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PROCESSES OF HEADCUT GROWTH AND MIGRATION IN RILLS AND GULLIES

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International journal of Sediment Research 2000年第1期15卷 69-82页

作者： Kerry M. Robinson(Plant Science and Water Conservation Research Laboratory, USDA-ARS, 1301 N. Western St., Stillwater, OK 74075, USA)sean j. Bennett(National Sedimentation Laboratory, USDA-ARS, P.O. Box 1157, Oxford, MS 38655, USA)javier Casali, and Grego

The formation and upstream migration of headcuts significantly increases soil losses and sediment yield from agricultural lands, threatens the structural integrity of earthen dams, and can undermine roads and bridges. Recent research using unique experimental facilities and methodologies has provided new insights on these erosion processes. Under controlled experimental conditions, steady-state soil erosion due to migrating headcuts has been simulated for rills and along crop furrows. During migration, headcut shape, size, rate of movement, and sediment yield remained constant. Downstream of the headcut, a soil bed was constructed where slope was dependent upon the sediment yield from the headcut and the flow transport capacity. Soil erosion processes were also examined in a large outdoor facility simulating gully headcuts. Using a compacted cohesive soil, headcut migration rate was observed to decrease as the average density and average unconfined compressive strength increased. While the flow rate and overfall height were not observed to have a major impact on advance rates, a sand layer at the base of an overfall did have a dramatic influence on advance rates. The erosion processes and flow structure within the large gully headcuts were strikingly similar to those in rills and crop furrows. The commonality of form and process in these soil erosion phenomena suggests that erosion prediction technology and mitigation measures may be developed and widely applied.

关键词： Headcut Soil loss Sediment yield Soil Erosion process Rill Gully

Expanding the genetic landscape of Rett syndrome to include lysine acetyltransferase 6A(KAT6A)

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journal of Genetics and Genomics 2020年第10期47卷 650-654页

作者： Simranpreet Kaur Nicole j.Van Bergen Bruria Ben-Zeev Emanuela Leonardi Tiong Y.Tan David Coman Benjamin Kamien Susan M.White Miya St john Dean Phelan Kristin Rigbye Sze Chern Lim Michelle C.Torres Melanie Marty Elena Savva Teresa Zhao sean Massey Alessandra Murgia Wendy A.Gold john Christodoulou Brain and Mitochondrial Research Group Murdoch Children's Research InstituteMelbourneAustralia Department of Paediatrics University of MelbourneMelbourneAustralia Paediatric Neurology Institute The Edmond and Lily Safra Paediatric HospitalSheba Medical CenterTel HaShomerIsrael Sackler School of Medicine Tel Aviv UniversityIsrael Molecular Genetics of Neurodevelopment Department of Woman and Child HealthUniversity of PadovaItaly Fondazione Istituto di Ricerca Pediatrica(IRP) Citta della SperanzaPadovaItaly Victorian Clinical Genetics Services Murdoch Children's Research InstituteMelbourneAustralia Department of Paediatrics The Wesley HospitalBrisbaneBrisbaneAustralia Queensland Children's Hospital BrisbaneAustralia School of Medicine University of QueenslandBrisbaneAustralia Genetic Services of Western Australia Western AustraliaAustralia Faculty of Health and Medical Sciences University of Western AustraliaAustralia Speech and Language Murdoch Children's Research InstituteParkvilleVictoriaAustralia Department of Audiology and Speech Pathology University of MelbourneParkvilleVictoriaAustralia The University of Sydney School of Medical Sciences and Discipline of Child and Adolescent HealthFaculty of Medicine and HealthSydneyAustralia Molecular Neurobiology Lab Kids ResearchWestmead Children's HospitalWestmeadSydneyAustralia Kids Neuroscience Centre Kids ResearchChildren's Hospital at WestmeadWestmeadSydneyAustralia

Pathogenic variants in methyl-Cp G protein 2(MECP2;OMIM300005)result in an X-linked,severe,and progressive epigenetic disorder,Rett syndrome(RTT,OMIM:312750),that predominantly affects females(Rett,1966).Using Neul’s revised diagnostic criteria,affected individuals can be clinically classified as classic or atypical RTT(Neul et al.,2010).

关键词： Rett al. landscape

Electroosmotic Water Vapor Transport across Novel, Smart, Functionalized Conducting Polymer Microporous Membranes in Active Mode at Very High Rates, with Concomitant Chemical Warfare (CW) Agent Blocking

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Advances in Materials Physics and Chemistry 2013年第4期3卷 217-237页

作者： Prasanna Chandrasekhar Petar Pirgov Brian j. Zay David Lawrence sean Morefield Tilghman L. Rittenhouse Salvatore G. Clementi Quoc Truong Russell R. Greene Ashwin-Ushas Corporation Marlboro NJ USA Chemical and Biological Technologies Directorate US Defense Threat Reduction Agency (DTRA) Fort Belvoir VA USA Hazardous Materials Research Center (HMRC) Battelle Columbus Laboratories Battelle Memorial Institute Columbus OH USA US Army Engineer Research and Development Center Construction Engineering Research Laboratory (ERDC-CERL) Champaign IL USA Warrior Science Technology and Applied Research Directorate US Army Natick Soldier Research Development and Engineering (RD&E) Center Natick MA USA

Electroosmotic water vapor transport (WVT) across very thin, flexible, functionalized conducting polymer (CP) microporous (μP) membranes at a very high rate is reported. Both passive and active (6 VDC applied) WVT are reported, the latter for the first time ever. WVT occurs with concomitant, effective blocking of chemical warfare (CW) agents, again demonstrated for the first time ever. Initial active liquid||membrane||liquid interface studies demonstrated WVT rates of >1.7 × 10-5g .mm-2s-1, >3 × the highest prior reported values of 5 × ***-2s-1. Subsequent vapor||membrane|| vapor interface studies using industry-standard methods (including ASTM E96B Upright Cup (“WVT”), ASTM F2298 (“Dynamic Moisture Permeation Cell”) and ASTM F1868 (“Sweating Guard Hotplate”) were done at independent, external labs for independent corroboration. These yielded, e.g., WVT values of2564.4 g.m2.d-1 (passive) and3706.7 g.m2d-1 (active), to be compared with the highest (passive) value ever reported previously,984.8 g.m2.d-1 for a μP-Nylon membrane. More than 15 different membrane configurations, porosities and types were studied, including membranes with CP + organophosphate hydrolase (OPH), an enzyme reactive to CW agents. Efficient blocking of the actual CW agents GB, HD, VX is also reported, using the TOP-8-2-501standard. Membranes also passed all Industry-standard durability tests, e.g. ASTM D2261 (Tearing), ASTM D5034 (Breaking), ASTM D3886 (Abrasion), ASTM F392 (Gelbo Flex). Incorporation into smart soldiers’ garments was demonstrated;power consumption was -2. Mechanisms of enhanced WVT and CW agent blocking in the membranes are discussed.

关键词： Electroosmotic Transport Smart Microporous Membrane Conducting Polymer Functionalized

Disruption of Drug Effects (Dopamine, Nicotine, Pilocarpine, κ-Opioid) in Planarians by UV Light

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Pharmacology & Pharmacy 2012年第3期3卷 358-363页

作者： Robert B. Raffa Christopher S. Tallarida Aruj Choudhry Nadia Sanni-Adam sean McGonigle Michael Baron Zhuo L. Chen Scott M. Rawls Ronald j. Tallarida Department of Pharmaceutical Sciences Temple University School of Pharmacy Philadelphia PA U.S.A. Department of Pharmacology Temple University School of Medicine and Center for Substance Abuse Research Temple University Philadelphia PA U.S.A.

Based on previous work, it has been hypothesized that the energetics of ultraviolet (UV) light disrupts effects induced by receptor-binding ligands. If this hypothesis is true, then UV light should (i) disrupt a broad variety of endpoints and (ii) disrupt effects produced by ligands that bind to diverse receptor types. This was tested directly in the present study by using ligands selective for four different receptors (one ionotropic, three metabotropic) and three different behavioral endpoints. The selective dopamine D2 receptor antagonist (–)sulpiride (0.1 uM) dose-relatedly decreased spontaneous locomotor velocity, the selective nicotinic acetylcholine receptor agonist nicotine (1, 3, 5 mM) and the selective muscarinic acetylcholine receptor agonist pilocarpine (20, 30, 50 mM) induced seizure-like activity, and the selective-opioid receptor agonist U-50,488H (10 uM) produced physical dependence (manifested as abstinence-induced withdrawal) in planarian models. Each of these diverse ligand and receptor-mediated effects were attenuated by UV light (254 nm = 7.83 × 10–19 j = 4.89 eV). These findings provide further evidence that UV light disrupts ligand-receptor mediated interactions and that UV light might provide a useful tool for examining drug-receptor interactions.

关键词： UV Light Drug-Receptor Interaction Locomotor Activity Seizure Physical Dependence Planarian

Geochronological,Geochemical and Paleomagnetic Clues for Existence of a~2.1Ga Dyke Generation in the Mashishing Area,South Africa

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 71-页

作者： Herve Wabo Georgy Belyanin Michiel O.de Kock Fabien humbert Ulf Soderlund Léonie P.Maré jan Kramers Nicolas j.Beukes Paleoproterozoic Mineralization Research Group(the PPM research group) DST-NRF Centre of Excellence for Integrated Mineral and Energy Resource Analysis(CIMERA) Department of GeologyUniversity of Johannesburg Department of Geology Lund University Council for Geoscience

Dyke swarms are widespread throughout the Kaapvaal Craton(KC)in South Africa and have been documented in some *** to date,only the^2.9 Ga SE-trending and the^2.7 to^2.66 Ga radiating dyke arrays are

关键词： Geochemical and Paleomagnetic Clues for Existence of a Geochronological South Africa Dyke Generation in the Mashishing Area Ga

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使用沃特世超高效合相色谱分析短杆菌肽

食品安全导刊 2013年第3期 30-31页

作者： sean M.McCarthy Andrew j.Aubin Michael D.jones 沃特世公司(美国马萨诸塞州米尔福德)

短杆菌肽是由芽孢杆菌产生的一种常见和已被良好表征的跨膜肽物质，被用作对抗革兰氏阳性和某些革兰氏阴性细菌的局部用抗生素。用反相液相色谱（RPLC）分析疏水性肽和蛋白质难度很大。因为溶液中经常需要使用洗涤剂保持疏水性物质的稳... 详细信息

短杆菌肽是由芽孢杆菌产生的一种常见和已被良好表征的跨膜肽物质，被用作对抗革兰氏阳性和某些革兰氏阴性细菌的局部用抗生素。用反相液相色谱（RPLC）分析疏水性肽和蛋白质难度很大。因为溶液中经常需要使用洗涤剂保持疏水性物质的稳定性，而这些洗涤剂容易发生聚集或沉淀，严重影响它们的回收，这些因素及其他原因使得难以用RPLC分离疏水性肽和蛋白质。

关键词：短杆菌肽色谱分析超高效疏水性物质革兰氏阴性细菌反相液相色谱芽孢杆菌 RPLC

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索他西普治疗肺动脉高压

中华高血压杂志(中英文) 2021年第8期29卷 799-799页

作者： humbert M McLaughlin V Gibbs jSR Gomberg-Maitland M Hoeper MM Preston IR Souza R Waxman A Subias PE Feldman j Meyer G Montani D Olsson KM Manimaran S Barnes j Linde PG Oliveira P Badesch D 周卫练桂丽

肺动脉高压具有肺血管重构、细胞增生、长期预后差的特点。骨形态发生蛋白信号通路的功能失调与遗传性和特发性亚型相关。索他西普是一种新的融合蛋白,它与激活素和生长分化因子结合,可能恢复生长促进或生长抑制信号通路之间的平衡。方... 详细信息

肺动脉高压具有肺血管重构、细胞增生、长期预后差的特点。骨形态发生蛋白信号通路的功能失调与遗传性和特发性亚型相关。索他西普是一种新的融合蛋白,它与激活素和生长分化因子结合,可能恢复生长促进或生长抑制信号通路之间的平衡。方法:在为期24周的多中心试验中,研究者随机分配接受肺动脉高压治疗的成人106名,分别接受皮下注射0.3或0.7mg/(kg·3周)索他西普或者安慰剂。主要终点是从基线到第24周肺血管阻力的变化。结果:

关键词：肺动脉高压最小二乘肺血管阻力安慰剂

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不同年龄和部位女性皮肤微循环变化

中国微循环 2004年第1期8卷 43-46,F002页

作者：李利 S.MAC MARY j.M.St HILLIER A.DEGOUY T.GHARBI O.de LACHARRIERE Ph.humbert 四川大学华西医院皮肤性病科四川成都610041 倍桑松孔泰大学医学和药学院工程和皮肤生物实验室倍桑松孔泰大学医学和药学院光学实验室欧莱雅临床研究部

目的观察不同部位皮肤血管结构和形态差异,研究年龄对真皮微循环功能的影响。方法采用活体电视毛细血管镜 (IntravitalVideo-capillaroscopy)和激光多谱勒血流仪(laserDopplerflowmetry)对50名年龄在20～74岁 ,光皮肤类型为II～III型白... 详细信息

目的观察不同部位皮肤血管结构和形态差异,研究年龄对真皮微循环功能的影响。方法采用活体电视毛细血管镜 (IntravitalVideo-capillaroscopy)和激光多谱勒血流仪(laserDopplerflowmetry)对50名年龄在20～74岁 ,光皮肤类型为II～III型白人女性志愿者的前额、眼角、前臂内侧和手背血管作初步观察。并用计算机图象处理技术 ,对前臂和手背活体真皮血管密度作定量分析。结果真皮乳头毛细血管襻在活体电视毛细血管镜下为点状或逗点状 ;乳头下的血管丛表现为线条状或网状 ;年轻人皮肤血管排列整齐 ,年龄较大者血管扩张增粗、扭曲 ,排列不规则。年龄与襻状血管数、襻状血管面积显著负相关 ;与襻状血管间距、平行血管总长正相关 ;真皮血流量面部高于肢端 ;随年龄的增加真皮血流有逐渐增加趋势。结论年龄影响真皮微循环的形态和功能。两种无创性检测技术联合应用能动态研究活体真皮血管的形态和结构 ,在皮肤血管性疾病的诊断和治疗方面有较高的应用前景。

关键词：皮肤微循环电视毛细血管镜激光多谱勒血流仪

Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis

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World journal of Hepatology 2015年第27期7卷 2774-2780页

作者： jonathan G Stine Puja M Shah Scott L Cornella sean R Rudnick Marwan S Ghabril George j Stukenborg Patrick G Northup Division of Gastroenterology and Hepatology University of Virginia Department of Surgery University of Virginia Department of Medicine University of Virginia Division of Gastroenterology and Hepatology Indiana University Department of Public Health Science University of Virginia

AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with ***: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%***: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.

关键词： Hepatology Coagulopathy Liver Ascites Hepatic ence