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Comparison of the pathological characteristics of uninjured skin tissues of diabetic rodents and diabetic patients

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中华内分泌外科杂志（中英文） 2024年第3期18卷 339-345页

作者： Du juan Liu Ying Zhu Anfeng Song Dongming Qu Shiguang Yuan Zhixin Emergency Critical and Translational Medicine LaboratoryJilin Province People’s HospitalChangchun 130021China Emergency Medicine Department of General Hospital of northern Theater Command Laboratory of Rescue Center of Severe Wound and Trauma PLAShenyang 110016China Department of Pathology the Centre Hospital of ChangchunChangchun 130021China Department of Emergency Surgery Jilin Province People’s HospitalChangchun 130021China

Objective To study uninjured diabetic skin structure and compare the pathological characteristics of skin tissue from mouse and rat models of diabetes mellitus(DM)and humans with *** Establishing the DM C57BL/6j mice skin tissue models and db/db mice skin tissue models,as well as DM rat skin tissue *** tissues were collected from the animal models and DM *** biopsy specimens were stained with hematoxylin and eosin(HE)staining,Masson trichrome staining and periodic acid-Schiff(PAS)***(1)Skin from mice with streptozotocin(STZ)-induced DM was thinner and had less hair than skin from control *** epidermis had abnormal keratinization and dermal collagen and elastin fibers were dense and significantly atrophied.(2)Compared with the control group,skin tissue from db/db mice was thinner and had less *** was no aberrant keratinization in the epidermis,and dermal collagen and elastin fibres were loose.(3)Skin tissue from rats with STZ-induced DM was significantly thinner than control *** epidermis had mildly abnormal keratinization,and the dermis layer was atrophied and partly *** focal lipofuscin was deposited.(4)Whole skin tissue from patients with diabetes was significantly thinner than skin from subjects without *** epidermis had mild hyper keratinization,and the dermal elastin fibers were atrophied,loose,irregular,and showed focal mucoid *** Uninjured DM skin tissues were thinner and more irregular than normal *** changes in rat DM skin were most like those seen in the skin of patients with DM.

关键词： Diabetes mellitus Skin Human Mouse Rat

社区何以促进终身学习?——基于联合国教科文组织社区学习中心项目运行实践的分析

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职业技术教育 2024年第5期45卷 58-63页

作者：李娟顾凤佳上海开放大学发展研究部上海200433

如何挖掘社区潜能、促进全民终身学习是我国加快建设学习型大国和学习型社会面临的研究课题。联合国教科文组织的社区学习中心项目作为支持各国实施终身学习战略而推出的重要举措,不仅实现了从扩大教育机会为主到促进社会治理、再到促... 详细信息

如何挖掘社区潜能、促进全民终身学习是我国加快建设学习型大国和学习型社会面临的研究课题。联合国教科文组织的社区学习中心项目作为支持各国实施终身学习战略而推出的重要举措,不仅实现了从扩大教育机会为主到促进社会治理、再到促进可持续发展社会的功能拓展,而且形成了系统的运行指导方案,促进各国在运行主体、服务对象、供给内容、合作伙伴、支持保障等方面积累了成功经验,还提出了社区学习中心可持续运行的行动原则。我国需要进一步引导社区学习中心逐步实现功能拓展,优化政府主导、社区主体、多元参与的运行机制,以现代信息技术为支撑赋能社区学习服务创新,加强社区学习中心的特色发展和持续保障。

关键词：社区学习中心终身学习功能路径启示

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大孔径太赫兹波成像光学系统设计

中国光学（中英文） 2024年第2期17卷 374-381页

作者：曹一青沈志娟莆田学院机电与信息工程学院福建莆田351100 福建省激光精密加工工程技术研究中心福建莆田351100

太赫兹波具有高穿透性、低能性及指纹谱性等特征,被广泛应用于探测领域,因此,设计太赫兹波成像光学系统具有重要的意义和广泛的应用前景。首先,以四块透镜构成的天塞物镜为参考结构,应用近轴光学系统像差理论构建系统像差平衡方程,给出... 详细信息

太赫兹波具有高穿透性、低能性及指纹谱性等特征,被广泛应用于探测领域,因此,设计太赫兹波成像光学系统具有重要的意义和广泛的应用前景。首先,以四块透镜构成的天塞物镜为参考结构,应用近轴光学系统像差理论构建系统像差平衡方程,给出了系统初始结构参数求解函数和方法,再结合光学设计软件进一步校正系统像差,最终设计了一种用于太赫兹波探测的大孔径光学成像系统。该光学系统由4块同轴折射透镜构成,焦距为70 mm,F数为1.4,全视场角为8°,在奈奎斯特频率10 lp/mm处全视场角范围内的调制传递函数(MTF)值均大于0.32,各视场内的弥散斑均方根(RMS)半径均小于艾里斑半径。最后对系统各种公差进行分析和讨论。设计结果表明,本文设计的太赫兹波探测光学成像系统具有孔径大、结构简单且紧凑、成像质量较好且加工性易于实现等特点,满足设计要求,它在太赫兹波段高分辨率探测领域具有重要应用价值。

关键词：光学系统设计太赫兹波大孔径像差平衡公差分析

Mutated trimeric RBD vaccines:a platform against variants of concern

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2038-2040页

作者： Belén Aparicio juan j.Lasarte Pablo Sarobe Programa de Inmunología e Inmunoterapia Centro de Investigación Médica Aplicada(CIMACCUN)Universidad de NavarraPamplona31008Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD) Pamplona31008Spain IdiSnA Instituto de Investigación Sanitaria de NavarraPamplona31008Spain

He et *** reported in nature Communications1 the development of a protein vaccine against SASR-CoV-2 Omicron variant consisting of a trimer of the spike protein receptor-binding domain(RBD)of the Delta variant fused to heptad-repeat sequences 1 and *** vaccine induced broad-spectrum neutralizing antibodies and fully protected mice and non-human primates against challenge with live Delta and Omicron virus.

关键词： vaccine vaccines

Statins for primary cardiovascular prevention in the elderly

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journal of Geriatric Cardiology 2015年第4期12卷 431-438页

作者： juan Pedro-Botet Elisenda Climent juan j Chillarón Rocio Toro David Benaiges juana A Flores-Le Roux Lipid and Vascular Risk Unit Endocrinology department Hospital del Mar. Spain Department of Medicine School of Medicine. Cáldiz University Cádiz Spain

The elderly population is increasing worldwide, with subjects 〉 65 years of age constituting the fastest-growing age group. Furthermore, the elderly face the greatest risk and burden of cardiovascular disease mortality and morbidity. Although elderly patients, particularly those older 〉 75, have not been well represented in randomized clinical trials evaluating lipid-lowering therapy, the available evidence supporting the use of statin therapy in primary prevention in older individuals is derived mainly from subgroup analyses and post-hoc data. On the other hand, elderly patients often have multiple co-morbidities that require a high number of concurrent medications; this may increase the risk for drug-drug interactions, thereby reducing the potential benefits of statin therapy. The aim of this review was to present the relevant literature regarding statin use in the elderly for theft primary cardiovascular disease, with the associated risks and benefits of treatment.

关键词： Cardiovascular disease Dyslipidaemia Elderly Primary prevention Statins

Detailed characterization of kHz-rate laser-driven fusion at a thin liquid sheet with a neutron detection suite

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High Power Laser Science and Engineering 2024年第1期12卷 13-23页

作者： Benjamin M.Knight Connor M.Gautam Colton R.Stoner Bryan V.Egner joseph R.Smith Chris M.Orban juan j.Manfredi Kyle D.Frische Michael L.Dexter Enam A.Chowdhury Anil K.Patnaik Department of Engineering Physics Air Force Institute of TechnologyWPAFBOHUSA Physics Department Marietta CollegeMariettaOHUSA Department of Physics The Ohio State UniversityColumbusOHUSA Department of Materials Science and Engineering and Department of Electrical and Computer ScienceThe Ohio State UniversityColumbusOHUSA Intense Energy Solutions LLCPlain CityOHUSA

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mj, 40 fs laser pulses on a thin(<1 μm) D_2O liquid sheet employing a measurement suite. At relativistic inte... 详细信息

We present detailed characterization of laser-driven fusion and neutron production(-10^(5)/second) using 8 mj, 40 fs laser pulses on a thin(ng a measurement suite. At relativistic intensity(~ 5 × 10^(18)W/cm^(2))and high repetition rate(1 kHz), the system produces deuterium±deuterium(D-D) fusion, allowing for consistent neutron generation. Evidence of D-D fusion neutron production is verified by a measurement suite with three independent detection systems: an Ej-309 organic scintillator with pulse-shape discrimination, a ~3He proportional counter and a set of 36 bubble detectors. Time-of-flight analysis of the scintillator data shows the energy of the produced neutrons to be consistent with 2.45 MeV. Particle-in-cell simulations using the WarpX code support significant neutron production from D-D fusion events in the laser±target interaction region. This high-repetition-rate laser-driven neutron source could provide a low-cost, on-demand test bed for radiation hardening and imaging applications.

关键词： high-repetition-rate laser-driven fusion laser-plasma interaction liquid target neutron detectors

Mechanical and histological properties of an electrospun scaffold with a modified surface by plasma polymerization implanted in an in vivo model

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BIOCELL 2022年第3期46卷 829-836页

作者： MARÍA G.FLORES-SÁnCHEZ ROBERTO OLAYO j.MORALES-COROnA ATLÁnTIDA M.RAYA-RIVERA DIEGO R.ESQUILIAnO-rendÓn Research Vice-Rectory Faculty of EngineeringUniversity La Salle México06140México Department of Physics Metropolitan Autonomous University09340México Department of Tissue Engineering Child Hospital of México Federico Gómez06720México

This article presents the construction of scaffolds composed of polylactic acid(PLA)with different concentrations of hydroxyapatite(HA)by electrospinning,which were superficially modified with polypyrrole(PPy/I)by plasma polymerization.A preliminary study was conducted of the biological and mechanical behavior of the scaffolds when they were implanted in the back of rabbits for 30 days;bone cells differentiated from mesenchymal stem cells(MSCs)were *** bone cell and scaffold structures were characterized by histological,immunohistochemical,and mechanical stress ***–eosin staining showed good tissue *** immunohistochemical tests highlighted the presence of the main bone tissue proteins,such as collagen,osteocalcin,and *** PLA/HA scaffolds were observed to exhibit cell adhesion and proliferation properties;however,the response was much better in the scaffolds that had a higher concentration of HA and that were coated with PPy/*** results of the mechanical tests of the scaffolds indicated that the plasma treatment improved the adhesion and cell proliferation properties and contributed to the mechanical support,allowing the formation of neotissues with good viability of cell growth.

关键词： Hydroxyapatite Polylactic acid pyrrole Electrospinning Surface activation

Boron in Plants: Deficiency and Toxicity

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journal of Integrative Plant Biology 2008年第10期50卷 1247-1255页

作者： juan j. Camacho-Cristóbal jesús Rexach Agustín Gonzlez-Fontes Departamento de Fisiología Anatomía y Biología Celular Facultad de Ciencias Experimentales Universidad Pablo de OlavideE-41013 Sevilla Spain

Boron （B） is an essential nutrient for normal growth of higher plants, and B availability in soil and irrigation water is an important determinant of agricultural production. To date, a primordial function of B is undoubtedly its structural role in the ceil wall; however, there is increasing evidence for a possible role of B in other processes such as the maintenance of plasma membrane function and several metabolic pathways. In recent years, the knowledge of the molecular basis of B deficiency and toxicity responses in plants has advanced greatly. The aim of this review is to provide an update on recent findings related to these topics, which can contribute to a better understanding of the role of B in plants.

关键词： boron-binding molecules boron transporter cell wall-related genes gene expression nitrogen metabolism,

不同回收和转移模式下再制造供应链生产决策研究

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计算机集成制造系统 2024年第1期30卷 329-343页

作者：刘志明晨宇龚本刚郑小雪唐娟安徽工程大学经济与管理学院安徽芜湖241000 上海大学悉尼工商学院上海201899 闽江学院新华都商学院福建福州350018

随着公众环保意识增强,许多制造企业出于社会形象和成本考虑选择将再制造业务转移给第三方企业。针对由原始设备制造商(OEM)和第三方再制造商(TPR)组成的再制造供应链,根据不同回收主体(OEM和TPR)和转移模式(外包和授权)构建4种再制造... 详细信息

随着公众环保意识增强,许多制造企业出于社会形象和成本考虑选择将再制造业务转移给第三方企业。针对由原始设备制造商(OEM)和第三方再制造商(TPR)组成的再制造供应链,根据不同回收主体(OEM和TPR)和转移模式(外包和授权)构建4种再制造供应链决策模型,对比分析4种模式下最优生产决策、利润、环境影响、消费者剩余和政府基金政策影响。研究结果表明:OEM青睐制造商回收外包模式,TPR在不同研发效率下有不同偏好;在不同模式下,提升环境税或补贴均会不同程度提高产品可再制造性水平并激励再制造。但提高补贴不一定有利于环境,环境税过高不利于社会总福利,因此政府需要综合考虑各方利益设置适当的环境税和补贴。

关键词：再制造供应链授权再制造回收渠道政府基金政策可再制造性设计