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Pediatric obesity prevention:From na?ve examination of energy imbalance towards strategies that influence the competition for nutrient resources among tissues

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World journal of Clinical Pediatrics 2015年第4期4卷 50-54页

作者： Lynae j Hanks Tina simpson Kenneth McCormick Krista Casazza Department of Kinesiology University of Montevallo Division of General Pediatrics and Adolescent Medicine Department of PediatricsUniversity of Alabama at Birmingham Division of Endocrinology Department of PediatricsUniversity of Alabama at Birmingham

Current pediatric obesity interventions have collectively yielded relatively unsuccessful results. In this Field of Vision, we present plausible physiologic underpinnings fostering ineffectiveness of conventional strategies grounded in requisite induction of negative energy imbalance. Moreover, such recommendations exacerbate the underlying metabolic dysfunction by further limiting metabolic fuel availability, lowering energy expenditure, and increasing hunger(recapitulating the starvation response amid apparent nutritional adequacy) which precede and promote obesity during growth and development. The qualitative aspects of musculoskeletal system(i.e., endocrine response, muscle functional capacity) are likely to improve metabolic function and increase nutrient delivery and utilization. An intricate and complex system including multiple feedback mechanisms operates to homeostatically regulate energy balance and support optimal body composition trajectories and metabolic health, during growth and development. Thus, ignoring the interdependencies of regulatory growth processes initiates a nuanced understanding of energy regulation and thus misguided attempts at preventive strategies. Importantly, these gains are not dependent upon weight-loss, rather we suggest can be achieved through resistance training. Collectively, optimizing musculoskeletal health via resistance training elicits augmentation of competitive capacity across systems. Further, substantial gains can be achieved in skeletal muscle mass, strength, and functional capacity through resistance training in a relatively short period of time.

关键词： Childhood obesity Metabolic control Energy balance Resistance training Effective intervention strategies Weight loss Musculoskeletal health

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Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations

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journal of Environmental Sciences 2016年第11期28卷 213-221页

作者： justin P.Miller-Schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.simpson Department of Chemistry University of Washington WA 98195-1700 USA. Department of Environmental and Occupational Health Sciences University of Washington WA 98195 Seattle USA Laboratory of Hygienic Chemistry Instkute of Medical Pharmaceutical and Health Sciences Faculty of Pharmacy Kanazawa UniversityKakurna-machi Kanazawa Ishikawa 920-1192 Japan Graduate School of Natural Science and Technology Kanazawa University Kakma-machi Kanazawa Ishikawa 920-1192 Japan Department of Enuironmental Health Sciences University of Georgia Athens CA 30602-2102 USA Asociacion del Aire Ambiental Lima Peru

The assessment of occupational exposure to diesel exhaust（DE） is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene（1NP）, a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples（10 m L） from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_（2.5）, 2-nitropyrene and 2-nitrofluoranthene, were also *** to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3（±standard deviation）. Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects（n = 17） studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle *** study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker.

关键词： Urinary biomarkers 1-Nitropyrene Diesel particulate matter

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In situ apatite and carbonate Lu-Hf and molybdenite Re-Os geochronology for ore deposit research:Method validation and example application to Cu-Au mineralisation

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Geoscience Frontiers 2024年第5期15卷 339-354页

作者： Alexander simpson Stijn Glorie Martin Hand Sarah E.Gilbert Carl Spandler Marija Dmitrijeva Greg Swain Angus Nixon jacob Mulder Carsten Münker Department of Earth Sciences University of AdelaideSA 5005Australia Mineral Exploration Cooperative Research Centre University of AdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia Fortescue Level 287Adelaide TerraceEast PerthWA 6005Australia Institute of Geology und Mineralogy University of Köln50674 KölnGermany British Geological Survey NottinghamUK

The development of laser ablation inductively coupled plasma quadrupole tandem mass spectrometry(LA-ICP-Q-MS/MS)opens new opportunities to rapidly date a variety of hydrothermal *** we present in situ Lu-Hf and Re-Os dates for hydrothermal apatite and molybdenite,*** further report the first in situ Lu-Hf dates for bastnäsite,dolomite,and siderite,and assess their potential for constraining ore deposit *** method validation,we report isotope-dilution Lu-Hf dates for apatite reference material Bamble-1(1102±5 Ma)and calcite reference material ME-1(1531±7 Ma),enabling improved accuracy on matrix-matched calibration for LA-ICP-MS/MS Lu-Hf *** new methods are applied to the Vulcan Iron-Oxide Copper-Gold(IOCG)prospect in the Olympic Cu-Au Province of South *** deposits have been difficult to accurately date,given the general lack of reliable mineral geochronometers that are cogenetic with IOCG *** apatite Lu-Hf dates and molybdenite Re-Os dates demonstrate that mineralisation at Vulcan largely occurred at ca.1.6 Ga,contemporaneous with the world class Olympic Dam *** data also indicates that the Lu-Hf system in apatite is more robust than the U-Pb system for determining the timing of primary apatite formation in an IOCG *** further demonstrate that dolomite can retain Lu-Hf growth ages over an extended time period(>1.5 billion years),providing constraints on the timing of primary ore mineral crystallisation during brecciation and IOCG ***,late Neoproterozoic(ca.589–544 Ma)and Carboniferous(ca.334±7 Ma)Lu-Hf dates were obtained for texturally late Cubearing carbonate veins,illustrating that the carbonate Lu-Hf method allows direct dating of Cu remobilisation *** has important implications for mineral exploration as the remobilised Cu may have been transferred to younger deposits hosted in Neoproterozoic sedimentary basins overlaying the Olympic IOCG provi

关键词： Reaction-cell ICP-MS In-situ geochronology Lu-Hf Re-Os Iron Oxide Copper Gold Metal fluids

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National preparedness training and exercises for Ebola cases in the United Kingdom

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World journal of Clinical Infectious Diseases 2016年第1期6卷 1-5页

作者： Andrew D Black Hilary j Moulsdale Mark R Evans john L simpson Emergency Response Department Public Health England

In response to the outbreak of Ebola Virus Disease in West Africa, the Emergency Response Department of Public Health England produced a series of training and exercising materials to help prepare health and partner organisations in England and other jurisdictions in the United Kingdom deal with a possible case of Ebola in the United Kingdom. They were produced with input from health(NHS England, Health Protection Scotland, Public Health Wales) and other partner organisations. The exercising materials have been used by colleagues working in national and local level organisations in the United Kingdom and other countries in the European Union. Presented here is a description of these training and exercising materials and how they were delivered to the end user.

关键词： Public health England Exercises Training Ebola Preparedness

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Bacterial TIR-like proteins:evading the host Innate Immune response

Bacterial TIR-like proteins:evading the host Innate Immune r...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Rana Rohini Aiguel Yilmaz simpson j Pete Matthews j Steve Spear Abigall Atkins Heien Byme Bernadette Imperial College London UK

＜正＞Recognition of highly specific pathogen-associated molecular patterns by Toll-like receptors（TLRs） initiates innate *** intracellular Toll/ Interleukin-1（TIR） domain of TLRs,is responsible for recruitment of downstream adapter proteins through homotypic TIR-TIR interactions that initiates the signaling cascade,culminating in proinflammatory ***-like proteins from pathogenic bacteria have been implicated to inhibit upregu-

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Free-Living Heterotrophic Flagellates from Freshwater Sites in Tasmania （Australia）, a Field Survey

Free-Living Heterotrophic Flagellates from Freshwater Sites ...

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12th International Congress of Protozoology

作者： Won je Lee Alastair G. B. simpson David j. Patterson Department of Environmental Engineering Kyungnam University 449 Wolyong-dongMasan 631-701Korea School of Biological SciencesUniversity of SydneySydney NSW 2006Australia School of Biological Sciences University of Sydney Sydney NSW 2006Australia Canadian Institute for Advanced ResearchDepartment of BiologyDalhousie University1355 Oxford StHalifaxNova ScotiaB3H 4J1Canada School of Biological Sciences University of Sydney Sydney NSW 2006Australia

＜正＞In order to contribute to an understanding of the geographic distribution of free-living freshwater flagellates, we have investigated the diversity of heterotrophic flagellates occurring in a number of freshwater sites in Tasmania （Australia）. This community of organisms has not previously been studied in Tasmania, and the isolation of the freshwater habitats from like habitats elsewhere in the world increases the probability of the emergence of an endem,ic community. Forty-four species are described with uninterpreted records based on light-microscopy of living cells in natural communities. The records

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胃肠病及肝病第2版

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丛书名：袖珍诊疗彩色图谱系列

2002年

作者：（英）P.C.Hayes （英）K.j.simpson 王谨等翻译

本书内容包括：手、色素沉着，皮肤，面部，口，咽，胃，小肠，胆道，胆囊，胰腺，肝，下消化道，直肠与肛门。

ISBN: (纸本)7543313898

本书内容包括：手、色素沉着，皮肤，面部，口，咽，胃，小肠，胆道，胆囊，胰腺，肝，下消化道，直肠与肛门。

关键词：胃肠病学科:诊疗肝疾病

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Brown Trout Spawn Timing, Redd Locations, and Stream Characteristics in Spearfish Creek within Spearfish, South Dakota, USA

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Open journal of Ecology 2020年第4期10卷 177-188页

作者： Shaylee Martling Greg simpson jeremy L. Kientz Alex j. Rosburg Michael E. Barnes South Dakota Department of Game Fish and Parks Cleghorn Springs State Fish Hatchery Rapid City SD USA South Dakota Department of Game Fish and Parks Outdoor Campus West Rapid City SD USA South Dakota Department of Game Fish and Parks McNenny State Fish Hatchery Spearfish SD USA

This study documented brown trout (Salmo trutta) spawning locations, redd construction timing, and associated environmental variables in an 850-m long mainstem section and a 400-m long diversion channel of Spearfish Creek within the city limits of Spearfish, South Dakota, USA in 2019. The first redds were observed on October 15, with no new redds observed after November 12. Redd construction peaked during the first week of November, when 23 redds were observed in the mainstem section and 50 in the diversion channel. Substrate size was significantly smaller, water temperatures significantly higher, and water velocities significantly greater in redd versus non-redd locations in both the mainstem reach and the diversion channel (P ˚C), but significant, increase in water temperature from the rest of the channel locations. This is the first study to document redd locations in Spearfish Creek and will provide a baseline to evaluate future spawning activity, particularly as it may be affected by likely future anthropogenic changes potentially affecting the stream environment.

关键词： Brown Trout Salmo trutta Spawning Redds Black Hills South Dakota

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石灰性稻田土壤上化肥氮损失的研究

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土壤学报 1989年第4期26卷 337-343页

作者：朱兆良 j.R.simpson 张绍林蔡贵信陈德立 j.R.Freney A.V.jackson 中国科学院南京土壤研究所 Division of Plant Industry CSIRO Canberra Australia. Division of Environmental Mechanics CSIRO Canberra Australia.

在田间用^(15)N示踪技术和微气象学的质量平衡法研究了石灰性稻田土壤上化肥氮的损失。结果表明:(1)碳铵和尿素在有水层下混施作基肥,氮素总损失分别高达72%和63%;其中氨挥发达到39%和30%,分别占总损失的54%和48%;都远高于以往在中性水... 详细信息

在田间用^(15)N示踪技术和微气象学的质量平衡法研究了石灰性稻田土壤上化肥氮的损失。结果表明:(1)碳铵和尿素在有水层下混施作基肥,氮素总损失分别高达72%和63%;其中氨挥发达到39%和30%,分别占总损失的54%和48%;都远高于以往在中性水稻土区酸性土壤上测得的结果。(2)石灰性稻田土壤氨挥发量大,是造成其氮素总损失远高于酸性稻田土壤的根本原因。两种土壤上,氮肥的反硝化损失量(差减法)似没有明显的差异。(3)石灰性土壤上氨挥发量大的主要原因是其高的土壤和灌溉水的pH。石灰性土壤的高pH和光照充足,促进了田面水中藻类的生长。由此引起的日间田面水pH的上升促进了尿素的氨挥发,而对碳铵的氨挥发的促进则不大。

关键词：石灰性土壤稻田化肥氮

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The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue:Emerging Investigators

Aggregate

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Aggregate 2023年第4期4卷 195-209页

作者： Bruce Lin Andrew Hung William Singleton Kevion K.Darmawan Rachael Moses Bicheng Yao Hongkang Wu Anders Barlow Marc-Antoine Sani Alastair j.Sloan Mohammed Akhter Hossain john D.Wade Yuning Hong Neil M.O’Brien-simpson Wenyi Li The Bio21 Institute of Molecular Science and Biotechnology University of MelbourneMelbourneVictoriaAustralia ACTV Research group Melbourne Dental SchoolCentre for Oral Health ResearchUniversity of MelbourneMelbourneVictoriaAustralia School of Science RMIT UniversityMelbourneVictoriaAustralia Melbourne Dental School Division of Basic and Clinical Oral SciencesUniversity of MelbourneMelbourneVictoriaAustralia Department of Biochemistry and Chemistry La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVictoriaAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia School of Chemistry University of MelbourneMelbourneVictoriaAustralia Materials Characterisation and Fabrication Platform University of MelbourneMelbourneVictoriaAustralia

Antimicrobial peptides(AMPs)are potentially powerful alternatives to conven-tional antibiotics in combating multidrug resistance,given their broad spectrum of *** mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures,resulting in permeability and destruction of target microorganism *** earlier work showed that two leading AMPs,MSI-78(4–20)and pardaxin(1–22),had potent antimicrobial activ-ity against a range of *** is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer,inducing membrane curvature,destabilization,and potential ***,in this work,we aimed to investigate the antimicrobial activity,oligomerization propensity,and lipid-membrane binding interactions of a range of N-terminal lipidated analogs of MSI-78(4–20)and pardaxin(1–22).Molecular modeling results suggest that aggregation of the N-lipidated AMPs may impart greater structural stability to the peptides in solu-tion and a greater depth of lipid bilayer insertion for the N-lipidated AMPs over the parental *** experimental and computationalfindings provide insights into how N-terminal lipidation of AMPs may alter their conformations,with subsequent effects on their functional properties in regard to their self-aggregation behavior,membrane interactions,and antimicrobial activity.

关键词： aggregation antimicrobial peptide lipidation membrane active peptide

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