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Heterometallic Mg-Ni-Mg Complex Promoted Hydrosilylation of Alkenes: Catalytic Performance and Intermediates Characterization

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Chinese journal of Chemistry 2024年第18期42卷 2133-2139页

作者： Yanping Cai Shengjie jiang Xin xu Key laboratory of Organic Synthesis of jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochowUniversitySuzhouJiangsu215123China

Background and Originality Content The catalytic hydrosilylation of unsaturated hydrocarbons,facilitated by transition metal(TM),is widely recognized as a proficient technique for the synthesis of high-value organosilicon compounds'ti-4l over the past few decades,the most dominant *** in hydrosilylation processes have been constituted by pre-Ccious metar complexesroceinerecent vears omore sustainabile earth-abundant metal catalysts have received increased attentionj2-14l The classcal mechanism of transition metal-catalyzed hydrosilylation is generally accomplished through a series of fundamental processes(Scheme 1a),including(i)coordination and oxidative addition of Si-H bond to a low-valent metal center to form e.g.,o-complex or silyl metal hydride;(ii)insertion of.C-C multipe bonds intometal-hdridelsior metal-silicon bond;jiol and(ii)reductive elimination that forwards the hydrosilylated product with Markovnikov or anti-Markovnikov selectivity.

关键词： Heterometallic complex Cooperative effect Hydrosilylation Magnesium Nickel hydride

lÉVY AREA ANAlYSIS AND PARAMETER ESTIMATION FOR FOU PROCESSES VIA NON-GEOMETRIC ROUGH PATH THEORY

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Acta Mathematica Scientia 2024年第5期44卷 1609-1638页

作者： Zhongmin QIAN Xingcheng xu Mathematical Institute University of OxfordOxfordOX26GGUK Shanghai Artificial Intelligence laboratory Shanghai200232China School of Mathematical Sciences Peking UniversityBeijing100871China

This paper addresses the estimation problem of an unknown drift parameter matrix for a fractional Ornstein-Uhlenbeck process in a multi-dimensional *** tackle this problem,we propose a novel approach based on rough path theory that allows us to construct pathwise rough path estimators from both continuous and discrete observations of a single *** approach is particularly suitable for high-frequency *** formulate the parameter estimators,we introduce a theory of pathwise Itôintegrals with respect to fractional Brownian *** establishing the regularity of fractional Ornstein-Uhlenbeck processes and analyzing the long-term behavior of the associated lévy area processes,we demonstrate that our estimators are strongly consistent and pathwise *** findings offer a new perspective on estimating the drift parameter matrix for fractional Ornstein-Uhlenbeck processes in multi-dimensional settings,and may have practical implications for fields including finance,economics,and engineering.

关键词： Itôintegration lévy area non-geometric rough path fOU processes pathwise stability long time asymptotic high-frequency data

The siphonic energy transfer between hot solar wind and cold martian ionosphere through open magnetic flux rope

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Fundamental Research 2024年第4期4卷 882-889页

作者： Xiaojun xu lou-Chuang lee Qi xu Qing Chang jing Wang Ming Wang Shaosui xu Christian Mosti Charles j.Farrugia Xing Wang Yudong Ye Zilu Zhou lei luo Peishan He Shaoguan Cheng State Key laboratory of lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA Macao Center for Space Exploration and Science Macao 999078China Institute of Earth Science Academia SinicaTaipei 115029China Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518000China Planetary Environmental and Astrobiological Research laboratory(PEARl) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519000China Nanjing University of Information Science and Technology Nanjing 210000China Space Sciencelaboratory Universityof CaliforniaBerkeleyCA94320USA Space Research Institute Austrian Academy of SciencesGraz 8010Austria University of New Hampshire NH 03824USA

A mechanism for energy transfer from the solar wind to the Martian ionosphere through open magnetic flux rope is proposed based on the observations by Mars Atmosphere and Volatile EvolutioN(MAVEN).The satellite was located in the dayside magnetosheath at an altitude of about 70o km above the northern *** between the hot solar wind protons and the cold heavy ions/neutrals in the subsolar region can cool the protons and heat the heavy *** a result,the magnetosheath protons are siphoned into the ionosphere due to the thermal pressure gradient of protons and the heated heavy ions escape along the open magnetic field *** direct collisions in the lower-altitude region were not detected,this physical process is demonstrated by MAVEN measurements of enhanced proton density,decreased proton temperature and oppositely directed motions of hot and cool protons within the flux rope,which are very different from the observational features of the flux transfer events near the Earth's *** mechanism could universally exist in many contexts where a collisionless plasma region is connected to a collisional plasma *** reconstructing the magnetic geometry and the cross-section of the flux rope using the Grad-Shafranov technique,the ion loss rates are quantitatively estimated to be on the order of 1023 s-l,which is much higher than previously estimated.

关键词： Mars Flux rope Solarwind Ionosphere Ion loss

Multifunctional RGD coated a single-atom iron nanozyme:A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer

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Nano Research 2024年第6期17卷 5469-5478页

作者： Haoqi Pan xu Chen Mingming Xiao He xu jiansheng Guo Zhiyi lu Dong Cen Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Key laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Qianwan Institute of CNITECHNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Pathology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Key laboratory of laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2)O_(2)via a traditional radical pathway and enhance cancer ***,short half-life period of hydroxyl radical(·OH)results in unsatisfied ***,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2)O_(2)via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer *** Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates *** magnetic resonance imaging(MRI)showed decreased T2 signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-l1 *** research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.

关键词： single-atom iron nanozyme pancreatic cancer immunotherapy ferroptosis

Mechanism analysis of foam penetration in EPB shield tunnelling with a focus on FER and soil particle size

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Underground Space 2024年第4期17卷 170-187页

作者： He Huang Quan Sun Tao xu Wanhuan Zhou State Key laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoMacao 999078China Department of Civil and Environmental Engineering University of MacaoMacao 999078China School of Transportation Southeast UniversityNanjing 210000China

Parameters of foam penetration in earth pressure balance(EPB)shield tunnelling,such as permeability coefficients and penetration distances,significantly impact tunnel face ***,existing studies have faced inaccuracies in analysing these parameters due to imitations in experimental *** study addresses this issue by employing enhanced methods for a more precise analysis of foam *** involving three distinct sand types(coarse,medium,and fine)and three foam expansion ratios(FER)(10,15,and 20)are conducted using a modified model test *** from a novel computer vision-based method,the model test outcomes unveil two distinct foam penetration paths:liquid migration(l_(w))and bubble migration(l_(f)).Three penetration phases-namely,injection,blockage&drainage,and breakage—are identified based on l_(w)and l_(f)*** initial"injection"phase conforms to Darcy’s law and is amenable to mathematical *** foam with FER of 15 has the maximum viscosity and,hence the l_(f)and permeability in the penetration tests with FER of 15 are the lowest in the same *** bubble size distribution of foam with different FER shows minor ***,the characteristics of foam penetration vary due to the distinct particle size distribution(PSD)of different *** penetration creates low-permeability layers in both medium and fine sands due to the larger bubble size of the foam compared to the estimated pore sizes of medium and fine *** the coarse sand results in a different situation due to its large pore *** distinctive characteristics of foam penetration in different sand strata are notably shaped by FER,PSD,and pore size *** insights shed light on the complex interactions during foam penetration at the tunnel face,contributing valuable knowledge to EPB shield tunnelling practices.

关键词： EPB Soil conditioning Foam penetration Permeability Tunnel face

Finely regulated luminescent Ag-In-Ga-S quantum dots with green-red dual emission toward white light-emitting diodes

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Opto-Electronic Advances 2024年第9期7卷 54-63页

作者： Zhi Wu leimeng xu jindi Wang jizhong Song Key laboratory of Materials Physics of Ministry of Education Laboratory of Zhongyuan LightSchool of PhysicsZhengzhou UniversityDaxue Road 75Zhengzhou 450052China

Ag-In-Ga-S(AIGS)quantum dots(QDs)have recently attracted great interests due to the outstanding optical properties and eco-friendly components,which are considered as an alternative replacement for toxic Pb-and Cd-based ***,enormous attention has been paid to how to narrow their broadband spectra,ignoring the application advantages of the broadband *** this work,the AIGS QDs with controllable broad green-red dual-emission are first reported,which is achieved through adjusting the size distribution of QDs by controlling the nucleation and growth of AIGS ***,the AIGS QDs exhibit broad dual-emission at green-and red-band evidenced by photoluminescence(Pl)spectra,and the Pl relative intensity and peak position can be finely ***,the dual-emission is the intrinsic characteristics from the difference in confinement effect of large particles and tiny particles confirmed by temperature-dependent Pl ***,the AIGS QDs(the size consists of 17 nm and 3.7 nm)with 530 nm and 630 nm emission could successfully be synthesized at 220°*** combining the blue light-emitting diode(lED)chips and dual-emission AIGS QDs,the constructed white light-emitting devices(WlEDs)exhibit a continuous and broad spectrum like natural sunlight with the Commission Internationale de l’Eclairage(CIE)chromaticity coordinates of(0.33,0.31),a correlated color temperature(CCT)of 5425 K,color rendering index(CRI)of 90,and luminous efficacy of radiation(lER)of 129 lm/W,which indicates that the AIGS QDs have huge potential for lighting applications.

关键词： quantum dots Ag-In-Ga-S dual emission white light-emitting diodes

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery l.Miller Nathan K.Evanson j.Michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh june 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

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Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi xu jianhong Yang Yao xu Xiaofeng Wang Xiang Gao jie Sun Chenhui Zhou Yi Huang Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Key laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province NingboZhejiang ProvinceChina

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier *** microvascular endothelial cells are a major component of the blood-brain *** mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial *** this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial *** found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial ***,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial *** established an in vitro brain microvascular endothelial cell model of the blood-brain *** found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain *** a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic *** found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic *** findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

Acetic acid-and furfural-based adaptive evolution of Saccharomyces cerevisiae strains for improving stress tolerance and lignocellulosic ethanol production

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Chinese journal of Chemical Engineering 2024年第8期72卷 26-33页

作者： Omama Rehman Youduo Wu Quan Zhang jin Guo Cuihuan Sun Huipeng Gao Yaqing xu Rui xu Ayesha Shahid Chuang xue State Key laboratory of Fine Chemicals Frontiers Science Centre for Smart Materials Oriented Chemical EngineeringEngineering Research Center of Application and Transformation for Synthetic BiologySchool of BioengineeringDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China SINOPEC Dalian Research Institute of Petroleum and Petrochemicals Co. Ltd.Dalian 116041China Microbial Research Institute of liaoning Province Chaoyang 122000China Yunnan Provincial Rural Energy Engineering Key laboratory Kunming 650600China US-Pak Center for Advanced Studies in Agriculture and Food Security University of AgricultureFaisalabadPakistan

Acetic acid and furfural are known as prevalent inhibitors deriving from pretreatment during lignocellulosic ethanol *** negatively impact cell growth,glucose uptake and ethanol biosynthesis of Saccharomyces cerevisiae *** of industrial *** strains with high tolerance towards these inhibitors is thus critical for efficient lignocellulosic ethanol *** this study,the acetic acid or furfural tolerance of different *** strains could be significantly enhanced after adaptive evolution via serial cultivation for 40 generations under stress *** acetic acid-based adaptive strain SPSC01-TA9 produced 30.5 g·l^(-1)ethanol with a yield of 0.46 g·g^(-1)in the presence of 9 g·l^(-1)acetic acid,while the acetic acid/furfural-based adaptive strain SPSC01-TAF94 produced more ethanol of 36.2 g·l^(-1)with increased yield up to 0.49 g·g^(-1)in the presence of both 9 g·l^(-1)acetic acid and 4 g·l^(-1)*** improvements were also observed during non-detoxified corn stover hydrolysate culture by SPSC01-TAF94,which achieved ethanol production and yield of 29.1 g·l^(-1)and 0.49 g·g^(-1),respectively,the growth and fermentation efficiency of acetic acid/furfural-based adaptive strain in hydrolysate was 95%higher than those of wildtype strains,indicating the acetic acid-and furfural-based adaptive evolution strategy could be an effective approach for improving lignocellulosic ethanol *** adapted strains developed in this study with enhanced tolerance against acetic acid and furfural could be potentially contribute to economically feasible and sustainable lignocellulosic biorefinery.

关键词： Saccharomyces cerevisiae lignocellulosic ethanol production Adaptive evolution Acetic acid Furfural