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泥石流危险性动量分区方法与应用

科学通报 2003年第3期48卷 298-301页

作者：韦方强胡凯衡 j.l.lopez 崔鹏中国科学院水利部成都山地灾害与环境研究所成都610041 委内瑞拉中央大学流体力学研究所

运用泥石流运动数值模拟和GIS相结合的方法模拟泥石流出山口后的运动全过程,求得泥石流流速和流深分布,确定泥石流过程中泛滥范围内任一点的最大动量,建立了泥石流危险性动量分区模型Z=Khv.根据考察和实验资料对委内瑞拉首都加拉加斯的C... 详细信息

运用泥石流运动数值模拟和GIS相结合的方法模拟泥石流出山口后的运动全过程,求得泥石流流速和流深分布,确定泥石流过程中泛滥范围内任一点的最大动量,建立了泥石流危险性动量分区模型Z=Khv.根据考察和实验资料对委内瑞拉首都加拉加斯的Chacaito沟百年一遇泥石流运动过程进行了模拟,利用动量分区方法划分出泥石流危险区.

关键词：动量分区方法泥石流数值模拟 GIS 危险性危险区流速流深

The importance of post-COVID condition phenotypes characterization to decipher the mechanisms underlying this post-viral syndrome

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World journal of Pediatrics 2024年第6期20卷 633-634页

作者： jon Izquierdo-Pujol Sara Moron-lopez IrsiCaixa and Institute for Health Science Research Germans Trias i Pujol(IGTP) Can Ruti CampusBadalonaSpain Biomedicine doctoral programme Faculty of BiologyUniversity of BarcelonaBarcelonaSpain CIBERINFEC MadridSpain

The coronavirus disease-19(COVID-19)outbreak,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),was declared a global pandemic in March *** has affected over 700 million people worldwide and resulted in almost 7 million deaths,equating to a 1%mortality *** present,the majority of COVID-19 cases are either asymptomatic or mild,typically resolving within two ***,between 1%and 10%of COVID-19 survivors do not fully recover and experience a post-viral syndrome referred to as"long COVID","post-acute COVID-19 syndrome"(PASC),or"post-COVID condition"(PCC).This post-viral syndrome affects both adult and pediatric ***,most of the studies published to date evaluate the adult population,leaving a gap in our understanding of its impact on children and adolescents.

关键词： acute mortality respiratory

Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco j.Escaray Amelia Felipo-Benavent Cristian j.Antonelli Begona Balaguer Maria Pilar lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus

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World journal of Diabetes 2024年第2期15卷 142-153页

作者： Omar Ramos-lopez Medicine and Psychology School Autonomous University of Baja CaliforniaTijuana 22390Baja CaliforniaMexico

Globally,type 2 diabetes mellitus(T2DM)is one of the most common metabolic disorders.T2DM physiopathology is influenced by complex interrelationships between genetic,metabolic and lifestyle factors(including diet),which differ between populations and geographic *** fact,excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM,whereas habitual intakes of plant-based healthy diets usually exert a protective ***,genomic studies have allowed the characterization of sequence DNA variants across the human genome,some of which may affect gene expression and protein functions relevant for glucose *** comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease progression,some of which have demonstrated a value as biomarkers of personal responses to certain nutritional ***,novel genotype-based dietary strategies have been developed for improving T2DM control in comparison to general lifestyle ***,progresses in other omics areas(epigenomics,metagenomics,proteomics,and metabolomics)are improving current understanding of genetic insights in T2DM clinical *** more investigation is still needed,the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of T2DM as well as offer further opportunities to personalize the screening,prevention,diagnosis,management,and prognosis of T2DM through precision nutrition.

关键词： Type 2 diabetes mellitus Nutrigenetics Single nucleotide polymorphism Genotype Diet Precision nutrition

硝铵生产中管式反应器的应用及空气全循环系统用于造粒塔污染的控制

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河北化工 1992年第2期15卷 63-64,40页

作者： j.l.lopez-NINO 唐朝友关宏举

本文介绍了压力管式反应器在由硝酸(50～53％)与氨生产硝铵溶液(95％)工艺中的应用及空气全循环系统在造粒塔污染控制中的应用。

关键词：硝铵管式反应器空气循环造粒塔

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泥石流危险性分区及其在泥石流减灾中的应用

中国地质灾害与防治学报 2007年第1期18卷 23-27页

作者：韦方强胡凯衡 j.l.lopez 中国科学院山地灾害与地表过程重点实验室委内瑞拉中央大学流体力学研究所

泥石流是一种突发性山地灾害,至今尚缺乏准确有效的预报方法。减灾工程也只能对一定规模的泥石流起到防御作用。泥石流危险性分区在泥石流减灾中具有重要作用。以泥石流运动数值模拟为基础,以数值模拟获得的流速和流深等参量为分区指标... 详细信息

泥石流是一种突发性山地灾害,至今尚缺乏准确有效的预报方法。减灾工程也只能对一定规模的泥石流起到防御作用。泥石流危险性分区在泥石流减灾中具有重要作用。以泥石流运动数值模拟为基础,以数值模拟获得的流速和流深等参量为分区指标的危险性分区是泥石流危险性分区研究的重点和发展方向。其中,泥石流危险性动量和动能分区充分反映了泥石流的破坏能力,可以提供更为精确的定量化的分区结果。该类分区方法在城镇等有重要危害对象的泥石流减灾中具有广泛的应用。不仅可以应用于泥石流危险区和安全区的划定、泥石流灾害预估、泥石流临灾预案制定、泥石流抢险救灾方案制定和泥石流灾情评估等,还可以应用到山区土地利用规划、山区城镇建设规划和财产保险评估等领域,并起到防灾和减灾的作用。

关键词：泥石流灾害危险性分区减灾流速流深

Metabolic reprogramming of the inflammatory response in the nervous system:the crossover between inflammation and metabolism

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Neural Regeneration Research 2024年第10期19卷 2189-2201页

作者： jesus Amo-Aparicio Charles A.Dinarello Ruben lopez-Vales Department of Medicine University of ColoradoAuroraCOUSA Institute of Neurosciences and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud Carlos ⅢSpain

Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism) or used to build macromolecules(anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions. Metabolic processes such as glycolysis, oxidative phosphorylation, and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response, facilitating the energetic and biosynthetic demands. This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation, with a special focus on central nervous system disorders. Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.

关键词： central nervous system fatty acid oxidation glycolysis inflammation macrophage metabolism microglia neurodegeneration oxidative phosphorylation

Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVIllANO javier PRECIADO-GARBAYO jorge SEVIl Francisco GUTIERREZ juan jMARTiNEZ Sonia MARTiN-lopez Miguel GONZAlEZ-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

Is the speed of adjusting to environmental change condition dependent?An experiment with house mice(Mus musculus)

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Current Zoology 2024年第3期70卷 350-360页

作者： Karem lopez-Hervas Neelam Porwal Mathilde Delacoux Alexandros Vezyrakis Anja Guenther RG Behavioural Ecology of Individual Differences Max Planck Institute for Evolutionary Biology24306 PlönGermany Department of Evolutionary Biology Faculty of BiologyAdam Mickiewicz UniversityWieniawskiego 161-712 PoznańPoland Department for Collective Behaviour Max Planck Institute of Animal Behaviour78464 ConstanceGermany Centre for the Advanced Study of Collective Behaviour University of Konstanz78464 ConstanceGermany Animal Ecology Institute for Biochemistry and BiologyUniversity of Potsdam14469 PotsdamGermany

Environmental conditions change constantly either by anthropogenic perturbation or naturally across space and ***,a change in behavior is the frst response to changing *** fexibility can potentially improve an organism’s chances to survive and ***,we lack an understanding on the time-scale such behavioral adjustments need,how they actually affect reproduction and survival and whether behavioral adjustments are suffcient in keeping up with changing *** used house mice(Mus musculus)to test whether personality and life-history traits can adjust to an experimentally induced food-switch fexibly in adulthood or by intergenerational plasticity,that is,adjustments only becoming visible in the offspring *** lived in 6 experimental populations of semi-natural environments either on high or standard quality food for 4 *** showed previously that high-quality food induced better conditions and a less risk-prone ***,we tested whether the speed and/or magnitude of adjustment shows condition-dependency and whether adjustments incur ftness ***-history but not personality traits reacted fexibly to a food-switch,primarily by a direct reduction of reproduction and sloweddown *** whose parents received a food-switch developed a more active stress-coping personality and gained weight at a slower rate compared with their respective ***,the modulation of most traits was condition-dependent,with animals previously fed with high-quality food showing stronger *** study highlights that life-history and personality traits adjust at different speed toward environmental change,thus,highlighting the importance of the environment and the mode of response for evolutionary models.

关键词： animal personality context dependence environmental change Match-mismatch non-genetic inheritance phenotypic flexibility phenotypic plasticity.