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中国天文学会高能分会2004年学术年会

作者： L.Piro E.Costa M.Feroci F.Frontera L.Amati D.Dal Fiume L.A.Antonelli j.heise j.in’t Zand A.Owens A.N.Parmar G.Cusumano M.Vietri G.C.Perola Istituto Astrofi sica Spaziale Consiglio Nazionale delle Ricerche Via Fosso del Cavaliere 100 00133 Rome Italy Istituto Astrofi sica Spaziale Consiglio Nazionale delle Ricerche Via Fosso del Cavaliere 100 00133 Rome Italy Istituto Astrofi sica Spaziale Consiglio Nazionale delle Ricerche Via Fosso del Cavaliere 100 00133 Rome Italy Istituto Tecnologie e Studio delle Radiazioni Extraterrestri Consiglio Nazionale delle Ricerche Via Gobetti 101 40129 Bologna Italy.Dipartimento di Fisica Universita` Ferrara Via Paradiso 12 Ferrara Italy Istituto Tecnologie e Studio delle Radiazioni Extraterrestri Consiglio Nazionale delle Ricerche Via Gobetti 101 40129 Bologna Italy Istituto Tecnologie e Studio delle Radiazioni Extraterrestri Consiglio Nazionale delle Ricerche Via Gobetti 101 40129 Bologna Italy BeppoSAX Scienti?c Data Center present address: Osservatorio Astron-omico di Roma Space Research Organization in the Netherlands Sorbonnelaan 2 3584 CA Utrecht Netherlands Space Research Organization in the Netherlands Sorbonnelaan 2 3584 CA Utrecht Netherlands Space Science Department of ESA European Space Research and Tech- nology Centre 2200 AG Noordwijk Netherlands Space Science Department of ESA European Space Research and Tech- nology Centre 2200 AG Noordwijk Netherlands Istituto Fisica Cosmica e Applicazioni Calcolo Informatico Consiglio Nazionale delle Ricerche Via La Malfa 153 90138 Palermo Italy Dipartimento di Fisica Universit Roma Tre Via della Vasca Navale 84 00146 Roma Italy Dipartimento di Fisica Universit Roma Tre Via della Vasca Navale 84 00146 Roma Italy

We report the possible detection (99.3% of statistical signi?cance) of redshifted iron line emission in the X-ray afterglow of gamma-ray burst GRB 970508 observed by BeppoSAX. Its energy is consisten

关键词： gamma rays: bursts — line: formation — X-rays: general

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Observation of X-ray Lines from a Gamma-Ray Burst （GRB991216）:Evidence of Moving Ejecta from the Progenitor

Observation of X-ray Lines from a Gamma-Ray Burst （GRB99121...

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中国天文学会高能分会2004年学术年会

作者： L.Piro G.Garmire M.Garcia G.Stratta E.Costa M.Feroci P.Mszros M.Vietri H.Bradt D.Frail F.Frontera j.Halpern j.heise K.Hurley N.Kawai R.M.Kippen F.Marshall T.Murakami V.V.Sokolov T.Takeshima A.Yoshida Istituto Astrofisica Spaziale Consiglio Nazionale delle Ricerche （CNR） Via Fosso del Cavaliere 00133 Roma Italy Department of Astronomy and Astro-physics 525 Davey Lab Pennsylvania State Universi-ty University Park PA 16802 USA Harvard–Smith- sonian Center for Astrophysics 60 Garden Street Cambridge MA 02138 USA Istituto Astro?sica Spaziale Consiglio Nazionale delle Ricerche （CNR） Via Fosso del Cavaliere 00133 Roma Italy Istituto Astro?sica Spaziale Consiglio Nazionale delle Ricerche （CNR） Via Fosso del Cavaliere 00133 Roma Italy Istituto Astro?sica Spaziale Consiglio Nazionale delle Ricerche （CNR） Via Fosso del Cavaliere 00133 Roma Italy Department of Astronomy and Astro-physics 525 Davey Lab Pennsylvania State Universi-ty University Park PA 16802 USA Department of Physics Universita’Roma Tre Via della Vasca Navale 84 00146 Roma Italy Massachusetts Institute of Tech-nology 77 Massachusetts Avenue Cambridge MA02139 USA National Radio Astronomy Observato-ry 1003 Lopezville Road Socorro NM 87801 USA Istituto Tecnologie e Studio Radiazioni Extraterrestri/CNR Via Gobetti 101 40129 Bologna Italy Depart-ment of Astrophysics Columbia University New York NY 10027 USA Space Research Organization in the Netherlands Sorbonnelaan 2 3584 CA Utrecht Netherlands University of California Space Science Laboratory Berkeley CA 94720 USA Institute of Physical and Chemical Research （RIKEN） 2-1 Hiro- sawa Wako-Shi Saitama 351-0198 Japan. Univer-sity of Alabama NASA/Marshall Space Flight Center Huntsville AL 35899 USA NASA/Goddard Space Flight Center Code 661 Greenbelt MD 20771 USA Institute of Space and Astronautical Science 3-1-1 Yoshinodai Sagamihara Kanagawa 229-8510 Japan Russian Academy of Sciences Special Astrophysical Observatory Nizhnij Arkhyz Zelenchukskaya Karachaevo-Cherkesia 369167Russia NASDA Na-tional Space Development Agency of Japan WTC Building 2-4-1 Hamamatsu-cho Minato-ku Tokyo 105-60 Japan. Institute of Physical and Chemi

We report on the discovery of two emission features observed in the x-ray spectrum of the afterglow of the gamma-ray burst (GRB) of 16 December 1999 by the Chandra X-ray Observatory. These features

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WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension

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Cell Research 2005年第1期15卷 6-10页

作者： Byung-Hoon LEE,Lisa LENERTZ,Charles j.heise,Steve STIPPEC,Elizabeth j GOLDSMITH,Melanie H. COBB Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA. Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA. Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA. Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA. Department of Biochemistry University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA. Department of Pharmacology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas USA.

The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential role in the regulation of electrolyte homeostasis. Intronic deletions in the WNK1 gene result in its overexpression and lead to pseudohypoaldosteronism type II, a disease with salt-sensitive hypertension and hyperkalemia. This review focuses on the recent evidence elucidating the structure of the kinase domain of WNK1 and functions of these kinases in normal and disease physiology. Their functions have implications for understanding the biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. The WNK kinases may be able to influence ion homeostasis through its effects on synaptotagmin function.

关键词： kinase hypertension synaptotagmin MAP3K MAP4K ERK5 RNAi.

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内镜下胃折叠术后反流症状的减轻可能与食管酸敏感度降低相关:一项试验性研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 17-18页

作者： Wenzel G Kuhlbusch R heise j Frieling T 王志宇 Department of Int ernal Medicine Klinikum KrefeldLutherplatz 40 47805 Krefeld Germany.Dr

Background and Study Aims: Although the new endoscopic techniques for the treatment of gastroesophageal reflux disease(GERD) lead to marked clinical benefit, the underlying mechanism of this is unknown. Materials and Methods: In this prospective study, the effect of endoscopic gastroplication was investigated in six patients with GERD, who were assessed before and 4 week s after treatment. The effect on reflux symptoms, quality of life, proton pump i nhibitor(PPI)-consumption, reflux esophagitis, acid exposure, esophageal motili ty,lower esophageal sphincter pressure(LESP),and gastric emptying was measured. Esophageal acid sensitivity before and after treatment was investigated using a standardized acid provocation test, and compared with that of six age-and sex- matched healthy controls. Results: Significant clinical benefit and discontinuation of PPI consumption after gastroplication was seen. Among the objectively measured parameters, only acid exposure was significantly reduced and gastric emptying si gnificantly delayed. However, acid exposure remained pathologically high. Esopha geal acid sensitivity was significantly reduced. The induction of heartburn and/ or pain was abolished in four patients after gastroplication. In two patients th e intensity of heartburn/pain was significantly reduced by 40%or 60%,and the t ime to provoke heartburn/pain significantly prolonged by 40%or 100%. Conclusio n: These preliminary data suggest that the decrease of esophageal sensitivity to acid after endoscopic gastroplication is part of the mechanism responsible for the reduction of reflux symptoms.

关键词：胃折叠术反流症状试验性研究胃灼热反流性食管炎胃食管反流疼痛强度镜下治疗胃排空激发试验

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运动传导研究可用于产后神经丛病变的预后评估

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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 52-53页

作者： heise C.O. Lorenzetti L. Marchese A.j.T. Gherpelli j.L.D. 邓剑平 Av. Lacerda Franco 220 S.ao Paulo SP Brazil

Early prognostic assessment of obstetrical brachial plexopathies (OBP) would f acilitate rational selection of infants for brachial plexus surgery. We performe d bilateral motor nerve conduction studies (MNCS) of axillary, musculocutaneous, radial, median, and ulnar nerves in 33 babies (age 10 60 days) with OBP in ord er to compare the amplitude of compound muscle action potentials (CMAPs). All ba bies were followed up until 6 months of age and the outcome was classified according to muscle strength and arm function. A CMAP a mplitude reduction of more than 90%, compared to the unaffected side, predicted severe weakness of the corresponding root level (p < .0.01). Our results indica te that MNCS are a useful tool for very early prognostic assessment of OBP.

关键词：神经丛病运动传导神经传导婴儿行动作电位振幅臂丛神经病中间神经上肢功能早期评估腋神经

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