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超高分辨光子计数CT评估冠状动脉支架通畅性：与有创法冠状动脉造影的对照研究

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国际医学放射学杂志 2024年第05期 619-620页

作者： M.T.Hagar M.Soschynski R.Saffar M.F.Molina-Fuentes j.weiss A.Rau 苗彦许振华

目的与有创冠状动脉造影（ICA）对照，评价超高分辨光子计数CT血管成像（UHR PCD-CTA）检测冠状动脉支架通畅性的准确度。方法前瞻性纳入2022年8月—2023

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The effect of active sitting on trunk motion

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journal of Sport and Health Science 2014年第4期3卷 333-337页

作者： Henry Wang Kaitlyn j.weiss Mason C.Haggerty jacqueline E.Heath School of Physical Education Sportand Exercise ScienceBall State UniversityMuncieIN 47306USA

Background： Prolonged sitting is a risk factor for low-back pain. The primary purpose of this study is to determine if prolonged active sitting will result in increased trunk motion. Methods： Fifteen healthy female participants volunteered to sit for 30 vain on each of three surfaces including an air-cushion, a stability ball, and a hard surface. Trunk motion was monitored using a Vicon motion capture system, and foot center of pressure was collected with two AMTI force plates. Results： Our findings indicated that the average speed of the trunk center of mass significantly increased with seating surface compliance. There were significant differences in fight and left foot centers of pressure in the antero-posterior direction between the ball and air-cushion conditions and the ball and chair conditions. Conclusion： Active sitting results in increased trunk motion and could have a positive effect on low-back health.

关键词： Active sitting Air-cushion Center of pressure Low-back pain Stability ball Trunk motion

Membrane-Anchored Metalloproteinases, Angiogenesis and Cancer

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Membrane-Anchored Metalloproteinases, Angiogenesis and Cance...

Lessons learned from hepatocellular carcinoma may cause a paradigm shift in intraductal papillary mucinous neoplasms:a narrative review and discussion of conceptual similarities in tumor progression and recurrence

第十五届国际药理学大会

作者： Stephen j.weiss University of Michigan

＜正＞ Cancer cells express tissue-invasive activity while simultaneously signaling en-dothelial cells to engage an angjogenic response. Despite decades of conjecture, the mechanisms by which matrix barriers are negotiated remain undefined as more than 500 proteases have been identified in mammalian genomes. To define the mechanisms that underlie pro-invasive activity, we have developed a series of ex vivo models which recapitulate each of the key steps involved in cancer progression and angjogenesis. Herein, we demonstrate that tissue-invasive activity is solely dependent on a sub-family of membrane-anchored matrix metalloproteinases （MMPs）. termed the MT-MMPs,which regulate tumor cell invasion and proliferation as well as the neovascularization process. Interestingly, while MT-MMPs are synthesized as inactive zymogens. the proteinases are processed to active enzymes in the constitutive secretory pathway by an intracellular mechanism involving one or more members of the proprotein convertases, a distinct gene family of subtilisin-like serine proteinases. Therapeutic interventions directed against this enzyme couple could prove useful in the control of tissue-destructive and/or invasive disease states.

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journal of Pancreatology 2022年第1期5卷 36-40页

作者： Georgios Antonios Margonis Nikolaos Andreatos jane Wang Matthew j.weiss Christopher L.Wolfgang Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY Department of Internal Medicine and Taussig Cancer Institute Cleveland ClinicClevelandOH Department of Surgery University of California San FranciscoSan FranciscoCA Department of Surgery Northwell Health Cancer Institute and Zucker School of Medicine at HofstraL ake Success Department of Surgery NYU Grossman School of MedicineNew YorkNYUSA

Although the natural history of recurrence/progression in patients with intraductal papillary mucinous neoplasms (IPMN) of the pancreas has not been studied thoroughly, the three principal mechanisms have been identified: (a) presence of residual disease at the transection margin, (b) presence of intraductal/intraparenchymal metastases and (c) development of new primary lesions. Mechanisms (a) and (b) result in metastatic lesions that are genetically related to the primary, while new primary lesions (mechanism c) are genetically distinct. Interestingly, recurrence/progression in IPMN displays conceptual parallels with the well-established paradigm of disease recurrence in patients with hepatocellular carcinoma (HCC). Specifically, patients with HCC may also develop recurrent tumors due to microscopic residual disease/intrahepatic metastasis which are genetically similar to the primary while the development of genetically unrelated, de novo HCC after curative-intent resection is also common. The latter has been attributed to the presence of a widespread genetic abnormality ( "field defect" ) in the liver (ie, cirrhosis). Given the conceptual similarities between IPMN and HCC, a pancreatic "field defect" may also be hypothesized to exist. This review does not suggest that HCC and IPMN have identical pathogeneses, but rather that they have conceptual similarities in tumor recurrence/progression;thus, lessons learned from HCC could be applied to IPMN research and subsequent management. Conceptual similarities in tumor progression and recurrence may also be observed between IPMN and other malignancies. However, HCC was selected because it is well studied and can serve as a paradigm.

关键词： Field defect Hepatocellular carcinoma Intraductal papillary mucinous neoplasm Progression Recurrence

Impact and clinical usefulness of genetic data in the surgical management of colorectal cancer liver metastasis: a narrative review

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Hepatobiliary Surgery and Nutrition 2020年第6期9卷 705-716页

作者： Georgios Antonios Margonis Martin E.Kreis jaeyun jane Wang Carsten Kamphues Christopher L.Wolfgang Matthew j.weiss Department of Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Department of General Visceral and Vascular SurgeryCharite Campus Benjamin FranklinBerlinGermany Department of Surgery Northwell Health Cancer Institute and Zucker School of MedicineLake SuccessNYUSA

Importance:In patients who undergo surgery for colorectal cancer liver metastases(CRLM),a number of somatic mutations have been associated with worse overall(OS)and recurrence-free survival(RFS).Although useful,an association with prognosis does not necessarily equate to an impact on surgical ***:The aim of this review was to investigate whether the best-studied somatic mutations impact surgical management of CRLM by informing:(I)post-hepatectomy surveillance;(II)selection of surgical technique;(III)selection of optimal margin width;and(IV)selection of patients for ***,we discuss the refinement of genetic data from overall mutation status to specific variants,as well as lesser studied somatic *** Review:We conducted a computerized search using PubMed and Google Scholar for reports published so far,using mesh headings and keywords related to genetic data and ***:Genetic data may impact surgical management of CRLM in three ***,KRAS mutations can predict lung ***,KRAS mutations may help tailor margin ***,KRAS mutations may help tailor surgical ***:Although genetic data may impact post-hepatectomy surveillance,selection of surgical technique and optimal margin width,their use to guide surgical selection remains elusive,as the data cannot support denying surgery to patients according to their somatic mutation profile.

关键词： Somatic mutations KRAS BRAF P53 SMAD-4 PIK3CA colorectal liver metastases

The Effect of Granulocyte Macrophage-Colony Stimulating Factor upon the Induction of Peripheral Blood Dendritic and Natural Killer Cells When Given Simultaneously with a Slow Continuous Doxorubicin Infusion

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journal of Cancer Therapy 2017年第7期8卷 637-644页

作者： Arthur j.weiss Irwin L.Stoloff Antonio C.Simoes Division of Medical Oncology Thomas Jefferson School of MedicinePhiladelphiaUSA Division of Surgery North Penn HospitalLandsdaleUSA

It has been demonstrated that it is safe to give Gm-Csf, together with Doxorubicin, by continuous intravenous infusion, thereby substantially increasing the amount of Doxorubicin administered to the average patient, and assuring that each patient receives an individually-determined safe and maximal amount of drug. It is known that Gm-Csf is a potent inducer of components that are major factors in an immunologic attack upon neoplasms. For that reason, we thought it would be worth evaluating in 4 patients’ surface markers of dendritic precursor cells, dendritic cells [DC], and natural killer [NK] cells during the infusion. While there was substantial variation in individual responses, all 4 patients receiving Gm-Csf developed persistent marked increases in cells with each of these markers. The significance of these findings will be discussed.

关键词： Doxorubicin Infusion Dendritic Killer Cells

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肝切除术治疗结直肠癌肝转移的患者选择

中国普通外科杂志 2013年第7期22卷 811-817页

作者： Matthew j.weiss Michael I.D'Angelica 夏发达姜晖美国纽约州凯特琳癌症中心外科不详

1简介结直肠癌最常见的血行转移器官为肝脏。大约有一半的患者在结直肠癌病程中发展为肝转移癌[1]。针对肝转移病灶,肝切除术仍是唯一可能的根治性治疗,其5年生存率约50%[2],10年治愈率接近20%[3]。此外,有效的系统和局部化疗结合手术... 详细信息

1简介结直肠癌最常见的血行转移器官为肝脏。大约有一半的患者在结直肠癌病程中发展为肝转移癌[1]。针对肝转移病灶,肝切除术仍是唯一可能的根治性治疗,其5年生存率约50%[2],10年治愈率接近20%[3]。此外,有效的系统和局部化疗结合手术切除可以达到在未治愈的情况下使患者长期存活[4]。因此,

关键词：肝切除术结直肠肿瘤肿瘤转移综述文献

Clinicopathological features and surgical outcomes of resected functional pancreatic neuroendocrine tumors: a single institution experience

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journal of Pancreatology 2019年第2期2卷 29-34页

作者： Ammar A.javed Alina Hasanain Aleezay Haider George jones Zunaira N.javed Kevin Soares Richard A.Burkhart john L.Cameron Matthew j.weiss Christopher L.Wolfgang jin He Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21287USA

Background:Functional pancreatic neuroendocrine tumors(f-PanNETs)are rare tumors of the pancreas that are associated with excess hormone production.A majority of literature available on these tumors is limited to case reports and small series and discusses a particular ***,we report the clinicopathological features and outcomes of all f-PanNETs from a high-volume pancreatectomy ***:A prospectively maintained database was used to identify patients who underwent resection for f-PanNETs between january 1995 and December *** were stratified by the type of f-PanNET,and their clinicopathological features and outcomes were analyzed and ***:We identified 69 patients with a mean age of 52±16 years,and the majority were female(62%).The most common type of f-PanNET were insulinomas(70%)followed by gastrinomas(15%),and vasoactive intestinal peptidomas(VIPomas)(10%).There was considerable heterogeneity in the presenting *** with insulinomas presented with smaller tumors compared to the other *** disease was most frequent in patients with VIPomas(71%),and gastrinomas(50%).The median overall survival(OS)was 7.4 *** Ki-67 and age>65 years were associated with poorer *** was observed in 8 patients(12%)and was most frequent in patients with *** was associated with a poorer OS(P=.012).Conclusion:f-PanNETs are exceedingly rare and present with a wide variety of symptoms,histopathological findings,and *** resection can help achieve good long-term survival.

关键词： Functional tumor Outcome Pancreatic neuroendocrine tumor

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动物界的爱因斯坦们

新东方英语（中学版） 2007年第4期 56-59页

作者： Michael j.weiss 咏希

新的研究表明:猴子可以进行艺术创作,海豚可以互相聊天,动物智力王国有更多“佼佼者”。提到智力,人类是动物王国中的佼佼者。或者我们是这样告诉自己的。

关键词：爱因斯坦动物界艺术创作人与动物智力研究者人类学家猴子动物园绘画技巧