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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： holly Flyger Samantha j.holdsworth Alistair j.Gunn Laura Bennet hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).however,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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鲟鱼育种及新品种选育研究进展

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 93-105页

作者：王巍宋海亮朱华董颖东天胡红霞北京市农林科学院水产科学研究所暨北京市渔业生物技术重点实验室北京100068 农业农村部“鲟鱼遗传育种”重点实验室浙江杭州311799 国家数字种业创新中心北京100097

鲟鱼是鲟形目鱼类的统称。它们不仅具有重要的进化地位,而且具有重要的经济价值。鲟鱼新品种选育研究在近几十年取得了显著进展。本文综述了鲟鱼新品种选育的主要方法,包括杂交育种、雌核发育、性逆转诱导、基因编辑、家系选育、基因组... 详细信息

鲟鱼是鲟形目鱼类的统称。它们不仅具有重要的进化地位,而且具有重要的经济价值。鲟鱼新品种选育研究在近几十年取得了显著进展。本文综述了鲟鱼新品种选育的主要方法,包括杂交育种、雌核发育、性逆转诱导、基因编辑、家系选育、基因组选择和细胞水平育种,讨论了各技术的应用现状,在育种上相关研究和取得的重要突破,并结合我们育种实践积累的经验,展望鲟鱼育种和种业的未来发展,为未来的鲟鱼育种研究提供理论基础和实践指导。

关键词：鲟鱼育种新品种

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Research on Two-stage Voltage and Reactive Power Optimization Coordinated Control Method Considering Flexible On-load Tap Changer

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Dianwang jishu/Power System Technology 2025年第1期49卷 272-283页

作者： Li, jiaming huo, Qunhai Yin, jingyuan Lu, hao Zhou, jing Zhu, Meisheng he, Wei dong, hongwei Institute of Electrical Engineering Chinese Academy of Sciences Haidian District Beijing 100192 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Shijingshan District Beijing 100049 China Shanghai jiguang Polytechnic College Baoshan District Shanghai 201901 China Three Gorges Electric Power Co. Ltd. Hubei Province Wuhan 430000 China

With the large-scale integration of distributed photovoltaic (DPV) in the distribution network, voltage exceeding limits and fluctuations are becoming increasingly severe. The voltage and reactive power optimization and coordination control method considering new power quality management devices needs to be further improved to adapt to the new changes in the power grid. This article considers the power quality regulation effect of the new flexible on-load tap changer (OLTC) and proposes a two-stage voltage and reactive power optimization coordinated control method. The first stage is the day before hour level scheduling stage. Based on distributed photovoltaic and load prediction data, the active output results of DPV and the switching results of flexible OLTC taps and capacitor banks are obtained through power flow calculation and iterative optimization. The second stage is the minute-level reactive power optimization stage. Based on the first stage, considering the reactive power output characteristics of flexible OLTC and DPV, adjusting the reactive power output of the equipment while correcting the capacitor bank switching combination in the first stage, further reducing the maximum voltage deviation of each node and making the distribution network voltage distribution more reasonable. An IEEE33 node distribution system simulation model is built in the paper. The proposed two-stage voltage and reactive power optimization coordination control method considering flexible OLTC can improve the DPV absorption level by 9.29% based on the conventional economic optimal goal of 88.07%, while meeting the requirement that the voltage deviation of the entire node is less than 0.1pu During the entire period, the overall economic efficiency improved by 7.8%. The results demonstrate the rationality and effectiveness of the proposed method. © 2025 Power System Technology Press. All rights reserved.

关键词： Quality management

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STUDY OF DYNAMIC RECRYSTALLIZATION OF LOW CARBON STEEL IN ThIN SLAB CONTINUOUS ROLLING PROCESS

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Acta Metallurgica Sinica(English Letters) 2006年第4期19卷 265-270页

作者： X.K. Liang X.j. Sun Q.Y. Liu h. dong State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute Beijing 100081 China

Combined with the technological characteristics of thin slab continuous rolling process （TSCR）, dynamic recrystallization of an extremely coarse austenite of low carbon steel is studied by Thermecmaster-Z hot simulator. By the analysis of true stress-strain curves and the observation of microstructures at different deformation stages, the critical stress and critical strain are determined under different deformation conditions. The effect of Z parameter on dynamic recrystallization of coarse austenite is studied. The microstructure evolution in real production is also discussed.

关键词： TSCR (thin slab continuous rolling process) coarse austenite dynamic recrystallization

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生物可降解聚乳酸共衣康酸丁二醇酯/纳米二氧化硅包装材料对发酵酸奶贮藏品质及活菌数的影响

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食品与发酵工业 2025年第1期51卷 108-115页

作者：蒋伟陈钟生张元董同力嘎内蒙古农业大学食品科学与工程学院内蒙古呼和浩特010018

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:... 详细信息

探讨不同阻隔性的聚乳酸共衣康酸丁二醇酯/纳米二氧化硅共聚物薄膜[poly(L-lactic-co-butanediol itaconate)nano-silica copolymer films,PLBI-SiO_(2)]包装对发酵酸奶贮藏效果,并对贮藏期间酸奶的理化指标和活菌数进行测定。结果表明:在4℃贮藏0~21 d期间,所有包装组的ph都呈现下降趋势,PLBI-SiO_(2)0.5%包装组与对照(市售)组在贮藏后期ph下降得到减缓;在贮藏期间,PLBI-SiO_(2)0.5%包装组与对照(市售)组能有效维持酸奶的质构特性与持水能力,同时也保持良好的感官评价与表观黏度;所有包装组的活菌数在整个贮藏期间都呈现逐渐降低的趋势,但随包装阻隔性的提高,下降幅度得到减缓,PLBI-SiO_(2)0.5%包装组与对照组在贮藏21 d时,保加利亚乳杆菌与嗜热链球菌都保持在10~7 CFU/mL以上。综合各项指标,PLBI-SiO_(2)0.5%包装组在贮藏21 d可以维持酸奶贮藏品质并几近于市售包装组,这为酸奶及其他发酵乳替代包装材料提供了一定的理论基础。

关键词：酸奶贮藏纳米二氧化硅聚乳酸共衣康酸丁二醇酯纳米二氧化硅共聚物阻隔性

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Characterization of intraocular pressure pattern and changes of retinal ganglion cells in DBA2j glaucoma mice

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International journal of Ophthalmology(English edition) 2016年第2期9卷 211-217页

作者： jing Wang Yu dong Cullen Eye Institute Baylor College of Medicine

AIM： To characterize the pattern of intraocular pressure （lOP） change and the deficit of retinal ganglion cells （RGCs） in DBA2j, which is most well-characterized chronic glaucoma mouse model and wild type （WT） C57bl/6 mice, and to study the relationship between lOP change and RGCs deficit. METhODS： lOP was monitored with a rebound tonometer in C57bl/6 and DBA2j mice from 3 to 15-month-old. Retinal function was evaluated by dark -adapted electroretinogram （ERG） in DBA2j and WT mice of 15-month-old. A dye （Neurobiotin） was applied to optic nerve stump to retrograde label RGCs. TO-PRO-3 visualized all nuclei of cells in the RGC layer. RESULTS： The lOP in WT mice was 9.03-0.6 mm hg on average and did not increase significantly as aging. The lOP in DBA2j mice, arranging from 7.2 to 28 mm hg, was increasing significantly as aging, and it was normal at 3-month--old compared with WT mice, slightly increased from 7-month-old and increased in 50% animals at 11-month-old and in 38% animals at 15-month-old. The RGCs density in DBA2j mice started reducing by 7-month-old, continuously decreased until reached about 20% of RGC in WT retina by 15-month-old. RGC density was not linearly correlated with lOP in 15-month- old DBA2j mice. The amplitude of positive scotopic threshold response, and negative scotopic threshold response of ERG were significantly reduced in DBA2j mice of 15-month-old than that in age-paired WT mice. CONCLUSION： The present study found that DBA2j mice display pathological and functional deficits of the retina that was not linearly correlated with lOP.

关键词： retinal ganglion cell glaucoma intraocularpressure retina mouse

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Chatter identification of thin-walled parts for intelligent manufacturing based on multi-signal processing

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Advances in Manufacturing 2021年第1期9卷 22-33页

作者： dong-dong Li Wei-Min Zhang Yuan-Shi Li Feng Xue jürgen Fleischer School of Mechanical Engineering Tongji UniversityShanghai 201804People's Republic of China Bosch Rexroth Endowed Chair for Automation&Electrification Solutions Sino-German College for Postgraduate StudyTongji UniversityShanghai 201804People's Republic of China China North Engine Research Institute Tianjin 300400People's Republic of China WBK Institute of Production Science Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Machine chatter is still an unresolved and challenging issue in the milling process,and developing an online chatter identification and process monitoring system towards smart manufacturing is an urgent *** this paper,two indicators of chatter detection are *** is the real-time variance of milling force signals in the time domain,and the other one is the wavelet energy ratio of acceleration signals based on wavelet packet decomposition in the frequency ***,a novel classification concept for vibration condition,called slight chatter,is proposed and integrated successfully into the designed multi-classification support vector machine(SVM)***,a mapping model between image and chatter indicators is established via a distance threshold on the *** multi-SVM model is trained by the results of three signals as an *** data and detection accuracy of the SVM model are verified in actual *** identification accuracy of 96.66%has proved that the proposed solution is feasible and *** presented method can be used to select optimized milling parameters to improve machining process stability and strengthen manufacturing system monitoring.

关键词： Chatter Milling force Acceleration Wavelet packet decomposition Multi-sensor

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单样本条件下邻域选择聚合零次知识图谱链接预测方法

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计算机应用研究 2025年第1期42卷 65-70页

作者：李猛董红斌哈尔滨工程大学计算机科学与技术学院哈尔滨150001

为了解决支持样本有限条件下零次知识图谱链接预测模型性能下降的问题,提出了一种单样本条件下邻域选择聚合零次知识图谱链接预测方法(NSALP)。该方法主要由特征提取器、生成器、判别器三个模块实现。借鉴图同构网络的思想对特征提取器... 详细信息

为了解决支持样本有限条件下零次知识图谱链接预测模型性能下降的问题,提出了一种单样本条件下邻域选择聚合零次知识图谱链接预测方法(NSALP)。该方法主要由特征提取器、生成器、判别器三个模块实现。借鉴图同构网络的思想对特征提取器模块进行改进,在聚合头尾邻域时为每个邻域节点分配一个可学习的参数,进而过滤无关特征,凸显有效特征;以头节点嵌入与关系文本描述的组合作为生成器学习过程的引导,使生成器生成的新组合特征更加接近真实的知识三元组结构特征。在NELL-ZS和Wiki-ZS两个零次知识图谱数据集上,所提模型的性能对比基线模型分别提升了2.5和0.7百分点。在NELL-ZS进行的消融实验中,所提extractor+和generator+模块的性能表现均优于未做改进的模型,佐证了改进方法的有效性。

关键词：知识图谱链接预测零样本

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企业视角下的当代工业建筑设计探索与实践

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城市建筑 2025年第1期22卷 167-172页

作者：闫冬北京首钢国际工程技术有限公司

随着社会生产力的提高和社会认识的转变,传统工业建筑的设计方法及设计理念已不能满足如今企业的建设需求。文章首先分析了工业建筑设计的发展过程和现阶段设计中存在的问题,从社会认识、生产能力、审美观念等角度总结了制约工业建筑发... 详细信息

随着社会生产力的提高和社会认识的转变,传统工业建筑的设计方法及设计理念已不能满足如今企业的建设需求。文章首先分析了工业建筑设计的发展过程和现阶段设计中存在的问题,从社会认识、生产能力、审美观念等角度总结了制约工业建筑发展的原因。结合实际项目案例和经验,针对当下企业在工业建筑设计建设中所关注的要点,从生产能力保障、内外因素融合、建设成本控制三个方面对当代工业建筑的设计方法和策略进行了探索和研究。从缩短建设周期、提供可变空间、彰显地域特征和企业文化、降低建造成本等方面为工业建筑的设计提供了有价值的参考和帮助。

关键词：工业建筑企业视角产能保障元素融合成本控制设计探索

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