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对比增强MRI预测局部进展期直肠癌新辅助放化疗后的T再分期

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国际医学放射学杂志 2023年第1期46卷 104-104页

作者： Q.y.Lu Z.Guan X.y.Zhang X.T.Li R.j.Sun Q.y.Li 陈红

摘要直肠癌新辅助放化疗(NCRT)后准确再分期,对于局部切除病人的选择至关重要。常规MRI中结合T2WI和DWI方法在再分期方面存在一定的局限性。目的确定对比

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单次与两次自体造血干细胞移植治疗血液肿瘤的远期结局比较:150例资料回顾

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中国组织工程研究与临床康复 2007年第42期11卷 8501-8505页

作者：靖彧于力刘海川姚善谦楼方定周绮李红华薄剑王全顺赵瑜朱海燕解放军总医院血液科北京市100853

目的:对没有与供者HLA配型相合的血液恶性肿瘤患者来说,自体造血干细胞移植不失为一种积极有效的治疗方法。评价比较单次与两次自体造血干细胞移植治疗血液肿瘤的效果。方法:①实验对象:选取1988～2001年解放军总医院血液科行自体造血... 详细信息

目的:对没有与供者HLA配型相合的血液恶性肿瘤患者来说,自体造血干细胞移植不失为一种积极有效的治疗方法。评价比较单次与两次自体造血干细胞移植治疗血液肿瘤的效果。方法:①实验对象:选取1988～2001年解放军总医院血液科行自体造血干细胞移植的150例患者,对本实验均知情同意。其中两次自体移植25例(两次骨髓移植3例、两次外周血造血干细胞移植1例、1次骨髓移植+1次外周血造血干细胞移植21例),单次自体移植125例(骨髓移植44例、外周血造血干细胞移植81例);急性非淋巴细胞白血病75例,急性淋巴细胞白血病43例,非霍奇金淋巴瘤22例,霍奇金淋巴瘤10例。②实验方法:应用化疗使白血病患者在移植前达到完全缓解,淋巴瘤患者要求移植前至少骨髓中没有肿瘤累及。动员化疗方案原则上采用对相应肿瘤有效的联合化疗方案,并适当增加剂量。骨髓移植及外周血造血干细胞移植患者回输单核细胞中位数分别为2.68×108/kg,4.20×108/kg。115例患者采用环磷酰胺/全身放疗方案,35例患者采用不含全身放疗的高剂量化疗方案。③实验评估:自体造血干细胞移植5年后血液肿瘤患者的无病存活率。结果:①急性非淋巴细胞白血病:69例患者单次移植,5年无病存活率58.0%(40例),复发率29.0%(20例),移植相关死亡率13.0%(9例)。6例患者两次移植,其中1例M5患者复发死亡,5例无病存活。②急性淋巴细胞白血病:29例患者单次移植,5年无病存活率34.5%(10例),复发率34.5%(10例),移植相关死亡率31.0%(9例)。14例患者两次移植,5年无病存活率42.9%。③非霍奇金淋巴瘤:18例患者单次移植,5年无病存活率61.1%(11例),复发率16.7%(3例),移植相关死亡率22.2%(4例)。4例患者两次移植,其中1例CR1期患者在首次移植后21个月复发,化疗获得PR后行第2次自体造血干细胞移植,17个月后复发死亡;其余3例均无病存活。④霍奇金淋巴瘤:9例患者单次移植,5年无病存活率100%。1例患者行两次移植,首次移植前13个化疗疗程未缓解,行自体外周血造血干细胞移植后达到部分缓解,9个月后行自体骨髓移植后完全缓解,无病存活。结论:①自体造血干细胞移植是治疗血液肿瘤安全有效的方法。②自体造血干细胞两次移植5年无病存活率明显优于单次移植效果,可改善血液肿瘤患者预后。

关键词：造血干细胞移植自体血液肿瘤 5年无病存活率

The roles of BmSRF gene in patterning the wing of silkworm,Bombyx mori

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The roles of BmSRF gene in patterning the wing of silkworm,B...

蒙古中南部地区地震各向异性及地球动力学意义

中国蚕学会第六届家蚕和柞蚕遗传育种学术研讨会

作者： X.-L.Tong1 2 F.-y.Dai2 j.Chen2.L Qiao2.Z.Zhang1 2 Q.-y.Xia1 2 C.Lu2 and Z.-H.Xiang2 1 Institute of Agriculture and Life Science Chongqing University Chongqing 400030 China 2 College of Biotechnology Institute of Sericulture and System Biology Southwest University Chongqing 400716 China

Serum response factor（SRF） is an ancient and evolutionarily conserved member of the MADS box family of transcriptional regulators that regulates a wide range of genes involved in cell growth,migration,cytoskeletal organization,and ***,we isolated the homolog of the vertebrate SRF in silkworm,Bombyx mori,referred to as *** of expression profiles showed that BmSRF was widely expressed in silkworm tissues,including the ovary,testis,head,midgut,fat body,wing disc,middle（MSG）,and posterior（PSG） silk glands,but we didn’t detected its expression in anterior（ASG）,epiderm,malpighian tubule and *** the wing development stage from the 5th instar larva to the first day adult,the BmSRF gene expressed persistently and exhibited the expression peak at the onset of the *** examine the function of BmSRF in the wing development of silkworm,we performed gene silencing by injected the BmSRF dsRNAs into wing disc on the first day of 5th instar（V1）,and then the treated silkworms were reared under standard conditions and developed to *** of the adults treated by the BmSRF dsRNA showed abnormal phenotype which exhibit additional veins and blister on the ***,more sockets and scales were present on the wings in the abnormal *** phenomenon may be resulted from the increased *** is well known that the tracheae which are scabbarded in the veins can transport the oxygen,and the oxygen has been shown to play a key role in the formation of *** conclusion,our results demonstrated that BmSRF plays an important role during wing development in *** silencing of BmSRF expression in silkworm produced additional veins and blistered wings.

关键词： BmSRF Bombyx mori expression pattern RNA interference

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世界地震译丛 2019年第6期50卷 536-548页

作者： Z.y.Qiang Q.j.Wu y.H.Li M.T.Gao S.Demberel M.Ulzibat U.Sukhbaatar L.M.Flesch 强正阳(译) 吴庆举(校) 不详中国地震局地球物理研究所

布设在蒙古中南部地区的69个宽频带流动台站为期两年的观测资料为我们研究该区域各向异性形成机制提供了很好的机会。使用远震SKS分裂方法测量得到的绝大多数各向异性快波方向为北西—南东向,并且具有很大的延迟时间(其中6个台站大于2.... 详细信息

布设在蒙古中南部地区的69个宽频带流动台站为期两年的观测资料为我们研究该区域各向异性形成机制提供了很好的机会。使用远震SKS分裂方法测量得到的绝大多数各向异性快波方向为北西—南东向,并且具有很大的延迟时间(其中6个台站大于2.0s)。我们认为这种各向异性应该与软流圈流动有关。而局部区域快波方向的改变可能与软流圈流动受西伯利亚克拉通岩石层根的阻挡发生偏折有关。戈壁沙漠地区观测到的各向异性延迟时间比较小,快波方向为北东—南西向,与该区域主要断层和构造走向平行,我们认为这可能是岩石层变形的反映。此外,在肯特山南部观测到了大量无效分裂结果,推测该区域存在小尺度地幔上涌。

关键词：地震各向异性蒙古软流圈流

基于超声的胰腺实性良恶性肿瘤预测模型的建立与验证

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国际医学放射学杂志 2023年第1期46卷 121-121页

作者： j.y.Huang j.yang j.M.Ding j.Zhou R.yang j.W.Li 刘月

摘要目的探讨常规超声和超声造影(CEUS)对胰腺实性恶性肿瘤(MSPL)和良性肿瘤(BSPL)的鉴别诊断能力,并建立一种简易实用的列线图模型。方法研究经机构伦理委

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超越侧支：脑衰弱还可提高急性缺血性卒中临床预后的预测

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国际医学放射学杂志 2022年第6期45卷 746-746页

作者： j.y.Zhou y.B.Shi C.Xia C.Q.Lu T.y.Tang T.Lu 巴伟丽

摘要目的旨在研究脑小血管疾病（SVD）在决定急性缺血性卒中（AIS）后临床预后方面的额外意义。方法回顾性分析了 2018 年 10 月 1 日—2021 年 10 月 31 日期间在症状

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基于无创性成像的影像组学特征和随机森林模型识别肺腺癌中的EGFR突变

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国际医学放射学杂志 2019年第6期 744-744页

作者： T.y.jia j.F.Xiong X.y.Li W.yu Z.y.Xu X.W.Cai 张羽 Department of Radiation Oncology Shanghai Chest Hospital Shanghai Jiao Tong University

摘要目的表皮生长因子受体(EGFR)的酪氨酸激酶抑制剂(TKI)敏感突变在肺腺癌的治疗中必不可少。手术和穿刺活检对检测EGFR存在一定的风险性,为解决该问题引入

关键词：肺腺癌影像组学随机森林模型

Exploring the synthesis conditions to control the morphology of gold-iron oxide heterostructures

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Nano Research 2019年第8期12卷 1781-1788页

作者： Pablo Tancredi Luelc Souza da Costa Sebastian Calderon Oscar Moscoso-Londono Leandro M. Socolovsky Paulo j. Ferreira Diego Muraca Daniela Zanchet Marcelo Knobel Laboratory of Amorphous Solids INTECINFaculty of EngineeringUniversity of Buenos Aires - CONICETBuenos AiresCP C1063ACVArgentina Department of Inorganic Chemistry Institute of ChemistryUniversity of Campinas (UNICAMP)CP615413083-970CampinasSPBrazil Brazilian Nanotechnology National Laboratory (LNNano) Rua Giuseppe Maximo Scolfaro 10000CampinasSPBrazil International Iberian Nanotechnology Laboratory (INL) Av. Mestre Jose Veiga s/n4715-330 BragaPortugal “Gleb Wataghin” Institute of Physics University of Campinas (UNICAMP)CEP 13083-859CampinasSPBrazil Autonomous University of Manizales Antigua Estacion del FerrocarrilManizalesCP 170001Colombia Facultad Regional Santa Cruz Universidad Tecnoldgica Nacional - CIT Santa Cruz (CONICET)- Av delos Inmigrantes 555Rio GallegosSanta CruzArgentina Materials Science and Engineering Program The University of Texas at AustinAustinTexas 78712USA

Gold-iron oxide nano-heterostructures with a clear and well-defined morphology were prepared via a seed-assisted method. The synthesis process and the events of heterogeneous nucleation during the decomposition of the iron precursor were carefully studied in order to understand the mechanism of the reaction and to tailor the architecture of the fabricated heterostructures. When employing Au seeds of 3 and 5 nm, nanoparticles with a dimer-like morphology were produced due to the occurrence of a single iron oxide nucleation event. Otherwise, multi-nucleation events could be favored by two mechanisms:(i) by the incorporation of a reducing agent and the slowing down of the heating protocol, leading to a core-shell system;(ii) by the increase of the Au seed size to 8 nm, leading to a flower-like system. Further increase of the Au seed size to 12 nm using similar synthesis conditions promotes the homogeneous nucleation and growth of the iron oxide phase, without formation of heterostructures. An in-depth study was performed on the gold-iron oxide heterostructures to confirm the epitaxial growth of the oxide domain over the Au seed and to analyze the elemental distribution of the components within the heterostructures. Finally, it was found that the modification of the plasmonic properties of the Au nanoparticles are strongly influenced by the architecture of the heterostructure, with a more pronounced damping effect for the systems produced after multi-nucleation events.

关键词： nanoparticles gold-iron oxide heterostructures heterogeneous nucleation epitaxial growth HR-microscopy

Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： Henry y.jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel jonathan Cools-Lartigue Stephen Gowing julie Berube Betty Giannias France Bourdeau Carlos HFChan jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri Thoracic and Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada Department of Experimental Surgery and Department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada Department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA Department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to determine the effects of NOD1 on ***1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate ***130,a specific NOD1 inhibitor,was used to block C12-iE-DAP *** knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus ***,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase *** data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell ***,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with ***,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and *** effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)*** is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.

关键词： NOD1 iE-DAP ML130 colon cancer metastasis cancer-extracellular matrix adhesion cancer migration p38 MAPK activation intravital microscopy survival analysis