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Reliability-based multidisciplinary design optimization using incremental shifting vector strategy and its application in electronic product design

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Acta Mechanica Sinica 2018年第2期34卷 285-302页

作者： Z.L.Huang Y.S.Zhou C.jiang j.zheng X.Han School of Mechanical and Electrical Engineering Hunan City University State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle Engineering Hunan University

Use of multidisciplinary analysis in reliabilitybased design optimization(RBDO) results in the emergence of the important method of reliability-based multidisciplinary design optimization(RBMDO). To enhance the efficiency and convergence of the overall solution process,a decoupling algorithm for RBMDO is proposed ***, to decouple the multidisciplinary analysis using the individual disciplinary feasible(IDF) approach, the RBMDO is converted into a conventional form of RBDO. Secondly,the incremental shifting vector(ISV) strategy is adopted to decouple the nested optimization of RBDO into a sequential iteration process composed of design optimization and reliability analysis, thereby improving the efficiency significantly. Finally, the proposed RBMDO method is applied to the design of two actual electronic products: an aerial camera and a car pad. For these two applications, two RBMDO models are created, each containing several finite element models(FEMs) and relatively strong coupling between the involved disciplines. The computational results demonstrate the effectiveness of the proposed method.

关键词： Reliability-based design optimization(RBDO) Multidisciplinary design optimization(MDO) Incremental shifting vector(ISV) Decoupling algorithm Electronic product

Effect of Y content and equal channel angular pressing on the microstructure, texture and mechanical property of extruded Mg-Y alloys

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journal of Magnesium and Alloys 2022年第1期10卷 210-224页

作者： W.Yang G.F.Quan B.ji Y.F.Wan H.Zhou j.zheng D.D.Yin Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031China Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China International joint Laboratory for Light Alloys(Ministry of Education) College of Materials Science and EngineeringShenyang National Laboratory for Materials ScienceChongqing UniversityChongqing 400044China

The microstructure, texture and mechanical property evolution of the extruded Mg-x Y(x = 1, 5 wt.%) alloys during equal channel angular pressing(ECAP) were systematically investigated using an optical microscope, electron backscatter diffraction(EBSD) and uniaxial tensile test. The Mg-Y alloys exhibited a weakened basal texture before the ECAP, and the texture was further weakened with the max basal poles dispersed along ~45° between the extrusion direction and the transverse direction after the ECAP. The Mg-5 Y alloys always exhibited a finer grain size comparing to that of Mg-1 Y for the same ECAP process. With a proper ECAP process, both the strength and elongation of Mg-5 Y alloy could be improved simultaneously after the ECAP, i.e., the yield strength(273.9 ± 1.2 MPa), ultimate strength(306.4 ± 3.0 MPa),and elongation(23.9 ± 1.0%) were increased by 10%, 6%, and 72%, respectively, comparing to that before the ECAP. This was considered to be arose from the combined effects of grain refinement, significant improved microstructure homogeneity and solid solution *** addition, it was found that Mg-Y alloy with better comprehensive properties could be obtained by the decreasing-temperature ECAP processes. The yield strength-grain size relationship could be well described by the Hall-Petch relation for all the ECAPed Mg-Y alloys,which was consistent with that the texture changes did not significantly affect the average Schmid factors of basal, prismatic and pyramidal slips for both Mg-Y alloys.

关键词： Mg-RE alloy Equal channel angular pressing Texture Mechanical property

Improving high-temperature mechanical properties of cast CrFeCoNi high-entropy alloy by highly thermostable in-situ precipitated carbides

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journal of Materials Science & Technology 2021年第13期72卷 29-38页

作者： X.W.Liu N.Gao j.zheng Y.Wu Y.Y.Zhao Q.Chen W.Zhou S.Z.Pu W.M.jiang Z.T.Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621999China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA Southwest Technology and Engineering Research Institute Chongqing 400039China Center for Electron Microscopy Wuhan UniversityWuhan 430072China

The Cr Fe Co Ni high-entropy alloy(HEA)exhibits excellent mechanical properties at lower temperatures due to its low stacking-fault energy,however,its medium-and high-temperature strengths are still *** consideration of the potential diversified applications,more strengthening approaches except for the previously proposed L12 phase hardening deserve further exploration due to its rapid coarsening tendency at high ***,we achieved significant high-temperature strengthening of the cast Cr Fe Co Ni HEA by in-situ precipitation of highly thermostable *** with 0.5 at.%and 1 at.%niobium and carbon were prepared by simple casting processes,*** cast,solute solution and aging.A highly thermostable microstructure was formed,which comprises very coarse grains accompanied with extensive thermostable carbide precipitates embedded,including submicrometer coherent Nb C particles in grain interiors and intergranular coherent M_(23)C_(6)*** high thermostability of microstructure,which is beneficial for the high-temperature loading,is ascribed to the synergy of lacking growth driving force and Zenner pinning effect by the *** properties tested at 673,873 and1073 K show that the yield strength and ultimate tensile strength are significantly increased by Nb/C doping,along with the elongation escalation at higher *** strengthening is mainly due to the precipitation hardening of carbide particles.

关键词： High-entropy alloy Carbides Precipitation High-temperature property Strengthening

Roof cracks investigation and cracking mechanism analysis of Niuchang ancient cave in Longyou,Southeast China

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Roof cracks investigation and cracking mechanism analysis of...

禽网状内皮组织增殖病病毒gp90蛋白单克隆抗体的制备及其识别区分析

中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： Z.H.Han A.Braun.L.Q.Zhang j.Zhou Z.F.Yang G.Chen Y.Fu j.zheng Institute of Geology and Geophysics Chinese Academy of Sciences

By means of Three-Dimensional(3D)terrestrial laser scanning and vertical projection,the distribution of roof cracks in Niuchang cave No,1 was investigated and a high-precision 3D geometrical model was established to conduct a FLAC 3D numerical analysis of the roof stress *** simulation results and their theoretical analysis showed that the layering of roof rock mass can increase the tensile stress concentration in the roof and may also affect the quantity and distribution of *** concentration zones of tensile stress on the roof are in accordance with the actual crack *** it is assumed that tensile stress of above 0.35 MPa can activate the *** work can not only provide some knowledge for the roof cracking mechanism and development trend of other ancient caves especially open to the public,but also help to improve the understanding of in-situ rock strength and long-term stability of ancient cases.

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生物工程学报 2015年第1期31卷 75-85页

作者：孙明铭李晓齐曹红王永强郑世军中国农业大学动物医学院农业生物技术国家重点实验室北京100193

为了制备禽网状内皮组织增殖病病毒(REV)gp90蛋白的单克隆抗体,应用His-gp90融合蛋白免疫BALB/c小鼠,取免疫鼠的脾细胞与骨髓瘤细胞(SP2/0)进行融合,经过筛选、3次亚克隆后获得3株稳定分泌抗REV-gp90蛋白的单克隆抗体杂交瘤细胞株,分别... 详细信息

为了制备禽网状内皮组织增殖病病毒(REV)gp90蛋白的单克隆抗体,应用His-gp90融合蛋白免疫BALB/c小鼠,取免疫鼠的脾细胞与骨髓瘤细胞(SP2/0)进行融合,经过筛选、3次亚克隆后获得3株稳定分泌抗REV-gp90蛋白的单克隆抗体杂交瘤细胞株,分别命名为3G5-B8、3G5-A10和1G12。经间接ELISA(Enzyme-linked immunosorbent assay)方法检测,单克隆抗体的亲和力解离常数(Kd)分别为6.483×10–10、4.844×10–10和9.330×10–10,3株单抗的亚型分别为Ig G1、Ig G1和Ig G2b。经Western blotting和间接免疫荧光实验检测,3株单抗均能识别REV感染DF-1细胞后产生的gp90蛋白。以Western blotting方法利用单抗检测不同截短的gp90蛋白,初步确定3G5-B8和3G5-A10 2株单抗抗原识别区均位于gp90蛋白第200-245位氨基酸,而1G12株单抗识别区包含第230-235位氨基酸。这些单抗为REV的诊断和致病机理研究奠定了基础。

关键词：禽网状内皮组织增殖病病毒 gp90蛋白单克隆抗体亲和力抗原表位

Comparative analysis of clinicoradiologic characteristics of lung adenocarcinomas with ALK rearrangements or EGFR mutations

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Comparative analysis of clinicoradiologic characteristics of...

Simulation of the Thomson scattering process in laser plasmas

2014年浙江省内科学学术年会青年医师论坛暨内科常见病规范化诊疗国家级学习班

作者： j.Y.Zhou j.zheng Z.F.Yu W.B.Xiao j.Zhao K.Sun B.Wang X.Chen L.N.jiang W.Ding j.Y.Zhou The First Affiliated Hospital College of MedicineZhejiang University

Objective To compare the clinicoradiologic features of tumours with echinoderm anaplastic lymphoma kinase(ALK)rearrangements,epidermal growth factor receptor(EGFR)mutations,or wild type(WT)for both genes in a cohort of patients with lung adenocarcinoma to identify useful characteristics of different gene *** In 346lung adenocarcinoma patients,ALK rearrangements were confirmed with fluorescence in situ hybridisation,and EGFR mutations were determined by pyrosequencing *** were divided into three groups:ALK rearrangement(ALK+group,n=48),EGFR mutation(EGFR+group,n=166),and WT for both genes(WT group,n=132).Chest computed tomography(CT)scans were performed in all of the *** percentages of ground-glass opacity volume(pGGO)and tumour shadow disappearance rate(TDR)were measured using semi-automated nodule assessment *** The pGGO was significandy lower in the ALK+group(25.1%±24.3)than in the EGFR+group(37.2%±25.7,p<0.001)and the WT group(36.1%±24.6,p=0.001).The TDR in the ALK+group(17.3%±25.1)was significantly lower than in the EGFR+group(26.8%±24.9,p=0.002)and the WT group(25.7%±24.6,p=0.003).Conclusions Solid pattern with lower incidence of lobulated border,fine spiculated margins,pleural retraction and bubble-like lucency on the CT imagings are the main characteristics of ALK rearrangement tumours.

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Simulation of the Thomson scattering process in laser plasma...

MRI在评估临床低风险前列腺癌中的性能特点:前瞻性研究

2004年全国强场激光物理会议

作者： Q. Z. Yu, j. Zhang, Y. T. Li, j.zheng, F.Yan, X. Lu Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, P.O.Box 603, Beijing 100080, China

＜正＞We develop a post-processor for the Thomson scattering process coupled with a hydrocode. This processor can simulate the temporal development of the Thomson scattering process. With the simulated images, experim... 详细信息

关键词： Thomson scattering MEDUSA hydrocode simulated images

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国际医学放射学杂志 2013年第1期 64-65页

作者： H.A.Vargas O.Akin A.Shukla-Dave j.Zhang K.L.Zakian j.zheng 柴超 Department of Radiology Memorial Sloan-Kettering Cancer Center1275 York AveRoom C-278New YorkNY 10065

目的对于临床诊断低风险前列腺癌的病人,前瞻性评价T2WI和MRS在检测不同病理体积和Gleason评分的前列腺癌中的诊断效能。材料与方法本前瞻性研究获得单位伦理委员会批准,符合HIPAA原则。对183例临床患低风险前列腺癌病人[T1-T2a期,活检G... 详细信息

目的对于临床诊断低风险前列腺癌的病人,前瞻性评价T2WI和MRS在检测不同病理体积和Gleason评分的前列腺癌中的诊断效能。材料与方法本前瞻性研究获得单位伦理委员会批准,符合HIPAA原则。对183例临床患低风险前列腺癌病人[T1-T2a期,活检Gleason评分≤6,前列腺特异性抗原(PSA)<10ng/mL]在前列腺切除前行MR检查,所有病人均签署了知情同意书。2名放射学医师分别在T2WI上对前列腺六分区中肿瘤存在的可能性进行评分,按照1～5分的标准(1分,绝对没有肿瘤;5分,确定存在肿瘤)。2名波谱学专家共同记录病灶的位置,评价其在MRS中的代谢特点是否与肿瘤相一致。参考标准为整体组织的病理学分析。评价前列腺六分区内0.5cm3或更大体积病灶的诊断效能(T2WI)和检测敏感性(T2WI联合MRS)。结果 2位阅片者在T2WI上发现六分区内病灶的ROC曲线下面积分别为0.77和0.82。当病灶体积≥0.5cm3而<1cm3时,对于Gleason评分≤6的病灶的敏感度(阅片者1,0.44;阅片者2,0.61)较Gleason评分≥7者的敏感度(阅片者1,0.73,P=0.02;阅读者2,0.84,P=0.05)明显降低。对于体积≥1cm3的病灶,病灶的Gleason评分对敏感度并无显著的影响(Gleason评分≤6,阅片者1,0.83,阅片者2,1.0;Gleason评分≥7,分别为0.82,0.92;P≥0.07)。MRS的敏感性较低,与病灶体积或Gleason评分无明显联系。结论对于临床低风险前列腺癌的病人,在T2WI上发现体积<1cm3的病灶明显受Gleason评分的影响;对于体积≥1cm3的病灶检测明显优于小病灶,并且不受病灶Gleason评分的影响。在这类病人中,单独应用MRS的作用有限。

关键词：前列腺癌病人病灶体积 MRI 前瞻性研究

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糖尿病足的非增强MR成像血管灌注区域

国际医学放射学杂志 2015年第2期 188-189页

作者： j.zheng M.K.Hastings D.Muccigross Z.Fan F.Gao j.Curci 庞国栋 Mallinckrodt Institute of Radiology Cardiovascular Imaging Lab510 South Kingshighway Blvd. Campus Box 8225 St. LouisMO 63110 USA

摘要目的本研究的摘要目的是开发一种非对比MRI方法来评估以足部的血管灌注区域为基础的糖尿病足的骨骼肌肉灌注情况。方法对5例健康志愿者和5例无外周动脉疾

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