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小井眼侧钻可降低钻井成本

国外油田工程 2000年第1期16卷 21-22页

作者： .j.scott 胡萍韩永刚四川石油钻井公司

小井眼侧钻井对于储量贫乏的油田仍具有一定的吸引力 ,它不仅技术可靠 ,而且经济 ,可降低钻井成本。与连续油管钻井技术相比 ,生产时间稍长 ,但使用的钻头却少得多 ,可有效地取代连续油管的钻井技术。

关键词：小眼井钻井连续油管钻井钻井成本采油井

Correction to:EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

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Protein & Cell 2020年第8期11卷 618-619页

作者： jing Tang Bowei Zhou Melanie j.scott Linsong Chen Dengming Lai Erica K.Fan Yuehua Li Qiang Wu Timothy R.Billiar Mark A.Wilson Ping Wang jie Fan The Department of Anesthesiology Affiliated hospital of Guangdong Medical UniversityZhanjiang 524000China Department of Surgery University of Pittsburgh School of MedicinePittsburghPA 15213USA Research and Development Veterans Affairs Pittsburgh Healthcare SystemPittsburghPA 15240USA Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China Department of Cardiovascular Surgery The Children's Hospital of Zhejiang University School of MedicineHangzhou 310052China University of Pittsburgh The Graduate School of Public Health PittsburghPA 15213USA Laboratory of Tropical Biomedicine and Biotechnology School of Tropical Medicine and Laboratory MedicineHainan Medical UniversityHaikou 571199China The Feinstein Institute for Medical Research ManhassetNY 11030USA McGowan Institute for Regenerative Medicine University of PittsburghPittsburghPA 15219USA Key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang Zhanjiang 524000China

Figure *** activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of PD or TAPI-1.(A)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(B)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(C and D)WT(C57BL76)mice were treated with LPS(10 mg/kg,i.p.).In some groups,mice were pretreated with erlotinib(100 mg/kg,gavage administration)at 30 min prior to LPS i.p.

关键词： activation surface phosphorylation

Local and global methods in representations of Hecke algebras

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Science China Mathematics 2018年第2期61卷 207-226页

作者： jie Du Brian j.Parshall Leonard L.scott School of Mathematics and Statistics University of New South Wales(UNSW) Department of Mathematics University of Virginia

This paper aims at developing a "local-global" approach for various types of finite dimensional algebras, especially those related to Hecke algebras. The eventual intention is to apply the methods and applications developed here to the cross-characteristic representation theory of finite groups of Lie type. We first review the notions of quasi-hereditary and stratified algebras over a Noetherian commutative ring. We prove that many global properties of these algebras hold if and only if they hold locally at every prime ideal. When the commutative ring is sufficiently good, it is often sufficient to check just the prime ideals of height at most one. These methods are applied to construct certain generalized q-Schur algebras, proving they are often quasi-hereditary(the "good" prime case) but always stratified. Finally, these results are used to prove a triangular decomposition matrix theorem for the modular representations of Hecke algebras at good primes. In the bad prime case, the generalized q-Schur algebras are at least stratified, and a block triangular analogue of the good prime case is proved, where the blocks correspond to Kazhdan-Lusztig cells.

关键词： quasi-hereditary algebra stratified algebra Hecke algebra Schur algebra left cell endomorphism algebra exact category height one prime

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Obesity and liver transplantation

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World journal of Transplantation 2015年第3期5卷 95-101页

作者： Subhashini Ayloo john armstrong scott Hurton Michele Molinari Department of Surgery Dalhousie University

The percentage of overweight and obese patients(OPs) waiting for a liver transplant continues to increase. Despite the significant advances occurred in bariatric medicine, obesity is still considered a relative contraindication to liver transplantation(LT). The main aim of this review is to appraise the literature on the outcomes of OPs undergoing LT, treatments that might reduce their weight before, during or after surgery, and discuss some of the controversies and limitations of the current knowledge with the intent of highlighting areas where future research is needed.

关键词： Liver transplantation Bariatric surgery Obesity End-stage liver disease Weight-loss Access to transplantation

The promise of immunotherapy in genitourinary malignancies

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Precision Clinical Medicine 2018年第3期1卷 97-101页

作者： Tian Zhang Andrew j.armstrong Daniel j.George jiaoti Huang Duke Cancer Institute Duke University School of MedicineDurhamNC27514

A broad understanding of the tumor immune landscape has led to a revolution of immune checkpoint inhibitors in the treatment of multiple cancer *** genitourinary malignancies,immune checkpoint inhibitors have improved outcomes for patients with metastatic renal cell carcinoma and metastatic urothelial carcinoma;however,these treatments have not yet proven broadly beneficial for patients with metastatic prostate *** prospective trials are ongoing to further improve outcomes with immunotherapy combinations and for biomarker development to predict benefit from immune checkpoint *** perspective article highlights our current immunotherapy approaches in each of the genitourinary malignancies and the ongoing clinical trials that may inform our future treatments in renal,urothelial,and prostate cancers.

关键词： immune checkpoint inhibition urothelial carcinoma renal cell carcinoma prostate cancer

Long-term monitoring of cycles in Clethrionomys rutilus in the Yukon boreal forest

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Integrative Zoology 2024年第1期19卷 27-36页

作者： Charles j.KREBS Alice j.KENNEY B.scott GILBERT Rudy BOONSTRA Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Renewable Resources Management Program Yukon UniversityWhitehorseYukonCanada Department of Biological Sciences University of Toronto ScarboroughTorontoOntarioCanada

Baseline studies of small rodent populations in undisturbed ecosystems are *** report here 50 years of mon-itoring and experimentation in Yukon of a dominant rodent species in the North American boreal forest,the red-backed vole Clethrionomys *** voles breed in summer,weigh 20–25 g,and reach a maximum density of 20 to 25 per *** populations have shown consistent 3–4-year cycles for the last 50 years with the only change being that peak densities averaged 8/ha until 2000 and 18/ha since that *** the last 25 years,we have measured food resources,predator numbers,and winter weather,and for 1-year social interactions,to estimate their contribution to changes in the rate of summer increase and the rate of overwinter *** these potential limiting factors could contribute to changes in density,and we measured their relative contributions statistically with multiple *** rate of winter decline in density was related to both food supply and winter *** rate of summer increase was related to summer berry crops and white spruce cone *** measure of predator numbers was related to winter or summer changes in vole *** was a large signal of climate change effects in these *** is no density dependence in summer population growth and only a weak one in winter population *** of our results provide a clear understanding of what generates 3–4-year cycles in these voles,and the major missing piece may be an understanding of social interactions at high density.

关键词： boreal forest climate change density dependence population cycles predation winter severity

Gastrointestinal manifestations of systemic mastocytosis

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World journal of Gastroenterology 2008年第45期14卷 7005-7008页

作者： jason K Lee scott j Whittaker Robert A Enns Peter Zetler Internal Medicine University of British Columbia St. Paul's Hospital Division of Gastroenterology University of British Columbia St. Paul's Hospital Division of Pathology University of British Columbia

Systemic mastocytosis (SM) is a rare disease with abnormal proliferation and infiltration of mast cells in the skin, bone marrow, and viscera including the mucosal surfaces of the digestive tract. Gastrointestinal (GI) symptoms occur in 14%-85% of patients with systemic mastocytosis. The GI symptoms may be as frequent as the better known pruritis, urticaria pigmentosa, and flushing. In fact most recent studies show that the GI symptoms are especially important clinically due to the severity and chronicity of the effects that they produce. GI symptoms may include abdominal pain, diarrhea, nausea, vomiting, and bloating. A case of predominantly GI systemic mastocytosis with unique endoscopic images and pathologic confirmation is herein presented, as well as a current review of the GI manifestations of this disease including endoscopic appearances. Issues such as treatment and prognosis will not be discussed for the purposes of this paper.

关键词： Systemic mastocytosis Idiopathic diarrhea Gastrointestinal manifestations

Mechanically induced phase transformation of zinc sulfide

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Particuology 2015年第1期13卷 1-10页

作者： Cornelia Damm Patrick armstrong Christian Roβkopf Stefan Romeis Wolfgang Peukert University Erlangen-Nuremberg Institute of Particle Technology

Molecular dynamics （MD） simulations of the consecutive compression-decompression cycles ot hexagonal zinc sulfide （wurtzite） nanoparticles predict an irreversible phase transformation to the cubic *** phase transformation commences at the contact area between the particle and the inden- ter and proceeds with the number of compression cycles. Dislocations are visible for a particle size above 5nm. Results from wet grinding and dry powder compression experiments on a commercial wurtzite pigment agree qualitatively with MD simulation predictions. X-ray diffraction patterns reveal that the amount of cubic polymorph in the compressed samples increases with pressure applied to the powder. In comparison with powder compression, wet milling leads to a more pronounced phase transformation. This occurs because the particles are exposed to a large number of stress events by collision with the grinding media, which leads to the formation of defects and new surface crystallites by particle fracture. According to the MD simulations, phase transformation is expected to occur preferentially in surface crystallites because they experience the highest mechanical load. Because of the phase transformation, the wet ground and compressed samples exhibit a lower photo- luminescence intensity than the feed material. In comparison with powder compression, milling reduces the photoluminescence intensity more substantially. This occurs because a higher defect concentration is formed. The defects contribute to the phase transformation and photoluminescence quenching.

关键词： Polymorph transformationZinc sulfide Molecular dynamics simulation Wet milling Powder compression