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A hydrodynamic modelling of wave-activated bodies for wavelet marine regions

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Clean Energy 2024年第2期8卷 35-47页

作者： j.S.Peh Mohammed W.Muhieldeen N.H.Shuaib Mechanical Engineering Department Faculty of EngineeringTechnology&Built EnvironmentUCSI UniversityKuala Lumpur56000Malaysia MTC Engineer Sdn.Bhd Shah AlamSelangorMalaysia

Recently,most wave energy research has targeted sea areas with high power density under extreme wave conditions for *** trend often leads to higher energy costs for wave power ***,many marine areas with low power density,characterized by wavelet conditions and less destructive forces than extreme wave conditions,remain ***,this study aimed to propose a wave-activated body model for sea regions with wavelet *** wave-activated body design process encompassed site selection,parameter determination,geometry design,comparison and performance evaluation using the ANSYS®AQWA *** results indicated that the proposed device achieved the desired heave motion,with an amplitude range of 1.2 to-2.5 m,validating its potential for deployment in marine regions with wavelet ***,while the proposed design is optimized for wavelet conditions,it was found to have potential limitations in extreme wave *** observation emphasizes the challenge of formulating a generalized design suitable for both ***,it is pivotal for wave-activated body designs to be customized based on the specific ocean conditions they target,underscoring the need for specialized designs of wave energy converters that consider the unique wave characteristics of their deployment sites.

关键词： wave energy converter South China sea renewable and sustainable energy wavelet ANSYS AQWA hydrodynamic wave-activated bodies

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Back to the drawing board:Overview of the next generation of combination therapy for inflammatory bowel disease

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World journal of Gastroenterology 2024年第25期30卷 3182-3184页

作者： jeffrey A Lowell Michael j Farber Keith Sultan Department of Medicine Zucker School of Medicine at HofstraNorth Shore University Hospital-Long Island Jewish Medical CenterManhassetNY 11030United States Preclinical Studies New York Institute of Technology College of Osteopathic MedicineGlen HeadNY 11545United States Division of Gastroenterology Northwell HealthNorth Shore University Hospital and Long Island Jewish Medical CenterGreat NeckNY 10021United States

Inflammatory bowel disease(IBD)is entering a potentially new era of combined *** et al provide an insightful review of the current state of combination therapy,with a focus on the use of a combined biologic and immunomodulator,as well as emerging data on the future potential of dual-biologic therapy(DBT).While current evidence for DBT is limited,encouraging safety profiles and ongoing trials suggest a brighter future for this *** importance of controlled trials should be stressed in establishing new treatment *** prospective randomized trials of DBT and perhaps future combinations of biologics and small molecule therapies will hopefully guide the next generation of IBD care.

关键词： Inflammatory bowel disease Biologics Immunomodulators Dual-therapy Combination therapy

Exploring public perception and willingness to pay for a renewable source of energy:evidence from an emerging economy of renewable-energy development

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Clean Energy 2024年第2期8卷 177-188页

作者： Mohammed j.K.Bashir Senadjki Abdelhak Wael A.Salah Mai Abuhelwa School of Engineering&Technology Central Queensland University120 Spencer St.MelbourneQLD 3000Australia Faculty of Business and Finance Universiti Tunku Abdul RahmanKamparPerakMalaysia Department of Electrical Engineering College of Engineering and TechnologyPalestine Technical University-KadooriePO Box 7Yafa StreetTulkarmPalestine Department of Electrical Engineering and Computer Science University of MissouriColumbiaMO 65211USA

The study focuses on the transition from conventional energy sources to sustainable renewable energy(RE)in Palestine,particularly in the West Bank and Gaza *** research aims to understand the relationship between key factors and residents’willingness to invest in the RE sector,with a specific focus on the impact of *** the unified theory of acceptance and use of technology,the study analyzes data from 400 residents through a questionnaire and employs ordinary least-squares regression analysis with Eviews *** key findings indicate that residents’inclination to invest in RE is significantly influenced by factors such as resource availability,knowledge level and power ***,the study suggests that educated residents are more likely to invest in RE when factors such as knowledge,effort expectation,enabling conditions and resource availability are relatively *** conclusion emphasizes the importance of policymakers’allocating sufficient funds to research and development to promote technological innovation in RE sources,thereby enhancing the population’s energy efficiency.

关键词： renewable energy technology energy security public perceptions sustainable development

Diagnosing health in composite battery electrodes with explainable deep learning and partial charging data

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Energy and AI 2024年第2期16卷 256-268页

作者： Haijun Ruan Niall Kirkaldy Gregory j.Offer Billy Wu Dyson School of Design Engineering Imperial College LondonSW72AZLondonUK Centre for E-Mobility and Clean Growth Research Coventry UniversityCoventryCV15FBUK Department of Mechanical Engineering Imperial College LondonSW72AZLondonUK The Faraday Institution Harwell Science and Innovation CampusOX110RADidcotUK

Lithium-ion batteries with composite anodes of graphite and silicon are increasingly being used. However, their degradation pathways are complicated due to the blended nature of the electrodes, with graphite and silicon degrading at different rates. Here, we develop a deep learning health diagnostic framework to rapidly quantify and separate the different degradation rates of graphite and silicon in composite anodes using partial charging data. The convolutional neural network (CNN), trained with synthetic data, uses experimental partial charging data to diagnose electrode-level health of tested batteries, with errors of less than 3.1% (corresponding to the loss of active material reaching ∼75%). Sensitivity analysis of the capacity-voltage curve under different degradation modes is performed to provide a physically informed voltage window for diagnostics with partial charging data. By using the gradient-weighted class activation mapping approach, we provide explainable insights into how these CNNs work;highlighting regions of the voltage-curve to which they are most sensitive. Robustness is validated by introducing noise to the data, with no significant negative impact on the diagnostic accuracy for noise levels below 10 mV, thus highlighting the potential for deep learning approaches in the diagnostics of lithium-ion battery performance under real-world conditions. The framework presented here can be generalised to other cell formats and chemistries, providing robust and explainable battery diagnostics for both conventional single material electrodes, but also the more challenging composite electrodes.

关键词： Lithium-ion battery Composite electrode Silicon Degradation diagnostic Explainable deep learning Partial charging

Improving colorectal cancer screening programs

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World journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar j Cordero lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

Effects of COL1A1 and SYTL2 on inflammatory cell infiltration and poor extracellular matrix remodeling of the vascular wall in thoracic aortic aneurysm

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Chinese Medical journal 2024年第9期137卷 1105-1114页

作者： Xinsheng Xie Ye Yuan Yulong Huang Xiang Hong Shichai Hong Gang Chen Yihui Chen Yue Lin Weifeng lu Weiguo Fu Lixin Wang Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Fudan UniversityShanghai 200032China

Background:Thoracic aortic aneurysm(TAA)is a fatal cardiovascular disease,the pathogenesis of which has not yet been *** study aimed to identify and validate the diagnostic markers of TAA to provide a strong theoretical basis for developing new methods to prevent and treat this ***:Gene expression profiles of the GSE9106,GSE26155,and GSE155468 datasets were acquired from the Gene Expression Omnibus(GEO)*** expressed genes(DEGs)were identified using the"limma"package in *** absolute shrinkage and selection operator(LASSO),support vector machine-recursive feature elimination(SVM-RFE),random forest,and binary logistic regression analyses were used to screen the diagnostic marker ***-sample gene set enrichment analysis(ssGSEA)was used to estimate immune cell infiltration in ***:A total of 16 DEGs were *** enrichment and functional correlation analyses showed that DEGs were mainly associated with inflammatory response pathways and collagen-related *** type I alpha 1 chain(COL1A1)and synaptotagmin like 2(SYTL2)were identified as diagnostic marker genes with a high diagnostic value for *** expression of COL1A1 and SYTL2 was considerably higher in TAA vascular wall tissues than in the corresponding normal tissues,and there were significant differences in the infiltration of immune cells between TAA and normal vascular wall ***,COL1A1 and SYTL2 expression were associated with the infiltration of immune cells in the vascular wall ***-cell analysis showed that COL1A1 in TAA was mainly derived from fibroblasts and SYTL2 mainly from cluster of differentiation(CD)8+T *** addition,single-cell analysis indicated that fibroblasts and CD8+T cells in TAA were significantly higher than those in normal arterial wall ***:COL1A1 and SYTL2 may serve as diagnostic marker genes for *** upregulation of SYTL2 and COL1A1 may be involved in the inflammat

关键词： Bioinformatics Thoracic aortic aneurysm Immune response Single cell analysis Machine learning

Photon orbits and phase transition for Letelier AdS black holes immersed in perfect fluid dark matter

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Chinese Physics C 2024年第6期48卷 247-259页

作者： Ashima Sood Md Sabir Ali j.K.Singh Sushant G.Ghosh Department of Mathematics Netaji Subhas University of TechnologyNew Delhi-110078India Centre for Theoretical Physics Jamia Millia IslamiaNew Delhi 110025India Department of Physics Mahishadal Raj CollegePurba MedinipurWest Bengal721628India Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China Key Laboratory of Quantum Theory and Applications of MoE Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China Astrophysics and Cosmology Research Unit School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa

We obtain an exact solution for spherically symmetric Letelier AdS black holes immersed in perfect fluid dark matter(PFDM).Considering the cosmological constant as the positive pressure of the system and volume as its conjugate variable,we analyze the thermodynamics of our black holes in the extended phase *** to the background clouds of strings parameter(a)and the parameter endowed with PFDM(β),we analyze the Hawking temperature,entropy,and specific ***,we investigate the relationship between the photon sphere radius and phase transition for the Letelier AdS black holes immersed in *** the analysis,with a particular condition,non-monotonic behaviors are found between the photon sphere radius,impact parameter,PFDM parameter,temperature,and *** can regard the changes in both the photon sphere radius and impact parameter before and after phase transition as the order parameter;their critical exponents near the critical point are equal to the same value,1/2,similar to that in ordinary thermal *** indicates that a universal relation of gravity may exist near the critical point for a black hole thermodynamic system.

关键词： AdS black holes perfect fluid dark matter Letelier spacetime photon orbit extended phase space thermodynamics correlation of photon orbit and thermodynamics

The Global Energy and Water Exchanges(GEWEX)Project in Central Asia:The Case for a Regional Hydroclimate Project

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Advances in Atmospheric Sciences 2024年第5期41卷 777-783页

作者： Michael BRODY Maksim KULIKOV Sagynbek ORUNBAEV Peter j.VAN OEVELEN International Agricultural University Tashkent 111200Uzbekistan George Mason University FairfaxVirginia 22030USA University of Central Asia Bishkek 720001Kyrgyz Republic American University of Central Asia Bishkek 720060Kyrgyz Republic International GEWEX project George Mason UniversityFairfaxVirginia 22030USA

Central Asia consists of the former Soviet Republics,Kazakhstan,Kyrgyz Republic,Tajikistan,Turkmenistan,and *** region’s climate is continental,mostly semi-arid to *** is a significant part of the region’s *** its nature of intensive water use,agriculture is extremely vulnerable to climate *** growth and irrigation development have significantly increased the demand for water in the *** climate change issues include melting glaciers and a shrinking snowpack,which are the foundation of the region’s water resources,and a changing precipitation *** glaciers are located in Kyrgyzstan and Tajikistan,leading to transboundary water resource *** already has extremely high *** indicate that Central Asia has been warming and precipitation might be *** warming is expected to increase,but its spatial and temporal distribution depends upon specific global *** of future precipitation show significant uncertainties in type,amount,and *** Hydroclimate Projects(RHPs)are an approach to studying these *** steps to develop an RHP began in 2021 with a widely distributed online survey about these climate *** was followed up with an online workshop and then,in 2023,an in-person workshop,held in Tashkent,*** for the Global Energy and Water Exchanges(GEWEX)project for the region include both observations and modeling,as well as development of better and additional precipitation observations,all of which are topics for the next workshop.A well-designed RHP should lead to reductions in critical climate uncertainties in policy-relevant timeframes that can influence decisions on necessary investments in climate adaptation.

关键词： GEWEX Central Asia climate change agriculture