检索结果-南通市图书馆

SCFD1 in amyotrophic lateral sclerosis:reconciling a genetic association with in vivo functional analysis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1201-1202页

作者： Ruben j.Cauchi Centre for Molecular Medicine and Biobanking Biomedical Sciences BuildingDepartment of Physiology and BiochemistryFaculty of Medicine and SurgeryUniversity of MaltaMsidaMalta

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons,resulting in muscle weakness and spasticity,eventually leading to death due to respiratory *** by our group of a casecontrol cohort from an isolated island population have found that genetics plays a significant role in disease etiology(Farrugia Wismayer et al.,2023).

关键词： sclerosis respiratory

维普期刊数据库

Enhancing Ulcerative Colitis Diagnosis:A Multi-Level Classification Approach with Deep Learning

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第7期140卷 1129-1142页

作者： Hasan j.Alyamani Department of Information Systems Faculty of Computing and Information Technology in RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia

the evaluation of disease severity through endoscopy is pivotal in managing patients with ulcerative colitis,a condition with significant clinical ***,endoscopic assessment is susceptible to inherent variations,both within and between observers,compromising the reliability of individual *** study addresses this challenge by harnessing deep learning to develop a robust model capable of discerning discrete levels of endoscopic disease *** initiate this endeavor,a multi-faceted approach is embarked *** dataset is meticulously preprocessed,enhancing the quality and discriminative features of the images through contrast limited adaptive histogram equalization(CLAHE).A diverse array of data augmentation techniques,encompassing various geometric transformations,is leveraged to fortify the dataset’s diversity and facilitate effective feature extraction.A fundamental aspect of the approach involves the strategic incorporation of transfer learning principles,harnessing a modified ResNet-50 *** augmentation,informed by domain expertise,contributed significantly to enhancing the model’s classification *** outcome of this research endeavor yielded a highly promising model,demonstrating an accuracy rate of 86.85%,coupled with a recall rate of 82.11%and a precision rate of 89.23%.

关键词： Ulcerative colitis deep learning CLAHE transfer learning geometric transformations

Intelligent Machine Learning Based Brain tumor Segmentation through Multi-Layer Hybrid U-Net with CNN Feature Integration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第4期79卷 1301-1317页

作者： Sharaf j.Malebary Department of Information technology Faculty of Computing and Information TechnologyKing Abdulaziz UniversityP.O.Box 344Rabigh21911Saudia Arabia

Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity ***, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitatingthe development of more precise and efficient methodologies. to address this formidable challenge, we proposean advanced approach for segmenting brain tumorMagnetic Resonance Imaging (MRI) images that harnesses theformidable capabilities of deep learning and convolutional neural networks (CNNs). While CNN-based methodshave displayed promise in the realm of brain tumor segmentation, the intricate nature of these tumors, markedby irregular shapes, varying sizes, uneven distribution, and limited available data, poses substantial obstacles toachieving accurate semantic segmentation. In our study, we introduce a pioneering Hybrid U-Net framework thatseamlessly integrates the U-Net and CNN architectures to surmount these challenges. Our proposed approachencompasses preprocessing steps that enhance image visualization, a customized layered U-Net model tailoredfor precise segmentation, and the inclusion of dropout layers to mitigate overfitting during the training ***, we leverage the CNN mechanism to exploit contextual information within brain tumorMRI images,resulting in a substantial enhancement in segmentation *** experimental results attest to the exceptionalperformance of our framework, with accuracy rates surpassing 97% across diverse datasets, showcasing therobustness and effectiveness of our approach. Furthermore, we conduct a comprehensive assessment of ourmethod’s capabilities by evaluating various performance measures, including the sensitivity, jaccard-index, andspecificity. Our proposed model achieved 99% accuracy. the implications of our findings are profound. theproposed Hybrid U-Net model emerges as a highly promising diagnostic tool, poised to revolutionize brain tumorimage segmentation for radiologists and clinician

关键词： Brain tumor Hybrid U-Net CLAHE transfer learning MRI images

the Soft X-ray Imager(SXI)on the SMILE Mission

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sembay A.L.Alme D.Agnolon t.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont t.Crawford j.P.Breuer t.Buggey G.Butcher R.Canchal j.A.Carter A.Cheney Y.Collado-Vega H.Connor t.Crawford N.Eaton C.Feldman C.Forsyth t.Frantzen G.Galgóczi j.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson j.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.j.Hubbard H.jeszenszky M.jones t.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale j.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel j.Pearson G.Peikert F.S.Porter t.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit j.Søndergaard R.Speight S.Stavland M.Steller tianRan Sun j.thornhill W.thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK Mullard Space Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Imaging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace technology MadridSpain EStEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space GmbH CH-8157 DielsdorfSwitzerland Space Acoustics GmbH CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway StM Engineering N-5165 LaksevagNorway john Hopkins University Applied Physics Laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Department of theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

the Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)*** is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in *** is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field *** sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many *** is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Imaging micropore optics large area CCD

维普期刊数据库

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+t cell activation,macrophage uptake,and the protein corona

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi jawaun j.Harris Kaitlyn Storm Edwin j.Yoo Ariel Isser Vivek P.jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe t.Hsieh Simone Sidoli Stephany Y.tzeng jonathan P.Schneck jordan j.Green translational tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACt)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACt,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+t cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo t-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate t-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific t cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo t cell activation and investigate possible mechanisms including the effects of aAPC elasticity on t cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Correlation of work function and stacking fault energy through Kelvin probe force microscopy and nanohardness in diluteα-magnesium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit türe Ali Arslan Kaya Hüseyin Aydin jiang Peng Servet turan Eskisehir technical University Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sitki Kocman University Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey Hüseying Aydın TUBITAK MRCTurkey jiang Peng Chongqing UniversityChina Eskisehir technical University Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Electronic interactions of the Group 2A elements with magnesium have been studied through the dilute solid solutions in binary Mg-Ca,Mg-Sr and Mg-Ba *** investigation incorporated the difference in the‘Work Function'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a property directly affected by interatomic bond types,*** electronic structure,nanoindentation measurements,and Stacking Fault Energy values reported in the *** was shown that the nano-hardness of the solid-solutionα-Mg phase changed in the order of Mg-Ca>Mg-Sr>***,it was shown,by also considering the nano-hardness levels,that SFE of a solid-solution is closely correlated with its‘Work Function'***-hardness measurements on the eutectics andΔWF difference between eutectic phases enabled an assessment of the relative bond strength and the pertinent electronic structures of the eutectics in the three *** withΔWF and at least qualitative verification of those computed SFE values with some experimental measurement techniques were considered important as those computational methods are based on zero Kelvin degree,relatively simple atomic models and a number of *** asserted by this investigation,if the results of measurement techniques can be qualitatively correlated with those of the computational methods,it can be possible to evaluate the electronic structures in alloys,starting from binary systems,going to ternary and then multi-elemental *** investigation has shown that such a qualitative correlation is *** all,the SFE values are not treated as absolute values but rather become essential in comparative investigations when assessing the influences of alloying elements at a fundamental level,that is,free electron density *** study indicated that the principles of‘electronic metallurgy'in developing multi-elemental alloy systems can be followed via practical experimental methods,i.e.ΔWF measurements using KPF

关键词： Mg alloys Dilute alloys Work function Stacking fault energy Kelvin probe force microscopy Short range order Miedema Nanoindentation Eutectics

维普期刊数据库

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

在线全文

学校读者我要写书评

暂无评论

journal of Ocean Engineering and Science 2024年第1期9卷 89-97页

作者： Usman Younas t.A.Sulaiman jingli Ren A.Yusuf State Key Laboratory of Power Grid Environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of Science Federal University DutseJigawaNigeria Department of Computer Engineering Biruni University IstanbulTurkey

In this paper,we describe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dispersive waves in(2+1)*** various wave formations are retrieved by using Hirota’s bilinear method(HBM)and various test function *** Hirota method is a widely used and robust mathematical tool for finding soliton solutions of nonlinear partial differential equa-tions(NLPDEs)in a variety of disciplines like mathematical physics,nonlinear dynamics,oceanography,engineering sciences,and others requires bilinearization of nonlinear *** different wave structures in the forms of new breather,lump-periodic,rogue waves,and two-wave solutions are *** addi-tion,the physical behavior of the acquired solutions is illustrated in three-dimensional,two-dimensional,density,and contour profiles by the assistance of suitable *** on the obtained results,we can assert that the employed methodology is straightforward,dynamic,highly efficient,and will serve as a valuable tool for discussing complex issues in a diversity of domains specifically ocean and coastal *** have also made an important first step in understanding the structure and physical be-havior of complex structures with our findings *** believe this research is timely and relevant to a wide range of engineering *** results obtained are useful for comprehending the fundamental scenarios of nonlinear sciences.

关键词： Hirota’s bilinear method Lump-periodic solutions Breather waves Rouge waves Multi-waves

New trends in diagnosis and management of gallbladder carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： Efstathios t Pavlidis Ioannis N Galanis theodoros E Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(Ct),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase Ct angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PEt)-Ct or ^(18)F-FDG PEt-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(t1a)to extended resections and including extended cholecystectomy(t1b),with wide lymph node resection in every case or IV-V segmentectomy(t2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(t3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms Extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

traveling wave solutions of the nonlinear Gilson-Pickering equation in crystal lattice theory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.t.Nguyen O.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

this paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-Pickering equa-tion(GPE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GPE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the PDE is converted to a system of nonlinear ODEs with the help of the radial *** the second step,a high-order ODE solver is adopted to discretize the nonlinear ODE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–Pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD Optimal shape parameter