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Quantification of corneal neovascularization after ex vivo limbal epithelial stem cell therapy

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International journal of Ophthalmology(English edition) 2014年第6期7卷 988-995页

作者： Adriano Guarnieri javier Moreno-Monta?és Belén Alfonso-Bartolozzi Alfonso l.Sabater María García-Guzmán Enrique j.Andreu Felipe Prosper Department of Ophthalmology Clínica Universidad de Navarra Department of Cell Therapy Clínica Universidad de Navarra

AIM: To assess cultured limbal epithelial stem cell transplantation in patients with limbal stem cell deficiency by analyzing and quantifying corneal ***: This retrospective, interventional case series included eight eyes with total limbal stem cell deficiency. Ex vivo limbal epithelial stem cells were cultured on human amniotic membrane using an animalfree culture method. The clinical parameters of limbal stem cell deficiency, impression cytology, and quantification of corneal neovascularization were evaluated before and after cultured limbal stem cell transplantation. The area of corneal neovascularization,vessel caliber(VC), and invasive area(IA) were analyzed before and after stem cell transplantation by image analysis software. Best-corrected visual acuity(BCVA),epithelial transparency, and impression cytology were also ***: One year after surgery, successful cases showed a reduction(improvement) of all three parameters of corneal neovascularization [neovascular area(NA), VC, IA], while failed cases did not. NA decreased a mean of 32.31%(P =0.035), invasion area29.37%(P =0.018) and VC 14.29%(P =0.072). BCVA improved in all eyes(mean follow-up, 76 ±21mo).Epithelial transparency improved significantly from 2.00 ±0.93 to 0.88±1.25(P =0.014). Impression cytology showed that three cases failed after limbal epithelial stem cell therapy before 1y of ***: This method of analyzing andmonitoring surface vessels is useful for evaluating the epithelial status during follow-up, as successful cases showed a bigger reduction in corneal neovascularization parameters than failed cases. Using this method,successful cases could be differentiated from failed cases.

关键词： limbal stem cell corneal neovascularization stem cell therapy impression cytology limbal stem cell deficiency

Induced Morphisms Between localization Genera of Groups

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Algebra Colloquium 2014年第2期21卷 285-294页

作者： j.C. Mba P.j. Witbooi University of the Western Cape Private Bag X17 7535 Bellville South Africa

For a certain class of groups under a given finite group F, we define and compute genus groups, which coincide with the known genus groups in the case that F＇ is the trivial group. We prove the existence of various induced homomorphisms between genus groups. We discover an induced morphism arising from factoring out a finite normal subgroup.

关键词： localization restricted genus groups under a finite group

Hazards and landscape Changes(Degradations) on Hungarian Karst Mountains Due to Natural and Human Effects

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journal of Mountain Science 2013年第1期10卷 16-28页

作者： Móga jNOS Kiss KlAUDIA Szabó MRIA Kériné Borsodi ANDREA Kéri ANDRS Mari lSZló Knáb MóNIKA Iván VERONIKA Geography and Earth Science Institute Etvs Loránd University Biology Institute Etvs Loránd University

In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the Bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water *** recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial *** the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst *** differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(*** intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes.

关键词： Karst landscape Geological hazards Soil erosion limestone mountain

BEST APPROXIMATION FOR WEIERSTRASS TRANSFORM CONNECTED WITH SPHERICAl MEAN OPERATOR

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Acta Mathematica Scientia 2012年第2期32卷 455-470页

作者： l.T.Rachdi N.Msehli Département de Math'ematiques Facult'e des Sciences de Tunis2092 El-ManarTunisia Département de Mathématiques et d'informatique Institut National des Sciences Appliquées et de Technologie de Tunis1080 TunisTunisia

Using reproducing kernels for Hilbert spaces, we give best approximation for Weierstrass transform associated with spherical mean operator. Also, estimates of extremal functions are checked.

关键词： Weierstrass transform spherical mean operator best approximation repro-ducing kernel extremal function

肾炎康复片联合恩格列净治疗糖尿病肾病的临床研究

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现代药物与临床 2024年第8期39卷 2072-2076页

作者：王瑶吕元军凌龙吴玉程姗姗赵欣桐天津市天津医院内分泌科天津300211 天津市天津医院检验科天津300211

目的探讨肾炎康复片联合恩格列净片治疗糖尿病肾病的临床效果。方法选取2022年7月—2023年11月天津市天津医院门诊收治的70例糖尿病肾病患者,用随机表法将患者分为对照组和治疗组,各35例。对照组空腹口服恩格列净片,10 mg/次,1次/d。治... 详细信息

目的探讨肾炎康复片联合恩格列净片治疗糖尿病肾病的临床效果。方法选取2022年7月—2023年11月天津市天津医院门诊收治的70例糖尿病肾病患者,用随机表法将患者分为对照组和治疗组,各35例。对照组空腹口服恩格列净片,10 mg/次,1次/d。治疗组在对照组的基础上口服肾炎康复片,5片/次,3次/d。两组连续治疗12周。比较两组的临床疗效、糖代谢指标、肾功能指标和血清炎症指标。结果治疗后,对照组总有效率为71.42%,治疗组的总有效率为88.57%,组间比较差异有统计学意义(P<0.05)。治疗后,两组的空腹血糖(FPG)、糖化血红蛋白(HbA1c)均显著降低(P<0.05),治疗后,两组FPG、HbA1c组间比较差异无统计学意义。治疗后,两组尿素氮(BUN)、血肌酐(Scr)、尿微量白蛋白/肌酐比值(UACR)均较前下降(P<0.05),治疗组BUN、Scr、UACR比对照组更低(P<0.05)。治疗后,两组血清转化生长因子(TGF)-β1、肿瘤坏死因子(TNF)-α水平均较前下降(P<0.05),治疗组患者血清TGF-β1、TNF-α水平比对照组更低(P<0.05)。结论肾炎康复片联合恩格列净片治疗糖尿病肾病提高了临床疗效,可改善其血糖水平,发挥肾脏保护作用,减轻患者的炎症反应。

关键词：肾炎康复片恩格列净片糖尿病肾病空腹血糖糖化血红蛋白尿素氮血肌酐尿微量白蛋白/肌酐比值血清转化生长因子-β1 肿瘤坏死因子-α

中国中老年人身体活动水平与脑卒中发生的相关性:基于CHARlS数据

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中国康复理论与实践 2024年第4期30卷 449-453页

作者：粟昭隐康巍瀚刘亚涛吕媛 Michael NERlICH 兰州大学第一临床医学院甘肃兰州市730000 兰州大学第一医院甘肃兰州市730000 兰州大学第二临床医学院甘肃兰州市730000 德国雷根斯堡大学医院德国雷根斯堡80333

目的探究中国中老年人身体活动水平与脑卒中发生的关联。方法分析中国健康与养老追踪调查(CHARlS)2020年数据中19395例受访者的自我报告数据。结果发生脑卒中1368例(7.05%)。年龄≥65岁(OR=1.049,95%CI 1.043~1.055,P<0.001)、与配偶分... 详细信息

目的探究中国中老年人身体活动水平与脑卒中发生的关联。方法分析中国健康与养老追踪调查(CHARlS)2020年数据中19395例受访者的自我报告数据。结果发生脑卒中1368例(7.05%)。年龄≥65岁(OR=1.049,95%CI 1.043~1.055,P<0.001)、与配偶分居(OR=2.004,95%CI 1.091~3.683,P=0.025)、丧偶(OR=1.669,95%CI 1.452~1.919,P<0.001)是脑卒中发生的危险因素。相比于教育水平为小学,初中(OR=0.766,95%CI 0.664~0.883,P<0.001)、高中及中专(OR=0.804,95%CI 0.665~0.972,P=0.024)、大学及以上(OR=0.568,95%CI 0.361~0.894,P=0.015)是脑卒中发生的保护因素;与低强度身体活动水平相比,中强度身体活动水平(OR=0.691,95%CI 0.598~0.799,P<0.001)、高强度身体活动水平(OR=0.417,95%CI 0.364~0.478,P<0.001)是脑卒中发生率的保护因素。调整婚姻状态、受教育程度后,年龄≥65岁(OR=2.398,95%CI 2.139~2.668,P<0.001)、女性(OR=0.834,95%CI 0.746~0.933,P=0.001)、中强度身体活动水平(OR=0.755,95%CI 0.652~0.874,P<0.001)、高强度身体活动水平(OR=0.498,95%CI 0.433~0.572,P<0.001)仍与脑卒中的发生相关。结论适度身体活动可能降低脑卒中的发生风险。

关键词：脑卒中中老年人身体活动中国健康与养老追踪调查

NUMERICAl SIMUlATION OF CEllUlAR/DENDRITIC PRIMARY SPACING

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Acta Metallurgica Sinica(English letters) 2004年第5期17卷 761-766页

作者： W.Q,Zhang l.Xiao DepartmentofMaterialsScienceandEngineering LiaoningTechnicalUniversityFuxin123000China

A numerical model has been established to calculate the primary spacing of cellular or dendritic structure with fluid flow considered. The computing results show that the primary spacing depends on the growing velocity, the temperature gradient on the interface and fluid flow. There is a critical growing velocity for the cell-dendrite transition, which has a relationship with the temperature gradient: Rcr = (3-4)×10-9GT. Fluid flow leads to an increase of the primary spacing for dendritic growth but a decrease for cellular growth, resulting in an instability on the interface.

关键词： primary spacing model fluid flow l/S interface

The Influence of Systematic Errors on the Asian Summer Monsoon Circulation

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Advances in Atmospheric Sciences 2000年第4期17卷 576-586页

作者： P. l. S. Rao IBM India Research laboratory Indian Institute of Technology

The systematic errors of wind field associated with the prediction of Asian summer monsoon and their impact on the monsoon circulation have been studied in this paper. The daily operational analyses and fore-casts (up to day-5) of the National Centre for Medium Range Weather Forecasting (NCMRWF), India, over the Asian summer monsoon domain for the period june, july and August of 1995 are made use for the purpose. The systematic errors associated with the low level flow delineate, reduction in the strength of trade winds leading to weakening of cross equatorial flow as well as westerly flow over Indian Ocean. The upper level errors connote weakening of Tibetan anticyclone and reduction in the strength of return flow into the Southern Hemisphere. Further, these errors evince growing tendency with increase in the forecast period. Apart from the general underestimation of kinetic energy budget terms, the model forecasts fail to represent the transient eddies. The forecasts show increasing trend in the conversion of eddy to mean kinetic energy. These errors enfeeble Asian summer monsoon circulation with increase in the forecast period. Key words Monsoon - Systematic errors - Kinetic energy budget The author is grateful to the NCMRWF for providing data and computing facilities to carry out the present study.

关键词： Monsoon Systematic errors Kinetic energy budget

Modified astrophysical S-factor of 12C+12C fusion reaction at sub-barrier energies

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Chinese Physics C 2020年第11期44卷 189-207页

作者： Y.j.li X.Fang B.Bucher K.A.li l.H.Ru X.D.Tang China Institute of Atomic Energy Beijing 102413China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Idaho National laboratory Idaho FallsID 83415USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The 12C+12C fusion reaction plays a crucial role in stellar evolution and *** main open reaction channels includeα,p,n,and *** more than a half century of efforts,large differences remain among the experimental data of this reaction measured using various *** this work,we analyze the existing data using a statistical *** calculation shows the following:1)the relative systematic uncertainties of the predicted branching ratios decrease as the predicted ratios increase;2)the total modified astrophysical S-factors(S^* factors)of the p andαchannels can be obtained by summing the S^* factors of their corresponding ground-state transitions and the characteristicγrays,while taking into account the contributions of the missing channels to the *** applying corrections based on branching ratios predicted by the statistical model,an agreement is achieved among the different data sets at Ecm>4 MeV,while some discrepancies remain at lower energies,suggesting the need for better measurements in the near *** find that the S^* factor recently obtained from an indirect measurement is inconsistent with the direct measurement value at energies below 2.6 *** recommend upper and lower limits for the 12C+12C S^* factor based on the existing models.A new 12C+12C reaction rate is also recommended.

关键词： carbon burning 12C+12C fusion statistical model quasi-molecular resonance astrophysical S-factor reaction rate stellar evolution