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Research on Resilience Assessment and Improvement Methods of New Energy Bases Under Strong Sandstorm

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Dianwang jishu/Power System Technology 2025年第1期49卷 124-135页

作者： Wang, jinyan Ding, Kun Sun, Yalu Wang, Xiang dong, haiying College of New Energy and Power Engineering Lanzhou Jiaotong University Gansu Province Lanzhou 730070 China State Grid Gansu Electric Power Company Gansu Province Lanzhou 730000 China Tsinghua Sichuan Energy Internet Research Institute Sichuan Province Chengdu 610213 China

The natural endowments of wind and solar resources in the desert and Gobi Desert areas of our country, as well as the reverse distribution of energy and load, make it of great significance to develop large-scale new energy bases and large-scale transmission of AC/DC hybrid power grids in the desert and Gobi Desert areas. The frequent occurrence of extreme sandstorms in the desert and Gobi Desert areas has seriously affected the centralized development and long-distance safe and stable transmission of new energy power generation bases. This article first quantifies the impact of two disaster-causing factors of sandstorms on new energy bases, establishes a mathematical model that reflects the relationship between sandstorms and new energy output, strong winds, and line failure rates, uses Monte Carlo sampling combined with system information entropy to select typical fault scenarios and construct a recovery model, obtains the system elasticity curve based on operating conditions, considers the entire process of system disaster, and adopts the Analytic hierarchy Process (AhP) method Establish elasticity evaluation indicators;Secondly, a flexible improvement method is proposed from a planning perspective, to minimize the equivalent annual investment cost of the line and energy storage and the system's loss of load cost. A joint planning model for line expansion and energy storage configuration for flexible improvement is established, which is transformed into a mixed integer linear programming (MILP) problem, and the expansion plan of the new energy baseline and the optimal configuration of energy storage are solved. Finally, taking the improved IEEE36 node system as an example for simulation analysis, the elasticity indicators before and after adopting improvement measures are compared to verify the effectiveness and accuracy of the proposed elasticity evaluation and improvement methods. © 2025 Power System Technology Press. All rights reserved.

关键词： Charge storage

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

CMU的科学哲学与珀尔的因果理论——科学哲学如何影响人工智能?

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自然辩证法通讯 2025年第1期47卷 28-35页

作者：董焕防清华大学科学史系

科学哲学之于科学的价值一直存在着争议。本文通过研究CMU的科学哲学对于朱迪·珀尔的因果理论的贡献来讨论科学哲学对于人工智能的影响。珀尔的因果理论是人工智能的最重要理论之一。CMU科学哲学研究成果“将‘干预’表示为图结构上的... 详细信息

科学哲学之于科学的价值一直存在着争议。本文通过研究CMU的科学哲学对于朱迪·珀尔的因果理论的贡献来讨论科学哲学对于人工智能的影响。珀尔的因果理论是人工智能的最重要理论之一。CMU科学哲学研究成果“将‘干预’表示为图结构上的变化”对珀尔建立其因果理论起到了非常关键的作用。由此可见，科学哲学对于人工智能具有重要影响。我们还尝试分析了CMU科学哲学研究对珀尔构建因果理论之所以能产生贡献的原因，以及科学哲学可以影响人工智能的原因。

关键词：朱迪·珀尔因果理论贝叶斯网络因果模型干预

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory hBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Composition and size dependent torsion fracture of metallic glasses

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journal of Materials Science & Technology 2021年第23期82卷 153-160页

作者： j.dong j.Shen Y.h.Sun h.B.Ke B.A.Sun W.h.Wang h.Y.Bai Institute of Physics Chinese Academy of SciencesBeijing100190PR China College of Materials Science and Opto Electronic Technology University of Chinese Academy of SciencesBeijing100049PR China Songshan Lake Materials Laboratory DongguanGuangdong523808PR China

The fracture of metallic glasses(MGs)of different compositions and sizes down to micrometers under torsion loading were systematically *** to the flat shear fracture along the circumferential plane as commonly supposed under torsion,we find that the torsion fracture of metallic glasses can deviate from flat shear plane,and the fracture angle is closely dependent on the composition and the size of MG *** a conversion method,we show that the torsion fracture of both millimeterand micrometer-sized MGs can be described by the ellipse fracture criterion as originally proposed for the tension *** deviation from the circumferential shear plane under torsion is further shown to intrinsically relate to the fracture toughness of *** tougher MG tends to have a smaller fracture angle with respect to the maximum shear plane,and vice versa,indicating a correlation between the fracture toughness and pressure/normal stress sensitivity in *** results provide new insights on the fracture mechanism and are helpful to design and control the deformation and fracture behavior of MGs under torsion loading.

关键词： Metallic glasses Torsion fracture Pressure sensitivity Fracture toughness

Six-fold swelling expansion microscopy assisted cell painting for high-content phenotypic screening

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Optoelectronics Letters 2025年

作者： junfang XIE Yipeng dong jin WANG Zhichao DENG jianguo TIAN Qing YE Key Laboratory of Weak-Light Nonlinear Photonics， Ministry of Education， School of Physics and TEDA Applied Physics， Nankai University

Imaging-based phenotypic screening uses cellular phenotypes to describe the drug performance， which generally focuses on single cellular feature， lacking of a comprehensive characterization. here， we propose a high content phenotypic screening method based on expansion microscopy (ExM) assisted Cell Painting， which enables multi-channel imaging with approximately 50 nm resolution. As a demonstration， we applied this method to a phenotypic screening involving five drugs. The morphological attributes of three subcellular structures were summarized to consist a “fingerprint” describing the drug effect. The proposed method can provide comprehensive and detailed clues for drug evaluation， enriching the content of phenotypic screening.

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我国乙烯产业链发展现状及对策建议

现代化工 2025年第1期45卷 1-6页

作者：董雁春中石化(上海)石油化工研究院有限公司上海201208

在全球能源转型加速、环保标准日益严格、产业升级浪潮迭起以及我国供给侧结构改革深入实施的背景下,乙烯产业链正面临着巨大的变革和重塑。综述了乙烯产业链发展现状,并从政策、需求、供应3个方面分析了乙烯产业链发展趋势,随着“油转... 详细信息

在全球能源转型加速、环保标准日益严格、产业升级浪潮迭起以及我国供给侧结构改革深入实施的背景下,乙烯产业链正面临着巨大的变革和重塑。综述了乙烯产业链发展现状,并从政策、需求、供应3个方面分析了乙烯产业链发展趋势,随着“油转化”、炼化一体化的深入推进,产业供需格局已发生根本性转变,乙烯产业链总体向原料多元化(降低生产成本)、产品高端化(提升产品附加值)发展转型,上游乙烷/混合轻烃裂解法占比逐步提升,下游向聚烯烃弹性体(POE)、超高分子量聚乙烯(UhMWPE)、光伏级乙烯-醋酸乙烯酯共聚物(EVA)等高端化工材料延伸趋势明显。针对国内乙烯产业链转型升级,从产业布局、企业转型、科技创新、国际拓展4个方面提出了发展建议。

关键词：乙烯及其下游乙烯产业链原料高端聚乙烯

Preparation and Microstructure Analysis of high Strength Cementitious Materials Containing Metakaolin

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武汉理工大学学报 2010年第17期32卷 117-122,136页

作者： YU R ShUI Z h dong j School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

The preparation and microstructure analysis of high strength cementitious materials containing metakaolin (MK) was studied in this paper. The MK was prepared firstly,and then was mixed with fly ash,ground blast furnace slag,quartz powder and cement with different percentage to produce high strength cementitious materials. After cured under different environment,the compressive strength of such materials was tested. Techniques of X-ray diffraction (XRD) and scanning electron microscopy (SEM) were further employed to identify the composition and microstructure. The results obtained reveal that the compressive strength of such materials mainly effected by component of raw materials,the water binder ratio (W/B) and the curing regime. When the three factors above are optimized,the compressive strength of such materials can get to 156 MPa in maximum. The X-ray diffraction analysis and the scanning electron microscopic images indicated that under optimal curing condition,more raw materials can take chemical reaction and the microstructure is dense to yield good mechanical properties.

关键词： preparation microstructure analysis high strength cementitious materials metakaolin

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times