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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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journal of Energy Chemistry 2025年第1期100卷 317-326页

作者： Binglu Deng jie shen jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng Liu School of Materials Science and Hydrogen Energy Foshan University School of Chemistry and Chemical Engineering Guangzhou University Guangdong Key Laboratory for Hydrogen Energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen shen Zhenghao Wu xingying Lan Yi xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An xiao Huang Qian Zhang Chenhao Zhang Tao shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong Yang Haochen shen xiaoming xiao Zhichao Li Qi Zhou Wei Yang Bin jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

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低空经济的内涵、特征和运行模式

新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 108-117,F0002页

作者：沈映春北京航空航天大学公共管理学院北京100083

低空经济作为低空飞行活动与产业融合的新型综合性经济形态,具有空间立体性、区域依赖性、数字生态性、产业融合性以及辐射带动性等特征。党和政府高度重视发展低空经济,将其确定为国家战略性新兴产业,各地加紧布局,发展势头良好。但具... 详细信息

低空经济作为低空飞行活动与产业融合的新型综合性经济形态,具有空间立体性、区域依赖性、数字生态性、产业融合性以及辐射带动性等特征。党和政府高度重视发展低空经济,将其确定为国家战略性新兴产业,各地加紧布局,发展势头良好。但具体实践中仍存在发展低空经济的体制机制不畅、技术创新支持不足、新型基础设施不全、产业领域需不断拓展等问题。针对上述问题,文本依据螺旋理论,提出“政产学研金服用”的低空经济开放式创新生态模式。

关键词：低空经济新质生产力战略性新兴产业开放式创新生态运行模式

ON THE MONTE CARLO SIMULATION OF NORMAL GRAIN GROWTH

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Acta Metallurgica Sinica(English Letters) 2008年第4期21卷 282-288页

作者： Y.T. Liu x.j. Guan x.M. shen x.F. Ma L.j. Wang School of Materials Science and Engineering Shandong University Jinan 250061 China

The microstructures and their kinetics of normal grain growth are simulated using different Monte Carlo （MC） algorithms. Compared with the relative figures and the theoretical normal grain growth exponents of n =0.5, the effects of some factors of MC algorithm, i.e. the lattice types, the methods of selecting lattice sites, and the neighbors selection for energy calculations, on the simulation results of grain growth are studied. Two methods of regression were compared, and the three-parameter nonlinear regression is much more suitable for fitting the grain growth kinetics. A better model with appropriate factors included triangular lattice, the attempted site randomly selected, and the first and second nearest neighbors for energy calculations is obtained.

关键词： Grain growth Microstructure Monte Carlo method Computer simulation Grain growth kinetics Nonlinear regression

Bulk nanocrystalline W-Ti alloys with exceptional mechanical properties and thermal stability

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journal of Materials Science & Technology 2022年第19期114卷 16-28页

作者： H.x.xue x.C.Cai B.R.Sun x.shen C.C.Du x.j.Wang T.T.Yang S.W.xin T.D.shen Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China CSSC 723rd Research Institute China State Shipbuilding Corporation LimitedYangzhou 225000China

Nanocrystalline(NC)W metals and alloys often exhibit higher radiation tolerance and strength than their coarse-grained ***,their thermal stability is low,making it difficult to achieve bulk NC W metals and alloys by consolidation using conventional techniques such as pressure-less sintering,hot-explosive-compaction sintering,and spark plasma *** we report the synthesis and mechanical properties of bulk NC W_(100-x)Ti_(x)(x=10 at.%-30 at.%)alloys prepared by consolidating mechanically alloyed NC powders under a high-temperature/high-pressure *** 20 at.%-30 at.%Ti largely improves the sinterability of NC W-Ti alloy *** room-temperature microhardness and compressive yield strength of consolidated bulk NC W_(80)Ti_(20) alloy are∼16.9 and 6.0 GPa,respectively,which are mainly caused by grain boundary strengthening and significantly higher than those of previously reported W and W *** ultimate compressive strength of bulk NC W_(80)Ti_(20) measured between 900 and 1100°C deceases with increasing *** behavior can be explained by the activation of Rachinger grain boundary *** grain growth is observed in bulk NC W_(80)Ti_(20) after compression at 1000°*** calculation suggests that it is the segregation of Ti at grain boundaries that decreases the specific grain boundary free energy and makes the NC W_(80)Ti_(20) alloy thermodynamically stable.

关键词： Nanocrystalline W-Ti alloys Segregation Grain boundary energy Strength Hardness

Investigation on 3Dt wake flow structures of swimming bionic fish

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Acta Mechanica Sinica 2012年第5期28卷 1494-1508页

作者： G.-x.shen G.-K.Tan G.-j.Lai Fluid Mechanics Institute Beihang University

A bionic experimental platform was designed for the purpose of investigating time accurate three-dimensional flow field, using digital particle image velocimetry （DSPIV）. The wake behind the flapping trail of a robotic fish model was studied at high spatial resolution. The study was performed in a water channel. A robot fish model was designed and built. The model was fixed onto a rigid support frame- work using a cable-supporting method, with twelve stretched wires. The entire tail of the model can perform prescribed motions in two degrees of freedom, mainly in carangiform mode, by driving its afterbody and lunate caudal fin respectively. The DSPIV system was set up to operate in a trans- lational manner, measuring velocity field in a series of parallel slices. Phase locked measurements were repeated for a number of runs, allowing reconstruction of phase average flow field. Vortex structures with phase history of the wake were obtained. The study reveals some new and complex three-dimensional flow structures in the wake of the fish, including ＂reverse hairpin vortex＂ and ＂reverse Karman S-H vortex rings＂, allowing insight into physics of this complex flow.

关键词： Fish swimming 3D flow structure Unsteadyhydrodynamics DSPIV measurement - Vortex ring