Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic ...
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Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.
Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...
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Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).
The nanocrystalline samples Nd1-xmxFeO3(x=0.0 and 0.1;m:Co2+and Ni2+) were prepared using the citrate combustion *** X-ray diffraction(XRD) pattern confirmed that the nanoparticles were synthesized in an orthorhombi...
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The nanocrystalline samples Nd1-xmxFeO3(x=0.0 and 0.1;m:Co2+and Ni2+) were prepared using the citrate combustion *** X-ray diffraction(XRD) pattern confirmed that the nanoparticles were synthesized in an orthorhombic *** particle size of Nd1-xmxFeO3is in the range of 29-59 *** selected area electron diffraction(SAED) indicates the samples were prepared in a polycrystalline *** samples Nd1-xmxFeO3(x=0.0 and 0.1;m:Co2+and Ni2+) have anti ferromagnetic *** Fe3+spins are aligned antiparallel,forming the antiferromagnetic(AFm) properties,which are affected by many factors such as the bond angle between the Fe3+(Fe3+-O2--Fe3+) and the Dzyaloshinskii-moriya(D-m) *** doping of Co2+and Ni2+ions in NdFeO3enhances the magnetic properties of the *** saturation magnetization(ms) of Nd0.90Co0.10FeO3increases 1.8times more than that of *** exchange bias field(HEX) of the Co-doped sample is two times greater than that of *** magnetic anisotropy constant(K) of the 10% Co-doped sample increases by 11 factors compared to that of *** Tauc plot illustrates that the samples have a direct optical *** divalent cation substitution(Co2+and Ni2+) decreases the optical band gap of NdFeO3,leading to the recommendation of using the samples Nd0.90Co0.10FeO3and Nd0.90Ni0.10FeO3in photocatalysis of dye degradation from *** removal efficiencies of Cr6+at pH=6 are 88.06%,85.54%,and 85.52% for the samples NdFeO3,Nd0.90Co0.10FeO3,and Nd0.90Ni0.10FeO3,*** Freundlich isotherm mode is the best-fit model for NdFeO3to adsorb Cr6+ions from aqueous solutions.
There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons...
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There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).
The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser facility. The spatial-temporal evolution of X-ray emi...
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The interaction of high-power laser pulses with undercritical foams produced by different techniques but with the same average density is studied at the PALS laser facility. The spatial-temporal evolution of X-ray emission is observed using an X-ray streak camera, electron and ion temperatures are measured by X-ray spectroscopy, and hot-electron production is characterized by monochromatic X-ray imaging. Transmission of a femtosecond laser probe pulse through foams is observed in the near and far fields. In spite of large differences in pore size and foam structure, the velocity of ionization front propagation is quite similar for all the foams studied and is slower than that in a homogeneous material of the same average density. The ion temperature in the plasma behind the ionization front is a few times higher than the electron temperature. Hot-electron production in plastic foams with small pores is strongly suppressed compared with that in solid targets, whereas in foams produced by additive manufacturing, it is significantly increased to the level observed in bare copper foil targets.(c) 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license(https://***/licenses/by/4.0/).
Inspired by nature's self-similar designs, novel honeycomb-spiderweb based self-similar hybrid cellular structures are proposed here for efficient energy absorption in impact applications. The energy absorption is enh...
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作者:
Naser, m.Z.
Clemson University Clemson South Carolina29634 United States
Clemson University ClemsonSC29634 United States
Causality, the science of cause and effect, has made it possible to create a new family of models. Such models are often referred to as causal models. Unlike those of mathematical, numerical, empirical, or machine lea...
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The NEutron Detector Array (NEDA) is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated neutrons. This a...
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The NEutron Detector Array (NEDA) is designed to be coupled to gamma-ray spectrometers to enhance the sensitivity of the setup by enabling reaction channel selection through counting of the evaporated neutrons. This article presents the implementation of a double trigger condition system for NEDA, which improves the acquisition of neutrons and reduces the number of gamma rays acquired. Two independent triggers are generated in the double trigger condition system: one based on charge comparison (CC) and the other on time-of-flight (TOF). These triggers can be combined using OR and AND logic, offering four distinct trigger modes. The developed firmware is added to the previous one in the Virtex 6 field programmable gate array (FPGA) present in the system, which also includes signal processing, baseline correction, and various trigger logic blocks. The performance of the trigger system is evaluated using data from the E703 experiment performed at GANIL. The four trigger modes are applied to the same data, and a subsequent offline analysis is performed. It is shown that most of the detected neutrons are preserved with the AND mode, and the total number of gamma rays is significantly reduced. Compared with the CC trigger mode, the OR trigger mode allows increasing the selection of neutrons. In addition, it is demonstrated that if the OR mode is selected, the online CC trigger threshold can be raised without losing neutrons.
Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic...
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Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).
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