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基于320层CTA的腔内密度衰减梯度和无创血流储备分数对血流动力学上冠状动脉显著狭窄的诊断效能:一项NXT亚实验

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国际医学放射学杂志 2016年第3期 310-311页

作者： B.S.Ko d.T.Wong B.L.Nφrgaard d.P.Leong j.d.cameron S.Gaur 倪倩倩 Monash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre) Monash University and Monash Heart

摘要目的以有创血流储备分数为标准,比较基于320层CT冠状动脉成像的无创血流储备分数(FFR;FFRCT)、腔内衰减梯度(TAG;TAG320)以及CT冠状动脉成像自身用于诊断血流动力学上冠状动脉狭窄的效能。材料与方法作为前瞻NXT研究(编号:NCT017576... 详细信息

摘要目的以有创血流储备分数为标准,比较基于320层CT冠状动脉成像的无创血流储备分数(FFR;FFRCT)、腔内衰减梯度(TAG;TAG320)以及CT冠状动脉成像自身用于诊断血流动力学上冠状动脉狭窄的效能。材料与方法作为前瞻NXT研究(编号:NCT01757678)的一项亚实验,本研究

关键词：血流储备分数衰减梯度冠状动脉血流动力诊断效能无创腔内密度 NXT

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker juliAnne Allgood jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

320层CT冠状动脉成像预期稳定性冠状动脉疾病是否需要血管重建并作为行有创性血管造影的决定指标:储备血流分数的相关性研究

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国际医学放射学杂志 2014年第3期 298-298页

作者： B.S.Ko d.T.L.Wong j.d.cameron d.P.Leong M.Leung I.T.Meredith 唐光健 Monash Heart 246 Clayton RoadClayton 3168VICAustralia

摘要目的明确以储备血流分数(FFR)作为参考标准,320层多层CT冠状动脉血管成像(M320-CCTA)检出稳定性冠状动脉疾病功能性狭窄与预期血管重建的准确性。方法

关键词：冠状动脉疾病血管重建分数 CCTA 有创血流储备 CT

急性胸痛病人调查研究:心脏CT血管成像联合肌钙蛋白检测的应用价值

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国际医学放射学杂志 2011年第5期 483-483页

作者： A.Nasis I.T.Meredith N.Nerlekar j.d.cameron P.R.Antonis P.M.Mottram 付娇慧 Monash Cardiovascular Research Centre Monash-HEART246 Clayton RoadClaytonVIC 3168Australia and Southern Health and Monash University Department of MedicineMelbourneAustralia

目的评价心脏CT血管成像(CTA)对急诊室(Ed)内具有低至中度缺血风险且伴胸痛病人的等待时间和常见心血管不良事件发生率的影响。材料与方法该研究获得机

关键词：血管成像 CTA 肌钙蛋白肌肉蛋白 CT 病人心脏

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi james d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Carbon storage and net primary productivity in Canadian boreal mixedwood stands

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journal of Forestry Research 2019年第5期30卷 1667-1678页

作者： Nicholas j.Payne d.Allan cameron jean-denis Leblanc Ian K.Morrison Canadian Forest Service Great Lakes Forestry Centre

Canadian boreal mixedwood forests are extensive,with large potential for carbon sequestration and storage;thus,knowledge of their carbon stocks at different stand ages is needed to adapt forest management practices to help meet climate-change mitigation *** stocks were quantified at three Ontario boreal mixedwood sites.A harvested stand,a juvenile stand replanted with spruce seedlings and a mature stand had total carbon stocks(±SE)of 133±13 at age 2,130±13 at age 25,and 207±15 Mg C ha^-1 at age 81 *** the clear-cut site,stocks were reduced by about 40%or 90 Mg C ha^-1 at *** held 27,34 and 62%of stocks,while detritus held 34,29 and 13%of stocks at age 2,25 and 81,*** soil carbon stocks averaged 51 Mg C ha^-1,and held 38,37 and 25%of *** net primary productivity(±SE)in the harvested and juvenile stand was 2.1±0.2 and 3.7±0.3 Mg C ha^-1 per annum(p.a.),compared to 2.6±2.5 Mg C ha^-1 *** the mature *** mature canopies studied had typical boreal mixedwood composition and mean carbon densities of 208 Mg C ha^-1,which is above average for managed Canadian boreal forest ecosystems.A comparison of published results from Canadian boreal forest ecosystems showed that carbon stocks in mixedwood stands are typically higher than coniferous stands at all ages,which was also true for stocks in vegetation and ***,aboveground net primary productivity was typically found to be higher in mixedwood than in coniferous boreal forest stands over a range of *** from this study,together with those published from the other boreal forest stands demonstrate the potential for enhanced carbon sequestration through modified forest management practices to take advantage of Canadian boreal mixedwood stand characteristics.

关键词： Aboveground net primary productivity Boreal mixedwood forest Carbon stocks Mixedwood stand management Stand age

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko jeremic Lydia jiménez-díaz juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru