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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Development process for a higher capacity Propsetter~ system

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International journal of Mining Science and Technology 2018年第1期28卷 121-126页

作者： Christopher j.brown Product Development-Strata Worldwide LLC

As longwall tailgate support technologies continue to be developed and improved, strata worldwide has worked to design and manufacture a revised Propsetter to provide additional support capacity and enable applications at greater mine *** support is targeted for tailgate applications, however, it can also be utilized for roof support in various types of mining *** paper describes the design changes for enhancing the support capacity of the Propsetter to more closely align its performance with other support technologies currently being employed in longwall *** changes to each design aspect of the Propsetter was key to successfully improving the roof support's load capacity while maintaining controlled *** the load capacity would allow a mine to improve support efficiency with a smaller, less intrusive support compared to support alternatives and reduce the cost per foot of supported *** target support capacity was 711–890 k N at 50 mm of deformation to more closely match the performance of competing tailgate supports such as the 610 mm-diameter CAN~.To achieve this goal, changes were made to all design aspects of the Propsetter: diameter, wedge cut depth and angle, pod size, and confinement *** results from the NIOSH Mine Roof Simulator verified that these design changes were successful in increasing the capacity of the Propsetter to the 711–890 k N range at fifty mms of deformation.

关键词： Propsetter Can Longwall mining Tailgate roof support Controlled deformation

PREPARATION OF ASYMMETRIC POLYETHERKETONE FLAT AND HOLLOW FIBER MEMBRANES FOR GAS SEPARATION USING ACETIC ACID BASED COAGULANTS

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Chinese journal of Polymer Science 2008年第3期26卷 263-273页

作者：杨继萍 Philip j.brown School of Material Science and Engineering Beihang UniversityBeijing 100083China School of Materials Science and Engineering Clemson UniversitySC29634USA

Membranes for gas separation have developed significantly in the last twenty years,however,there is still a need for high temperature and chemically resistant membranes that exhibit good selectivity and gas *** study examines the fundamental properties of polyetherketone (PEK,a thermally stable and chemically resistant polymer) membranes prepared using concentrated sulphuric acid (98% H_2SO_4) as the ***-solvents used in the work included acetic acid,ethanol,methanol,glycerol,and water....

关键词： Polyetherketones Membranes Gas permeation Internal coagulant effect Morphology

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布朗医生日记——马还是斑马

中国全科医学 2013年第31期16卷 3761-3762页

作者： Sanford j.brown 周淑新 A solo practice Fort BraggMendocinoCalifornia95437 USA 中国石油天然气集团公司中心医院

如果每次老年人告诉我他或她感到疲劳时我都能得到1美元,那我现在肯定都是高税级纳税人了(译者注:医生挣得钱越多,交的税越多)。76岁的埃伦在年度体检中的主诉是乏力,于是我让她体检时除了做全血细胞计数和化学检测外,还做了促甲状腺激... 详细信息

如果每次老年人告诉我他或她感到疲劳时我都能得到1美元,那我现在肯定都是高税级纳税人了(译者注:医生挣得钱越多,交的税越多)。76岁的埃伦在年度体检中的主诉是乏力,于是我让她体检时除了做全血细胞计数和化学检测外,还做了促甲状腺激素检查。每项结果都正常。1周后,埃伦来电话说症状加重了,每天低热、食欲减退、乏力且关节疼痛。我让埃伦来复诊。

关键词：家庭医生乏力结缔组织疾病

Comparative efficacy of gypsy moth(Lepidoptera:Erebidae)entomopathogens on transgenic blight-tolerant and wild-type American,Chinese,and hybrid chestnuts(Fagales:Fagaceae)

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Insect Science 2020年第5期27卷 1067-1078页

作者： Aaron j.brown Andrew E.Newhouse William A.Powell Dylan Parry Department of Environmental and Forest Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

American chestnut(Castanea dentata[Marsh.]Borkh.)was once the dominant hardwood species in Eastern North America before an exotic fungal pathogen,Cryphonec-tria parasitica(Murrill)Barr,functionally eliminated it across its *** promising approach toward restoring American chestnut to natural forests is development of blight-tolerant trees using genetic ***,transformation and related processes can result in unexpected and unintended phenotypic changes,potentially altering ecologi-cal *** assess unintended tritrophic impacts of transgenic American chestnut on plant herbivore interactions,gypsy moth(Lymantria dispar L.)caterpillars were fed leaf disks excised from two transgenic events,Darling 54 and Darling 58,and four control American chestnut *** disks were previously treated with an LDso dose of either the speces-specific Lymantria dispar multiple nucleopolyhedrovirus(LdMNPV)or the generalist pathogen Bacillus thuringiensis ***(Btk).Mortality was quantified and compared to water blank *** genotype had a strong efect on the efficacies of both *** mortality from Btk-treated foliage from only one transgenic event,Darling 54,differed from its isogenic progenitor,Ellis l,but was similar to an unre-lated wild-type American chestnut *** efficacy was unaffected by genetic *** suggest that although genetic modification of trees may affect interactions with other nontarget organisms,this may be due to insertion effects,and varia-tion amnon diMterent genvtypes(wlether uasgeic ul wild-typc)iupaults a giealci change in response than transgene presence.

关键词： Bacillus thuringiensis LdMNPV nontarget restoration tri-trophic unin-tended effects

Effects of Climate Change and Shifts in Forest Composition on Forest Net Primary Production

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journal of Integrative Plant Biology 2008年第11期50卷 1426-1439页

作者： jyh-Min Chiang Louts R.Iverson Anantha Prasad Kim j.brown Department of Environmental and Plant Biology Ohio University United States Department of Agriculture Forest Service Northern Research Station Department of Life Science Tunghai University

Forests are dynamic in both structure and species composition, and these dynamics are strongly influenced by climate. However, the net effects of future tree species composition on net primary production （NPP） are not well understood. The objective of this work was to model the potential range shifts of tree species （DISTRIB Model） and predict their impacts on NPP （PnET-Ⅱ Model） that will be associated with alterations in species composition. We selected four 200 × 200 km areas in Wisconsin, Maine, Arkansas, and the Ohio-West Virginia area, representing focal areas of potential species range shifts. PnET-Ⅱ model simulations were carried out assuming that all forests achieved steady state, of which the species compositions were predicted by DISTRIB model with no migration limitation. The total NPP under the current climate ranged from 552 to 908 g C/m^2 per year. The effects of potential species redistributions on NPP were moderate （-12% to ＋8%） compared with the influence of future climatic changes （-60% to ＋25%）. The direction and magnitude of climate change effects on NPP were largely dependent on the degree of warming and water balance. Thus, the magnitude of future climate change can affect the feedback system between the atmosphere and biosphere.

关键词： carbon sequestration climate change leaf traits net primary production tree species range shifts.

Surgery for pancreatic cancer:recent progress and future directions

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 376-378页

作者： Zachary j.brown jordan M.Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOHUSA

Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive malignancy in which multimodality therapy is necessary to achieve good long-term *** recent seminar by Mizrahi et *** in The Lancet not only summarizes the fundamental knowledge of PDAC but also provides a concise overview of landmark studies that guide modern clinical practice(1).

关键词： Surgery al. adenocarcinoma

Physical activity and the prevention of chronic illness in the BRICS nations:Issues relating to gender equality

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journal of Sport and Health Science 2019年第6期8卷 507-508页

作者： Gregore I.Mielke Wendy j.brown Centre for Research on Exercise Physical Activity and HealthSchool of Human Movement and Nutrition SciencesThe University of Queensland

*** BRICS is an acronym for an international association of 5countries(Brazil,Russia,India,China,and South Africa),which together represent the world's major emerging economies and almost one-half of the worlds popula... 详细信息

关键词： population. BRICS prevention

Drug targets beyond HMG-CoA reductase:Why venture beyond the statins?

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Frontiers in Biology 2011年第3期6卷 197-205页

作者： Ingrid C.GELISSEN Andrew j.brown Faculty of Pharmacy The University of SydneySydney NSW 2006Australia BABS School of Biotechnology and Biomolecular SciencesThe University of New South WalesSydney NSW 2052Australia

In this review,we aim to convey a brief,select history of the development of cholesterol-lowering *** focus particularly on the highly successful statins as well as setbacks that should serve as cautionary *** go on to preview recent developments that may complement,if not one day replace,the *** focus is on pharmacological interventions,particularly those targeting the cholesterol biosynthetic ***,we examine therapies under current investigation that target the assembly of atherogenic lipoproteins(via apolipoprotein B or microsomal triglyceride transfer protein),the stability of the low-density lipoprotein-receptor(via PCSK9,proprotein convertase subtilisin kexin 9),or are designed to increase high-density lipoprotein-cholesterol(via inhibition of cholesteryl ester transfer protein).

关键词： statins cholesterol-lowering drugs side-effects adverse reactions cholesterol synthesis

A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson Wendy j.brown Alison K.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:We identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations