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journal of Semiconductors 2013年第8期34卷 19-24页

作者： R.Suresh V.Ponnuswamy j.chandrasekaran D.Manoharan R.Mariappan Department of Physics Sri Ramakrishna Mission Vidyalaya College of Arts and ScienceCoimbatore-641020Tamil NaduIndia

Polyaniline,ZnO and polyaniline/ZnO nanocomposite thin films are coated on glass substrates using the spray pyrolysis *** samples are characterized by the XRD,SEM,EDAX,UV-Vis and I-V characteristics. The XRD analyses confirm that the spray-coated polyaniline and ZnO thin films have orthorhombic and hexagonal structures,respectively,and optical bandgap energy decreases from 3.81 to 3.41 eV with the addition of a Zn *** analysis of the polyaniline/ZnO nanocomposite thin films shows that there is an agglomeration of ZnO particles with uniform distribution in the polyaniline matrix,and the diode characteristics of the polyaniline /ZnO nanocomposite show weak rectification *** such as the ideality factor,reverse saturation current and barrier height are calculated from the I-V characteristics.

关键词： thin films X-ray diffraction optical properties I-V characteristics

Solvation number, thermochemical parameter, and viscosity study of sweeteners in aqueous and non-aqueous media through ultrasonic measurements

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ChemPhysMater 2023年第4期2卷 303-314页

作者： j.H.Rakini chandrasekaran S.Nithiyanantham Centre for Research-Department of Physics Arignar Anna Government Arts CollegeMusiri 621211India PG and Research Department of Physics Vi.Kalyanansundaram Govt Arts&Science CollegeBharathidasan UniversityThiruvarur 610003India

Ultrasonic velocity measurements are used to elucidate various aspects of solvation chemistry,including solute–solute and solute–solvent ***,an attempt is made to study a behavior of two sweeteners,D-fructose and D-sorbitol,in aqueous and non-aqueous media was attempted.D-fructose is a simple sugar found in many foods and can be consumed by diabetics and people suffering from hypoglycemia.D-Sorbitol is a sugar substitute used in diet foods,sugar-free chewing gum,mints,cough syrups,mouthwash,toothpaste etc.,D-sorbitol is an excellent humectant and texturizing agent that is also used in other products such as pharmaceuticals and *** interactions between the solute and solvent molecules are explained in terms of the solvation numbers of both aqueous and non-aqueous solutions of D-fructose and *** viscosity study correlates the viscosity of the solution with solvation;here,density,ultrasonic velocity,and viscosity of aqueous and non-aqueous solutions at various concentrations are measured at different temperatures ranging from 35 to 55℃.These parameters provide sufficient information on the interaction between molecules that may aid chemists in analyzing the mechanisms of the behavior of D-fructose and D-sorbitol in water and the water–ethanol medium through which they are *** Fourier transforms infrared spectra of pure solvent,salt,and their solutions were recorded and analyzed for confirmation.

关键词： Ultrasonic velocity Density Viscosity Solvation number Thermochemical parameters Molecular interactions FTIR spectra

Multifaceted Signaling Networks Mediated by Abscisic Acid Insensitive 4

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Plant Communications 2020年第3期1卷 20-29页

作者： Umashankar chandrasekaran Xiaofeng Luo Wenguan Zhou Kai Shu School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710012China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China

Although ABSCISIC ACID INSENSITIVE 4(ABI4)was initially demonstrated as a key positive regulator in the phytohormone abscisic acid(ABA)signaling cascade,multiple studies have now shown that it is actually involved in the regulation of several other cascades,including diverse phytohormone biogenesis and signaling pathways,various developmental processes(such as seed dormancy and germination,seedling establishment,and root development),disease resistance and lipid *** with its versatile biological functions,ABI4 either activates or represses transcription of its target *** upstream regulators of ABI4 at both the transcription and post-transcription levels have also been documented in recent ***,a complicated network consisting of the direct target genes and upstreamregulators of ABI4,through which ABI4 participates in several phytohormone crosstalk networks,has been *** this review,we summarize current understanding of the sophisticated ABI4-mediated molecular networks,mainly focusing on diverse phytohormone(including ABA,gibberellin,cytokinin,ethylene,auxin,and jasmonic acid)*** also discuss the potential mechanisms through which ABI4 receives the ABA signal,focusing on protein phosphorylation modification events.

关键词： ABI4 transcription factor target genes phytohormones crosstalk

Cytogenetic studies of chromium(Ⅲ) oxide nanoparticles on Allium cepa root tip cells

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journal of Environmental Sciences 2015年第12期27卷 150-157页

作者： Deepak Kumar A.Rajeshwari Pradeep Singh jadon Gouri Chaudhuri Anita Mukherjee Natarajan chandrasekaran Amitava Mukherjee Centre for Nanobiotechnology VIT University Centre of Advanced Study Department of BotanyUniversity of Calcutta

The current study evaluates the cytogenetic effects of chromium（Ⅲ） oxide nanoparticles on the root cells of Allium *** root tip cells of *** were treated with the aqueous dispersions of Cr2O3 nanoparticles（NPs） at five different concentrations（0.01,0.1,1,10,and 100 μg/m L） for 4 *** colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size *** 4 hr exposure to Cr2O3 NPs,a significant decrease in mitotic index（MI） from 35.56%（Control） to 35.26%（0.01 μg/m L）,34.64%（0.1 μg/m L）,32.73%（1 μg/m L）,29.6%（10 μg/m L） and 20.92%（100 μg/m L） was *** optical,fluorescence and confocal laser scanning microscopic analyses demonstrated specific chromosomal aberrations such as-chromosome stickiness,chromosome breaks,laggard chromosome,clumped chromosome,multipolar phases,nuclear notch,and nuclear bud at different exposure *** concentration-dependent internalization/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme,superoxide dismutase to counteract the oxidative stress,which in turn resulted in observed chromosomal aberrations and cytogenetic *** results suggest that *** root tip assay can be successfully applied for evaluating environmental risk of Cr2O3 NPs over a wide range of concentrations.

关键词： A.cepa Bio-uptake Chromosomal aberration C2O3 nanoparticles Mitotic index SOD

ARGUS: Interactive visual analysis of disruptions in smartphone-detected Bio-Behavioral Rhythms

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Visual Informatics 2021年第3期5卷 39-53页

作者： Hamid Mansoor Walter Gerych Abdulaziz Alajaji Luke Buquicchio Kavin chandrasekaran Emmanuel Agu Elke Rundensteiner Worcester Polytechnic Institute USA

Human Bio-Behavioral Rhythms(HBRs)such as sleep-wake cycles(Circadian Rhythms),and the degree of regularity of sleep and physical activity have important health *** devices such as smartphones can sense HBRs by continuously analyzing data gathered passively by built-in sensors to discover important clues about the degree of regularity and disruptions in behavioral *** human behavior is complex and smartphone data is voluminous with many channels(sensor types),it can be challenging to make meaningful observations,detect unhealthy HBR deviations and most importantly pin-point the causes of *** work has largely utilized computational methods such as machine and deep learning approaches,which while accurate,are often not explainable and present few actionable insights on HBR patterns or *** assist analysts in the discovery and understanding of HBR patterns,disruptions and causes,we propose ARGUS,an interactive visual analytics *** a foundation of ARGUS,we design an intuitive Rhythm Deviation Score(RDS)that analyzes users’smartphone sensor data,extracts underlying twenty-four-hour rhythms and quantifies their degree of *** score is then visualized using a glyph that makes it easy to recognize disruptions in the regularity of *** also facilitates deeper HBR insights and understanding of causes by linking multiple visualization panes that are overlaid with objective sensor information such as geo-locations and phone state(screen locked,charging),and user-provided or smartphone-inferred ground truth *** array of visualization overlays in ARGUS enables analysts to gain a more comprehensive picture of HBRs,behavioral patterns and deviations from *** design of ARGUS was guided by a goal and task analysis study involving an expert versed in HBR and smartphone *** demonstrate its utility and generalizability,two different datasets were explored using ARGUS and our use ca

关键词： Interactive visual analytics Circadian rhythms Smartphone-sensed data

Measurement of natural radionuclides in bricks and brick-making clays from Cuddalore district,Tamilnadu,India

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Nuclear Science and Techniques 2010年第4期21卷 218-220页

作者： G.Viruthagiri R.Ravisankar B.Rajamannan K.Thillaivelavan A.chandrasekaran V.Meenkshisundram Deptartment of physics Annamalai University Post Graduate and Research Department of Physics Govt.Arts College Department of Physics Govt.Arts College Department of Physics Sacred Heart College Radiological Safety Division Indira Gandhi Centre for Atomic Research(IGCAR)

In India,bricks as building materials are mainly prepared by clay using the deposited sediments of rivers,and the radionuclide contents in bricks and brick-making clays should vary with origin and geological *** this paper,the radionuclide contents of these materials from river bank areas of Cuddalore district,Tamilnadu India are measured by gamma ray spectrometer using NaI(Tl) detector,and compared with those of other *** radiation hazard indices,which are evaluated by radium-equivalent(Raeq) activity,are lower than that of NEA-OECD.

关键词：射线测量天然放射性核素制砖粘土印度放射性核素含量河流沉积物建筑材料

INPHOVIS:Interactive visual analytics for smartphone-based digital phenotyping

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Visual Informatics 2023年第2期7卷 13-29页

作者： Hamid Mansoor Walter Gerych Abdulaziz Alajaji Luke Buquicchio Kavin chandrasekaran Emmanuel Agu Elke Rundensteiner Angela Incollingo Rodriguez Worcester Polytechnic Institute USA

Digital phenotyping is the characterization of human behavior patterns based on data from digital devices such as smartphones in order to gain insights into the users’state and especially to identify *** support supervised machine learning,digital phenotyping requires gathering data from study participants’smartphones as they live their ***,participants are then asked to provide ground truth labels about their health *** such complex data is challenging due to limited contextual information and imperfect health/wellness *** propose INteractive PHOne-o-typing VISualization(INPHOVIS),an interactive visual framework for exploratory analysis of smartphone health data to study *** visualization work has focused on mobile health data with clear semantics such as steps or heart rate data collected using dedicated health devices and wearables such as ***,unlike smartphones which are owned by over 85 percent of the US population,wearable devices are less prevalent thus reducing the number of people from whom such data can be *** contrast,the‘‘low-level"sensor data(e.g.,accelerometer or GPS data)supported by INPHOVIS can be easily collected using *** visualizations are designed to provide the essential contextualization of such data and thus help analysts discover complex relationships between observed sensor values and health-predictive *** guide the design of INPHOVIS,we performed a hierarchical task analysis of phone-o-typing requirements with health domain *** then designed and implemented multiple innovative visualizations integral to INPHOVIS including stacked bar charts to show diurnal behavioral patterns,calendar views to visualize day-level data along with bar charts,and correlation views to visualize important wellness predictive *** demonstrate the usefulness of INPHOVIS with walk-throughs of use *** also evaluated INPHOVIS with expert feedb

关键词： Interactive visual analytics Smartphone-sensed data Digital phenotyping

Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease

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Science China(Life Sciences) 2012年第12期55卷 1109-1119页

作者： SREEVISHNUPRIYA K. chandrasekaran P. SENTHILKUMAR A. SETHUMADHAVAN R. SHANTHI V. DAISY P. NISHA j. RAMANATHAN K. RAjASEKARAN R. Bioinformatics Division School of Biosciences and Technology Vellore Institute of TechnologyVellore 632014 Tamil Nadu India Department of Biotechnology Holy Cross CollegeTrichy 620002 Tamil Nadu India

In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA.

关键词： missense mutation Canavan's disease aspartoacylase NAA flexibility

Antibacterial activity of selected marine macro algae against vancomycin resistant Enterococcus faecalis

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journal of Coastal Life Medicine 2014年第12期 940-946页

作者： Manivachagam chandrasekaran Venugopalan Venkatesalu Gnanaprakasam Adaikala Raj Department of Botany Annamalai UniversityAnnamalainagar-608002Tamil NaduIndia Botany Wing-DDE Annamalai UniversityAnnamalainagar-608002Tamil NaduIndia

Objective:To evaluate the antibacterial activity of different extracts of Caulerpa chemnitzia(Epser)***,Caulerpa racemosa(Frosk.)Weber-van-Bosse(***),Caulerpa scalpelliformis(***.)Weber-van-Bosse,Ulva lactuca Lin,Ulva fasciata Dellie,Ulva reticulata Forsk,Stoechospermum marginatum(Ag.)Kutz(***),Sargassum wightii Grev,Gracilaria verrucosa(Huds.)Papenfuss and Gracilaria edulis(***)*** against Enterococcus faecalis(MTCC 439)(***)and one clinical isolate of vancomycin resistant ***:The selected marine macro algae were extracted with different solvents viz.,hexane,chloroform,ethyl acetate,acetone and *** assay was carried out by using disc diffusion method,determination of minimum inhibitory concentration and minimum bactericidal ***:The maximum antibacterial activity was recorded in the ethyl acetate extracts of *** and *** than the other *** mean zone of inhibition produced by the extracts in agar diffusion assays against the tested bacterial strains ranged from 7.1 to 14.5 *** minimum inhibitory concentration was between 250 and 500μg/mL,while the minimum bactericidal concentration was from 500 to 1000μg/*** ethyl acetate extracts of the seaweeds showed the presence of strong terpenoids,tannins and phenolic compounds compared with the other solvent ***:These findings suggest that ethyl acetate extracts of *** and *** can be used as an antibacterial substance for the treatment of infection caused by ***.

关键词： Marine macro algae Antibacterial activity Vancomycin resistant Enterococcus faecalis strains

Study on Classification Algorithms for Network Intrusion Systems

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通讯和计算机（中英文版） 2012年第11期9卷 1242-1246页

作者： Saravanan Subramanian Vijay Bhanu Srinivasan chandrasekaran Ramasamy Department of Computer Science&Engineering Annamalai UniversityAnnamalai 608002India