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Tuberculosis and Cysticercosis in Brazil: A Review

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Food and Nutrition Sciences 2018年第6期9卷 642-662页

作者： Ludmilla Santana Soares e Barros jana Kelly dos santos Maurício Mascarenhas Pedreira Sanmily santos Damacena Adriana dos santos silva Universidade Federal do Recô ncavo da Bahia (UFRB) Cruz das Almas Brazil

Tuberculosis and the taeniasis-cysticercosis complex, typical cases of zoonosis, have great importance for public health, since they cause economic liabilities to the Brazilian beef production chain. They are actually a synonym of technical inadequateness in Good Production Practices. Both diseases have existed since ancient times and their occurrence should be controlled by basic sanitary measures. However, there is a significant neglect attitude by authorities of countries with high occurrence rates, or rather, tropical underdeveloped nations, to focus on public policies for the control and decrease of the prevalence and the occurrence of these diseases. Current review elucidates the epidemiological profile of the diseases and contributes towards the elucidation and establishment of measures ensuring control.

关键词： Cysticercosis Health Tuberculosis Medicine Zoonosis

Analysis of the Cicatricial Acceleration Method (MAC®) in Skin Repair in Wistar Rattus norvegicus with Induced Chemical Burns

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journal of Biosciences and Medicines 2024年第9期12卷 204-214页

作者： Marcus Vinicius de Mello Pinto Sandroval Francisco Torres Aline Ronis Sampaio Karin Yuri Fernandez Iturra Miriam Viviane Baron Patricia Froes Carlos Ruiz da silva Daiane Paza Maria Elena silva Alvarez josefa jeanette Ugalde juliano Tibola Esteban Fortuny Celulare Institute Petrpolis Brazil State University of Santa Catarina (UDESC) Florianopolis Brazil Bienus Clinic Santiago Chile Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Brazil International Research Group (IRG) Natal Brazil Academic Training Center (CTA) College So Paulo Brazil Fibrafisio Clinic Brusque Brazil Fisiocare Clinic Curic Chile Lua Clinic Coyhaique Chile Finis Terrae University Santiago Chile

Introduction: The cicatricial acceleration method (MAC®) promotes photobiological effects of an anti-inflammatory and healing nature. Its therapeutic radiation is emitted, producing photobiostimulant effects that result in rapid tissue repair and better tissue quality. The treatment of burns has always been a challenge, which involves both performing surgery and controlling and guiding scar regeneration, avoiding possible morbidities. Objective: To evaluate the effects of applying the MAC methodology with an AlGa (aluminum, gallium arsenide) laser on the time and quality of tissue repair in the skin of rats after induced chemical burns. Method: 22 adult male rats were subjected to a second-degree chemical burn on the back using 50% trichloroacetic acid. After the burns, the animals were randomly separated into 2 groups: control and experimental. The control group (G1) received placebo laser therapy and the laser group (G2) underwent laser irradiation with an energy density of 100 j/cm2. Histological analysis and macroscopic evaluation were carried out by means of the paper template method. Results: Group G1 showed (53%) of the necrosis area and group G2 showed (11%) necrosis area. Conclusion: The cicatricial acceleration method (MAC®) favored the repair of wounds caused by a 2nd-degree chemical burn, optimizing time and improving quality.

关键词： Chemical Burn Healing Scarring Cicatricial Acceleration Method (MAC®) Tissue Repair

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana santos Calmon Marcel silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos santos Gabriel Lima Correa santos Hanna santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using joanna Briggs Institute(jBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

Whole body vibration and auriculotherapy improve handgrip strength in individuals with knee osteoarthritis

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journal of Traditional Chinese Medicine 2019年第5期39卷 707-715页

作者： Eloa Moreira-Marconi Carla F Dionello Danielle S Morel Danubia C Sa-Caputo Cintia R Sousa-Goncalves Laisa L Paineiras-Domingos Ygor Teixeira-silva Mario jose dos santos Pereira Mario Bernardo-Filho Postgraduate Program in Clinical and Experimental Physiopathology University of the State of Rio de JaneiroRio de JaneiroRJBrazil Department of Biophysics and Biometrics Laboratory of Mechanical Vibrations and Integrative Practices-LAVIMPIInstitute of Biology Roberto Alcantara GomesRio de Janeiro State UniversityRio de JaneiroRJBrazil Postgraduate Program in Medical Sciences Rio de Janeiro State UniversityRio de JaneiroRJBrazil Danubia C Sa-Caputo Faculdade Bezerra de AraujoRio de JaneiroBrazilCentro Universitario Serra dos OrgaosTeresopolisRio de JaneiroBrasil Universidade do Estado do Rio de janeiro Rio de JaneiroRJBrazil-Department of Biophysics and BiometricsInstitute of Biology Roberto Alcantara Gomes-Department of Physiological Sciences

OBjECTIVE: To verify the action of non-pharmacological interventions, whole body vibration exercise (WBVE) and auriculotherapy (AT) on the management of knee osteoarthritis (KOA) analyzing the handgrip strength (HS). METHODS: One hundred twelve participants with KOA were allocated in (a) WBVE group with peak-to-peak displacement of 2.5 to 7.5 mm, frequency from 5 up to 14 Hz, acceleration peak from 0.12 up to 2.95 g (2 d/weekly for 5 weeks),(b) AT group, points of both ears (Kidney, Knee-correspondent point and Shenmen) were stimulated with seeds,(c) WBVE + AT group and (d) respective control groups. HS was assessed in all the participants, in acute and cumulative responses. RESULTS: The intervention with WBVE alone and combined with AT improved (P < 0.05), in a cumulative response, the HS. CONCLUSION: WBVE alone or combined with AT might promote biological effects that interfere with the HS in individuals with KOA.

关键词： Osteoarthritis,knee Exercise therapy Physical and rehabilitation medicine Auriculotherapy Muscle strength dynamometer

Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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World journal of Gastroenterology 2009年第20期15卷 2512-2519页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira jr Regina Maria Pereira Renata da Cunha Ribeiro jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e silva Robson Augusto Souza dos santos Laboratory of Hypertension Department of Physiology Biological Sciences institute Federal University of Minas Gerais Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil Laboratory of Endocrinology Department of Medicine Faculty of Medicine Federal University of Minas Gerais Av. Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil Hospitalar Foundation of the State of Minas Gerais FHEMIG Belo Horizonte MG Brazil Department of Pediatrics Faculty of Medicine Federal University of Minas Gerais Av.Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil

AIM： To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system （RAS） components and hemodynamic changes. METHODS： Patients were allocated into 4 groups： mild-to-moderate liver disease （MLD）, advanced liver disease （ALD）, patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity （PRA）, angiotensin （Ang） Ⅰ, Ang Ⅱ, and Ang-（1-7） levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS： PRA and angiotensins were elevated in ALD when compared to MLD and controls （P 〈 0.05）. In contrast, Ang Ⅱ was significantly reduced in MLD. Ang-（1-7）/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-（1-7）/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation （0.52 ± 0.08 vs 0.38 ±0.04, P 〈 0.02）, whereas the peripheral circulating Ang Ⅱ/Ang Ⅰ ratio was elevated in comparison to splanchnic levels （0.18 ±0.02 vs 0.13 ±0.02, P 〈 0.04）. Ang-（1-7）/ Ang Ⅱ ratios positively correlated with cardiac output （r = 0.66） and negatively correlated with systemic vascular resistance （r = -0.70）. CONCLUSION： Our findings suggest that the relationship between Ang-（1-7） and Ang Ⅱ may play a role in the hemodynamic changes of human cirrhosis.

关键词： Renin-angiotensin system Liver cirrhosis Angiotensin-(1-7) Angiotensin Ⅱ Splanchnic circulation Angiotensin converting enzyme 2

Recovery of polyphenols from camu-camu(Myrciaria dubia ***)depulping residue by cloud point extraction

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Chinese journal of Chemical Engineering 2018年第12期26卷 2471-2476页

作者： Carlos Eduardo de Araujo Padilha juliana Chris silva de Azevedo Francisco Caninde de Sousa junior Sergio Dantas de Oliveira junior Domingos Fabiano de Santana Souza jackson Araujo de Oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos santos Laboratory of Biochemical Engineering Chemical Engineering Department Federal University of Rio Grande do Notre(UFRN)NatalRNBrazil Laboratory of Food Bioactive Compounds and Dairy Technology Chemical Engineering DepartmentFederal University of Rio Grande do Notre(UFRN)NatalRNBrazil

In this study the potential of cloud point extraction formed by a non-ionic surfactant was used in order to separate polyphenols from industrial residues of camu-camu. The effects of operational conditions of the cloud point extraction(CPE) on the polyphenol recovery and volumetric ratio were investigated. The results showed a maximum recovery of 95.71% that was obtained using 7.0 wt% Triton X-114, native pH(3.25), and 80 wt%polyphenol extract at 30 °C. The use of cloud point extraction was successful to recover the polyphenols from agroindustrial residue since it is a simple as well as of low-cost technique.

关键词： Cloud point extraction Recovery Polyphenols Camu-camu Depulping residue

Wood Ash Fertilization on Structural Characteristics and Chlorophyll Index of Tropical Forage Grasses

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American journal of Plant Sciences 2015年第9期6卷 1341-1348页

作者： Edna Maria Bonfim-silva Claudia Cardoso dos santos Tonny josé Araújo da silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

The appropriate nutrient supply via fertilization is essential for an adequate plant growth and development. The objective of this study was to evaluate the structural characteristics and chlorophyll index of Marandu and Xaraes grasses fertilized with wood ash. The experiment was conducted in a greenhouse;the experimental design was entirely randomized, with 12 treatments and six replications arranged in a 2 × 6 factorial scheme: two forage grasses (Marandu and Xaraes) and six wood ash doses (0;3;6;9;12;and 15 g·dm-3). Each plot was composed of pots with 7 dm3 soil and five plants. Soil moisture was maintained by the gravimetric method at 60% of the maximum soil water retention capacity. Three harvests of the plant aerial part were performed at 30-day intervals. The evaluated characteristics were plant height, leaf number, tiller number, and chlorophyll index. Results were submitted to the variance analysis by F test and, after verification of the significant effects on Marandu and Xaraes characteristics, were also submitted to Tukey test;the wood ash doses were evaluated according to the regression analysis at 5% probability. Wood ash doses ranging from 10.15 to 15 g·dm-3 resulted in quadratic responses of plant height, leaf number, and tiller number for both Marandu and Xaraes grasses. The highest values of chlorophyll index derived from wood ash doses of 9.44 and 10.92 g·dm-3, with increments greater than 50%, 25%, and 9% at the first, second, and third harvests, respectively. The wood ash, when used as a fertilizer, improves structural characteristics and increases chlorophyll indices of Marandu and Xaraes grasses cultivated in Cerrado Rhodic Hapludox.

关键词： Alternative Fertilizer Brachiaria brizantha Marandu Xaraes

Three-Dimensional Shear Wave Velocity Structure of the Northeastern Brazilian Lithosphere

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International journal of Geosciences 2016年第6期7卷 849-872页

作者： jorge Luis de Souza Newton Pereira dos santos Carlos da silva Vilar Coordena?ao de Geofísica MCTI/Observatório Nacional Rio de Janeiro Brazil Departamento de Física da Terra e do Meio Ambiente Universidade Federal da Bahia (UFBA) Brazil

A large number of Rayleigh wave dispersion curves recorded at twenty three seismic stations was used to investigate the 3-D shear wave velocity structure of the northeastern Brazilian lithosphere. A simple procedure to generate a three-dimensional image of Mohorovicic;discontinuity was applied in northeastern Brazil and the Moho 3-D image was in agreement with several isolated crustal thicknesses obtained with different geophysical methods. A detailed 3-D S wave velocity model is proposed for the region. In the crust, our model is more realist than CRUST2.0 global model, because it shows more details either laterally or in depth than global model, i.e., clear lateral variation and gradual increase of S wave velocity in depth. Down to 100 km depth, the 3-D S wave velocity model in northeastern Brazil is dominated by low velocities and this is consistent either with heat flow measurements or with measurements of the flexural strength of the lithosphere developed in the South American continent. Our 3-D S wave velocity model was also used to obtain the lithosphere thickness in each cell of the northeastern Brazil and the results were consistent with global studies about the Lithosphere-Asthenosphere Boundary worldwide.

关键词： Rayleigh Waves Group-Velocity Tomography Three-Dimensional Shear Wave Velocity Lithosphere Spatial Resolution Northeastern Brazil

Dental impact of anti-fibroblast growth factor 23 therapy in X-linked hypophosphatemia

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International journal of Oral Science 2023年第4期15卷 691-700页

作者： Elis j.Lira dos santos Kenta Nakajima julien Po Ayako Hanai Volha Zhukouskaya Martin Biosse Duplan Agnès Linglart Takashi Shimada Catherine Chaussain Claire Bardet UniversitéParis Cité Institut des maladies musculo-squelettiquesLaboratory Orofacial PathologiesImaging and Biotherapies URP2496 and FHU-DDS-NetDental Schooland Plateforme d’Imagerie du Vivant(PIV)MontrougeFrance R&D Division Kyowa KirinCo.Ltd3-6-6 Asahi-machiMachida-shiTokyoJapan UniversitéParis Cité Institut ImagineINSERM UMR 1163ParisFrance AP-HP Reference Center for Rare Disorders of the Calcium and Phosphate MetabolismDental Medicine DepartmentBretonneau HospitalGHN-UniversitéParis CitéParisFrance Paris-Saclay University AP-HPINSERM U1185DMU SEAEndocrinology and Diabetes for ChildrenReference Center for Rare Diseases of the Calcium and Phosphate MetabolismOSCAR filièreEndoRareand BOND ERNsBicêtre Paris Saclay HospitalLe Kremlin-BicêtreFrance Medical Affairs Department Kyowa KirinCo.Ltd1-9-2 OtemachiChiyoda-kuTokyoJapan

Elevated fibroblast growth factor 23(FGF23)in X-linked hypophosphatemia(XLH)results in rickets and phosphate wasting,manifesting by severe bone and dental ***,a FGF23-neutralizing antibody,an alternative to conventional treatment(phosphorus and active vitamin D analogs),showed significant improvement in the long bone ***,we examined whether FGF23 antibody(FGF23-mAb)also improved the dentoalveolar features associated with ***-week-old male Hyp mice were injected weekly with 4 or 16 mg·kg−1 of FGF23-mAb for 2 months and compared to wild-type(WT)and vehicle(PBS)treated Hyp mice(n=3–7 mice).Micro-CT analyses showed that both doses of FGF23-mAb restored dentin/cementum volume and corrected the enlarged pulp volume in Hyp mice,the higher concentration resulting in a rescue similar to WT ***23-mAb treatment also improved alveolar bone volume fraction and mineral density compared to vehicle-treated *** revealed improved mineralization of the dentoalveolar tissues,with a decreased amount of osteoid,predentin and *** periodontal ligament attachment was also observed,evidenced by restoration of the acellular *** preclinical data were consistent with the retrospective analysis of two patients with XLH showing that burosumab treatment improved oral *** together,our data show that the dentoalveolar tissues are greatly improved by FGF23-mAb treatment,heralding its benefit in clinics for dental abnormalities.

关键词： doses vitamin treatment