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冷水珊瑚丘的高分辨率成像

海洋地质 2019年第2期35卷 60-76页

作者： Luis A.Conti Aaron Lim Andrew j.wheeler 曲佳(翻译) 张伙带(校对) 不详广州海洋地质调查局技术方法所

冷水珊瑚(CWC)丘是一种生物成因的持久的形态结构,主要由钙化的冷水珊瑚和半远洋沉积物组成,形成复杂的深海微生物栖息地。它发育于全球范围内,尤其在欧洲大西洋边缘。本文利用高分辨率图像识别爱尔兰Porcupine Seabight海岸Piddington... 详细信息

冷水珊瑚(CWC)丘是一种生物成因的持久的形态结构,主要由钙化的冷水珊瑚和半远洋沉积物组成,形成复杂的深海微生物栖息地。它发育于全球范围内,尤其在欧洲大西洋边缘。本文利用高分辨率图像识别爱尔兰Porcupine Seabight海岸Piddington冷水珊瑚丘的冷水珊瑚种分布与分区特征。本文利用基于海洋对象的图像分析方法和不同的机器学习分类方法(决策树、逻辑回归和深度神经网络)对分辨率高达2 mm的珊瑚礁视频和ROV釆集的多波束数据进行分析,研究珊瑚骨架的空间结构特征和冷水珊瑚丘的环境因素。研究结果显示,利用上述方法能进行精确的定量预测,珊瑚骨架和海绵不均匀地覆盖于冷水珊瑚丘的局部地方,珊瑚覆盖率为14.5%(其中活珊瑚约2%,死珊瑚约12.5%),海绵覆盖率约3.5%。这是首次对整个冷水珊瑚丘上的活珊瑚和死珊瑚骨架以及海绵进行量化。该方法可用于栖息地研究及保护,为碳收支评估提供量化工具,并为评估冷水珊瑚丘的变化提供基准。该方法可改进应用于其他栖息地。

关键词：深度神经网络高分辨率成像决策树高分辨率图像图像分析方法深海微生物空间结构特征环境因素

Post-compression of high-energy,sub-picosecond laser pulses

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High Power Laser Science and Engineering 2023年第2期11卷 117-126页

作者： P.-G.Bleotu j.wheeler S.Yu.Mironov V.Ginzburg M.Masruri A.Naziru R.Secareanu D.Ursescu F.Perez j.De Sousa D.Badarau E.Veuillot P.Audebert E.Khazanov G.Mourou LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Doctoral School of Physics University of BucharestBucharest-MagureleRomania Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania IZEST Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Independent Researcher Bourg-La-ReineFrance Federal Research Center Institute of Applied Physics of the Russian Academy of Sciences(IAP RAS) Nizhny NovgorodRussia

The post-compression technique based on self-phase modulation of high-energy pulses leads to an increase in achievable peak power and ***,the pulses considered in experiments have been less than 100 fs in ***,the method is applied to the ELFIE laser system at the LULI facility,for a pulse of 7 j energy and an initial measured duration of 350 fs.A 5-mm-thick fused silica window and a 2 mm cyclic-olefin polymer were used as optical nonlinear *** 9 cm diameter beam was spectrally broadened to a bandwidth corresponding to 124 fs Fourier-limited pulse duration,and then it was partly post-compressed to 200 *** measuring the spatial spectra of the beam fluence,a uniform gain factor of 4 increase in the fluctuations over the studied range of frequencies is observed,due to small-scale self-focusing.

关键词： high-power laser nonlinear pulse interaction post-compression self-phase modulation

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Study of the wall adhesive tensile contact of moist iron ore bulk solids

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Particuology 2020年第3期18卷 67-75页

作者： Tao Fang Wei Chen jens Plinke Craig wheeler Alan Roberts School of Civil Engineering East China Jiaotong UniversityNanchang 330013China School of Engineering The University of NewcastleCallaghan 2308Australia

The adhesive tensile stress between moist bulk iron ore solids and wall surfaces are critical to control and avoid blockage in large throughput material handling *** this study,an experimental system was designed to investigate the adhesive tensile contact between a range of iron ore materials and wall lining *** contact mechanism between the material specimen and the wall surface was initially *** experimental results indicated that the adhesive tensile stress is dependent on both the moisture content and the applied major consolidation stress,with the former exhibiting more significant contribution to increasing the magnitude of *** surface roughness of the wall showed a negligible effect in determining the adhesive tensile ***,the iron ore sample with a higher fines content was observed to be able to achieve a higher adhesive tensile stress compared to the coarse ***,the insights resulting from the study demonstrated practical applicability through measures such as blending and/or beneficiation,which reduce the adhesive tensile stress and minimise blockages.

关键词： Wet sticky material Adhesive tensile stress Wall linings Liquid bridge force Capillary stress Soil texture

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Generic functional modelling of multi-pulse auto-transformer rectifier units for more-electric aircraft applications

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Chinese journal of Aeronautics 2018年第5期31卷 883-891页

作者： Tao YANG Serhiy BOZHKO Patrick wheeler Shaoping WANG Shuai WU Department of Electrical and Electronic Engineering University of Nottingham School of Automation Science and Electrical Engineering Beihang University

The Auto-Transformer Rectifier Unit（ATRU） is one preferred solution for high-power AC/DC power conversion in aircraft. This is mainly due to its simple structure, high reliability and reduced k VA ratings. Indeed, the ATRU has become a preferred AC/DC solution to supply power to the electric environment control system on-board future aircraft. In this paper, a general modelling method for ATRUs is introduced. The developed model is based on the fact that the DC voltage and current are strongly related to the voltage and current vectors at the AC terminals of ATRUs. In this paper, we carry on our research in modelling symmetric 18-pulse ATRUs and develop a generic modelling technique. The developed generic model can study not only symmetric but also asymmetric ATRUs. An 18-pulse asymmetric ATRU is used to demonstrate the accuracy and efficiency of the developed model by comparing with corresponding detailed switching SABER models provided by our industrial partner. The functional models also allow accelerated and accurate simulations and thus enable whole-scale more-electric aircraft electrical power system studies in the future.

关键词： Asymmetric transformer Functional modelling More-Electric Aircraft Multi-pulse rectifier Transformer rectifier unit

Protein profiles of enzymatically isolated rumen epithelium in sheep fed a fibrous diet

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journal of Animal Science and Biotechnology 2019年第2期10卷 449-462页

作者： j.j.Bond A.j.Donaldson j.V.F.Coumans K.Austin D.Ebert D.wheeler V.H.Oddy NSW Department of Primary Industries Extensive Livestock Industry CentreUniversity of New EnglandTrevenna RdArmidaleNSW 2351Australia School of Rural Medicine University of New EnglandArmidaleNSW 2351Australia NSW Department of Primary Industries Orange Agricultural InstituteOrangeNSW 2800Australia.

Background: The rumen wall plays a major role in efficient transfer of digested nutrients in the rumen to peripheral tissues through the portal venous system. Some of these substrates are metabolised in the epithelium during this process. To identify the specific proteins involved in these processes, we used proteomic technologies. Protein extracts were prepared from ventral rumen tissue of six sheep fed a fibrous diet at 1.5× maintenance energy *** a newly developed method, we were able to enzymatically isolate the epithelial cells from underlying tissue layers, thus allowing cytosol and membrane fractions to be independently analysed using liquid chromatography tandem mass spectrometry(LC MS/MS).Results: Using our procedure we identified 570 epithelial proteins in the Ovis aries sequence database. Subcellular locations were largely cytosolic(n = 221) and extracellular(n = 85). However, a quarter of the proteins identified were assigned to the plasma membrane or organelle membranes, some of which transport nutrients and metabolites. Of these 91 were transmembrane proteins(TMHMM), 27 had an N-terminal signal peptide(signalP) and TMHMM motif,13 had a glycosylphosphatidylinositol(GPI) anchor and signalP sequence, 67 had beta(β) strands or 17 β strands and a transit peptide sequence, indicating the identified proteins were integral or peripheral membrane proteins. Subunits of the 5 protein complexes involved in mitochondrial cellular energy production were well represented. Structural proteins(15%), proteins involved in the metabolism of lipids and proteins(26%) and those with steroid or cytokine action were a feature of the ***: Our research has developed a procedure to isolate rumen epithelium proteins from the underlying tissue layers so that they may be profiled using proteomic technologies. The approach improves the number of proteins that can be profiled that are specific to the epithelium of the rumen wall. It provides new insights

关键词： Epithelium Metabolism Nutrition Proteome Rumen Sheep

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times