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Acta metallurgica Sinica(English Letters) 2004年第4期17卷 560-568页

作者： j.m.gong Y.jiang S.T.Tu Nanjing University of Technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 China East China University of Science and Technology Shanghai 200237 China

In this paper, the effect of carbon migration on creep properties of Cr5mo dissimilar welded joints with Ni-based (Inconel 182) and Cr23Nil3 (A302) austenitic weld metal was investigated. Carbon migration near the weld metal/ferritic steel interface of Cr5mo dissimilar welded joints was analyzed by aging method. Local creep deformations of the dissimilar welded joints were measured by a long-term local creep deformation measuring technique. The creep rupture testing was performed for Cr5mo dissimilar welded joints with Inconel 182 and A302 weld metal. The research results show that the maximum creep strain rate occurs in the decarburized zone located on heat affect zone (HAZ) of Cr5mo ferritic steel. The creep rupture life of Cr5mo dissimilar welded joints with A 302 weld metal decreases due to carbon migration and is about 50% of that welded with Inconel 182 weld metal.

关键词： dissimilar welded joint carbon migration creep rupture localized deformation

A NEW mETHOD FOR mEASURING LONG-TERmCREEP DEFORmATION IN A SmALL REGION

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Acta metallurgica Sinica(English Letters) 1998年第6期11卷 442-448页

作者： j.m.gong S.T.Tu j.Xia X.Ling Nanjing Univ of Chemical Technology Nanjing China

Creep deformation localization is generally found in structures at high temperamture,typically in weldments. As the heat affected zone (HAZ) in a weldment is very narrow, deformation in HAZ region can hardly be measured by conventional displacement gauge. A new method for measuring long-term local creep deformation was developed by quartz optical fiber and technique of digital image analysis. The creep deformations of base metal, weld metal and HAZ in weldments are thereby determined with crossweld specimens.

关键词： creep deformation weldment quartz optical fiber image analysis

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

黄土高原森林林下植被物种多样性及其影响因素

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东北林业大学学报 2025年第2期53卷 66-74页

作者：宫正黄河文明与可持续发展研究中心(河南大学) 开封475001

以黄土高原不同密度刺槐(Robinia pseudoacacia)林为研究对象,通过调查样地的地形及土壤理化性质,利用方差分析、线性拟合、冗余分析等方法,分析林下植被物种多样性特征,探究影响林下植被物种多样性的因素。结果表明:不同林分密度的刺... 详细信息

以黄土高原不同密度刺槐(Robinia pseudoacacia)林为研究对象,通过调查样地的地形及土壤理化性质,利用方差分析、线性拟合、冗余分析等方法,分析林下植被物种多样性特征,探究影响林下植被物种多样性的因素。结果表明:不同林分密度的刺槐林林下植被物种多样性存在显著差异(Pmargalef丰富度指数随坡向的增大而减小,林下草本植物margalef丰富度指数随坡度的增加而减小。刺槐林下灌木植物物种多样性的主要影响因素是密度、坡向、土壤全氮质量分数、土壤铵态氮质量分数,草本植物物种多样性的主要影响因素是土壤速效磷质量分数。

关键词：刺槐林物种多样性影响因素冗余分析黄土高原

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng gong Yangping Zhuang jiali Wu Yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical medical College of Fujian medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the mAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

PREPARATION　AND　CHARACTERIZATION　OF　NIOBIUm－CONTAINING　DImOLYBDO－15－TUNGSTODIPHOS－PHORIC　SALT

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Chinese Chemical Letters 1996年第2期7卷 199-200页

作者： gong, j Qu, LY NE NORmAL UNIV DEPT CHEMCHANGCHUN 130024PEOPLES R CHINA

Preparation of P2W15m15mo2NbO627- was reported in the paper. It was characterized by elementry analysis, IR,UV, polarography, 183 W-NmR and XPD spectra. All results showed the structure of the heteropoly anion was the...

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Advances in immuno-oncology biomarkers for gastroesophageal cancer:programmed death ligand 1,microsatellite instability,and beyond

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World journal of Gastroenterology 2018年第25期24卷 2686-2697页

作者： Emily m Lin jun gong Samuel j Klempner joseph Chao Department of Internal medicine Harbor-UCLA Medical CenterTorranceCA 90509United States Department of medical Oncology and Developmental Therapeutics City of Hope Comprehensive Cancer CenterDuarteCA 91010United States The Angeles Clinic and Research Institute Los AngelesCA 90404United States Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States

Blockade of the programmed death ligand 1(PD-L1) and programmed cell death 1(PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction(GEj) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEj cancer. microsatellite instability(mSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatmentrefractory solid tumors with mSI status and the thirdline or greater treatment of PD-L1 positive advanced gastric/GEj cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEj cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEj cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEj cancer.

关键词： Immunotherapy programmed cell death 1 programmed death ligand 1 microsatellite instablility Gastric cancer

A semi-analytical approach for calculating the equilibrium structure and radial breathing mode frequency of single-walled carbon nanotubes

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Acta mechanica Sinica 2016年第6期32卷 1075-1087页

作者： j.gong L.Thompson G.Li Department of mechanical Engineering Clemson University

A semi-analytical model for determining the equilibrium configuration and the radial breathing mode (RBm) frequency of single-wall carbon nanotubes (CNTs) is presented. By taking advantage of the symmetry characteristics, a CNT structure is represented by five independent variables. A line search optimization procedure is employed to determine the equilibrium values of these variables by minimizing the potential energy. With the equilibrium configuration obtained, the semi-analytical model enables an efficient calculation of the RBm frequency of the CNTs. The radius and radial breathing mode frequency results obtained from the semi-analytical approach are compared with those from molecular dynamics (mD) and ab initio calculations. The results demonstrate that the semi-analytical approach offers an efficient and accurate way to determine the equilibrium structure and radial breathing mode frequency of CNTs.

关键词： Carbon nanotubes Equilibrium structure Radial breathing mode frequency