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Impact of transjugular intrahepatic porto-systemic shunt on post liver transplantation outcomes: Study based on the United Network for Organ Sharing database

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world journal of Hepatology 2017年第2期9卷 99-105页

作者： Khalid Mumtaz Sherif Metwally Rohan M Modi Nishi Patel Dmitry Tumin Anthony j Michaels james Hanje Ashraf El-Hinnawi Don Hayes jr Sylvester M Black wexner Medical Center Gastroenterology Hepatology and Nutrition Division the Ohio State University Department of Internal Medicine the Ohio State University Department of Pediatrics the Ohio State University Department of Surgery the Ohio State University Section of Pulmonary Medicine the Ohio State University

AIMTo determine the impact of transjugular intrahepatic porto-systemic shunt (TIPS) on post liver transplantation (LT) outcomes. METHODSUtilizing the United Network for Organ Sharing (UNOS) database, we compared patients who underwent LT from 2002 to 2013 who had underwent TIPS to those without TIPS for the management of ascites while on the LT waitlist. The impact of TIPS on 30-d mortality, length of stay (LOS), and need for re-LT were studied. For evaluation of mean differences between baseline characteristics for patients with and without TIPS, we used unpaired t-tests for continuous measures and χ2 tests for categorical measures. we estimated the impact of TIPS on each of the outcome measures. Multivariate analyses were conducted on the study population to explore the effect of TIPS on 30-d mortality post-LT, need for re-LT and LOS. All covariates were included in logistic regression analysis. RESULTSwe included adult patients (age ≥ 18 years) who underwent LT from May 2002 to September 2013. Only those undergoing TIPS after listing and before liver transplant were included in the TIPS group. we excluded patients with variceal bleeding within two weeks of listing for LT and those listed for acute liver failure or hepatocellular carcinoma. Of 114770 LT in the UNOS database, 32783 (28.5%) met inclusion criteria. Of these 1366 (4.2%) had TIPS between the time of listing and LT. we found that TIPS increased the days on waitlist (408 ± 553 d) as compared to those without TIPS (183 ± 330 d), P P P = 0.001) by TIPS to LOS. CONCLUSIONTIPS did increase time on waitlist for LT. More importantly, TIPS was not associated with 30-d mortality and re-LT, but it did lengthen hospital LOS after transplantation.

关键词： Transjugular intrahepatic porto-systemic shunt Shunt Liver Transplantation Ascites Model for end-stage liver disease Mortality Transjugular

whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar(Panthera onca) populations

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journal of Genetics and Genomics 2022年第1期49卷 77-80页

作者： Gustavo P.Lorenzana Henrique V.Figueirò jeremy johnson Elinor Karlsson Ronaldo G.Morato Dênis A.Sana Laury Cullen joares A.May jr. Edsel A.Moraes jr. Daniel L.Z.Kantek Leandro Silveira william j.Murphy Oliver A.Ryder Eduardo Eizirik Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Christopher B.Kaelin Gregory S.Barsh HudsonAlpha Institute for BiotechnologyHuntsvilleAL 35806USA Vertebrate Genome Biology Broad InstituteCambridgeMA 02142USA CENAP/ICMBio AtibaiaSP 12952Brazil PPG Biologia Animal Instituto de Bioci^enciasUFRGSPorto AlegreRS 90650Brazil Instituto de Pesquisas Ecol ogicas Teodoro SampaioSP 19280Brazil UniSul TubarãoSC 88704Brazil Instituto Prò-CarnivorosAtibaiaSP 12945Brazil Instituto Biotr opicos DiamantinaMG39100Brazil Estacão Ecologica de Taiamã ICMBioCaceresMT 78200Brazil Instituto Onca-pintada-jaguar Conservation Fund MineirosGO 75830Brazil Texas A&M University College StationTX 77843USA San Diego Zoo Institute for Conservation Research San DiegoCA 92027USA Pontiﬁcal Catholic University of Rio Grande do Sul PUCRS.School of Health and Life SciencesPorto AlegreRS 90619Brazil Instituto Pr o-Carni¬vorosAtibaiaSP 12945Brazil Centro Regional del Bajio INECOLP atzcuaroMIC61600Mexico Smithsonian Conservation Biology Institute WashingtonDC20008USA

whole-genome sequences provide massive amounts of data that can illuminate many aspects of a species’biology and evolutionary history,as well as valuable information for conservation *** is particularly important for large carnivores,whose large area requirements and typical low densities make them prone to undergo rapid genetic erosion(*** of runs of homozygosity,Diez del Molino et al.,2018;Leroy et al.,2018)in the face of habitat loss and human *** such species is the jaguar(Pan-thera onca),the largest extant felid in the Americas,whose range has already declined by>50%and some of whose remaining popu-lations have been severely impacted by human-induced habitat frag-mentation(De La Torre et al.,2018).

关键词： whole habitat erosion

Improving bermudagrass in the Southeastern United States with alfalfa as an alternative nitrogen source in grazing systems

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Grassland Research 2022年第4期1卷 280-289页

作者： justin C.Burt Lisa L.Baxter Christopher G.Prevatt Mary Kimberly Mullenix R.Lawton Stewart jr. jennifer j.Tucker Department of Animal and Dairy Science University of GeorgiaTiftonGeorgiaUSA Department of Crop and Soil Science University of GeorgiaTiftonGeorgiaUSA Regional Specialized Agent Range Cattle RECUniversity of FloridaGainesvilleFloridaUSA Department of Animal Science Auburn UniversityAuburnAuburnUSA Department of Animal and Dairy Science University of GeorgiaAthensGeorgiaUSA

Background Bermudagrass(Cynodon spp.)is one of the most common perennial warm-season forages grown in the Southeastern United *** incorporation of alfalfa(Medicago sativa)into bermudagrass pastures could serve as an alternative source of nitrogen(N)while also improving the nutritive value of the forage *** A 2-year grazing evaluation arranged in a randomized complete block design was conducted from May to September 2018(Year 1)and May–August 2019(Year 2)in Tifton,GA,*** objective was to compare the production of alfalfa–bermudagrass mixed pastures(BGA)with bermudagrass monoculture pastures with(BGN)or without(BG)the application of synthetic nitrogen on forage production and stocker cattle *** Differences were observed for average daily gain(p=0.10),gain per hectare(p=0.02)and stocking rate(p=0.01),in that BGA was greatest compared to BGN and BG,which did not differ from each ***,BGA had increased forage crude protein(p=0.01)and total digestible nutrients(p=0.01)compared to BGN and ***,BGA provided the greatest economic return per hectare compared to BG or *** These data illustrate improved animal performance and forage nutritive value using alfalfa–bermudagrass systems and offer a viable option for producers seeking alternatives to synthetic N sources for bermudagrass pastures in the Southeastern United States.

关键词： alfalfa-bermudagrass mixtures forage management grazing management

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新型的可溶性聚醚型聚氨酯的合成和鉴定

世界橡胶工业 1983年第5期 8-13页

作者： j.w.Mead C.Arnold jr. 李树国

研制了两种可溶性聚氨酯,该聚合物作为浇铸型的可拆装的封装剂用于电子元件。这两种聚氨酯均以二异氰酸二甲苯酯（TODI）为原料,用聚（四甲撑醚）二醇封端,用1,4-丁二醇进行链的增长。选用TODI是为了对该体系提供一部分的异氰酸酯,因为... 详细信息

研制了两种可溶性聚氨酯,该聚合物作为浇铸型的可拆装的封装剂用于电子元件。这两种聚氨酯均以二异氰酸二甲苯酯（TODI）为原料,用聚（四甲撑醚）二醇封端,用1,4-丁二醇进行链的增长。选用TODI是为了对该体系提供一部分的异氰酸酯,因为它易于形成半结晶的聚合物,生成延迟蠕变的物理交联。通过对异氰酸酯的脱尿素,醚和醇的脱水,使产品的物理性能足使用要求(蠕变小,伸长率400％,屈服强度～20（?）磅/英寸2,玻璃化温度Tg<55℃)。为了获得所要求的性能,将封装剂在80℃下硫化16小时。经过红外测试表明,在一次硫化后,产品中仍存在异氰酸酯,待二次硫化后,产品的物理性能仍未得到改进。

关键词：机械性能聚氨酯力学性质聚氨基甲酸乙酯异氰酸酯大分子化合物聚合物物理性能电性能二次硫化体积电阻率相互作用力 IR 光谱红外光谱无源器件电子元件预聚体聚醚

Five Colletotrichum species are responsible for mango anthracnose in northeastern Brazil

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Fungal Diversity 2013年第4期61卷 75-88页

作者： Nelson B.Lima Marcus Vinicius de A.Batista Marcos A.De Morais jr Maria A.G.Barbosa Sami j.Michereff Kevin D.Hyde Marcos P.S.Câmara Departamento de Agronomia Universidade Federal Rural de Pernambuco52171-900 RecifeBrazil Departamento de Genética Universidade Federal de Pernambuco50732-970 RecifeBrazil Embrapa Semiárido 56302-970 PetrolinaBrazil Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand

Colletotrichum species are the most important and widespread form of decay affecting mango fruit *** this study,Colletotrichum species associated with fruit anthracnose isolated from mango in northeastern Brazil were subject to molecular and morphological *** partial sequences of the glyceraldehyde-3-phosphate dehydrogenase gene of 143 Colletotrichum isolates was amplified,as an initial measure of genetic diversity.A subset of 47 isolates,selected to represent the range of genetic diversity and geographic origin,were further sequenced using the partial actin,β-tubulin,calmodulin,glutamine synthetase genes and rDNA-ITS *** multilocus sequence analysis,together with a critical examination of the phenotypic characters,revealed four previously described species(Colletotrichum asianum,Colletotrichum fructicola,Colletotrichum tropicale and Colletotrichum karstii)and one new *** new species is introduced as Colletotrichum dianesei and formally described,illustrated and compared with similar *** *** and *** have previously been reported from mango,while the other species represent the first report associated with the mango fruits *** species are reported for the first time associated with the mango fruits in Brazil.

关键词： Multilocus phylogeny Morphology New species Plant disease

单纯疱疹病毒扩增子载体转导的ATM基因在活体的异位表达(英文)

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神经解剖学杂志 2001年第4期17卷 319-327,T054-T055页

作者：齐建国王苏鸣 Charles j.Link jr 华西医科大学组织学与胚胎学教研室成都610041 美国衣阿华州立大学人体基因治疗研究所

小脑性共济失调与血管扩张症 (A-T)是一种常染色体隐性遗传性疾病 ,具多效表型。此病的特征是小脑变性、免疫缺陷、生长迟缓、早熟性衰老、染色体不稳定、肿瘤易患体质和对辐射的过度敏感。目前尚未发现有效的方法阻断此病的进行性发展... 详细信息

小脑性共济失调与血管扩张症 (A-T)是一种常染色体隐性遗传性疾病 ,具多效表型。此病的特征是小脑变性、免疫缺陷、生长迟缓、早熟性衰老、染色体不稳定、肿瘤易患体质和对辐射的过度敏感。目前尚未发现有效的方法阻断此病的进行性发展。基因治疗是此病的潜在希望。ATM是此病的致病基因 ,编码 ATM蛋白激酶。本研究将 ATM c DNA完整的读码框架克隆进 1型单纯疱疹病毒 (HSV-1)扩增子载体 (p TO-ATM)。培养的 A-T细胞经 p TO-ATM病毒载体转导后 ,用免疫组织化学方法证明了 ATM在这些细胞的异位表达。为了进一步研究在活体应用此载体系统的可能性 ,选择大鼠脑作为实验靶区。先用免疫组织化学方法观察了内源性 ATM在成年大鼠前脑和小脑的正常分布 ,发现在尾壳核有低水平的 ATM出现 ,而在其余脑区 ,ATM水平则显著地高于尾壳核区。将 p TO-ATM病毒载体注射到成年大鼠的一侧尾壳核 ,3 d后在注射区 (包括针道周围的区域 )观察到密集的 ATM免疫反应阳性神经元。本研究结果证明 ,HSV扩增子病毒载体可以稳定地运载相当大的 c DNA片段 ,转基因在离体和活体均能有效地表达。本研究为使用基因治疗的方法治疗

关键词：小脑性共济失调与血管扩张症 ATM基因 HSV-1扩增子载体基因转移免疫组织化学大鼠脑致病基因异位表达

Quantitative assessment of sensory functions after 3 surgical approaches for trigeminal neuralgia by current perception threshold measurement

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journal of Medical Colleges of PLA(China) 2008年第5期23卷 300-307页

作者： Chen Ruoping Ouyang Huoniu wang Bingyu Ding Meixiu Charles j. Hodge jr Department of Neurosurgery Shanghai Ninth People＇s Hospital School of Medicine Shanghai Jiaotong University Shanghai 200011 China Department of Neurosurgery SUNY Upstate Medical University Syracuse New York13210 USA

Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers

关键词： Trigeminal neuralgia Sensory dysfunction Microvascular decompression Peripheral nerve block Percutaneous radiofrequency thermocoagulation Quantitative sensory testing Current perception threshold measurement

冷藏法处理带有桔小实蝇和瓜实蝇的水果和蔬菜

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植物检疫 1987年第1期 69-72页

作者： A.K.Burditt jr. j.w.Balock 邹进明

桔小实蝇Dacus dorsalis Hendel和瓜实蝇*** coquillet是夏威夷和亚洲等其它地区的水果蔬菜的重要害虫,这两种实蝇在加利福尼亚零星的为害屡被发现,一旦蔓延,必将导致当地水果蔬菜生产的经济损失,而且,由于它们的存在,必将使该地区的水... 详细信息

桔小实蝇Dacus dorsalis Hendel和瓜实蝇*** coquillet是夏威夷和亚洲等其它地区的水果蔬菜的重要害虫,这两种实蝇在加利福尼亚零星的为害屡被发现,一旦蔓延,必将导致当地水果蔬菜生产的经济损失,而且,由于它们的存在,必将使该地区的水果蔬菜禁运,或者使国际间的贸易以及在美国州之间运输的这些产品被迫接受检疫处理。多年来,低温储藏的方法,已被美国农业部(USDA)的动植物检疫部门认可,作为对来自48个国家的14种水果蔬菜的检疫处理,这些国家大多遭受地中海实蝇Ceratitis capitata(wiedemann)墨西哥桔实蝇Anas-

关键词：桔小实蝇番木瓜检疫处理地中海实蝇多年生草本果瓜大实蝇瓜实蝇实蝇幼虫水果

Discovery of japalura chapaensis Bourret,1937(Reptilia:Squamata:Agamidae)from Southeast Yunnan Province,China

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Zoological Research 2018年第2期39卷 105-113页

作者： Kai wang Ke jiang Yu-Fan wang Nikolay A.Poyarkov jr. jing Che Cameron D.Siler Sam Noble Oklahoma Museum of Natural History & Department of Biology University of Oklahoma Kunming Institute of Zoology Chinese Academy of Sciences Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Zhejiang Forest Resource Monitoring Center Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University

Due to a paucity of surveys in northern Indochina and lack of international collaborations among neighboring countries, recognized distributional ranges for many amphibian and reptile species end at the political borders for some countries, despite seemingly continuous suitable habitat spanning the region. Combining both morphological and genetic data, we report the first discovery of japalura chapaensis, a rare agamid lizard believed previously to be endemic to northern Vietnam only, along the border region of southeastern Yunnan Province,China. To facilitate future research on the genus japalura sensu lato in Indochina, we provide detailed descriptions of additional specimens of this rare species, including the first description of coloration in life and an expanded diagnosis, and discuss the species boundary of j. chapaensis with respect to its congeners.

关键词： Draconinae Indochina Morphological Variation New record Range extension Systematics Taxonomy