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病毒唑对EHF患者特异性体液免疫反应的影响

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Virologica Sinica 1987年第3期 41-44页

作者：肖书渊朱宝莲郑志明向近敏 j.Meegan j.w.Leduc j.w.huggins T.Cosgriff j.I.Smith 湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所美国军事医学科学院传染病研究所美国军事医学科学院传染病研究所美国军事医学科学院传染病研究所美国军事医学科学院传染病研究所美国军事医学科学院传染病研究所武汉武汉武汉武汉美国美国美国美国美国

本文采用微量酶联免疫吸附技术对病毒唑-安慰剂对照治疗流行性出血热(EHF)双盲法临床试验的EHF患者血清特异性IgG及IgM抗体进行了系统的动态观察并比较了两组患者抗体反应水平的差异,发现病毒唑治疗组两种抗体水平均较安慰剂对照组为低(... 详细信息

本文采用微量酶联免疫吸附技术对病毒唑-安慰剂对照治疗流行性出血热(EHF)双盲法临床试验的EHF患者血清特异性IgG及IgM抗体进行了系统的动态观察并比较了两组患者抗体反应水平的差异,发现病毒唑治疗组两种抗体水平均较安慰剂对照组为低(IgG,P<0.001;IgM,P<0.05),说明患者用药后体内特异性体液免疫反应水平有所下降,从而减少免疫复合物的形成,有利于病情改善。

关键词：病毒唑患者抗体滴度特异性体液免疫反应 IgM 病毒哩循环免疫复合物 IgG 病毒抗原 EHF

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病毒唑对EHF患者白细胞和血小板的影响

中国免疫学杂志 1988年第5期 33-34页

作者：张天明,向近敏,牛春生,周文华,张天衡,j.w.huggins,T.M.Cosgriff,j.I.Smith 湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所美国陆军传染病医学研究所美国陆军传染病医学研究所美国陆军传染病医学研究所武汉武汉武汉武汉武汉

本文研究病毒唑对EHF患者白细胞和血小板的影响.将病毒唑组与安慰剂组的白细胞和血小板在各期、各天、各型中进行比较,结果提示病毒唑具有抗病毒感染的作用,能降低EHF患者增高的白细胞总数和异形淋巴细胞数,并能使降低的血小板数量迅速... 详细信息

本文研究病毒唑对EHF患者白细胞和血小板的影响.将病毒唑组与安慰剂组的白细胞和血小板在各期、各天、各型中进行比较,结果提示病毒唑具有抗病毒感染的作用,能降低EHF患者增高的白细胞总数和异形淋巴细胞数,并能使降低的血小板数量迅速恢复到正常范围,从而有助于患者康复.

关键词：病毒唑流行性出血热白细胞血小板

病毒唑对肾综合征出血热患者特异性抗体应答的影响

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病毒学报 1987年第3期 243-247页

作者：肖书渊,朱宝莲,张美英,郑志明,向近敏,j.M.Meegan,j.w.LeDuc,j.w.huggins,T.Cosgriff,j.I.Smith 湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所美国陆军传染病研究所美国陆军传染病研究所美国陆军传染病研究所美国陆军传染病研究所美国陆军传染病研究所

在用病毒唑(Ribavirin)治疗肾综合征出血热(Hemorrhagic fever with renal syndrome,HFRS)(以安慰剂作对照)的双盲法临床试验中,用微量酶联免疫吸附技术对确诊的64例患者血清和尿液中特异性IgG及IgM抗体水平进行动态观察与分析,结果发现... 详细信息

在用病毒唑(Ribavirin)治疗肾综合征出血热(Hemorrhagic fever with renal syndrome,HFRS)(以安慰剂作对照)的双盲法临床试验中,用微量酶联免疫吸附技术对确诊的64例患者血清和尿液中特异性IgG及IgM抗体水平进行动态观察与分析,结果发现,病毒唑治疗组两种血清抗体水平均较安慰剂对照组低(IgG,P<0.001;IgM,P<0.05),而两组患者尿液中两种抗体水平与阳性率均无明显差异,表明病毒唑对HFRS患者抗体的生成具有抑制作作用,本文就该作用的原因与后果进行了分析评价。

关键词：肾综合征出血热病毒唑酶联免疫吸附试验血清抗体

病毒唑对EHF患者特异性体液免疫反应的影响

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武汉大学学报(医学版) 1987年第2期 135-139页

作者：肖书渊朱宝莲张美英郑志明向近敏 j.M.Meegan j.w.LeDuc j.w.huggins T.Cosgriff j.I.Smith 湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所湖北医学院病毒研究所美国军事医科院传染病研究所美国军事医科院传染病研究所美国军事医科院传染病研究所美国军事医科院传染病研究所美国军事医科院传染病研究所

采用微量酶联免疫吸附技术对病毒唑-安■剂双盲法对照治疗EHF的患者血清特异性IgG及IgM抗体进行了系统的动态观察和比较,发现病毒唑治疗组两种抗体水平均较安慰剂对照组为低,说明患者用药后体内特异性体液免疫反应水平有所下降,从而减... 详细信息

采用微量酶联免疫吸附技术对病毒唑-安■剂双盲法对照治疗EHF的患者血清特异性IgG及IgM抗体进行了系统的动态观察和比较,发现病毒唑治疗组两种抗体水平均较安慰剂对照组为低,说明患者用药后体内特异性体液免疫反应水平有所下降,从而减少免疫复合物的形成,有利于病情改善。

关键词：出血热,流行性三氮唑核苷酶联免疫吸附试验

Visually Modelling Collaborative Research into Innovative Community Disaster Resilience Practice,Strategy,and Governance

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International journal of Disaster Risk Science 2015年第3期6卷 282-294页

作者： Thomas j.huggins Robin Peace Stephen R.Hill David M.johnston Alicia Cuevas Muniz joint Centre for Disaster Research School of PsychologyMassey University School of Psychology Massey University School of Psychology Massey University Joint Centre of Disaster ResearchMassey University Faculty of Science University of Colima

In 2013 a new collaborative center was established in wellington, New Zealand to focus on integrating resilience research with the region’s community disaster resilience strategy. An earlier study with parties to this center had indicated that researcher and practitioner groups were divided by attention to their own immediate knowledge and skills, but agreed there was a need to maximize community resilience benefits amongst a regional population. An action research workshop of researchers and practitioners used a visual logic model to focus on the pragmatic benefits of improving community resilience. The visual logic model was used to design research activities that would improve the regional community resilience strategy, which was still in an early implementation *** of 14 workshop participants were interviewed following the workshop. Statistical content analysis of interview data highlighted certain strengths of the action research process: visual monitoring and evaluation planning was a catalyst for complicated conversations between two very different groups of professionals; and researchers became more focused on practical issues as a result. Other findings suggested that in future collaborative researchgovernance would benefit from wider cycles of strategic intelligence, enhanced research contributions, and the use of different information formats for different *** formats for different purposes should also be considered when developing and implementing large-scale disaster risk reduction policies and strategies.

关键词： Collaborative research Community resilience Content analysis Emergency management Visual communication

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Ecology and management of rodents in no-till agriculture in washington, USA

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Integrative Zoology 2007年第3期2卷 154-164页

作者： Gary wITMER Rodney SAYLER David huggins jason CAPELLI US Department of Agriculture/Animal and Plant Health Inspection Service/wildlife Services National Wildlife Research CenterFort CollinsColoradoUSA washington State University PullmanWashingtonUSA

No-till farming is an important approach to sustainable agriculture because it can conserve soil and water ***, rodent populations can thrive under no-till conditions because burrow systems are not disrupted byannual plowing and plant residues build-up on the surface, providing cover and insulation. This can result in substantialcrop damage. we assessed rodent populations, habitat use, food habits, and crop damage in a no-till croppingsystem in washington, USA. we also conducted preliminary trials of methods to reduce rodent populationsand crop damage. In the fall, many more rodents were captured in fields with unharvested crops than in fieldscontaining only plant stubble, suggesting that rodents leave fields after crop harvest, providing that suitable habitatsare nearby, even when adequate cover is still available in harvested crop fields. By spring, the number of volescaptured was much lower relative to fall. Despite this, capture rates were much higher in surrounding permanentgrass areas than in crop (barley, wheat, pea) fields, suggesting that these grassy areas serve as refugia for ***, the permanent grass cover type was the landscape variable most associated with rodent capture *** three winter pea fields, rodents removed 5–15% of the pea plants over winter. Examination of stomach contentsrevealed that voles mainly fed on grain plants in spring, but that their diet was more diversified in fall. Deer micefed heavily on grain plants in both spring and fall, but also used insects as food. Metal barrier exclosures (9 m × 9m), extending above and below ground, did not prevent access by rodents. Rodent populations in areas treated withzinc phosphide on grain were comparable to untreated areas 1 year after application of the rodenticide, perhaps becauseof immigration and recruitment, suggesting that baiting does not provide a long-term solution to rodent damagein no-till agricultural fields.

关键词： agriculture damage deer mouse feeding ecology Microtus Peromyscus rodent vole

Risk Evaluation Based on Variable Fuzzy Sets and Information Diffusion Method

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journal of Applied Mathematics and Physics 2020年第5期8卷 821-830页

作者： w. Gong K. Chen T. j. huggins L. Yang Southern University of Science and Technology Shenzhen China Department of Mathematical Southern University of Science and Technology Shenzhen China

Risk evaluation is an effective way to reduce the impacts of natural hazards and it plays an increasingly important role in emergency management. Traditional methods of assessing risks mainly utilize Geographic Information System (GIS) to get risk map, and information diffusion method (IDM) to deal with incomplete data sets. However, there are few papers discuss the uncertainty of integrated hazards and consider dynamic risk under time dimension. The model proposed in this study combines the variable fuzzy set theory with information diffusion method (VFS-IDM) to solve the uncertainness of multiple hazards dynamic risk assessment when data sets are incomplete. This study employs fuzzy set theory (VFS) to calculate the relative membership degree and applies information entropy method (IEM) to obtain the weights of criteria indicators for multiple hazards evaluation. Then applies information diffusion method (IDM) to estimate condition probability distribution and vulnerability curve with the VFS-IEM model results, time data and multiple hazards losses. Then the expected value of multiple hazards dynamic risk can be calculated by using the normal information diffusion estimator so as to improve the accuracy of risk evaluation results.

关键词： Risk Evaluation Integrated Risk Dynamic Risk Fuzzy Sets VFS-IDM

Risk Evaluation Based on Variable Fuzzy Sets and Information Diffusion Method

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Risk Evaluation Based on Variable Fuzzy Sets and Information...

INTERRUPTION STUDY OF VIREMIA OF PATIENTS wITH HEMORRHAGIC FEVER wITH RENAL SYNDROME IN THE FEBRILE PHASE

作者： w.Gong K.Chen T.j.huggins L.Yang Southern University of Science and Technology Department of Mathematical Southern University of Science and Technology

Risk evaluation is an effective way to reduce the impacts of natural hazards and it plays an increasingly important role in emergency management. Traditional methods of assessing risks mainly utilize Geographic Information System（GIS） to get risk map, and information diffusion method（IDM） to deal with incomplete data sets. However, there are few papers discuss the uncertainty of integrated hazards and consider dynamic risk under time dimension. The model proposed in this study combines the variable fuzzy set theory with information diffusion method（VFS-IDM） to solve the uncertainness of multiple hazards dynamic risk assessment when data sets are incomplete. This study employs fuzzy set theory（VFS） to calculate the relative membership degree and applies information entropy method（IEM） to obtain the weights of criteria indicators for multiple hazards evaluation. Then applies information diffusion method（IDM） to estimate condition probability distribution and vulnerability curve with the VFS-IEM model results, time data and multiple hazards losses. Then the expected value of multiple hazards dynamic risk can be calculated by using the normal information diffusion estimator so as to improve the accuracy of risk evaluation results.

关键词： Risk Evaluation Integrated Risk Dynamic Risk Fuzzy Sets VFS-IDM

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中华医学杂志(英文版) 1991年第2期104卷 149-153页

作者： Yang Zhan-qiu Zhang Tien-ming Zhang Mei-ying Zheng Zhi-ming Hu Zhen-jiao Qu Chun-feng Xiang jin-min john w huggins T. M. Cosgriff j. I. Smith Virus Research Institute Hubei Medical College Wuhan 430071 U. S. Army Medical Research Institute of Infectious Diseases Fort Detrick MD U.S.A.

Kinetic changes of viremia were observed in 287 cases of hemorrhagic fever with renal syndrome (HFRS) in whom ribavirin was administered with double blind random control studied by means of virus isolation, indirect immunofiuorescence assay and enzyme-linked immunosorbent assay. The positive rate of viremia was 79.7% (Sp=3%) and positive rate of HERS IgM was 85% (Sp=3.1%) before treatment. Viremia could be interrupted by ribavirin as in the ribavirin treated group, the viremia positive rate decreased, duration of viremia was shortened, viral antigen products, virus fiter and HFRS IgG antibody level were reduced as compared with the control group. This showed that viremia was very frequent in patients in the febrile phase and ribavirin is an effective antiviral drug in HFRS during the febrile phase. Dosage and course of treatment of this drug are discussed.

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