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GEANT4 simulation of gamma ray in a double-gap resistive plate chamber

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Chinese Physics B 2006年第1期15卷 108-115页

作者： j. T. rhee M. jamil Steve Hall y. j. jeon Institute for Advanced Physics Physics Department Konkuk University Seoul 143-701 Korea School of Science and Engineering Ballarat University Ballarat Victoria 3353 Australia Department of Chemistry Konkuk University Seoul 143-701 Korea

For more than 20 years nuclear physicists have used the GEANT code to simulate particle-matter interaction. In most recent version, GEANT4 is a toolkit for simulating the passage of particles though matter, which contains a complete range of functionality including tracking, geometry, physics models, and hits. In this article, an attempt to use GEANT4 to model a double-gap resistive plate chamber （RPC） with its improved efficiency is presented. The efficiencies of the double-gap RPC have been evaluated as a function of gamma energy range 0.005-1000MeV. A comparison to available previous simulation package GEANT3 data is also performed.

关键词： GEANT4 Monte Carlo simulation efficiency resistive plate chamber

基于深度学习的MRI影像组学无创识别HER2低表达状态可预测乳腺癌病人的无病生存期

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国际医学放射学杂志 2024年第2期 252-253页

作者： y.Guo X.T.Xie W.j.Tang S.y.Chen M.y.Wang y.H.Fan 侯唯姝

摘要目的建立基于深度学习的MRI影像组学（DLR）特征模型，以预测人表皮生长因子受体2(HER2)低表达状态，并进一步通过DLR模型验证乳腺癌病人在预后方面的

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So yung Choi Susan Win yoo jin Lee Shaohong yang Talin Haritunians Gil y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres j yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi Sy were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee yj and yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

阿尔茨海默病患者血液中生物指标的变化及其与全因痴呆事件的关系

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中国临床药理学杂志 2024年第18期40卷 2639-2639页

作者： LU y PIKE j R CHEN j 孟海峰

为评估临时血浆生物指标的变化及其与全因痴呆症、总体和社区居住成年人亚组之间的联系,课题组在美国社区动脉粥样硬化风险研究(ARIC)的1525例受试者中,用其中中年(1993~1995年,平均年龄58.3岁)和老年(2011~2013年,平均年龄76.0岁)受试... 详细信息

为评估临时血浆生物指标的变化及其与全因痴呆症、总体和社区居住成年人亚组之间的联系,课题组在美国社区动脉粥样硬化风险研究(ARIC)的1525例受试者中,用其中中年(1993~1995年,平均年龄58.3岁)和老年(2011~2013年,平均年龄76.0岁)受试者的存储样本测量血浆生物指标;紧随其后的是2016~2019年,平均年龄80.7岁。本研究还评估了中年风险因素(高血压、糖尿病、高血脂、冠心病、吸烟和体育活动)与血浆生物指标随时间变化的关系。在2011~2013年无痴呆症并在1993~1995年和2011~2013年进行了生物指标测量的亚人群(1339例)中评估了具有全因痴呆症事件的生物指标关联。

关键词：生物指标动脉粥样硬化痴呆症指标关联指标测量高血脂冠心病高血压

Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3y alloy prepared by selective laser melting and spark plasma sintering

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journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková S.Šašek j.Dittrich M.Knapek F.Lukáˇc D.Koutný j.jaroš R.Král Faculty of Mathematics and Physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of Plasma Physics of the Czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial Design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3y preparation by two modern powder metallurgy techniques–spark plasma sintering(SPS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SPS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 MPa in tension and compression and relatively good deformability of∼9%and∼21%for the SLM and SPS materials,*** corrosion resistance of the SPS material in 0.1 M NaCl solution was superior to the SLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SPS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium yttrium Powder metallurgy Microstructure Mechanical strength Corrosion resistance

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Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s jazan Region

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International journal of Mental Health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.Alharbi Ahmad y.Alqassim Mohammed A.Muaddi Najat H.Aldubayyan Rana I.Abuhadi Futon A.Akoor Sarah j.Mobarki Imtenan A.Oberi Ghaidaa H.Alharbi yara Ajeebi Adnan M.Alkhayat Hafiz Malhan Mohammed Bakkar Anwar M.Makeen Family and Community Medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal Medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia Hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince Mohammed bin Nasser Hospital(PMNH).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9(PHQ-9)–between March–May *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy jazan region Saudi Arabia

Improving colorectal cancer screening programs

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World journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar j Cordero Lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

新辅助化疗加卡瑞利珠单抗治疗局部晚期宫颈癌(NACI研究):一项多中心、单臂、2期试验

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中国临床药理学杂志 2024年第1期40卷 149-149页

作者： LI K Z CHEN j HU y j 王超群

引自:LI K Z,CHEN j,HU y j,et *** chemotherapy plus camrelizumab for locally advanced cervical cancer(NACI study):a multicentre,single-arm,phase 2 trial[j/OL].Lancet Oncol,2023.2023-12-01[2023-12-05].https://***/38048802/.局部晚期宫颈癌约占全球宫颈癌病例的37%,由于治疗选择有限,预后较差。免疫检查点抑制剂在新辅助治疗中可以解决这些挑战。本研究的目的是探讨新辅助化疗-免疫治疗局部晚期宫颈癌的有效性和安全性。在这项在中国8家三级医院进行的单臂2期试验中,招募了年龄在18~70岁的未经治疗的宫颈癌患者(ⅠB3、ⅡA2或ⅡB/ⅢC1r,肿瘤直径≥4 cm(国际妇产科学联合会,2018),东方肿瘤合作组织(Eastern Cooperative Oncology Group,ECOG)状态为0或1。符合条件的患者接受了一个周期的启动双重化疗(75~80 mg·m^(-2)顺铂,静脉注射,加上260 mg·m^(-2)白蛋白结合型紫杉醇,静脉注射),随后在第1天进行了两个周期的联合化疗(顺铂加白蛋白结合型紫杉醇),在第2天给予卡瑞利珠单抗(200 mg,静脉注射),治疗周期间隔为3周。

关键词：局部晚期宫颈癌白蛋白结合型紫杉醇新辅助化疗新辅助治疗联合化疗妇产科学 chemotherapy 免疫治疗

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Population Dynamics and Key Influencing Factors of Microthrix parvicella Caused Sludge Bulking

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Huanjing Kexue/Environmental Science 2024年第11期45卷 6766-6774页

作者： Su G.-X. Qi R. Xiao S.-M. Dou D.-C. Guo y.-X. Gao j. Tianjin Key Laboratory of Aquatic Science and Technology School of Environmental and Municipal Engineering Tianjin Chengjian University Tianjin 300384 China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Given the frequent occurrence of the sludge bulking phenomena caused by Microthrix parvicella（M. parvicella）overgrowth during the low-temperature period in the full-scale municipal wastewater treatment plant，the filamentous bacteria dynamics of the M. parvicella population were systematically investigated during the completed bulking period using the multi-dimensional integrated filamentous monitoring method combined with the molecular quantitative method. A lab-scale reactor was constructed and successfully simulated bulking phenomena under the low-temperature condition. The trend of dominant filamentous bacterial shift and the main influencing parameters were estimated during the bulking period，to verify the key factors for filament growth and extinction of the sludge bulking phenomenon in the full-scale plant. The results showed that the bulking-caused M. parvicella was characterized by significant changes in the diversity of filamentous bacteria，and the dominant filamentous bacterial succession was reflected in the competition between the skeleton filamentous bacteria Type 0092 and Type 0041 and M. parvicella. At lower temperatures，sludge loading was an important controlling factor for the competitive growth advantage of M. parvicella：when the temperature was lower（approximately 15°C），low sludge loading［0.05 kg·（kg·d）−1］could lead to the stabilized elevation of M. parvicella，and with the loading increased to 0.1 kg·（kg·d）−1 or more，M. parvicella populations showed a targeted decline despite the presence of the low temperature factor. © 2024 Science Press. All rights reserved.

关键词： filamentous bacteria Microthrix parvicella population dynamics sludge bulking sludge loading