiaokun Zhang min Tang Feiye ju Zuodong Qin Gregory j Duns Wei-Dong Zhang jiang-jiang Qin Xin Luan Hunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources College of Chemistry and BioengineeringHunan University of Science and EngineeringYongzhou 425199China Shanghai Frontiers Science Center of TCm Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Institute of Medicinal Plant DevelopmentChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100700China

Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade *** demand for targeted therapeutics for multidrug-resistant cancer is more important than ***,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug *** review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(mDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family ***,the current clinical applications of representative peptides in combating mDR cancers and their potential directions for medicinal chemistry research have been thoroughly *** review offers essential insights into the novel treatment approaches for mDR cancers and highlights the trends and perspectives in this field.

关键词： Drug resistance Antitumor peptides mechanism of action Targeted therapeutics Immunotherapy medicinal chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermoelastic Analysis of Non-uniform Pressurized Functionally Graded Cylinder with Variable Thickness Using First Order Shear Deformation Theory(FSDT) and Perturbation method

引用

Chinese journal of mechanical Engineering 2015年第6期28卷 1149-1156页

作者： KHOSHGOFTAR m j mIRZAALI m j RAHImI G H Faculty of mechanical Engineering Tarbiat Modares University Department of mechanical Engineering Faculty of Engineering Arak University Department of mechanical Engineering Politecnico di Milano

Recently application of functionally graded materials（FGms） have attracted a great deal of interest. These materials are composed of various materials with different micro-structures which can vary spatially in FGms. Such composites with varying thickness and non-uniform pressure can be used in the aerospace engineering. Therefore, analysis of such composite is of high importance in engineering problems. Thermoelastic analysis of functionally graded cylinder with variable thickness under non-uniform pressure is considered. First order shear deformation theory and total potential energy approach is applied to obtain the governing equations of non-homogeneous cylinder. Considering the inner and outer solutions, perturbation series are applied to solve the governing equations. Outer solution for out of boundaries and more sensitive variable in inner solution at the boundaries are considered. Combining of inner and outer solution for near and far points from boundaries leads to high accurate displacement field distribution. The main aim of this paper is to show the capability of matched asymptotic solution for different non-homogeneous cylinders with different shapes and different non-uniform pressures. The results can be used to design the optimum thickness of the cylinder and also some properties such as high temperature residence by applying non-homogeneous material.

关键词： non-homogenous cylinder First order Shear Deformation Theory matched asymptotic method perturbation method functionally graded material

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three subspecies of Black-tailed Godwit share non-breeding sites in the world's largest river delta

引用

Avian Research 2025年第01期 1-10页

作者： Delip K.Das Wouter m.G.Vansteelant Bingrun Zhu Shariful Islam Naim Khandakar marco van der Velde Chris j.Hassell jesse R.Conklin Pierrick Bocher jos C.E.W.Hooijmeijer Yvonne I.Verkuil Theunis Piersma Department of Zoology Faculty of Life and Earth Sciences Jagannath University Conservation Ecology Group Groningen Institute for Evolutionary Life Sciences University of Groningen Bird Eyes Centre for Global Ecological Change at the Faculties of Science & Engineering and Campus Fryslan University of Groningen Theoretical and Computational Ecology Institute for Biodiversity and Ecosystem Dynamics University of Amsterdam Hunan Global messenger Technology Co. Ltd Behavioural & Physiological Ecology Groningen Institute for Evolutionary Life Sciences University of Groningen Global Flyway Network Littoral Environnement et Sociétés UmR LIENSs 7266 CNRS La Rochelle University NIOZ Royal Netherlands Institute for Sea Research Department of Coastal Systems

During the non-breeding season(September–April), Black-tailed Godwits(Limosa limosa) are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-meghna Delta in Bangladesh. We hypothesize that the Ganges-Brahmaputra-meghna Delta, at the overlap between the Central Asian and East Asian–Australasian flyways, may host three subspecies that breed in disjunct areas of temperate and northern Asia: L. l. limosa, L. l. melanuroides, and L. l. bohaii. We used mitochondrial DNA(mt DNA) haplotype network and biometric analysis to determine subspecies in captured individuals, and deployed GPS–GSm transmitters to verify breeding areas of individuals with subspecies assignments. To test for differential habitat preferences, we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh: Nijhum Dweep National Park, a tidal coastal habitat with brackish water on the south-central coast, and Tanguar Haor(‘backmarsh'), a seasonal freshwater floodplain in the north. During the non-breeding seasons of 2021–2022 and 2022–2023, we sampled and measured 93 Black-tailed Godwits, 54 of which were equipped with GPS–GSm transmitters. Our mt DNA haplotype network analysis confirmed the presence of limosa, melanuroides, and bohaii subspecies at the study sites. Thus, indeed, Black-tailed Godwits subspecies, despite having distinct breeding ranges, exhibit(partially) overlapping non-breeding ranges in Asia. The subspecies composition differed significantly between sites, with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum Dweep. Of the 21 individuals that were tracked to their breeding grounds, 18 migrated to the expected breeding range of their respective subspecies. However, one bird with a limosa haplotype migrated to a known breeding area of bohaii, whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of limosa. Therefore, while ecologic

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

High-quality control of receiver functions using a capsule neural network

引用

Earthquake Science 2025年第2期38卷 93-109页

作者： mona H. Hegazi Ahmad m. Faried Omar m. Saad National Research Institute of Astronomy and Geophysics (NRIAG) Cairo 11421 Egypt Division of Physical Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia

The Red Sea-Gulf of Suez-Cairo-Alexandria Clysmic-Trend in northern Egypt is the main earthquake zone in the country, with a moderate-to-high seismic hazard and a history of significant earthquakes caused by rifting and active faulting. To improve our understanding of the tectonic and seismic processes in this area, more comprehensive imaging of the crustal structure is required. This can be achieved by increasing the number of receiver functions (RFs) recorded by the seismic stations in northern Egypt and the southeastern mediterranean. Data handling and processing should also be automated to increase process efficiency. In this study, we developed a capsule neural network for automated selection of RFs. The model was trained on a dataset containing RFs (both selected and unselected) from five broadband stations in northern Egypt. Stations SLm, SIWA, KOT, NBNS, and NKL are located in the unstable shelf region of Egypt, where limited knowledge of the deep crustal structure is available. The proposed capsule neural network achieved an average precision of 80% on the test set. The automated selection of RFs using a capsule neural network has the potential to significantly improve the efficiency and accuracy of RF analysis, as demonstrated by the stacking test. This could lead to a better understanding of crustal structure and tectonic processes in northern Egypt and the southeastern mediterranean.

关键词： crustal structure receiver functions deep learning northern Egypt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting peak ground acceleration using the Convmixer network

引用

Earthquake Science 2025年第2期38卷 126-135页

作者： mohammed, mona Saad, Omar m. Keshk, Arabi Ahmed, Hatem m. National Research Institute of Astronomy and Geophysics (NRIAG) Cairo 11511 Egypt Division of Physical Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia Delta Technological University Menoufia 32684 Egypt Faculty of Computers and Information Menoufia University Menoufia 32512 Egypt

The level of ground shaking, as determined by the peak ground acceleration (PGA), can be used to analyze seismic hazard at a certain location and is crucial for constructing earthquake-resistant structures. Predicting the PGA immediately after an earthquake occurs allows for the issuing of a warning by an earthquake early warning system. In this study, we propose a deep learning model, Convmixer, to predict the PGA recorded by weak-motion velocity seismometers in japan. We use 5-s three-component seismograms, from 2 s before until 3 s after the P-wave arrival time of the earthquake. Our dataset comprised more than 50,000 single-station waveforms recorded by 10 seismic stations in the K-NET, Kiki-NET, and Hi-Net networks between 2004 and 2023. The proposed Convmixer is a patch-based model that extracts global features from input seismic data and predicts the PGA of an earthquake by combining depth and pointwise convolutions. The proposed Convmixer network had a mean absolute error of 2.143 when applied to the test set and outperformed benchmark deep learning models. In addition, the proposed Convmixer demonstrated the ability to predict the PGA at the corresponding station site based on 1-second waveforms obtained immediately after the arrival time of the P-wave. © 2025 The Authors

关键词： deep learning (DL) earthquake early warning system (EEWS) peak ground acceleration (PGA)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanostructured grinding wheels for ultra-precision engineering applications

引用

Nanotechnology and Precision Engineering 2021年第3期4卷 63-75页

作者： m.j.jackson Integrated Studies College of Technology and AviationKansas State UniversitySalinaKansas 67401USA

manufacturers face challenges when dealing with abrasives that lose roundness,wear excessively,and suffer from pitting of the surface of the grinding wheel that needs rectification using dressing *** abrasive grits manufactured by hybrid fusion processes and by sintering/extrusion/printing processes are found to reduce pitting quite *** phenomenon of wheel collapse is increasing and cycle times developed during the grinding of aerospace alloys are much smaller compared to using conventional *** paper reviews the phenomenon of wheel collapse induced by pitting and takes a critical look at the production and analysis of hybrid fused and printed/sintered abrasives.A mathematical analysis is carried out of the diffusion of primary and secondary phases due to mechanical and ultrasonic agitation with the aim of producing abrasive grits with improved strength and *** developments in extruded,printed,and sintered grits for use in precision grinding applications are critically *** paper concludes by explaining how such abrasives are used in practice by industrial manufacturers of high-precision products.

关键词： Nanotechnology Abrasives Alloys Finishing Grinding machining

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frequency-dependent viscoelasticity effects on the wave attenuation performance of multi-layered periodic foundations

引用

Applied mathematics and mechanics(English Edition) 2024年第3期45卷 407-424页

作者： m.SAFI m.VAKILIFARD m.j.mAHmOODI Faculty of Civil Water&Environmental EngineeringShahid Beheshti UniversityTehran ***Iran Faculty of mechanical and Energy Engineering Shahid Beheshti UniversityTehran ***Iran

In this paper,layered periodic foundations(LPFs)are numerically examined for their responses to longitudinal and transverse modes in the time and frequency *** different unit-cells,i.e.,2-layer,4-layer,and 6-layer unit-cells,comprising concrete/rubber,concrete/rubber/steel/rubber,and concrete/rubber/steel/rubber/lead/rubber materials,respectively,are taken into ***,the viscoelasticity behavior of the rubber is modeled with two factors,i.e.,a frequency-independent(FI)loss factor and a linear frequency-dependent(FD)loss *** the extraction of the complex dispersion curves and the identification of the band gaps(BGs),the simulations of wave transmission in the time and frequency domains are performed using the COmSOL *** parametric studies evaluate the effects of the rubber viscoelasticity models on the dispersion curves and the wave transmission for the longitudinal and transverse *** results show that considering the rubber viscoelasticity enhances the wave attenuation ***,the transverse-mode damping is more sensitive to the viscoelasticity model than its longitudinal *** 6-layer unit-cell LPF exhibits the lowest BG,ranging from 4.8 Hz to 6.5 Hz.

关键词： layered metamaterial periodic foundation complex dispersion curve wave transmission diagram

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Health risk of whole body vibration in mining trucks during various operational conditions

引用

journal of Central South University 2017年第8期24卷 1808-1816页

作者： Rahimdel m.j mirzaei m Sattarvand j Hoseinie S.H Department of mining Engineering Sahand University of TechnologyTabriz ***Iran Department of mechanical Engineering Sahand University of TechnologyTabriz ***Iran Department of mining Engineering Isfahan University of TechnologyIsfahan ***Iran

mining machineries are generally exposed to intensive vibrations in harsh mining environment. If vibrations are beyond the tolerable limit, the machine and its operator health will be under the risk. In this work, the vibration of a mining truck at different operational conditions are simulated and discussed. To achieve this aim, three haul roads with low, medium and poor qualities are considered based on the ISO standard. Accordingly, the vibration of a mining truck in different speeds, payload and distribution qualities of materials in the dump body are evaluated in each haul road quality using Trucksim software. The simulation results with statistical discussions indicate that the truck speed and the materials distribution quality have significant effects on the root mean square(RmS) of vertical vibrations. However, the effect of the payload is not considerable on the RmS. moreover, the accumulation of materials on the rear side of the truck dump body is efficient on the vibrational health risk.

关键词： mining trucks operational conditions health risk whole body vibration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface morphology and impurity distribution of electron beam recrystallized silicon films on low cost substrates for solar cell absorber

引用

Rare metals 2006年第Z1期25卷 195-200页

作者： GROmBALL F müLLER j Department of mikrosystemtechnik Technische Universitt Hamburg-Harburg Hamburg 21073 Germany

A line shaped electron beam recrystallised polycrystalline silicon film on the low cost substrate was investigated for the use of the solar cell absorber. The applied EB energy density strongly influences the surface morphology of the film system. Lower EB energy density results in droplet morphology and the rougher SiO2 capping layer due to the low fluidity. With the energy increasing, the capping layer becomes smooth and continuous and less and small pinholes form in the silicon film. Tungstendisilicide (WSi2) is formed at the interface tungsten/silicon but also at the grain boundaries of the silicon. Because of the fast melting and cooling of the silicon film, the eutectic of silicon and tungstendisilicide mainly forms at the grain boundary of the primary silicon dendrites. The SEm-EDX analysis shows that there are no chlorine and hydrogen in the area surrounding a pinhole after recrystallization because of outgassing during the solidification.

关键词： polycrystalline silicon film solar cell recrystallization energy surface morphology outgassing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic mechanical Relaxation in Bulk metallic Glasses:A Review

引用

journal of materials Science & Technology 2014年第6期30卷 523-545页

作者： j.C.Qiao j.m.Pelletier Université de Lyon CNRS France INSA-Lyon MATEIS UMR5510 F-69621 Villeurbanne France

metallic glasses have aroused considerable interest in the past decades because they exhibit fascinating properties. First, this article briefly outlines the mechanical, thermal properties and application of the metallic glasses. In addition, we focus on the dynamic mechanical relaxation behaviors, i.e. main （α） and secondary （β） relaxations, in metallic glasses. The mechanical relaxation behaviors are connected to the mechanical properties and physical properties in glassy materials. The main relaxation in glassy materials is related to the glass transition phenomenon and viscous flow. On the other hand, the β relaxation is linked to many fundamental issues in metallic glasses. In these materials relaxation processes are directly related to the plastic deformation mechanism. The mechanical relaxations, particularly, the β relaxation provides an excellent opportunity to design metallic glasses with desired physical and mechanical properties. We demonstrate the universal characteristics of main relaxation in metallic glasses. The phenomenological models and the physical theories are introduced to describe the main relaxation in metallic glasses. In parallel, we show the dependence of the α. and β relaxations on the thermal treatments in metallic glasses. Finally, we analyze the correlation between the atomic mobility and the thermo-mechanical treatments in metallic glasses. On the one hand, the atomic mobility in metallic glasses is reduced by physical aging or crystallization. On the other hand, the atomic mobility in metallic glass is enhanced by deformation （i.e. compression and cold rolling）. Importantly, to analyze the atomic mobility in amorphous materials, a physical theory is introduced. This model invokes the concept of quasi-point defects, which correspond to the density fluctuations in the glassy materials.

关键词： metallic glasses mechanical properties main relaxation Secondary relaxation Physical analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：