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Highly efficient passive Tesla valves for microfluidic applications

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Microsystems & Nanoengineering 2022年第5期8卷 125-136页

作者： Sebastian bohm Hai Binh Phi Ayaka Moriyama Erich Runge Steffen Strehle jörg König Christian Cierpka Lars Dittrich Theoretical Physics I Technische Universität IlmenauWeimarer Straße 2598693 IlmenauGermany Research and Development 5microns GmbHMargarethenstraße 698693 IlmenauGermany Institute of Micro-and Nanotechnologies Gustav-Kirchhoff-Straße 798693 IlmenauGermany Microsystems Engineering Technische Universität IlmenauMax-Planck-Ring 1298693 IlmenauGermany Physics and Astronomy Carleton CollegeOne North CollegeNorthfield 55057 MinnesotaUSA Engineering Thermodynamics Technische Universität IlmenauAm Helmholtzring 198693 IlmenauGermany

A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates,characteristic,e.g.,for almost all microfluidic systems,where passive valves have intrinsic advantages over active *** report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20μl s^(−1) corresponding to a Reynolds number of *** of the design is a topological optimization based on the finite element *** is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic *** numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel *** on the threedimensionally extruded optimized designs,various test structures were fabricated using standard,widely available microsystem manufacturing *** manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic *** the experimentally fabricated chips,the efficiency of the different valve designs,i.e.,the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions,respectively,is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla *** agreement is *** addition to the direct measurement of the diodicities,the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry(μPIV)***,a reasonable good agreement of the measured flow profiles with simulated predictions is observed.

关键词： backward Highly optimization

Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability

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Molecular Plant 2016年第3期9卷 428-436页

作者： j. bohm S. Scherzer S. Shabala E. Krol E. Neher T.D. Mueller R. Hedrich julius-yon-Sachs Institute Department for Molecular Plant Physiology and Biophysics University of Wurzburg Julius-von-Sachs Platz 2 97082 Wurzburg Germany School of Land and Food University of Tasmania Hobart TAS 7001 Australia Zoology Department College of Science King Saud University PO Box 2455 Riyadh 11451 Saudi Arabia Department for Membrane Biophysics Max Planck Institute for Biophysical Chemistry 37077 Goettingen Germany

The animal diet of the carnivorous Venus flytrap, Dionaea muscipula, contains a sodium load that enters the capture organ via an HKT1-type sodium channel, expressed in special epithelia cells on the inner trap lobe surface. DmHKT1 expression and sodium uptake activity is induced upon prey contact. Here, we analyzed the HKT1 properties required for prey sodium osmolyte management of carnivorous Dionaea. Analyses were based on homology modeling, generation of model-derived point mutants, and their functional testing in Xenopus oocytes. We showed that the wild-type HKT1 and its Na^＋- and K^＋-permeable mutants function as ion channels rather than K^＋ transporters driven by proton or sodium gradients. These structural and biophysical features of a high-capacity, Na^＋-selective ion channel enable Dionaea glands to manage prey-derived sodium loads without confounding the action potential-based information management of the flytrap.

关键词： sodium channel HKT1 Dionaea muscipula action potential glands sodium uptake

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乳癌的规范性预后因素

放射学实践 1995年第1期10卷 17-19页

作者： bohm.,j 张文同济医科大学附属同济医院

乳癌的预后取决于各种参数，即使放射医师也有必要在行乳房Ｘ线摄片时熟悉其有效的预后因素。

关键词：乳腺癌预后淋巴结类型类甾醇激素受体

Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

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Cellular & Molecular Immunology 2022年第2期19卷 222-233页

作者： Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.bohm jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian j.Ward Medicago Inc. QuébecQCCanada. Institute for Immunity Transplantation and InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA. Tulane National Primate Research Center CovingtonLAUSA. New Iberia Research Center University of Louisiana at LafayetteNew IberiaLAUSA. Department of Pathology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Department of Microbiology and Immunology Tulane University School of MedicineNew OrleansLAUSA. Department of Microbiology and Immunology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Institute for Immunity Transplantation&InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA Research Institute of the McGill University Health Centre MontrealQCCanada.

Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)***-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against ***,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)*** a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted *** micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T *** were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of *** viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with *** clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated *** CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials.

关键词： SARS-CoV-2 Virus-like particles Non-humane primates AS03 CpG1018

Correction to“Asymmetrically hypointense veins on T2*w imaging and susceptibility-weighted imaging in ischemic stroke”[World j Radiol 2013;5(4):156-165]

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World journal of Radiology 2018年第1期10卷 7-8页

作者： Ulf jensen-Kondering Ruwen bohm Institute of Neuroradiology University of Schleswig-HolsteinCampus KielKiel 24105Germany Institute of Experimental and Clinical Pharmacology University of Schleswig-HolsteinCampus KielKiel 24105Germany

Correction to:jensen-Kondering U,B?hm *** hypointense veins on T2*w imaging and susceptibility-weighted imaging in ischemic *** j Radiol 2013;5(4):156-165 PMID:23671751 DOI:10.4329/wjr.v5.i4.156[1].Results Third paragraph:(1)(n=17441 patients)should read(n=441 patients)instead;(2)(n=4111 patients)should read(n=111 patients)*** paragraph:(1)(>6 h,n=15579 patients)should read(>6 h,n=579 patients)instead;(2)(≤6 h=11337 patients)should read(≤6 h=337 patients)instead;(3)(170 patients)should read(180 patients)instead.

关键词： pat

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

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从微观到宏观水平的完整量子实在论

世界科学 1988年第5期 54-56页

作者： D.bohm B.j.Hiley 肖巍

利用量子势解释,我们表明无需割裂地去考虑量子水平和经典水平的实在性。

关键词：实在性经典极限宏观量子现象雅可比方程量子干涉延迟选择实验本体论地位超导量子干涉仪德布罗意波长定态

Diversity,endemism and conservation of the freshwater crabs of China(Brachyura:Potamidae and Gecarcinucidae)

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Integrative Zoology 2011年第1期6卷 45-55页

作者： Neil CUMBERLIDGE Peter K.L.NG Darren C.j.YEO Tohru NARUSE Kirstin S.MEYER Lara j.ESSER Department of Biology Northern Michigan UniversityMarquetteMichiganUSA Department of Biological Sciences National University of SingaporeSingapore University of the Ryukyus NishiharaOkinawaJapan Imperial College University of LondonLondonUK

China lies at the heart of the global center of freshwater crab diversity in tropical Asia,where the 2 most diverse families occur:Potamidae(505 species,95 genera)and Gecarcinucidae(344 species,59 genera).China stands out as the country with the highest species richness of freshwater crabs *** fauna comprises 243 species in 37 genera and in 2 families,and species discovery is still progressing at a rapid *** vast majority of the species are distributed in southwest,south central and eastern China in the Oriental zoogeographical *** also stands out as having a highly endemic freshwater crab fauna at the species level(96%)and at the genus level(78%).Although the recent International Union for the Conservation of Nature(IUCN)red list conservation assessment found only 6 out of 228 species(2%)to be threatened(5 potamids and 1 gecarcinucid),the majority(more than 75%)of Chinese species are regarded as data deficient,so the number of threatened species is likely to be a serious *** from increasing habitat destruction and pollution are a major concern due to the rapidly growing economy and massive developments taking place in *** is therefore an urgent need for increased species exploration and for the development of a conservation strategy for China’s threatened(and potentially threatened)endemic freshwater crab species.

关键词： China conservation distribution endemism Potamoidea

On the Real Einstein Beauty E = Kmc²

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World journal of Condensed Matter Physics 2016年第1期6卷 1-6页

作者： A. j. Babchin M. S. El Naschie Alberta Research Council (ARC) Edmonton Canada Department of Physics University of Alexandria Alexandria Egypt

The paper suggests that E = mc2 may be open to misinterpretation and that in this form it is not what Einstein advanced first. It is further suggested to return to the slightly less compact formula E = Kmc2 where a < ... 详细信息

关键词： Special Relativity Nuclear Physics Quantum Relativity Quantum Entanglement E = Kmc2 Dark Energy Ordinary Energy Pair Annihilation Pair Creation Dvoretzky’s Theorem bohm Guiding Wave