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Perfluorocarbon in vitreoretinal surgery and preoperative bevacizumab in diabetic tractional retinal detachment

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World journal of Diabetes 2014年第5期5卷 724-729页

作者： j Fernando Arevalo Martin A serrano juan D Arias From the Retina Division Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore MD 21287 United States the Vitreoretinal Division King Khaled Eye Specialist Hospital Riyadh 11462 Saudi Arabia Division of Ophthalmology Faculty of Medicine and Health Sciences University of Stellenbosch Stellenbosch 7600 South Africa the Retina and Vitreous Service Clinica Oftalmologica Centro Caracas Caracas 1010 Venezuela

AIM: To describe the en bloc perfluorodissection(EBPD) technique and to demonstrate the applicabilityof using preoperative intravitreal bevacizumab duringsmall-gauge vitreoretinal surgery(23-gauge transconjunctival sutureless vitrectomy) in eyes with advancedproliferative diabetic retinopathy(PDR) with tractionalretinal detachment(TRD).METHODS: This is a prospective, interventional caseseries. Participants included 114(eyes) with advancedproliferative diabetic retinopathy and TRD. EBPD wasperformed in 114 eyes(consecutive patients) during23-gauge vitrectomy with the utilization of preoperativebevacizumab(1.25 mg/-0.05 mL). Patients mean age was 45 years(range, 21-85 years). Surgical time had a mean of 55 min(Range, 25-85 min). Mean follow up of this group of patients was 24 mo(range, 12-32 mo). Main outcome measures included best-corrected visual acuity(BCVA), retinal reattachment, and ***: Anatomic success occurred in 100%(114/-114) of eyes. Significant visual improvement [≥ 2 Early Treatment Diabetic Retinopathy Study(ETDRS) lines] was obtained in 69.2%(79/-114), in 26 eyes(22.8%) BCVA remained stable, and in 8 eyes(7%) BCVA decreased(≥ 2 ETDRS lines). Final BCVA was 20/-50 or better in 24% of eyes, between 20/-60 and 20/-400 in 46% of eyes, and worse than 20/-400 in 30% of eyes. Complications included cataract in 32(28%) eyes, iatrogenic retinal breaks in 9(7.8%) eyes, vitreous hemorrhage requiring another procedure in 7(6.1%) eyes, and phthisis bulbi in 1(0.9%) ***: This study demonstrates the usefulne-ss of using preoperative intravitreal bevacizumab and EBPD during smallgauge vitreoretinal surgery in eyes with TRD in PDR.

关键词： Avastin Intravitreal bevacizumab Intravitreal injections Proliferative diabetic retinopathy Tractional retinal detachment Perfluorodissection Minimally invasive vitreoretinal surgery Vitrectomy

Preparation and Microstructural Characterization of Activated Carbon-Metal Oxide Hybrid Catalysts:New Insights into Reaction Paths

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journal of Materials Science & Technology 2015年第8期31卷 806-814页

作者： A.Barroso-Bogeat M.Alexandre-Franco C.Fernndez-Gonzlez V.Gómez-serrano Department of Organic and Inorganic Chemistry Faculty of SciencesUniversity of Extremadura

In catalysis processes, activated carbon （AC） and metal oxides （MOs） are widely used either as catalysts or as catalyst supports because of their unique properties. A combination of AC and MO nanoparticles in a single hybrid material usually entails both chemical and microstructural changes, which may largely influence the potential catalytic suitability and performance of the resulting product. Here, the prepa- ration of a wide series of AC-MO hybrid catalysts is studied. Three series of such catalysts are prepared by support first of MO （Al2O3, Fe2O3, SnO2, TiO2, WO3, and ZnO） precursors on a granular AC by wet impregnation and oven-drying at 120 ℃, and by subsequent heat treatment at 200 or 850℃ in inert atmosphere. Both the chemical composition and microstructure are mainly investigated by powder X-ray diffraction. Yield and ash content are often strongly dependent on the MO precursor and heat treatment temperature, in particular for the Sn catalysts. With the temperature rise, trends are towards the transformation of metal hydroxides into metal oxides, crystallinity improvement, and occurrence of drastic composition changes, ultimately leading to the formation of metals in elemental state and even metal carbides. Reaction paths during the preparation are explored for various hybrid catalysts and new insights into them are provided.

关键词： Activated carbon Metal oxides Hybrid catalysts Preparation Microstructural characterization X-ray diffraction

Dexamethasone in coronavirus disease 2019 care:Dosage and utilization insights

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World journal of Virology 2025年第1期14卷 1-4页

作者： Laiba Shamim Imshaal Musharaf Abdulqadir j Nashwan Department of Clinical Medicine Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan Department of Medicine Jinnah Sindh Medical UniversityKarachi 75510SindhPakistan Department of Nursing and Midwifery Research Hamad Medical CorporationDoha 3050Qatar

Coronavirus disease 2019(COVID-19)is a contagious disease caused by severe acute respiratory syndrome coronavirus *** was declared a global pandemic on March 11,2020,by the World Health *** excessive inflammatory response is a severe respiratory manifestation of COVID-19,which becomes predominant in later *** to its immunosuppressive and anti-inflammatory properties,dexamethasone is the first systemic glucocorticoid to treat severe COVID-19 *** editorial reviews the efficacy and safety of highdose vs low-dose dexamethasone in patients with *** indicate that using low-dose dexamethasone is beneficial and emphasize the need for additional research on the use of high-dose *** the study provides a robust evidence base,it is limited by the lack of long-term data,focus on specific outcomes and heterogeneity of the included *** research should focus on the long-term effects of dexamethasone and its impact across varying disease severities and patient populations to refine treatment strategies and improve patient care.

关键词： COVID-19 Severe acute respiratory syndrome Corticosteroid Dexamethasone Anti-inflammatory

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A homozygous nonsense mutation in DNAjC30 causes Leber’s hereditary optic neuropathy with Leigh-like phenotypes

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Genes & Diseases 2023年第4期10卷 1165-1168页

作者： Chao Shen Kitty Wang Wei Li Alvaro serrano Kelly Powers Chengwan Zhang jianjun Chen Miao Sun Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Division of Medical Genetics Department of PediatricsChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Division of Neurology Children’s Hospital Los AngelesLos AngelesCA 90027USA Division of Genomic Medicine Department of Pathology and Laboratory MedicineChildren’s Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

Nuclear encoded genes can cause early-onset mitochon-dria-related disorders such as Leigh or Leigh-like *** in DNAjC30 have been implicated in mitochondria-related diseases such as Leber’s hereditary optic neuropa-thy(LHON)and Williams syndrome(WS).However,the role of DNAjC30 in disease progression concerning mitochon-drial dysfunction has yet to be fully *** we report a 12-year-old boy with acute dystonia onset at age 10.

关键词： Leigh Leber acute

Evaluation of Variable Rate Technology for Fertilizer Application in Permanent Pastures

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journal of Agricultural Science and Technology(A) 2011年第4X期1卷 489-499页

作者： j. M. serrano j. M. Peca Shahidian ICAAM Rural Engineering Department University of Evora Evora 7002-554 Portugal

This paper describes the field tests carried out to evaluate the new Vicon RS-EDW centrifugal fertilizer spreader, to be used in Precision Agriculture. The results of initial dynamic calibration tests showed a significant and systematic difference between the application rates of the two discs （about 20%）. This difference had to be corrected by the manufacturer that carried out the necessary changes to the electric actuators. The fertilizer spreader had good distribution homogeneity, considering different working velocities and different positions in the parcel. The pattern distribution curve for 18% super phosphate fertilizer led to an effective working width of 28 meters, with a coefficient of variation of 15%. The longitudinal test, under experimental working conditions led to a machine delay time of 6-7 seconds. The results show an actual fertilization application density between 74%-90% of that determined for each location. These results confirm that the spreader can be used to spread fertilizer differentially in the field.

关键词： Calibration centrifugal fertilizer spreader, evaluation, precision agriculture, variable rate technology.

Classification and authentication of spices and aromatic herbs by means of HPLC-UV and chemometrics

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Food Bioscience 2023年第2期52卷 515-521页

作者： josep Pages-Rebull Clara Perez-Rafols Nuria serrano Manel del Valle jose Manuel Diaz-Cruz Department of Chemical Engineering and Analytical Chemistry Universitat de Barcelona(UB)Martii Franques 1-1108028BarcelonaSpain Water Research Institute(IdRA) University of Barcelona(UB)Martii Franques 1-1108028BarcelonaSpain Sensors&Biosensors Group Department of ChemistryUniversitat Autonoma de Barcelona(UAB)Edifici Cn08193BellaterraSpain

Recent increase in the adulteration of spices and aromatic herbs in food industry constitutes a problem that requires exhaustive quality *** every spice has a different composition with characteristic biomarkers,chromatographic profiles are especially valuable to authenticate these ***,in this work a new high performance liquid chromatography(HPLC)method with UV-vis detection was developed for the characterization,identification and authentication of cinnamon,oregano,thyme,sesame,bay leaf,clove,cumin,and *** separation was optimized based on the separation of six characteristic biomarkers(sesamol,eugenol,thymol,carvacrol,salicylaldehyde and vainillin)and was performed using a C18 reversed-phase column under a 35 min gradient elution based on 0.1%(v/v)formic aqueous solution and methanol by means of UV-Vis detection at 280 nm.87 samples,purchased in local supermarkets,were analyzed and the obtained profiles were processed by chemometric ***,data treatment was evaluated by principal component analysis(PCA);next soft independent modelling by class analogy(SIMCA)and partial least squares discriminant analysis(PLS-DA)were carried out in order to verify if classification according to their biomarkers was *** study concluded that PLS-DA(0.14-0.75%global error)classifies better the types of spice or aromatic herb than SIMCA(0.82-3.67%global error).

关键词： Spices Herbs Food authentication Liquid chromatography Chemometrics

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基于果萼图像的猕猴桃果实夜间识别方法

农业工程学报 2017年第2期33卷 199-204页

作者：傅隆生孙世鹏 Vázquez-arellano Manuel 李石峰李瑞崔永杰西北农林科技大学机械与电子工程学院杨凌712100 Institute of Agricultttral Engineering University of HohenheimStuttgart 70599Germany

根据猕猴桃的棚架式栽培方式,提出了一种适用于猕猴桃采摘机器人夜间识别的方法。采用竖直向上获取果实图像的拍摄方式,以果萼为参考点,进行果实的识别,并测试该方法对光照的鲁棒性。试验结果表明:基于果萼能够有效的识别猕猴桃果实,成... 详细信息

根据猕猴桃的棚架式栽培方式,提出了一种适用于猕猴桃采摘机器人夜间识别的方法。采用竖直向上获取果实图像的拍摄方式,以果萼为参考点,进行果实的识别,并测试该方法对光照的鲁棒性。试验结果表明:基于果萼能够有效的识别猕猴桃果实,成功率达94.3%;未识别和误识别的果实一般出现在5果及5果以上的簇中,原因是果实相互挤压导致的果萼部分不在果实图像的中心区域,以及果实之间的三角区形成暗色封闭区域;光照过小或过大会导致成像模糊或过曝,对正确率有细微影响;识别速度达到了0.5 s/个。因此,基于果萼的猕猴桃果实夜间识别方法在正确识别率和速度上都有很大提升,更接近实际应用。

关键词：机器人图像识别农作物猕猴桃果萼夜间识别毗邻果实

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting