检索结果-南通市图书馆

Volumetric changes in the focal areas of seismic events corresponding to destress blasting

International journal of Mining Science and Technology 2019年第4期29卷 541-547页

作者： P.Konicek j.schreiber L.Nazarova Department of Geomechanics and Mining Research Institute of Geonics of the Czech Academy of SciencesOstrava 70800Czech Republic Laboratory of Mining Informatics Chinakal Institute of Mining of the Siberian Branch of the Russian Academy of ScienceNovosibirsk 630091Russia

The typical development of total volumetric change in the focal areas of seismic events,corresponding to destress blasting,is characterized as an explosive phase followed by an implosive phase and with alternating additional phases following on from that.In a few cases,a non-typical development of volumetric change was identified,where the first phase was implosive and the second phase,explosive.This development is mainly typical for induced seismic events recorded during mining,not for destress blasting.Seismic events were recorded during longwall mining in the Czech part of the Upper Silesian Coal Basin,where the destress blasting technique is used as a rockburst prevention active measure.Kinematic source processes in the focal areas of selected seismic events were analyzed by the seismic moment tensor inversion method,as well as by studying geomechanical rock mass conditions at the localities of the seismic events.The main goal of the analysis was to attempt to identify the reasons for non-typical development of volumetric changes in these cases.Volumetric changes were analyzed for seismic events with energy greater than 104 j,recorded in the period of time from 1993 to 2009(1109 events).80%(891)of the recorded seismic events were induced seismic events that were registered during longwall mining and 20%(218)corresponded to destress blasting events.Research shows that the main reason for the non-typical development of volumetric changes in the focal areas of seismic events is an association with destress blasting in the rock mass,which is very close to rock mass overstressing.The detonation of explosives in boreholes,which would dominate the first phase of volumetric changes,probably obscured stress release in the rock mass,as manifested in the first implosion phase of the volumetric changes in this case.

关键词： Destress blasting Seismic event Volumetric changes Stress release

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ion-bunch energy acoustic tracing by modulation of the depth-dose curve

引用

High Power Laser Science and Engineering 2023年第3期 90-97页

作者： A.Pra?elsperger F.Balling H.-P.Wieser K.Parodi j.schreiber Fakult?t für Physik Ludwig-Maximilians-Universit?t München

Characterizing exact energy density distributions for laser-accelerated ion bunches in a medium is challenging due to very high beam intensities and the electro-magnetic pulse emitted in the laser±plasma interaction. Ion-bunch energy acoustic tracing allows for reconstructing the spatial energy density from the ionoacoustic wave generated upon impact in water. We have extended this approach to tracing ionoacoustic modulations of broad energy distributions by introducing thin foils in the water reservoir to shape the acoustic waves at distinct points along the depth-dose curve. Here, we present first simulation studies of this new detector and reconstruction approach, which provides an online read-out of the deposited energy with depth within the centimeter range behind the ion source of state-of-the-art laser-plasma-based accelerators.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Trends in oxycodone and oxycodone-containing analgesics administration for back pain in emergency departments in the USA(2007–2018)

引用

World journal of Emergency Medicine 2024年第3期15卷 169-174页

作者： jonathan Chabon jemer Garrido Deanna schreiber-Gregory jefferson Drapkin Sergey Motov Department of Emergency Medicine Maimonides Medical CenterBrooklyn 11219USA

BACKGROUND:To describe trends in oxycodone and oxycodone-containing analgesic prescribing for the treatment of back pain among adults in emergency departments(EDs) in the USA from 2007 to 2018.METHODS:Data were gathered from the National Hospital Ambulatory Medical Care Survey(NHAMCS) from 2007 to 2018.The study population included individuals of all ages presenting to USA EDs.The NHAMCS reasons for visit and oxycodone drug ID codes were used to isolate patients with back pain.The main outcome was the proportion of oxycodone and oxycodone-containing analgesics prescribed for back pain in the EDs over the specified time period.RESULTS:There was a relative decrease in the overall administration of oxycodone for back pain in the EDs by 62.3% from 2007(244,000 visits) to 2018(92,000 visits).The proportion of ED patients prescribed with oxycodone-containing analgesics for back pain increased among patients aged 45 years and older(from 43.8% to 57.6%),female patients(from 54.5% to 62.0%),black patients(from 22.5% to 30.4%),and Hispanic/Latino patients(from 9.4% to 19.6%).Oxycodone/acetaminophen was most prescribed and accounted for 90.2% of all oxycodone-containing analgesics in 2007,with a decrease to 68.5% in 2018.Pure oxycodone was the second most prescribed medication,accounting for 6.1% in 2007 and 31.5% in 2018.CONCLUSION:The overall number of oxycodone-containing analgesics decreased significantly from 2007 to 2018.However,that number trended upward in 45-year-old and older,female,black,or Hispanic/Latino patients from 2007 to 2018.The total amount of pure oxycodone increased significantly from 2007 to 2008.

关键词： Oxycodone Back pain Emergency department

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ion-bunch energy acoustic tracing by modulation of the depth-dose curve

引用

高功率激光科学与工程:英文版 2023年第3期11卷 86-93页

作者： A.Praßelsperger F.Balling H.-P.Wieser K.Parodi j.schreiber Fakultät für Physik Ludwig-Maximilians-Universität MünchenGarchingGermany

Characterizing exact energy density distributions for laser-accelerated ion bunches in a medium is challenging due to very high beam intensities and the electro-magnetic pulse emitted in the laser-plasma interaction.Ion-bunch energy acoustic tracing allows for reconstructing the spatial energy density from the ionoacoustic wave generated upon impact in water.We have extended this approach to tracing ionoacoustic modulations of broad energy distributions by introducing thin foils in the water reservoir to shape the acoustic waves at distinct points along the depth-dose curve.Here,we present first simulation studies of this new detector and reconstruction approach,which provides an online read-out of the deposited energy with depth within the centimeter range behind the ion source of state-of-the-art laser-plasma-based accelerators.

关键词： ion-bunch energy acoustic tracing ion detector ionoacoustics laser-ion acceleration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient scar-free knock-ins of several kilobases in plants by engineered CRISPR-Cas endonucleases

引用

Molecular Plant 2024年第5期17卷 824-837页

作者： Tom schreiber Anja Prange Petra Schafer Thomas Iwen Ramona Grutzner Sylvestre Marillonnet Aurelie Lepage Marie javelle Wyatt Paul Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany Limagrain Centre de RechercheRoute d’EnnezatCS 9012663720 ChappesFrance

In plants and mammals,non-homologous end-joining is the dominant pathway to repair DNA doublestrand breaks,making it challenging to generate knock-in events.In this study,we identified two groups of exonucleases from the herpes virus and the bacteriophage T7 families that conferred an up to 38-fold increase in homology-directed repair frequencies when fused to Cas9/Cas12a in a tobacco mosaic virus-based transient assay in Nicotiana benthamiana.We achieved precise and scar-free insertion of several kilobases of DNA both in transient and stable transformation systems.In Arabidopsis thaliana,fusion of Cas9 to a herpes virus family exonuclease led to 10-fold higher frequencies of knock-ins in the first generation of transformants.In addition,we demonstrated stable and heritable knock-ins in wheat in 1%of the primary transformants.Taken together,our results open perspectives for the routine production of heritable knock-in and gene replacement events in plants.

关键词： homology-directed repair knockin gene replacement CRISPR-Cas 50 exonuclease plants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of relativistic laser–ion acceleration

引用

High Power Laser Science and Engineering 2014年第4期2卷 74-85页

作者： j.schreiber F.Bell Z.Najmudin Fakultt fr Physik Ludwig-Maximilians-Universitt Mnchen Am Coulombwall 1D-85748 Garching Germany Max-Planck-Institut fr Quantenoptik Hans-Kopfermann-Str.1D-85748 Garching Germany The john Adams Institute Blackett Laboratory Imperial College LondonLondon SW7 2AZ United Kingdom

Experiments have shown that the ion energy obtained by laser–ion acceleration can be optimized by choosing either the appropriate pulse duration or the appropriate target thickness. We demonstrate that this behavior can be described either by the target normal sheath acceleration model of schreiber et al. or by the radiation pressure acceleration model of Bulanov and coworkers. The starting point of our considerations is that the essential property of a laser system for ion acceleration is its pulse energy and not its intensity. Maybe surprisingly we show that higher ion energies can be reached with reduced intensities.

关键词： laser–ion acceleration relativistic laser plasma interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three-dimensional acoustic monitoring of laser-accelerated protons in the focus of a pulsed-power solenoid lens

引用

高功率激光科学与工程:英文版 2023年第3期11卷 57-63页

作者： S.Gerlach F.Balling A.K.Schmidt F.E.Brack F.Kroll j.Metzkes-Ng M.Reimold U.Schramm M.Speicher K.Zeil K.Parodi j.schreiber Fakultät für Physik Ludwig-Maximilians-Universität MünchenGarchingGermany Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany

The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution.By adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals,I-BEAT(Ion-Bunch Energy Acoustic Tracing)3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual bunches.Relative changes in energy spread and lateral bunch size can also be monitored.Our experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm resolution.In addition to this 3D bunch information,the signal strength correlates also with the absolute bunch particle number.

关键词： ion diagnostics ionoacoustics laser-driven plasma source laser-ion acceleration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights from an academic endeavor into central nervous system drug discovery

引用

Neural Regeneration Research 2025年第6期 1717-1718页

作者： Lieve van Veggel An M.Voets Tim Vanmierlo Rudy schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life Sciences Hasselt University Department of Psychiatry and Neuropsychology Division of Translational Neuroscience European Graduate School of Neuroscience School for Mental Health and Neuroscience Maastricht University University MS Center (UMSC) Section of Psychopharmacology Neuropsychology and Psychopharmacology Faculty of Psychology and Neuroscience Maastricht University

Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to (late) development,regulatory approval,and marketing (Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia (Mazzucato,2013).

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effects of torpedo blasting on rockburst prevention during deep coal seam mining in the Upper Silesian Coal Basin

引用

journal of Rock Mechanics and Geotechnical Engineering 2017年第4期9卷 694-701页

作者： L. Wojtecki P. Konicek j. schreiber Polish Mining Group Powstanców 30 Katowice 40-039 Poland Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Sciences Studentska 1768 Ostrava-Poruba 708 00 Czech Republic

In the Upper Silesian Coal Basin(USCB),coal seams are exploited under progressively more difficult geological and mining conditions(greater depth,higher horizontal stress,more frequent occurrence of competent rock layers,etc.).Mining depth,dislocations and mining remnants in coal seams are the most important factors responsible for the occurrence of rockburst hazards.Longwall mining next to the mining edges of neighbouring coal seams is particularly disadvantageous.The levels of rockburst hazards are minimised via the use of rockburst prevention methods.One active prevention method is torpedo blasting in roof rocks.Torpedo blastings are performed in order to decrease local stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on excavations.The estimation of the effectiveness of torpedo blasting is particularly important when mining is under difficult geological and mining conditions.Torpedo blasting is the main form of active rockburst prevention in the assigned colliery in the Polish part of the USCB.The effectiveness of blasting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of explosives are taken into consideration.The seismic effect method was developed in the Czech Republic and is always being used in collieries in the Czech part of the coal basin.Now,this method has been widely adopted for our selected colliery in the Polish part of the coal basin.The effectiveness of torpedo blastings in the faces and galleries of the assigned longwall in coal seam 506 has been estimated.The results show that the effectiveness of torpedo blastings for this longwall was significant in light of the seismic effect method,which corresponds to the in situ observations.The seismic effect method is regularly applied to estimating the blasting effectiveness in the selected colliery.

关键词： Rockburst prevention Torpedo blasting Seismic effect Upper Silesian Coal Basin(USCB)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

引用

National Science Review 2024年第1期11卷 8-10页

作者： David j.Bottjer Department of Earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：