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中华内分泌代谢杂志 2024年第7期40卷 621-624页

作者： j Diabetes编辑部

综述/Review Article

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Development of a toroidal soft x-ray imaging system and application for investigating three-dimensional plasma on j-TEXT

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Plasma Science and Technology 2024年第3期26卷 94-99页

作者：赵传旭李建超张晓卿王能超丁永华杨州军江中和严伟李杨波毛飞越任正康 the j-TEXT Team International joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic Engineering and School of PhysicsHuazhong University of Science and TechnologyWuhan 430074People's Republic of China Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205People's Republic of China International joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics State Key Laboratory of Advanced Electromagnetic Engineering and TechnologySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074People's Republic of China

A toroidal soft x-ray imaging(T-SXRI)system has been developed to investigate threedimensional(3D)plasma physics on *** T-SXRI system consists of three sets of SXR *** sets are newly developed and located on the vacuum chamber wall at toroidal positionsφof 126.4°and 272.6°,respectively,while one set was established previously atφ=*** set of SXR arrays consists of three arrays viewing the plasma poloidally,and hence can be used separately to obtain SXR images via the tomographic *** sawtooth precursor oscillations are measured by T-SXRI,and the corresponding images of perturbative SXR signals are successfully reconstructed at these three toroidal positions,hence providing measurement of the 3D structure of precursor *** observed 3D structure is consistent with the helical structure of the m/n=1/1 *** experimental observation confirms that the T-SXRI system is able to observe 3D structures in the j-TEXT plasma.

关键词： SXR imaging j-TEXT tokamak three-dimensional measurement MHD

Universal insertion of molecules in ionic compounds under pressure

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National Science Review 2024年第1期11卷 120-128页

作者： Feng Peng Yanming Ma Chris j.Pickard Hanyu Liu Maosheng Miao College of Physics and Electronic Information Luoyang Normal University Department of Chemistry and Biochemistry California State University Northridge State Key Laboratory of Superhard Materials & Key Laboratory of Material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University Department of Materials Science & Metallurgy University of Cambridge Advanced Institute for Materials Research Tohoku University Department of Earth Science University of California Santa Barbara

Using first-principles calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, N2, CO2, NH3, H2O and CH4may react with NaC l, a prototype ionic solid,and form stable compounds under pressure while retaining their molecular structure. These molecules,despite whether they are homonuclear or heteronuclear, polar or non-polar, small or large, do not show strong chemical interactions with surrounding Na and Cl ions. In contrast, the most stable molecule among all examples, N2, is found to transform into cyclo-N5-anions while reacting with NaC l under high pressures. It provides a new route to synthesize pentazolates, which are promising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization propensity of covalently bonded molecules and solid compounds under pressure. This surprising miscibility suggests possible mixing regions between the molecular and rock layers in the interiors of large planets.

关键词： molecule-solid hybrid materials high-pressure crystal structure prediction density functional theory planet interior

2024年 journal of Diabetes第7期中文导读

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中华内分泌代谢杂志 2024年第8期40卷 716-718页

作者： j Diabetes编辑部

论著/Original Article

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三维打印技术在色谱分离中的应用

分析化学 2024年第5期52卷 624-633页

作者：李强陆浩男温翰荣王宗鹏张博江西赣锋锂业集团股份有限公司厦门大学化学化工学院晋江精纯科技有限公司

色谱法是生产活动和学术研究中最重要的分离分析技术之一。随着应用需求的日益增长，开发具有针对性的分离装置成本高昂，同时由于模型制作困难，色谱理论研究通常难以得到验证。三维(3D)打印技术通过堆砌材料的方式自下而上地制造器件... 详细信息

色谱法是生产活动和学术研究中最重要的分离分析技术之一。随着应用需求的日益增长，开发具有针对性的分离装置成本高昂，同时由于模型制作困难，色谱理论研究通常难以得到验证。三维(3D)打印技术通过堆砌材料的方式自下而上地制造器件，可以针对特定需求自定义打印复杂结构，具有低成本、低废料、高精度、高自由度和平行制造等优势，在色谱分离领域展现出巨大的应用潜力。近年来，随着3D打印技术的飞速发展，打印分辨率和打印速度不断提高，可打印的材料种类也大幅增加，3D打印技术在色谱分离领域得到了初步的研究和应用。本文介绍了3D打印技术在色谱分离研究领域中的最新应用进展，包括3D打印色谱柱管、3D打印色谱固定相和3D打印固相萃取器件，讨论了3D打印技术在色谱领域应用的现有挑战和应用前景。

关键词：色谱分离三维打印分离技术评述

A multidimensional platform of patient-derived tumors identifies drug susceptibilities for clinical lenvatinib resistance

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Acta Pharmaceutica Sinica B 2024年第1期14卷 223-240页

作者： Lei Sun Arabella H.Wan Shijia Yan Ruonian Liu jiarui Li Zhuolong Zhou Ruirui Wu Dongshi Chen Xianzhang Bu jingxing Ou Kai Li Xiongbin lu Guohui Wan Zunfu Ke Department of Pathology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Local joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability(Cultivation)Guangdong Province Key Laboratory of New Drug Design and EvaluationSchool of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Department of Hepatic Surgery and Liver Transplantation Center Third Affiliated HospitalOrgan Transplantation InstituteSun Yat-sen UniversityOrgan Transplantation Research Center of Guangdong ProvinceGuangdong Province Engineering Laboratory for Transplantation MedicineGuangzhou 510630China Guangdong Provincial Key Laboratory of Liver Disease Research Guangzhou 510630China Department of Ultrasound Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Melvin and Bren Simon Comprehensive Cancer Center Indiana UniversityIndianapolisIN 46202USA

Lenvatinib,a second-generation multi-receptor tyrosine kinase inhibitor approved by the FDA for first-line treatment of advanced liver cancer,facing limitations due to drug ***,we applied a multidimensional,high-throughput screening platform comprising patient-derived resistant liver tumor cells(PDCs),organoids(PDOs),and xenografts(PDXs)to identify drug susceptibilities for conquering lenvatinib resistance in clinically relevant *** and passaging of PDCs and PDOs from resistant patient liver tumors retained functional fidelity to lenvatinib treatment,expediting drug repurposing *** screening identified romidepsin,YM155,apitolisib,NVP-TAE684 and dasatinib as potential antitumor agents in lenvatinib-resistant PDC and PDO ***,romidepsin treatment enhanced antitumor response in syngeneic mouse models by triggering immunogenic tumor cell death and blocking the EGFR signaling pathway.A combination of romidepsin and immunotherapy achieved robust and synergistic antitumor effects against lenvatinib resistance in humanized immunocompetent PDX ***,our findings suggest that patient-derived liver cancer models effectively recapitulate lenvatinib resistance observed in clinical settings and expedite drug discovery for advanced liver cancer,providing a feasible multidimensional platform for personalized medicine.

关键词： Lenvatinib Drug resistance High-throughput screening Drug discovery Patient-derived model Romidepsin EGFR Liver cancer

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基于U-Net变体的医学图像分割算法综述

计算机工程与应用 2024年第11期60卷 32-49页

作者：崔珂田启川廉露北京建筑大学电气与信息工程学院北京100044

U-Net简单高效的网络结构,被广泛应用于医学图像分割任务中,学者们针对U-Net结构进行了很多的研究和改进。基于U-Net网络结构的改进方法从以下方面进行归纳总结:总结了U-Net网络在医学图像分割领域的关键挑战;归纳了常用于U-Net网络的... 详细信息

U-Net简单高效的网络结构,被广泛应用于医学图像分割任务中,学者们针对U-Net结构进行了很多的研究和改进。基于U-Net网络结构的改进方法从以下方面进行归纳总结:总结了U-Net网络在医学图像分割领域的关键挑战;归纳了常用于U-Net网络的医学图像数据集格式及特点;重点总结U-Net和U-Net变体算法六大改进机制:跳跃连接机制、生成对抗网络、残差连接机制、3D-UNet、Transformer机制、密集连接机制。最后,探讨六大改进机制与常用医学数据之间的关系,并指出未来改进思路和方向,激发U-Net在医学图像分割的无限潜力。

关键词： U-Net变体医学图像分割语义分割深度学习改进机制

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油浸式变压器的全域热网络模型

计量学报 2024年第1期45卷 9-17页

作者：鲁非苏翔李化林福昌卢仰泽国网湖北省电力有限公司电力科学研究院湖北武汉430077 华中科技大学电气与电子工程学院湖北武汉430074

热点温度是衡量变压器绝缘性能和安全裕度的重要指标,对其进行快速准确计算具有重要的意义。对油浸式变压器内部的产热和传热机理进行了分析,得到自然对流边界层中速度和温度分布与流体普朗特数Pr的关系,考虑到局部自然对流换热系数的... 详细信息

热点温度是衡量变压器绝缘性能和安全裕度的重要指标,对其进行快速准确计算具有重要的意义。对油浸式变压器内部的产热和传热机理进行了分析,得到自然对流边界层中速度和温度分布与流体普朗特数Pr的关系,考虑到局部自然对流换热系数的沿程变化以及不同区域传热特性的差异,对油浸式变压器进行了分区分层处理。基于热电类比法定义了多种热阻类型,构建了油浸式变压器的全域热网络模型;通过有限元仿真对比了热网络模型的计算结果。二者所得绕组温度变化趋势相同,热点温度相差约1.9%,热点位置相差约7.7%。相比于有限元仿真,热网络模型在求解时间和效率上更有优势,能够实现油浸式变压器运行状态的在线监测、实时分析和动态评估。

关键词：温度测量变压器热点温度自然对流局部对流换热系数热网络模型有限元仿真

Low-Temperature Nitriding by Means of SMAT

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材料热处理学报 2004年第5期25卷 301-306页

作者： W.P.Tong H.W.Zhang N.R.Tao Z.B.Wang j.lu K.lu ShenyangNationalLaboratoryforMaterialsScience InstituteofMetalResearchChineseAcademyofSciencesShenyang110016China LASMIS UniversityofTechnologyofTroyes10000TroyesFrance.

The microstructure in the surface layer of iron and steel samples can be refined at the nanometer scale by means of a surface mechanical attrition treatment (SMAT) that generates repetitive severe plastic deformation to the surface layer. The subsequent nitriding kinetics of the as-treated samples with the nanostructured surface layer is greatly enhanced so that the nitriding temperatures can be reduce to 300 - 400 °C regions. This enhanced processing method demonstrates both the technological significance of nanomaterials in advancing the traditional processing techniques, and provides a new approach for selective surface reactions in solids. This article reviews the present state of the art in this field. The microstructure and properties of SMAT samples nitrided will be summarized. Further considerations of the development and applications of this new technique will also be presented.

关键词：低温渗氮 SMAT 纳米结晶表面机械损耗

Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez j.E.Velázquez-Pérez Y.M.Meziani j.M.Caridad j.A.Delgado-Notario Department of Applied Physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en luz y Materia Estructurada(luMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic